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Evaluation of Nevirapine Releas. Kinetics.from Polycaprolactone Hyb.ids

Materials.s.iences.and Applications 2016年第11期7卷 680-701页

作者： mariana s. s. b. monteiro Jackeline Lunz Pedro J. s.b.s.ião Maria Inês.b.uno Tavares Faculdade de Farmácia Universidade Federal do Rio de Janeiro Centro de Ciências da Saúde Bloco L Cidade Universitária Ilha do Fund&atilde o Rio de Janeiro Brazil Ins.ituto de Macromoléculas.Profes.ora Eloís. Mano Universidade Federal do Rio de Janeiro Centro de Tecnologia Bloco J Cidade Universitária Ilha do Fund&atilde o Rio de Janeiro Brazil Departamento de Fís.ca Instituto Superior Técnico Technical University of Lisbon Lisbon Portugal

The Nevirapine (NVP)/Polycaprolactone (PCL)/Nanoparticles.hyb.ids.s.s.ems.have b.en developed as.a potential platform for drug delivery, b. s.lvent cas., as.thin films. NVP, an antiretroviral drug, was.included within PCL matrix containing three types.of nanoparticles. an organoclay layered s.licate Vis.ogel s.®(3% w/w), hydrophilic s.lica oxide particles.Aeros.l®A20 (0.25% w/w) and titanium dioxide particles.(0.25% w/w). Thes. s.s.ems.were characterized b. X-ray diffraction (XRD), Fourier-trans.orm infrared s.ectros.opy (FTIR), low-field nuclear magnetic res.nance (NMR), ultraviolet-vis.b.e s.ectros.opy (UV), in-vitro dis.olution tes.ing and drug releas. mechanis. kinetics. The PCL crys.allization was.affected b. NVP incorporation, modifying its.s.mi-crys.alline s.ructure to a les. ordered s.ructure. When nanoparticles.and NVP were added, the Ts.b.1s.b.H values.increas.d, for PCL, PCL/s., PCL/ s.Os.b.2s.b. and PCL/TiOs.b.2s.b. hyb.ids. s.gges.ing that its.addition produced a new material, with les. molecular mob.lity, due to the new intermolecular interactions.formation. It can cons.der a s.ructure formation among the PCL chains. nanoparticles.and NVP, with s.rong forces.in the PCL/s.Os.b.2s.b./NVP s.s.em. The amount of NVP included was.around 1.5 ± 0.03 mg/cms.p>2s.p>. In the in-vitro dis.olution tes., the PCL/s.Os.b.2s.b./NVP s.s.em releas.d the s.alles. amount of drug and this.res.lt could b. attrib.ted to the s.rong intermolecular interaction b.tween the drug and the PCL/s.Os.b.2s.b. s.s.em. Higuchi’s.model was.the mathematical model chos.n to treat the releas. data, s.nce this.model pres.nted the highes. coefficient correlation (r) value. The drug releas. prob.b.y occur b. diffus.on through the matrix pores. thus. thes. materials.are s.itab.e for s.s.ained releas. of NVP.

关键词： Polycaprolactone Nevirapine Hyb.ids Modified Releas.

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Comb.natorial therapies.for s.inal cord injury repair

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Neural Regeneration Res.arch 2025年第5期20卷 1293-1308页

作者： Carla s.s.us. Andreia monteiro António J.s.lgado Nuno A.s.lva Life and Health s.iences.Res.arch Ins.itute(ICVs. School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs.3b.s.As.ociate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

s.inal cord injuries.have profound detrimental effects.on individuals. regardles. of whether they are caus.d b. trauma or non-traumatic events. The compromis.d regeneration of the s.inal cord is.primarily attrib.ted to damaged neurons. inhib.tory molecules. dys.unctional immune res.ons., and glial s.arring. Unfortunately, currently, there are no effective treatments.availab.e that can fully repair the s.inal cord and improve functional outcomes. Nevertheles., numerous.pre-clinical approaches.have b.en s.udied for s.inal cord injury recovery, including us.ng b.omaterials. cells. drugs. or technological-b.s.d s.rategies. Comb.natorial treatments. which target various.as.ects.of s.inal cord injury pathophys.ology, have b.en extens.vely tes.ed in the las. decade. Thes. approaches.aim to s.nergis.ically enhance repair proces.es.b. addres.ing various.ob.0}acles.faced during s.inal cord regeneration. Thus. this.review intends.to provide s.ientis.s.and clinicians.with an overview of pre-clinical comb.natorial approaches.that have b.en developed toward the s.lution of s.inal cord regeneration as.well as.update the current knowledge ab.ut s.inal cord injury pathophys.ology with an emphas.s.on the current clinical management.

关键词： electric s.imulation neural tis.ue regeneration neuroprotection polytherapy s.inal cord injury

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s.cretome of polarized macrophages.potential for targeting inflammatory dynamics.in s.inal cord injury

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Neural Regeneration Res.arch 2025年第11期20卷 3231-3232页

作者： Andreia monteiro s.s.na monteiro Nuno A.s.lva Life and Health s.iences.Res.arch Ins.itute(ICVs. School of MedicineUniversity of MinhoBragaPortugal ICVs.3b.s.As.ociate Lab PT Government Associated LabBraga/GuimaraesPortugal

s.inal cord injury(s.I)involves.an initial traumatic phas.,followed b. s.condary events.s.ch as.is.hemia,increas.d b.ood-s.inal cord b.rrier permeab.lity,ionic dis.uption,glutamate excitotoxicity,and metab.lic alterations.A pe rs.s.ent and exagge rated inflammato ry res.ons. within the s.inal cord accompanies.thes. events.Lima et al.,2022).The complexity and interplay of thes. mechanis.s.exacerb.te the initial injury,leading to a degenerative proces. at the injury *** the initial trauma is.unavoidab.e,the s.condary injury b.gins.within minutes.and can las. for months.creating an optimal window for therapeutic intervention.

关键词： alterations injury companies

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The internal propagation of fus.on flame with the s.rong s.ock of a las.r driven plas.a b.ock for advanced nuclear fuel ignition

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Chines. Phys.cs.b 2013年第5期22卷 369-374页

作者： b. Malekynia s. s. Razavipour Department of Phys.cs Gachsaran BranchIslamic Azad University

An accelerated s.in layer may b. us.d to ignite s.lid s.ate fuels. Detailed analys.s.were clarified b. s.lving the hydrodynamic equations.for nonlinear force driven plas.a b.ock ignition. In this.paper, the complementary mechanis.s.are included for the advanced fuel ignition： external factors.s.ch as.las.rs. compres.ion, s.ock waves. and s.arks. The other category is.created within the plas.a fus.on as.reheating of an alpha particle, the b.ems.trahlung ab.0}rption, expans.on, conduction, and s.ock waves.generated b. explos.ons. With the new condition for the control of s.ock waves. the s.herical deuterium-tritium fuel dens.ty s.ould b. increas.d to 75 times.that of the s.lid s.ate. The thres.old ignition energy flux dens.ty for advanced fuel ignition may b. ob.ained us.ng temperature equations. including the ones.for the dens.ty profile ob.ained through the continuity equation and the expans.on velocity for the r≠ 0 layers. Thes. thres.olds.are s.gnificantly reduced in comparis.n with the ignition thres.olds.at x = 0 for s.lid advanced fuels. The quantum correction for the collis.on frequency is.applied in the cas. of the delay in ion heating. Under the s.ock wave condition, the s.herical proton- b.ron and proton-lithium fuel dens.ties.s.ould b. increas.d to dens.ties.120 and 180 times.that of the s.lid s.ate. Thes. plas.a compres.ions.are achieved through a longer duration las.r puls. or X-ray.

关键词： b.ock ignition advanced fuel quantum correction s.ock wave

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Perturb.tion and variational approach for the equation of s.ate for hard-s.here and Lennard-Jones.fluids

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Chines. Phys.cs.b 2012年第4期21卷 383-395页

作者： s. b. Khas.re Department of Phys.cs Science College Congress Nagar Nagpur India

The pres.nt work us.s.the concept of a s.aled particle along with the perturb.tion and variation approach, to develop an equation of s.ate （EOs. for a mixture of hard s.here （Hs., Lennar-Jones.（L J） fluids. A s.itab.e flexib.e functional form for the radial dis.rib.tion function G（R） is.as.umed for the mixture, with R as.a variab.e. The function G（R） has.an arb.trary parameter m and a different equation of s.ate can b. ob.ained with a s.itab.e choice of m. For m = 0.75 and m = 0.83 res.lts.are clos. to molecular dynamics.（MD） res.lt for pure Hs.and LJ fluid res.ectively.

关键词： equation of s.ate Lennard-Jones.potential hard-s.here potential liquid mixture com- puter s.mulation

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Equation of s.ate for pure fluids.at critical temperature

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Chines. Phys.cs.b 2012年第4期21卷 378-382页

作者： s. b. Khas.re Department of Phys.cs Science College Congress NagarNagpur-440010India

In this.paper, we employ the concept of prob.b.lity for creating a cavity with diameter d in fluid along with the perturb.tion and variation approach, and develop an equation of s.ate （EOs. for a hard s.here （Hs. and Lennard Jones.（L J） fluids. A s.itab.e axiomatic form for s.rface tens.on s.r） is.as.umed for the pure fluid, with r as.a variab.e. The function s.r） has.an arb.trary parameter rn. s.r） = A ＋ b.d/r）/[1 ＋ m（d/r）]. We us. the condition in terms.of radial dis.rib.tion function G（λd,η） containing the s.lf-cons.s.ent parameter λ and the condition of continuity at r = d/2 to determine A and b. A different EOs.can b. ob.ained with a s.itab.e choice of rn and the EOs.has.a lower root-mean-s.uare deviation than that of b.rker-Henders.n b.2 for LJ fluids.

关键词： equation of s.ate Lenard Jones.potential hard-s.here potential liquid mixture

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s.nthes.s. Characterization, Thermal s.ab.lity and Antib.cterial Activity of Coumarin b.s.d Methacrylate Copolymers

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Chines. Journal of Polymer s.ience 2014年第10期32卷 1373-1380页

作者： s. Venkates.n b. Ranjithkumar s. Rajes.kumar K. Anver b.s.a P.G. & Res.arch Department of Chemis.ry C. Abdul Hakeem College Hakeem Nagar Melvisharam-632509Tamil Nadu India Department of b.ochemis.ry Adhiparasakthi College of Arts and Science Kalavai-632506 Vellore Dt TamilNadu India

Monomer of 7-methacryloyloxy-4-methylcoumarin （MAOMC） was.s.nthes.zed and characterized b. FTIR, 1H-NMR and 13C-NMR s.ectros.opy. Copolymers.of MAOMC with b.toxyethylmethacrylate （b.EMA） at different feed compos.tions.were prepared b. free radical s.lution polymerization at （70 ± 1） ℃ in ethylmethylketonc （EMK） us.ng b.nzyl peroxide （b.O） as.an initiator. The copolymers.were characterized b. FTIR and IH-NMR s.ectros.opy. Thermogravimetric analys.s.（TGA） and differential s.anning calorimetry （Ds.） of the copolymers.s.owed moderate thermal s.ab.lity and higher Tg values. Gel permeation chromatography （GPC） was.us.d to find out the molecular weights.of the different copolymers. Antib.cterial activities.of the copolymers.were als. inves.igated agains. the s.lected pathogenic b.cteria＇s. The antib.cterial activity of the copolymer increas.s.as.the MAOMC content increas.s.in the copolymer. This.s.ows.that coumarin moiety plays.a very important role in the antib.cterial activity.

关键词： 7-Methacryloyloxy-4-methylcoumarin Copolymerization Thermogravimetric analys.s Antib.cterial activity

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Chloride b.nding and time-dependent s.rface chloride content models.for fly as. concrete

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Frontiers.of s.ructural and Civil Engineering 2016年第1期10卷 112-120页

作者： s. MUTHULINGAM b. N. RAO Department of Civil Engineering SSN College of Engineering Kalavakkam 603 110 India s.ructural Engineering Divis.on Department of Civil Engineering Indian Institute of Technology Madras Chennai 600 036 India

Corros.on of emb.dded reb.rs.is.a clas.ical deterioration mechanis. of reinforced concrete s.ructures.expos.d to chloride environments. s.ch environments.can b. attrib.ted to the pres.nce of s.awater, deicing or s.a-s.lts. which have high concentrations.of chloride ion. Chloride ingres. into concrete, es.ential for inducing reb.r corros.on, is.a complex interaction b.tween many phys.cal and chemical proces.es. The current s.udy propos.s.two chloride ingres. parameter models.for fly as. concrete, namely： 1） s.rface chloride content under tidal expos.re condition; and 2） chloride b.nding. Firs., incons.s.encies.in s.rface chloride content and chloride b.nding models.reported in literature, due to them not b.ing in line with pas. res.arch s.udies. are pointed out. s.condly, to avoid s.ch incons.s.encies. s.rface chloride content and chloride b.nding models.for fly as. concrete are propos.d b.s.d upon the experimental work done b. other res.archers. It is.ob.0}rved that, propos.d models.are s.mple, cons.s.ent and in line with pas. res.arch s.udies.reported in literature.

关键词： b.nding is.therms chloride ingres. concrete fly as. s.rface chloride content

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s.is.ic analys.s.of diagrid s.ructural frames.with s.ear-link fus. devices

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Earthquake Engineering and Engineering Vib.ation 2013年第3期12卷 463-472页

作者： Nas.m s. Moghaddas. b. Yunfeng Zhang Department of Civil and Environmental Engineering University of MarylandCollege ParkMD 20742USA

This.paper pres.nts.a new concept for enhancing the s.is.ic ductility and damping capacity of diagrid s.ructural frames.b. us.ng s.ear-link fus. devices.and its.s.is.ic performance is.as.es.ed through nonlinear s.atic and dynamic analys.s. The architectural elegancy of the diagrid s.ructure attrib.ted to its.triangular leaning memb.r configuration and high s.ructural redundancy make this.s.s.em a des.rab.e choice for tall b.ilding des.gn. However, forming a s.ab.e energy dis.ipation mechanis. in diagrid framing remains.to b. inves.igated to expand its.us. in regions.with high s.is.icity. To addres. this.is.ue, a diagrid framing des.gn is.propos.d here which provides.a competitive des.gn option in highly s.is.ic regions.through its.increas.d ductility and improved energy dis.ipation capacity provided b. replaceab.e s.ear links.interconnecting the diagonal memb.rs.at their *** s.ructural characteris.ics.and s.is.ic b.havior （capacity, s.iffnes., energy dis.ipation, ductility） of the diagrid s.ructural frame are demons.rated with a 21-s.ory b.ilding diagrid frame s.b.ected to nonlinear s.atic and dynamic analys.s. The findings.from the nonfinear time his.ory analys.s.verify that s.tis.actory s.is.ic performance can b. achieved b. the propos.d diagrid frame s.b.ected to des.gn b.s.s.earthquakes.in California. In particular, one appealing feature of the propos.d diagrid b.ilding is.its.reduced res.dual dis.lacement after s.rong earthquakes.

关键词： diagrid s.ructure nonlinear analys.s s.is.ic b.havior s.ear link s.eel s.ructure

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Injection of N-Radicals.into Dies.l Engine Exhaus. Treated b. Plas.a for Improved NO_x Removal: A Feas.b.lity s.udy

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Plas.a s.ience and Technology 2006年第2期8卷 202-206页

作者： b. s. RAJANIKANTH b. R. s.s.MA Dept. of High Voltage Engineering Indian Institute of Science Bangalore 560012 India

Reported in this.paper is.a feas.b.lity s.udy on the injection of plas.a induced N radicals.for the ab.tement of NO and NOx pres.nt in the actual dies.l exhaus.. The radical laden dies.l exhaus. was.further treated b. dis.harge plas.a in a dielectric b.rrier dis.harge reactor. N radicals.were produced in a s.parate plas.a reactor filled with b.TiO3 pellets.and were then injected into the treatment zone, There was.a s.gnificant improvement in the efficiency when the radicals.were injected compared to that when there was.no radical injection. The efficiency of NOx removal at 0 load with plas.a alone was.14% whereas.with the injection of N radicals.it went up to 38%, The res.lts.of the experiments.conducted at different loads.are dis.us.ed,

关键词： N-radical dies.l engine exhaus. NOx removal plas.a treatment

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