检索结果-南通市图书馆

World Journal of Gastrointestinal Surgery 2024年第9期16卷 2774-2777页

作者： Marco Bocchetti Gabriella Misso Silvia Zappavigna marianna Scrima Michele Caraglia Francesca Pentimalli Alessia Maria Cossu Department of Precision Medicine University of Campania“Luigi Vanvitelli”Naples 80138Italy Department of Molecular and Precision Oncology Biogem ScarlInstitute of Genetic ResearchAriano Irpino 83031Italy Department of Medicine and Surgery LUM University Giuseppe De GennaroCasamassima 70010Italy

The recently published study by Duan et al introduces a promising method that combines genomic instability and long non-coding RNAs to improve the prognostic evaluation of hepatocellular carcinoma(HCC),a deadly cancer associated with considerable morbidity and *** editorial aims to analyze the methodology,key findings,and broader implications of the study within the fields of gastroenterology and oncological surgery,highlighting the shift towards precision medicine in the management of HCC.

关键词： Genomic instability Long non-coding RNA Hepatocellular carcinoma Prognosis

Storylines of family medicine Ⅻ:family medicine and the healthcare system

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Family Medicine and Community Health 2024年第S3期12卷 109-118页

作者： William B Ventres Leslie A Stone Jeannette E South-Paul Kendall M Campbell Aerial R Petty Hima Ekanadham Kurt C Stange Rebecca S Etz William L Miller Robert L Ferrer marianna Kong Thomas Bodenheimer Roger Strasser Sharon C M Reece Joshua Freeman John M Westfall Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Meharry Medical College NashvilleTennesseeUSA Family Medicine University of Texas Medical Branch at Galveston School of MedicineGalvestonTexasUSA Family Medicine Residency Program New York-Presbyterian Columbia University Medical CenterNew YorkNew YorkUSA Center for Family and Community Medicine Columbia University Vagelos College of Physicians and SurgeonsNew YorkNew YorkUSA Center for Community Health Integration Case Western Reserve University School of MedicineClevelandOhioUSA Family Medicine and Population Health Virginia Commonwealth University School of MedicineRichmondVirginiaUSA Family Medicine Lehigh Valley Health NetworkAllentownPennsylvaniaUSA University of South Florida Morsani College of Medicine TampaFloridaUSA Family and Community Medicine UT Health San Antonio Long School of MedicineSan AntonioTexasUSA Family and Community Medicine University of California San Francisco School of MedicineSan FranciscoCaliforniaUSA Northern Ontario School of Medicine University SudburyOntarioCanada Family Medicine Baylor Scott and White HealthTempleTexasUSA Family Medicine University of Kansas School of MedicineKansas CityKansasUSA DARTNet Insitute AuroraColoradoUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine,as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅻ:Family medicine and the future of the healthcare system’,authors address the following themes:‘Leadership in family medicine’,‘Becoming an academic family physician’,‘Advocare—our call to act’,‘The paradox of primary care and three simple rules’,‘The quadruple aim—melding the patient and the health system’,‘Fit-for-purpose medical workforce’,‘Universal healthcare—coverage for all’,‘The futures of family medicine’and‘The 100th essay.’May readers of these essays feel empowered to be part of family medicine’s exciting future.

关键词： system illustration family

Rare case of cryptogenic brain abscess caused by Raoultella ornithinolityca

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2017年第7期5卷 299-302页

作者： marianna Luongo Department of Neurosurgery San Carlo Hospital

Cerebral abscess is a potentially fatal neurosurgical condition,despite improvements in technology,new antimicrobial agents and modern neurosurgical instruments and techniques.I report the case of a 64-yearold woman,affected by a right frontobasal brain abscess,compressing the homolateral frontal horn of lateral ventricle,with a second mass partially occupying the right orbital *** presented also with inflammatory sinusopathy involving the right maxillary,ethmoid and frontal *** 14 d of clinical observation and antimicrobial therapy,the patient received a computed tomography scan,which showed growth of the cerebral mass,with a ring of peripheral contrast enhancement and surrounding *** promptly underwent neurosurgical treatment and recovered well,except for the sight in her right eye,which remained compromised,as before the *** is believed to be the first case of cryptogenic cerebral abscess caused by Raoultella ornithinolityca isolated from the brain,with more than 1-year follow-up.

关键词： Brain abscess Headache Raoultel a ornithinolityca Visual loss

The intricacies of neurotrophic factor therapy for retinal ganglion cell rescue in glaucoma: a case for gene therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2016年第6期11卷 875-877页

作者： marianna Foldvari Ding Wen Chen School of Pharmacy Waterloo Institute of Nanotechnology and Center for Bioengineering and Biotechnology University of Waterloo

Regeneration of damaged retinal ganglion cells（RGC） and their axons is an important aspect of reversing vision loss in glaucoma patients. While current therapies can effectively lower intraocular pressure, they do not provide extrinsic support to RGCs to actively aid in their protection and regeneration. The unmet need could be addressed by neurotrophic factor gene therapy, where plasmid DNA, encoding neurotrophic factors, is delivered to retinal cells to maintain sufficient levels of neurotrophins in the retina. In this review, we aim to describe the intricacies in the design of the therapy including： the choice of neurotrophic factor, the site and route of administration and target cell populations for gene delivery. Furthermore, we also discuss the challenges currently being faced in RGC-related therapy development with special considerations to the existence of multiple RGC subtypes and the lack of efficient and representative in vitro models for rapid and reliable screening in the drug development process.

关键词： neurotrophic glaucoma ganglion RGCs retina intraocular Regeneration administration representative populations

Damage detection with image processing: a comparative study

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Earthquake Engineering and Engineering Vibration 2023年第2期22卷 333-345页

作者： marianna Crognale Melissa De Iuliis Cecilia Rinaldi Vincenzo Gattulli Department of Structural and Geotechnical Engineering Sapienza University of Romevia Eudossiana 18Rome 00167Italy

Large structures,such as bridges,highways,etc.,need to be inspected to evaluate their actual physical and functional condition,to predict future conditions,and to help decision makers allocating maintenance and rehabilitation *** assessment of civil infrastructure condition is carried out through information obtained by inspection and/or monitoring *** techniques in structural health monitoring(SHM)involve visual inspection related to inspection standards that can be time-consuming data collection,expensive,labor intensive,and *** address these limitations,machine vision-based inspection procedures have increasingly been investigated within the research *** this context,this paper proposes and compares four different computer vision procedures to identify damage by image processing:Otsu method thresholding,Markov random fields segmentation,RGB color detection technique,and K-means clustering *** first method is based on segmentation by thresholding that returns a binary image from a grayscale *** Markov random fields technique uses a probabilistic approach to assign labels to model the spatial dependencies in image *** RGB technique uses color detection to evaluate the defect ***,K-means algorithm is based on Euclidean distance for clustering of the *** benefits and limitations of each technique are discussed,and the challenges of using the techniques are *** show the effectiveness of the described techniques in damage detection of civil infrastructures,a case study is *** show that various types of corrosion and cracks can be detected by image processing techniques making the proposed techniques a suitable tool for the prediction of the damage evolution in civil infrastructures.

关键词： damage detection image processing image classification civil infrastructure inspection structural health monitoring analysis

Nonalcoholic fatty liver disease and vascular disease:State-of-the-art

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第37期20卷 13306-13324页

作者： Silvia Fargion marianna Porzio Anna Ludovica Fracanzani Department of Pathophysiology and Transplantation Metabolic Liver Diseases Research CenterCa’ Granda IRCCS FoundationPoliclinico Hospital Pad Granelli

Nonalcoholic fatty liver disease(NAFLD), the most common of chronic liver disease in Western Country, is closely related to insulin resistance and oxidative stress and includes a wide spectrum of liver diseases ranging from steatosis alone, usually a benign and non-progressive condition, to nonalcoholic steatohepatitis(NASH), which may progress to liver fibrosis and cirrhosis. NAFLD is considered the hepatic manifestation of the metabolic syndrome with which shares several characteristics, however recent data suggest that NAFLD is linked to increased cardiovascular risk independently of the broad spectrum of risk factors of metabolic syndrome. Accumulating evidence suggests that the clinical burden of NAFLD is not restricted to liver-related morbidity and mortality, with the majority of deaths in NAFLD patients related to cardiovascular disease and cancer and not to the progression of liver disease. Retrospective and prospective studies provide evidence of a strong association between NAFLD and subclinical manifestation of atherosclerosis(increased intima-media thickness, endothelial dysfunction, arterial stiffness, impaired left ventricular function and coronary calcification). A general agreement emerging from these studies indicates that patients with NASH are at higher risk of cardiovascular diseases than those with simple steatosis, emphasizing the role of chronic inflammation in the pathogenesis of atherosclerosis of these patients. It is very likely that the different mechanisms involved in the pathogenesis of atherosclerosis in patients with NAFLD have a different relevance in the patients according to individual genetic background. In conclusion, in the presence of NAFLD patients should undergo a complete cardiovascular evaluation to prevent future atherosclerotic complications. Specific lifestyle modification and aggressive pharmaceutical modification will not only reduce the progression of liver disease, but also reduce morbidity for cardiovascular diseas

关键词： Intima-media thickness Steatosis Nonalcoholic fatty liver disease Non-alcoholic steatohepatitis Early atherosclerosis Cardiovascular risk Inflammation Epicardic fat

Cultivating Pleurotus ostreatus and Pleurotus eryngii mushroom strains onagro-industrial residues in solid-state fermentation. Part II: Effect onproductivity and quality of carposomes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Carbon Resources Conversion 2022年第1期5卷 52-60页

作者： Eirini-Maria Melanouri marianna Dedousi Panagiota Diamantopoulou Laboratory of Edible Fungi Institute of Technology of Agricultural ProductsHellenic Agricultural Organization-Demeter1 S.Venizelou Street14123 LykovrysiAttiki Greece

The potential of selected Pleurotus ostreatus and P. eryngii wild-type and commercial strains to colonize andproduce carposomes after solid-state fermentation of five substrates constituted of agro-residues namely wheatstraw (WS), beech wood shavings (BWS), coffee residue (CR), barley and oats straw (BOS), rice bark (RB),supplemented with wheat bran was investigated. The effect of substrate composition on bioprocess feasibilitywas assessed for the different strains by quantitative (i.e., mushroom yield and Biological Efficiency-BE %) andcarposome qualitative parameters (i.e., weight, size, colour, firmness). P. ostreatus strains produced carposomesearlier than P. eryngii ones. Early fruiting formation was promoted in WS for P. ostreatus strains, whereas forP. eryngii the lowest values of earliness were observed on BOS substrate. As for crop productivity, P. ostreatusstrain AMRL 150 provided the highest BE (>70%) in all substrates except for RB, while P. ostreatus strain AMRL144 achieved the highest yield and BE in BOS and BWS (75.30 and 64.26%, respectively). P. eryngii stainsproduced less number but heavier carposomes. The highest values of BE% for these strains were recorded on WSand BOS substrates. The BE was further correlated to growth parameters of fungal vegetative phase. As formushroom colour, P. ostreatus were lighter than P. eryngii and BOS substrate promoted lightness in both *** P. ostreatus mushrooms were produced at CR. No differences in the whiteness and firmness were detectedamong P. eryngii mushrooms and at any substrate used. The data included in this paper showed that Pleurotusmushrooms can be cultivated on low- or zero-value agro-industrial residues of great financial and environmentalimportance towards the production of value-added food products.

关键词： Oyster mushrooms Biological efficiency Carposomes Pileus Stipe Colour Texture

Carposome productivity of Pleurotus ostreatus and Pleurotus eryngii growing on agro-industrial residues enriched with nitrogen,calcium salts and oils

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Carbon Resources Conversion 2023年第2期6卷 150-165页

作者： marianna Dedousi Eirini-Maria Melanouri Panagiota Diamantopoulou Laboratory of Edible Fungi Institute of Technology of Agricultural Products(ITAP)Hellenic Agricultural Organization-Dimitra1 S.Venizelou Str14123 LykovryssiGreece Laboratory of Food Microbiology and Biotechnology Department of Food Science and NutritionAgricultural University of Athens75 Iera Odos Str11855 AthensGreece

The suitability of the abundant agro-industrial residues wheat straw(WS;control),barley and oats straw(BOS)and rice husk(RH),supplemented with various sources of oils(sunflower,corn oil),nitrogen(peptone,yeast extract)and calcium salts(CaSO_(4)⋅2H_(2)O,CaCl2),as novel substrates in solid-state fermentation of selected Pleurotus ostreatus and *** mushrooms was *** possible effect of different additives on mycelial growth rate,biomass production and endoglucanase,laccase and lipase biosynthesis were ***,their impact on essential cultivation aspects(earliness,total mushroom yield,biological efficiency)and carposome quality parameters(weight,morphological characteristics)was *** fungi showed their highest growth rates on BOS substrates and the most positive implementation was CaSO_(4)⋅2H_(2)O 6%w/w(Kr=9.58 mm/day;***,Kr=9.42 mm/day;***),while different additives led to enhancement of biomass *** species demonstrated minimal levels of endoglucanase activity,with values ranging from 0.01 to 0.42 U/g of dry weight,regardless of the substrate and the stage of *** the contrary,the maximum values of laccase activity were observed at 50%of colonization on BOS and RH,while supplementation with nitrogen and calcium sources positively affected its *** and *** cultivated on BOS supplemented with peptone at 2 and 5%w/w,synthesized significant laccase amounts,i.e.,12,165.78 and 8,624.55 U/g d.w.,*** amounts of lipase were produced,especially in substrates supplemented with sunflower 2%w/w,in quantities up to 1.42 U/g d.w.,whereas the highest lipase activity was achieved by *** on WS supplemented with corn oil at 2%w/w,with a value of 4.25 U/g *** *** fermentation of Pleurotus species in polypropylene bags,WS and BOS supported faster colonization and shorter earliness period than RH substrates,whereas supplementation did no

关键词： Oyster mushrooms Residues Additives Biomass Endoglucanase Laccase Lipase Weight

HBV-HCV Coinfection: Viral Interactions, Management, and Viral Reactivation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2018年第3期6卷 296-305页

作者： marianna G.Mavilia George Y.Wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Hepatitis B virus(HBV)and hepatitis C virus(HCV)coinfec-tion is a complex clinical entity that has an estimated world-wide prevalence of 1–15%.Most clinical studies have shown that progression of disease is faster in HBV-HCV coinfected patients compared to those with ***-lular carcinoma development appears to have higher rate in *** replication in coinfected cells is character-ized by a dominance of HCV over HBV *** are no established guidelines for treatment of HBV-HCV *** on interferon-based therapies and direct-acting antivirals have shown varying levels of *** reports have indicated that treatment of HCV without sup-pression of HBV increases the risk for HBV *** this review,we appraise studies on both direct-acting antivirals and interferon-based therapies to evaluate the efficacy and rates of reactivation with each *** for and prevention of coinfection are important to prevent serious HBV reactivations.

关键词： Hepatitis B virus Hepatitis C virus Coinfection Viral reactivation

Functionalization of nitrogen-doped graphene quantum dot:A sustainable carbon-based catalyst for the production of cyclic carbonate from epoxide and CO_(2)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2023年第4期126卷 408-422页

作者： Zahra Eshaghi Gorji Abbas Ali Khodadadi Siavash Riahi Timo Repo Yadollah Mortazavi marianna Kemell Catalysis and Nanostructured Materials Research Laboratory School of Chemical EngineeringCollege of EngineeringUniversity of TehranTehran ***Iran Department of Chemistry University of HelsinkiHelsinki 00014Finland Institute of Petroleum Engineering School of Chemical EngineeringCollege of EngineeringUniversity of TehranTehran ***Iran

A series of organic compounds were successfully immobilized on an N-doped graphene quantum dot (N-GQD) to prepare a multifunctional organocatalyst for coupling reaction between CO_(2)and propylene oxide (PO).The simultaneous presence of halide ions in conjunction with acidic-and basic-functional groups on the surface of the nanoparticles makes them highly active for the production of propylene carbonate (PC).The effects of variables such as catalyst loading,reaction temperature,and structure of substituents are *** proposed catalysts were characterized by different techniques,including Fourier transform infrared spectroscopy (FTIR),field emission scanning electron microscopy/energy dispersive X-ray microanalysis (FESEM/EDX),thermogravimetric analysis (TGA),elemental analysis,atomic force microscopy (AFM),and ultraviolet–visible (UV-Vis) *** optimal reaction conditions,3-bromopropionic acid (BPA) immobilized on N-GQD showed a remarkable activity,affording the highest yield of 98%at 140℃ and 106Pa without any co-catalyst or *** new metal-free catalysts have the advantage of easy separation and reuse several *** on the experimental data,a plausible reaction mechanism is suggested,where the hydrogen bonding donors and halogen ion can activate the epoxide,and amine functional groups play a vital role in CO_(2)adsorption.

关键词： Heterogeneous organocatalyst CO_(2) Propylene carbonate N-doped graphene quantum dot Nanomaterials