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New avenues for the treatment of immunotherapy-resistant pancreatic cancer

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1134-1153页

作者： Luis Guilherme de Oliveira silva Fabian Fellipe Bueno Lemos Marcel silva Luz samuel Luca Rocha Pinheiro mariana dos sant.s calmon Gabriel Lima Correa sant.s Gabriel Reis Rocha Fabrício Freire de Melo Instituto Multidisciplinar em saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Pancreatic cancer(PC)is characterized by its extremely aggressive nature and ranks 14th in the number of new cancer cases ***,due to its complexity,it ranks 7th in the list of the most lethal cancers *** pathogenesis of PC involves several complex processes,including familial genetic factors associated with risk factors such as obesity,diabetes mellitus,chronic pancreatitis,and *** in genes such as KRAs,TP53,and sMAD4 are linked to the appearance of malignant cells that generate pancreatic lesions and,consequently,*** this context,some therapies are used for PC,one of which is immunotherapy,which is extremely promising in various other types of cancer but has shown little response in the treatment of PC due to various resistance mechanisms that contribute to a drop in immunotherapy *** is therefore clear that the tumor microenvironment(TME)has a huge impact on the resistance process,since cellular and non-cellular elements create an immunosuppressive environment,characterized by a dense desmoplastic stroma with cancerassociated fibroblasts,pancreatic stellate cells,extracellular matrix,and immunosuppressive *** to this are genetic mutations in TP53 and immunosuppressive factors that act on T cells,resulting in a shortage of CD8+T cells and limited expression of activation markers such as *** this way,finding new strategies that make it possible to manipulate resistance mechanisms is ***,techniques such as the use of TME modulators that block receptors and stromal molecules that generate resistance,the use of genetic manipulation in specific regions,such as microRNAs,the modulation of extrinsic and intrinsic factors associated with T cells,and,above all,therapeutic models that combine these modulation techniques constitute the promising future of PC ***,this study aims to elucidate the main mechanisms of resistance to immunotherapy in PC and new ways of manipulating thi

关键词： Pancreatic cancer Immunotherapy Resistance Tumor microenvironment manipulation Combined immunotherapy

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Urea breath test for Helicobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy

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World Journal of Gastroenterology 2024年第6期30卷 579-598页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Marcel silva Luz Gabriel Reis Rocha Gabriel Lima Correa sant.s Luís Guilherme de Oliveira silva mariana sant.s calmon Cláudio Lima souza Ana Carla Zarpelon-schutz Kádima Nayara Teixeira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Instituto de saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919-899ParanáBrazil Laboratory of Research in Bacteriology UFMGBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Helicobacter pylori(***)infection has been well-established as a significant risk factor for several gastrointestinal *** urea breath test(UBT)has emerged as a leading non-invasive method for detecting *** numerous studies confirming its substantial accuracy,the reliability of UBT results is often compromised by inherent *** findings underscore the need for a rigorous statistical synthesis to clarify and reconcile the diagnostic accuracy of the UBT for the diagnosis of *** *** To determine and compare the diagnostic accuracy of 13C-UBT and 14C-UBT for *** infection in adult patients with *** We conducted an independent search of the PubMed/MEDLINE,EMBAsE,and Cochrane Central databases until April *** search included diagnostic accuracy studies that evaluated at least one of the index tests(^(13)C-UBT or ^(14)C-UBT)against a reference *** used the QUADAs-2 tool to assess the methodo-logical quality of the *** utilized the bivariate random-effects model to calculate sensitivity,specificity,positive and negative test likelihood ratios(LR+and LR-),as well as the diagnostic odds ratio(DOR),and their 95%confidence *** conducted subgroup analyses based on urea dosing,time after urea administration,and assessment *** investigate a possible threshold effect,we conducted spearman correlation analysis,and we generated summary receiver operating characteristic(sROC)curves to assess ***,we visually inspected a funnel plot and used Egger’s test to evaluate publication *** both as reliable diagnostic tools in clinical *** In summary,our study has demonstrated that ^(13)C-UBT has been found to outperform the ^(14)C-UBT,making it the preferred diagnostic ***,our results emphasize the significance of carefully considering urea dosage,assessment timing,and measurement techniques for both tests to enh

关键词： Helicobacter pylori Urea breath test Diagnosis Diagnostic test accuracy Meta-analysis

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Immune pathway through endometriosis to ovarian cancer

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World Journal of Clinical Oncology 2024年第4期15卷 496-522页

作者： mariana sant.s calmon Fabian Fellipe Bueno Lemos Marcel silva Luz samuel Luca Rocha Pinheiro Luis Guilherme de Oliveira silva Gabriel Lima Correa sant.s Gabriel Reis Rocha Fabrício Freire de Melo Instituto Multidisciplinar em saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Endometriosis is an estrogen-dependent inflammatory disease,defined by the presence of functional endometrial tissue outside of the uterine *** disease is one of the main gynecological diseases,affecting around 10%-15%women and girls of reproductive age,being a common gynecologic *** endometriosis is a benign disease,it shares several characteristics with invasive *** support that it has been linked with an increased chance of developing endometrial ovarian cancer,representing an earlier stage of neoplastic *** is particularly true for women with clear cell carcinoma,low-grade serous carcinoma and ***,the carcinogenic pathways between both pathologies remain poorly *** studies suggest a connection between endometriosis and endometriosis-associated ovarian cancers(EAOCs)via pathways associated with oxidative stress,inflammation,and *** article aims to review current data on the molecular events linked to the development of EAOCs from endometriosis,specifically focusing on the complex relationship between the immune response to endometriosis and cancer,including the molecular mechanisms and their *** recent developments in immunotherapy and their potential to boost the effectiveness of future treatments.

关键词： Ovarian neoplasms Endometriosis Endometriosis-associated ovarian cancers Immune response Immunotherapy

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Forensic data management and database systems in forensic investigations for cases of missing and unidentified persons in Brazil

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Forensic sciences Research 2022年第4期7卷 599-608页

作者： Melina calmon Grupo de Pesquisa em Antropologia Forense e Identificação de Pessoas Academia Nacional de Polícia-Polícia Federal do BrasilBrasiliaBrazil

Forensic investigations,especially those related to missing persons and unidentified remains,produce different types of data that must be managed and *** data collected and produced are extensive and originate from various sources:the police,non-governmental organizations(NGOs),medical examiner offices,specialised forensic teams,family members,and *** examples of information include,but are not limited to,the investigative background information,excavation data of burial sites,antemortem data on missing persons,and postmortem data on the remains of unidentified *** complex data must be stored in a secured place,analysed,compared,shared,and then reported to the investigative actors and the public,especially the families of missing persons,who should be kept informed of the ***,a data management system with the capability of performing the tasks relevant to the goals of the investigation and the identification of an individual,while respecting the deceased and their families,is critical for standardising *** management is crucial to assure the quality of investigative processes,and it must be recognised as a holistic integrated *** aim of this article is to discuss some of the most important components of an effective forensic data management *** discussion is enriched by examples,challenges,and lessons learned from the erratic development and launching of databases for missing and unidentified persons in *** main objective of this article is to bring attention to the urgent need for an effective and integrated system in Brazil.

关键词： Forensic sciences forensic data management database missing persons unidentified persons Brazil

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soil organic carbon storage in forest restoration models and environmental conditions

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Journal of Forestry Research 2022年第4期33卷 1123-1134页

作者： Ranieri Ribeiro Paula Miguel calmon Maria Leonor Lopes-Assad Eduardo de sáMendonça Departamento de Agronomia Programa de Pós-Graduação em Produção VegetalUniversidade Federal do Espírito SantoAlto UniversitárioGuararemaAlegreEspírito Santo CEP 29500-000Brazil World Resources Institute SalvadorBahia CEP 40290-040Brazil Departamento de Recursos Naturais e Proteção Ambiental Universidade Federal de São CarlosArarasSão Paulo CEP 13600-970Brazil

The scale of forest and landscape restoration is expected to increase during the UN Decade on Ecosystem Restoration and its contribution to the provision of critical ecosystem services to *** models of forest restoration may improve ecosystem services,including soil organic carbon(sOC)storage.A review was carried out to access:(1)the variability of sOC storage between worldwide forest restoration models and,(2)the effects of climate,soil class,soil texture,and vegetation type on sOC *** reviewed 119 primary studies with information on sOC and soil texture for different forest restoration *** restoration models were grouped into four categories:natural regeneration,monocultures,agroforestry,and mixed *** data was extracted from these four restoration models,other land uses(cropland,bare land,grassland,and natural forest),climate regimes,and soil *** sOC storage in the forest restoration models and other land uses at a global scale ranged between 0.1 to 514 Mg ha^(-1).The overall mean value for sOC storage was higher for natural regeneration(112 Mg ha^(-1)),followed by agroforestry(74 Mg ha^(-1)),mixed forest(73 Mg ha^(-1)),and monocultures(68 Mg ha^(-1)).However,the average sOC storage was similar among the four restoration models in the moist warm climate *** sOC storage mean value in the moist cool zone was 23%higher than the dry cool zone(81 and 62 Mg ha^(-1),respectively),and 50%higher for the moist warm zone when compared to the dry warm climatic zone(74 and 38 Mg ha^(-1),respectively).The sOC storage of the restoration models was positively related to soil depth(0.59;pstand age(0.17;ps of sOC storage were 26,66,and 139 Mg ha^(-1) at zero-10,zero-30,and zero-100 cm depths,*** addition,sandy soils showed smaller mean values of sOC storage than medium to clay soils,especially in deeper soil ***,sOC storage was positively re

关键词： Forest restoration Land uses soil type soil texture Climate

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Bayesian inference of biomass growth characteristics for sugi(***)and hinoki(***)forests in self-thinned and managed stands

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Forest Ecosystems 2021年第4期8卷 1006-1023页

作者： Valerie Nicoulaud-Gouin Marc-Andre Gonze Pierre Hurtevent Phillippe calmon Institut de Radioprotection et de surete Nucleaire St Paul-Lez-DuranceFrance

Background:Forests are an important sink for atmospheric carbon and could release that carbon upon deforestation and *** stand biomass dynamic of evergreen forests has become necessary to improve current biomass production *** different growth processes of managed forests compared to self-managed forests imply an adaptation of biomass prediction ***:In this paper we model through three models the biomass growth of two tree species(Japanese cedar,Japanese cypress)at stand level whether they are managed or not(self-thinning).One of them is named self-thinned model which uses a specific self-thinning parameterαand adapted to self-managed forests and an other model is named thinned model adapted to managed *** latter is compared to a Mitscherlich *** self-thinned model takes into account the light competition between trees relying on easily observable parameters(*** density).A Bayesian inference was carried out to determine parameters values according to a large database ***:In managed forest,Bayesian inference results showed obviously a lack of identifiability of Mitscherlich model parameters and a strong evidence for the thinned model in comparison to Mitscherlich *** self-thinning forest,the results of Bayesian inference are in accordance with the self-thinning 3/2 rule(α=1.4).structural dependence between stand density and stand yield in self-thinned model allows to qualifying the expression of biological time as a function of physical time and better qualify growth and mortality *** mortality rate is 2.5 times more important than relative growth rate after about 40 years *** density and stand yield can be expressed as function of biological time,showing that yield is independent of initial ***:This paper addressed stand biomass dynamic models of evergreen forests in order to improve biomass growth dynamic assessment at regional scale relying on easily observable

关键词： Dynamic Biomass self-thinning sugi Hinoki Competition-Density rule

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Usher syndrome:Genetic diagnosis and current therapeutic approaches

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World Journal of Otorhinolaryngology 2024年第1期11卷 1-17页

作者： Beatriz Rocha Cuzzuol Jonathan sant.s Apolonio Ronaldo Teixeira da silva Júnior Lorena sousa de Carvalho Luana Kauany de sásant.s Luciano Hasimoto Malheiro Marcel silva Luz mariana sant.s calmon Henrique de Lima Crivellaro Fabian Fellipe Bueno Lemos Fabrício Freire de Melo Instituto Multidisciplinar em saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Usher syndrome(UsH)is the most common deaf-blind syndrome,affecting approximately 1 in 6000 people in the deaf *** genetic condition is characterized by a combination of hearing loss(HL),retinitis pigmentosa,and,in some cases,vestibular *** the subtypes of UsH,UsH type 1 is considered the most severe form,presenting profound bilateral congenital deafness,vestibular areflexia,and early onset *** type 2 is the most common form,exhibiting congenital moderate to severe HL for low frequencies and severe to profound HL for high ***,type 3 is the rarest,initially manifesting mild symptoms during childhood that become more prominent in the first decades of *** dual impact of UsH on both visual and auditory senses significantly impairs patients'quality of life,restricting their daily activities and interactions with *** date,9 genes have been confirmed so far for UsH:MYO7A,UsH1C,CDH23,PCDH15,UsH1G,UsH2A,ADGRV1,WHRN and *** genes are inherited in an autosomal recessive manner and encode proteins expressed in the inner ear and retina,leading to functional *** non-genetic methods can assist in patient triage and disease extension evaluation,genetic and molecular tests play a pivotal role in providing genetic counseling,enabling appropriate gene therapy,and facilitating timely cochlear implantation(CI).The CRIsPR/Cas9 system and viral-based gene replacement therapy have recently emerged as highly promising techniques for treating *** drug therapy,PTC-124 and Nb54 have been identified as promising drug interventions for genetic HL in ***,CI has proven to be critical in the restoration of *** review aims to summarize the genetic and molecular diagnosis of UsH and highlight the importance of early diagnosis in Cuzzuol BR et *** and current treatments of UsH WJO https://*** 2 January 19,2024 Volume 11 Issue 1 guiding appropriate treatment strategies and i

关键词： Usher syndromes Hearing loss Retinitis pigmentosa Diagnosis Genetic therapies Cochlear implantation Quality of life

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The reality of the dead in Brazil:perspectives on identification in forensic anthropology

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Forensic sciences Research 2022年第4期7卷 577-579页

作者： Eugénia Cunha Bridget Algee-Hewitt Melina calmon National Institute of Legal Medicine and Forensic sciences CoimbraPortugal Centre for Functional Ecology Department of Life SciencesUniversity of CoimbraCoimbraPortugal CCSRE Center for Comparative Studies in Race and Ethnicity(CCSRE)Stanford UniversityStanfordCAUSA Grupo de Pesquisa em Antropologia Forense e Identificação de Pessoas-ANP/CNPq Lago SulBrazil

What is the current state of Forensic Anthropology in Brazil and where do we stand when identification is concerned?Coming to terms with the reality of identifying the dead in Brazil is the challenge we proposed to several Brazilian forensic anthropology experts and it is the focus of this special *** asked the contributor to drill-down to the fundamental questions in order to define the baseline upon which we can build our understanding and establish the future pathways for the *** are the most typical cases?Is there a more frequent case type?Does the way the issues are being solved reflect advancements in the discipline in the country?Are standards procedures being followed?What are the main obstacles faced by the experts in this field?

关键词： dead Brazil concerned

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Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis

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World Journal of Gastroenterology 2023年第14期29卷 2202-2221页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro mariana sant.s calmon Marcel silva Luz samuel Luca Rocha Pinheiro Clara Faria souza Mendes dos sant.s Gabriel Lima Correa sant.s Hanna sant.s Marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio Lima souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em saúde Universidade Federal da BahiaVitória da Conquista 45029094BahiaBrazil Instituto de saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45029094BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919899ParanáBrazil

BACKGROUND Gastric mucosa-associated lymphoid tissue(MALT)lymphoma(GML)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(***)-induced chronic *** practice guidelines currently recommend *** eradication as the preferred initial treatment for early-stage *** determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GML,an updated analysis and review of available evidence is *** To perform a meta-analysis to assess the rate of complete remission(CR)of ***-positive early-stage GML following bacterial *** We performed independent,computer-assisted literature searches using the PubMed/MEDLINE,Embase,and Cochrane Central databases through september *** and retrospective observational studies evaluating the CR of early-stage GML following bacterial eradication in ***-positive *** risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal *** pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects *** and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P50%,*** and meta-regression analyses were conducted to explore potential sources of *** The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text ***,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational *** overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 ***-positive early-stage GML patients,in whom *** was successfully eradicated,were incl

关键词： Lymphoma B-cell Marginal zone Gastric mucosa-associated lymphoid tissue lymphoma stomach lymphoma Helicobacter pylori Therapeutics Eradication therapy

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Using Condensed Water of Air Conditioners for Toilet Flushing： A Case study in Brazil

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Journal of Civil Engineering and Architecture 2013年第1期7卷 98-104页

作者： Celso silva Bastos Joao Luiz calmon Postgraduate Program in Civil Engineering Technology Center Federal University of Espirito Santo Vit6ria 29000-000 Brazil

Within the concept of sustainable construction, with sensible and conscious use of finite natural resources, every effort to save and reuse raw-materials is considered an important step to be adopted in buildings, from project, implantation and construction to operation and maintenance throughout their lifecycle. This study aims at showing the application of a system that reuses condensed water drained from air-conditioner evaporators （which are usually disposed of）, and a plan to use this water for toilet flushing, reducing consumption of treated water bought from water companies. The authors verified that each air-conditioner specified in the project of a commercial building--used as reference here--produces 4.8 L of water per hour of operation. This result in a daily accumulated volume of 4,290 L, which represents a significant part of the amount needed to supply all the toilets in the building. A water capture system located at a strategic intermediate floor would be able to store this water and pump it into a special reservoir on the roof of the building, to be distributed into toilet flush pipes. By applying this technology, the authors seek to considerably reduce the expected treated water consumption and consequently decrease water bill costs.

关键词： Water reuse air-conditioner toilet flush.

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