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药学进展 1961年第Z1期 7-8页

作者： Shih Chu Jack E.har Henry G.Man 赵连昌

作者鉴于将氮芥类化合物中的双(β—氯乙基)胺基和抗疟药、氨基酸、甾醇类化合物等分子相联,可以增强其制癌效用;同时又根据“交链结合”的假說,于是合成了黄嘌吟、次黃嘌吟、腺嘌吟的8—双(β—氯乙基)胺基等衍生物。

关键词：氮芥类抗疟药氯乙基交链闭水气月于明

Orbital Floor Fractures: Epidemiological, Clinical and Therapeutical Study at Sylvanus Olympio University Teaching Hospital in Loméabout 51 Cases

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Open Journal of Stomatology 2021年第9期11卷 373-386页

作者： Saliou Adam Hamza Dolès Sama Yao Messanvi Akpoto haréfétéguéna Bissa Palakina Agoda Winga Foma Essobozou Plaoudézina Pegbessou Bathokédéou Amana Essohanam Boko Eyawèlohn Kpemissi Department of Stomatology and Maxillofacial Surgery Sylvanus Olympio University Teaching Hospital of Lomé Togo Department of ENT Sylvanus Olympio University Teaching Hospital of Lomé Togo Department of Anesthesia and Intensive Care Sylvanus Olympio University Togo Military Medical Department Sylvanus Olympio University Teaching Hospital of Lomé Togo Department of Stomatology Campus University Teaching Hospital of Lomé Togo Department of ENT Campus University Teaching Hospital of Lomé Togo

Introduction: Orbital floor fractures are a significant pathology among maxillofacial injuries. They can cause oculomotor, sensory, and sometimes esthetic disorders. The goal of this study was to determine the epidemiological profile of orbital floor fractures and show their clinical and therapeutic approach in Lomé. Patients and method: This was a descriptive retrospective study of orbital floor fractures collected in the ENT and maxillofacial surgery department of Sylvanus Olympio University Hospital in Lomé over 8 years (January 1, 2011 to December 31, 2018). Results: We reviewed 63 cases of orbital floor fractures out of 552 cases of facial trauma. According to the inclusion and non-inclusion criteria, we retained 51 cases. The hospital frequency of orbital floor fractures was 9.24% of facial fractures. The average age of the patients was 35 ± 10.34 years. Males were predominant (ratio = 7.5). The main etiology was road accidents (92.16%). Ophthalmological signs were dominated by vertical diplopia (31.37%), limited eye movement (25.49%), and enophthalmia (29.41%). The sensory sign was dominated by suborbital hypoesthesia (13.73%). Surgical treatment was performed in 86.27% of patients. The average intervention time was 17.84 ± 12.69 days after the trauma. The main approach was the subciliary route (65.91%). The surgical procedures consisted of muscle and fat removal (20.45%) and orbital floor repair by mesh plate (50%). The average length of hospitalization was 9.63 ± 5.23 days. Surgical site infection was the main postoperative complication observed in 3.92% of patients. The main sequelae were diplopia (4.55%), suborbital hypoesthesia (4.55%), and enophthalmos (4.55%). Conclusion: Orbital floor fractures are mainly due to road accidents. Management must be multidisciplinary and adequate in order to avoid irreversible functional and/or morphological sequelae. Their prevention consists of effecti

关键词： Orbital Floor Fracture Diplopia Facial Bone Road Accidents Lomé (Togo)

Labio-Jugal Squamous Cell Carcinoma on HIV Site: Surgical Excision and Reconstruction with a Musculocutaneous Flap of the Pectoralis Major: A Case Report

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Open Journal of Stomatology 2021年第11期11卷 460-466页

作者： Salio Adam Hamza Dolès Sama Essobozou Plaoudézina Pegbessou Yao Messanvi Akpoto Palakina Agoda Winga Foma haréfétéguéna Bissa Bathokédéou Amana Mohaman Awalou Djibril Essohanam Boko Eyawèlohn Kpemissi Department of Stomatology and Maxillofacial Surgery Sylvanus Olympio University Teaching Hospital of Lomé Togo Lomé Department of ENT Sylvanus Olympio University Teaching Hospital of Lomé Togo Lomé Department of Anesthesia and Intensive Care Sylvanus Olympio University Teaching Hospital of Lomé Togo Lomé Department of ENT Campus University Teaching Hospital of Lomé Togo Lomé Department of Military Medical Sylvanus Olympio University Teaching Hospital of Lomé Togo Lomé Department of Stomatology Campus University Teaching Hospital of Lomé Togo Lomé

Introduction: Malignant skin tumors are very frequent lesions, induced by sustained sun exposure. Cutaneous squamous cell carcinoma is a dangerous cancer of the skin. It’s more frequent in white people than black people. Squamous cell carcinomas sometimes pose a real problem of local reconstruction after their removal. Reconstructions may involve the production of regional pedunculated flaps to repair the loss of substance. We report the case of a labio-jugal squamous cell carcinoma in an HIV-positive patient. The excision of the tumor required repair by a musculocutaneous flap of the pectoralis major. The aim of this paper is to show the dangerousness of that cancer, the particularity of its location around the mouth. We also want to call for a reflection about the recurrence of that disease on HIV infection ground, despite correct resection. Clinical Case: This was a 47-year-old HIV-positive patient on antiretroviral therapy (ARVs), treated 23 years ago for pulmonary tuberculosis. He presented with an ulcerated lower lip wound extending to the right labial commissure, right cheek, and the right lateral third of the upper lip. This lesion had progressed for about 6 months without a tendency to spontaneous healing. There was no palpable lymphadenopathy, especially in the cervicofacial region. The biopsy of the lower labial lesion concluded that it was a differentiated, mature, infiltrating squamous cell carcinoma. The craniofacial CT scan did not note any regional tumor invasion. We indicated tumor excision, functional lymph node dissection, and reconstruction by a flap of the pectoralis major muscle. The operative procedure was performed under general anesthesia. The edge cuts after carcinoma removal were healthy. Three months later, the patient is seen again with a local right submandibular recurrence. Radiotherapy was offered to him. Discussion: Squamous cell carcinomas are frequent in sub-Saharan Africa with pre

关键词： Squamous Cell Carcinoma Labio-Jugal Pectoralis Major Flap HIV Site

从定期安全性更新报告过渡到定期受益-风险评价报告:初步经验和挑战

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中国药物警戒 2014年第4期11卷 210-215页

作者：张晓兰 Lester REICH 梁冰 Donald PUCCIO Craig har TFORD 辉瑞有限公司全球研发中心全球安全和注册事务部上海201203

人用药品注册技术要求国际协调会议(ICH)提供了定期安全性更新报告指南(PSUR,ICH E2C(R1))和新的定期受益-风险评价报告指南(PBRER,ICH E2C(R2))。PBRER由PSUR演变而来,实现了从比较传统的获批后药物警戒定期总结报告到现代定期受益-风... 详细信息

人用药品注册技术要求国际协调会议(ICH)提供了定期安全性更新报告指南(PSUR,ICH E2C(R1))和新的定期受益-风险评价报告指南(PBRER,ICH E2C(R2))。PBRER由PSUR演变而来,实现了从比较传统的获批后药物警戒定期总结报告到现代定期受益-风险评价总结报告的转变,根据累积信息对批准上市产品做出最新的受益-风险评价。通过总结ICH E2C PSUR指南和PBRER指南的主要区别,介绍了某跨国制药公司在由编写PSUR改为编写PBRER的转变过程中所积累的初步经验及其遇到的挑战,讨论了中国在推进药物警戒系统的背景下实行PBRER的可能性。

关键词：人用药品注册技术要求国际协调会议定期安全性更新报告药物警戒药品上市后监测

Synthesis,Spectroscopic Characterization,Thermogravimetric and Biological Activity Evaluation of Te(Ⅳ),Se(Ⅳ),V(Ⅲ),Nb(Ⅴ),Ta(Ⅴ)Complexes With Indole-3-Acetic Acid Plant Hormone Ligand

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光谱学与光谱分析 2021年第2期41卷 658-664页

作者： Jehan YAl-Humaidi Foziah AAl-Saif Dalal NB injawhar Hanan ABakhsh Moamen SRefat Department of Chemistry College of SciencePrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia Department of Chemistry Faculty of ScienceTaif UniversityAl-Haweiah21974TaifSaudi Arabia

Te(Ⅳ),Se(Ⅳ),V(Ⅲ),Nb(Ⅴ)and Ta(Ⅴ)complexes of indole-3-acetic acid(IAAH)ligand were synthesized,characterized by elemental analysis and various spectroscopic techniques like,IR,1H-NMR,X-ray powder diffraction,UV-Visible,thermogravimetry analysis,magnetic measurements,molar conductance and surface morphology using *** the synthesized complexes of IAAH ligand have 1∶2 stoichiometry of the types[Te(IAA)2(NH 3)2]·2Cl(Ⅰ),[Se(IAA)2(NH 3)2]·2Cl(Ⅱ),[V(IAA)2(NH 3)(Cl)](Ⅲ),[Nb(IAA)2(Cl)3](Ⅳ),and[Ta(IAA)2(Cl)3](Ⅴ).Spectral analysis indicates octahedral geometry for the Te(Ⅳ),Se(Ⅳ)and V(Ⅲ)complexes,whereas both Nb(Ⅴ)and Ta(Ⅴ)have a *** bonding sites are the oxygen atoms of carboxylate group for the deprotonated indole-3-acetic acid(IAA)*** thermogravimetry analysis studies gave evidence for the presence of other coordinated molecules(Cl or NH 3)in the composition of IAA complexes,which were further supported by IR and micro analytical *** higher molar conductance data of tellurium and selenium(Ⅳ)complexes reveal that these chelates are electrolytes,while low conductivity values for the vanadium(Ⅲ),niobium and tantalum(Ⅴ)chelates indicated a *** test the antibacterial property of the five complexes in this study,four bacterial strains Klebsiella(G-),Escherichia coli(G-),Staphylococcus aureus(G+)and Staphylococcus epidermidis(G+)were used in the *** effects of the five complexes in the cytotoxicity of Caco-2 and Mcf-7 human cancer cell lines were studied Neutral red uptake assay for the estimation of cell viability/cytotoxicity protocol.

关键词： Indole-3-acetic acid chelation IR Metal ions TEM Antimicrobial test

Naso-Labio-Palatine Clefts: Humanitarian Care in Togo

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Open Journal of Stomatology 2021年第10期11卷 411-421页

作者： Saliou Adam Hamza Dolès Sama Winga Foma haréfétéguéna Bissa Palakina Agoda Bina Béténora Essobozou Plaoudézina Pegbessou Bathokédéou Amana Essohanam Boko Mohaman Awalou Djibril Eyawèlohn Kpemissi Department of Stomatology and Maxillofacial Surgery at Sylvanus Olympio University Teaching Hospital of Lomé Lomé Togo Department of ENT at Sylvanus Olympio University Teaching Hospital of Lomé Lomé Togo Department of Anesthesia and Intensive Care at Sylvanus Olympio University Lomé Togo Department of Stomatology at Campus University Teaching Hospital of Lomé Teaching Hospital of Lomé Lomé Togo Department of ENT at Campus University Teaching Hospital of Lomé Lomé Togo Military Medical Department at Sylvanus Olympio University Teaching Hospital of Lomé Lomé Togo

Introduction: The management of nasolabial-palatal clefts in precarious environments is one of the topics most addressed by many humanitarian missions, especially in Africa and Asia. The aim of our study was to propose a humanitarian and not expensive care to the patients presenting with facial clefts during the fairgrounds in disadvantaged areas. Patients and Method: We carried out a prospective study on 32 patients who were operated with very limited means during the mobile clinics inside Togo during the year 2013. These patients were followed over a period of one year after their surgery. Included in our series were native patients with facial clefts, who had no means of managing their condition, and who therefore needed humanitarian support. We have reported the clinical history of some patients to illustrate our results. Results: Our study included 32 children, including 15 boys and 17 girls, with a sex ratio of around 1. The average age of patients was 5 years, with extremes of 6 months and 13 years. We performed 13 clefts (including 12 unilateral clefts and 1 bilateral cleft), 17 clefts palate (including 12 unilateral clefts and 5 bilateral clefts), and 2 velar clefts. We described the clinical history of a few patients in this humanitarian setting and showed the surgical results obtained.

关键词： Nasolabial-Palatal Clefts Humanitarian Care Togo

“泛谋略化”与“去诗心化”:以谋略学为中心的《三国演义》应用研究的理论误区

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湖北师范大学学报（哲学社会科学版） 2019年第3期39卷 15-19页

作者：鲁小俊哈亭羽武汉大学文学院

以谋略学为中心的《三国演义》应用研究确有其学术价值,但我们仍应警惕它的理论误区,即“泛谋略化”和“去诗心化”。过多地以“谋略”之眼看待《三国演义》,小说的“诗心”易被遮蔽,甚至消磨殆尽。应用研究的本质是追求成功、避免失败... 详细信息

以谋略学为中心的《三国演义》应用研究确有其学术价值,但我们仍应警惕它的理论误区,即“泛谋略化”和“去诗心化”。过多地以“谋略”之眼看待《三国演义》,小说的“诗心”易被遮蔽,甚至消磨殆尽。应用研究的本质是追求成功、避免失败,而就总体而言,《三国演义》偏偏不以成败论英雄。

关键词：《三国演义》应用研究理论误区

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实施过程评估量表的汉化及信效度检验

护理学杂志 2022年第17期37卷 94-97页

作者：周禹君王青王艳 Miriam hartveit 韩琳兰州大学护理学院循证护理中心甘肃兰州730000 Department of Global Public Health and Primary Care University of Bergen 甘肃省人民医院护理部

目的汉化英文版实施过程评估量表并检验其信效度,为测量新型卫生技术或干预措施在临床实施过程中的促进与阻碍因素提供评价工具。方法基于Brislin翻译模型对实施过程评估量表进行翻译和回译,采用专家咨询及预试验对中文版量表进行初... 详细信息

目的汉化英文版实施过程评估量表并检验其信效度,为测量新型卫生技术或干预措施在临床实施过程中的促进与阻碍因素提供评价工具。方法基于Brislin翻译模型对实施过程评估量表进行翻译和回译,采用专家咨询及预试验对中文版量表进行初步检验;选取506名临床护士进行信效度验证。结果中文版实施过程评估量表包含4个维度共26个条目,4个公因子累积方差贡献率为71.284%,量表结构模型适配指标的χ^(2)/df=2.424,RMSEA=0.075,CFI=0.939,TLI=0.932。量表的I-CVI为0.833~1.000,S-CVI/Ave为0.903,Cronbach′sα系数为0.959,重测信度为0.898。结论中文版实施过程评估量表具有良好的信效度,可用于评估护士应用新型卫生技术或干预措施的促进和阻碍因素。

关键词：护士实施过程评估量表实施科学信度效度促进因素阻碍因素评价工具循证护理

鲜食葡萄的二氧化硫薰蒸处理:果实和包装对二氧化硫的相对吸附、二氧化硫残留、葡萄腐败及漂白伤害

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中国果品研究 1989年第3期9卷 27-30,33页

作者： John M.harvey C.Max har ris Thomas A.Hanke Preston L.Hasrtsell 张光弟

包装材料对薰蒸剂的吸附,早已被认为是确定薰蒸处理效果的一个重要因素。用二溴乙烯处理柑桔,溴甲烷或二氧化硫处理葡萄,都可表现出包装吸附对薰蒸效果的影响。

关键词：鲜食葡萄葡萄品种薰蒸二溴乙烯处理效果二氧化硫含量牛皮纸浆箱型结合型箱纸板

大豆生殖生长阶段与产量及种子质量的相关研究(英文)

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大豆科学 1999年第2期18卷 130-133页

作者： Pham thi Dao1hari har Ram2 (1 The Food Crop Research Center, Phu do, Me tri, Tu liem,Hanoi, Vietnam2 Professor and Head, Vegetable Science, G.B.P.U.A&T, Pantnagar, India.)

本试验的目的是明确：（１）株型对各生殖生长阶段长度的影响；（２）各生殖生长阶段长度的遗传力及其与产量和种子质量的相关。试验用２５个生育期不同的品种于１９９２和１９９３年的雨季进行。除Ｒ１－Ｒ２期外，株型不影响其它生殖... 详细信息

本试验的目的是明确：（１）株型对各生殖生长阶段长度的影响；（２）各生殖生长阶段长度的遗传力及其与产量和种子质量的相关。试验用２５个生育期不同的品种于１９９２和１９９３年的雨季进行。除Ｒ１－Ｒ２期外，株型不影响其它生殖生长阶段长度。所有生殖生长阶段长度的遗传力都较高（＞０．７４）。鼓粒期（Ｒ２－Ｒ７）长度与种子寿命呈不显著负相关，与种子产量及种子大小呈不显著正相关。总生殖生长期长度可作为选择长鼓粒期品系的初始选择指标。种子寿命与开花前日数间存在显著的正相关。

关键词：大豆生殖生长阶段产量种子质量