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Lung cancer risk in never-smokers:An overview of environmental and genetic factors

Chinese Journal of Cancer Research 2021年第5期33卷 548-562页

作者： Elvin S Cheng marianne weber Julia Steinberg Xue Qin Yu The Daffodil Centre the University of Sydneya joint venture with Cancer Council NSWSydneyNSW 2011Australia

Lung cancer is the leading cause of cancer-related mortality globally,accounting for 1.8 million deaths in *** the vast majority are caused by tobacco smoking,15%-25%of all lung cancer cases occur in lifelong *** International Agency for Research on Cancer(IARC)has classified multiple agents with sufficient evidence for lung carcinogenesis in humans,which include tobacco smoking,as well as several environmental exposures such as radon,second-hand tobacco smoke,outdoor air pollution,household combustion of coal and several occupational ***,the IARC evaluation had not been stratified based on smoking status,and notably lung cancer in never-smokers(LCINS)has different epidemiological,clinicopathologic and molecular characteristics from lung cancer in *** several risk factors proposed for the development of LCINS,environmental factors have the most available evidence for their association with LCINS and their roles cannot be ***,while initial genetic studies largely focused on lung cancer as a whole,recent studies have also identified genetic risk factors for *** article presents an overview of several environmental factors associated with LCINS,and some of the emerging evidence for genetic factors associated with *** increased understanding of the risk factors associated with LCINS not only helps to evaluate a never-smoker’s personal risk for lung cancer,but also has important public health implications for the prevention and early detection of the *** evidence on causal associations could inform longer-term policy reform in a range of areas including occupational health and safety,urban design,energy use and particle emissions,and the importance of considering the impacts of second-hand smoke in tobacco control policy.

关键词： Lung cancer never-smoker risk factor environmental factor genetic factor

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Widening socioeconomic disparity in lung cancer incidence among men in New South Wales, Australia, 1987–2011

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Chinese Journal of Cancer Research 2017年第5期29卷 395-401页

作者： Xue Qin Yu Qingwei Luo Clare Kahn Camilla Cahill marianne weber Paul Grogan Ahmedin Jemal Dianne L O'Connell Cancer Research Division Cancer Council NSW Sydney School of Public Health University of Sydney Sanofi Australia Cancer Council Australia Surveillance and Health Services Research American Cancer Society School of Medicine and Public Health University of Newcastle

Objective：We assessed the trends in lung cancer incidence over a 25-year period by socioeconomic groups for men in New South Wales（NSW）,***：Men diagnosed with lung cancer between 1987 and 2011 were divided into five quintiles according to an Index of Education and Occupation（IEO）.We assessed relative socioeconomic differences over time by calculating age-standardized incidence ratios（SIRs）by 5-year period of diagnosis,and estimated absolute differences by comparing the observed and expected numbers of cases using the highest IEO quintile as the ***：Lung cancer incidence for men decreased from 1987 to 2011 for all IEO quintiles,with a greater rate of decline for men living in the highest IEO ***,the relative disparity increased significantly over the 25-year period（P=0.0006）.For example,the SIR for the lowest IEO quintile increased from 1.28 during 1987–1991 to 1.74during 2007–*** differences also increased with the proportion of＂potentially preventable＂cases doubling from 14.5% in 1987–1991 to 30.2% in 2007–***：Despite the overall decline in lung cancer incidence among men in NSW over the past 25 years,there was a significant increase in disparity across socioeconomic areas in both relative and absolute terms.

关键词： Australia lung cancer socioeconomic inequality temporal trends tobacco control tobacco smoking

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Physics of porous materials under extreme laser-generated conditions

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Matter and Radiation at Extremes 2024年第3期9卷 1-3页

作者： V.T.Tikhonchuk S.weber Extreme Light Infrastructure ERIC ELI Beamlines Facility25241 DolníBrezanyCzech Republic CELIA University of Bordeaux33405 TalenceFrance

Porous materials offer unique possibilities for the production of plasmas with controlled density profiles for experiments on laser–matter *** are of growing relevance to many applications,such as inertial confinement fusion,fundamental research,and secondary *** the processes of transformation of a porous solid into a plasma is of fundamental interest and is needed for producing materials with desired properties.

关键词： interaction. properties. porous

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Dissociation cross sections ofψ(3770),ψ(4040),ψ(4160),andψ(4415)mesons with nucleons

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Communications in Theoretical Physics 2024年第4期76卷 93-112页

作者： Ruo-Qing Ding Xiao-Ming Xu H J weber Department of Physics Shanghai UniversityBaoshanShanghai 200444China Department of Physics University of VirginiaCharlottesvilleVA 22904United States of America

We study the dissociation of ψ(3770), ψ(4040), ψ(4160), and ψ(4415) mesons in collision with nucleons, which takes place in high-energy proton-nucleus collisions. The quark interchange between a nucleon and a ■ meson leads to the dissociation of the ■ meson. We consider the reactions:■, and■, where R stands for ψ(3770), ψ(4040), ψ(4160), or ψ(4415). A reaction of a neutron and a ■ meson corresponds to a reaction of a proton and the ■ meson by replacing the up quark with the down quark and vice versa. Transition-amplitude formulas are derived from the S-matrix *** cross sections are calculated with the transition amplitudes for scattering in the prior form and in the post form. The cross sections relate to nodes in the radial wave functions of ψ(3770), ψ(4040), ψ(4160), and ψ(4415) mesons.

关键词： inelastic nucleon-charmonium scattering quark interchange relativistic constituent quark potential model

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Collective coherent emission of electrons in strong laser fields and perspective for hard x-ray lasers

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Matter and Radiation at Extremes 2024年第2期9卷 1-3页

作者： E.G.Gelfer A.M.Fedotov O.Klimo S.weber Extreme Light Infrastructure ERIC ELI Beamlines Facility25241 Dolní BřežanyCzech Republic HiLASE Centre Institute of Physics of the Czech Academy of Sciences25241 Dolní BřežanyCzech Republic National Research Nuclear University MEPhI Moscow 115409Russia FNSPE Czech Technical University in Prague11519 PragueCzech Republic

Coherent motion of particles in a plasma can imprint itself on *** recent advent of high-power lasers—allowing the nonlinear inverse Compton-scattering regime to be reached—has opened the possibility of looking at collective effects in laser–plasma *** certain conditions,the collective interaction of many electrons with a laser pulse can generate coherent radiation in the hard x-ray *** perspective paper explains the limitations under which such a regime might be attained.

关键词： laser scattering coherent

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Microfluidic bubble-generator enables digital light processing 3D printing of porous structures

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Aggregate 2024年第1期5卷 280-291页

作者： Philipp weber Ling Cai Francisco Javier Aguilar Rojas Carlos Ezio Garciamendez-Mijares Maria Celeste Tirelli Francesco Nalin Jakub Jaroszewicz Wojciech Swi eszkowski Marco Costantini Yu Shrike Zhang Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMassachusettsUSA Institute of Physical Chemistry—Polish Academy of Sciences KasprzakaPoland Biomaterials Group Materials Design DivisionFaculty of Materials Science and EngineeringWarsaw University of TechnologyWoloskaPoland

Three-dimensional(3D)printing is an emerging technique that has shown promising success in engineering human tissues in recent *** development of vatphotopolymerization printing modalities has significantly enhanced the complexity level for 3D printing of various functional structures and ***,the development of microfluidic chip systems is an emerging research sector with promising medical *** work demonstrates the coupling of a digital light processing(DLP)printing procedure with a microfluidic chip system to produce size-tunable,3D-printable porosities with narrow pore size distributions within a gelatin methacryloyl(GelMA)hydrogel *** is found that the generation of size-tunable gas bubbles trapped within an aqueous GelMA hydrogel-precursor can be controlled with high ***,the porosities are printed in two-dimensional(2D)as well as in 3D using the DLP *** addition,the cytocompatibility of the printed porous scaffolds is investigated using fibroblasts,where high cell viabilities as well as cell proliferation,spreading,and migration are *** is anticipated that the strategy is widely applicable in a range of application areas such as tissue engineering and regenerative medicine,among others.

关键词： 3D printing biofabrication bubble digital light processing microfluidics porous

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Effect of Intrauterine Laser Therapy at the IVF Success Rate on Infertile Patients with a History of IVF Failure: A Pilot Non-Blinded Study

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Advances in Sexual Medicine 2024年第3期14卷 21-30页

作者： Fateme Hoseinzade Hatav Tehrani Shahriyar Mirshams Yasaman Zandi Mehran Michael Hans weber Department of Physical Medicine and Rehabilitation Isfahan University of Medical Sciences Isfahan Iran Department of Obstetrics and Gynecology Isfahan University of Medical Sciences Isfahan Iran Department of Physical Medicine and Rehabilitation Novin Comprehensive Physical Medicine Center Isfahan Iran Biomedical Engineering Center Dubai UAE International Society of Medical LASER Applications Lauenfoerde Germany

Backgrounds: While there’s developing proof aimed toward improving embryo implantation thru a focal point on great development, restrained studies have been performed on enhancing endometrial receptivity. Intrauterine Laser Therapy (LT) can be powerful in selling endometrial cell proliferation, therefore enhancing the achievement of assisted reproductive techniques (ART). The contemporary look at aimed to research the effectiveness of effective intrauterine lasers in growing endometrial thickness and the achievement of being pregnant rate. Materials and Methods: In the current clinical randomized trial (RTC) study, the infertile women (20 - 42 years old) referred to the infertility clinic in 2023-2024 who were candidates for IVF treatment with recurrent implantation failure (RIF) history were included. The patients were divided into two main groups: the intervention group;low level laser therapy (LLLT) after hormone administration) (n = 52) and the control group (hormone administration without LT) (n = 52). The IVF success rate and change in endometrial thickness before and after the LT were compared in groups. Results: There was a significant difference between groups (p Conclusion: It appears that the incorporation of Intrauterine LT in the realm of infertility could significantly impact as a novel supplementary treatment in improving endometrial receptivity and pregnancy rate.

关键词： Infertility IVF Implementation Intrauterine Low Level Laser Therapy

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2024年值得关注的5种ETF

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商业周刊（中文版） 2024年第2期 21-22页

作者： Joel weber 竹西(译) 不详

彭博行业研究(BI)高级分析师埃里克·巴尔丘纳斯(Eric Balchunas)带领其交易所交易基金(ETF)研究团队,对他们精选而出的全球24只基金再度精选,最终的名单缩减到下面几只。更多信息请收听彭博的Trillions播客。

关键词：埃里克分析师值得关注研究团队彭博

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Achievements and Challenges in European Energy Markets

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Journal of Modern Power Systems and Clean Energy 2023年第3期11卷 698-704页

作者： Christoph weber University of Duisburg-Essen EssenGermany IEEE

The European electricity and gas markets have been deregulated more than two decades *** rather diverse starting points,they have continuously evolved over the years to accommodate with new challenges and to improve *** 2005,these markets have been complemented by the market for emission certificates established by the European Union(EU)emission trading *** partly competing paradigms have thereby shaped the markets and continue to drive their on-going transformation:effective competition,subsidiarity and sustainability.

关键词： Electricity marker Europe carbon pricing market design deregulation decarbonization sustainable energy system

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Machine-learning assisted design principle search for singlet fission:an example study of cibalackrot

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npj Computational Materials 2022年第1期8卷 1703-1716页

作者： Fabian weber Hirotoshi Mori Department of Applied Chemistry Chuo University112-8551 Tokyo-toBunkyo-kuKasuga1-13-27Japan Department of Theoretical and Computational Molecular Science Institute for Molecular ScienceOkazaki444-8585Japan

This work uses quantum chemistry calculations and machine learning to explore design rules for singlet fission in a chemical space of four million indigoid *** identify~400,000 derivatives of 2,2′-diethenyl cibalackrot,which theoretically fulfil the energy conditions for exoergic singlet fission above the silicon band gap *** this database with a random forest classifier,we observe that small substituents with positive mesomeric effects and weak negative inductive effects reinforce the desired energetic conditions when placed at specific ***,a subset of molecules that reflects the random forest classifier’s rules are investigated for their quantum chemical properties to translate the desirable structural motifs into wavefunction-based design ***,direct correlations between the energetic condition for singlet fission,the biradical character and the charge and triplet spin density in prominent molecular regions are identified,providing insights that may serve as a guide for singlet fission core structure development.

关键词： singlet quantum classifier

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