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Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients:A systematic review and meta-analysis of randomized controlled trials

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Journal of sport and Health science 2023年第2期12卷 147-157页

作者： Antonio García-Hermoso Robinson Ramírez-Vélez Javier Díez Arantxa González Mikel Izquierdo Navarrabiomed Public University of Navarra(UPNA)Health Research Institute of Navarra(IdiSNA)University Hospital of NavarraPamplona 310008Spain CIBER of Frailty and Healthy Aging(CIBERFEs) Carlos Ⅲ Institute of HealthMadrid 28029Spain Institute for Health Research of Navarra(IDIsNA) Pamplona 31008Spain Program of Cardiovascular Diseases Center for Applied Medical ResearchUniversity of NavarraPamplona 31008Spain Centre for Biomedical Research in Cardiovascular Disease Network Carlos Ⅲ Institute of HealthMadrid 28029Spain Departments of Nephrology and Cardiology University of Navarra ClinicPamplona 31008Spain

Background:This study investigates the effects of exercise training on exerkines in patients with type 2 diabetes mellitus to determine the optimal exercise ***:A systematic search for relevant studies was performed in 3 *** controlled trials investigating the effects of exercise training on at least one of the following exerkines were included:adiponectin,apelin,brain-derived neurotrophic factor,fetuin-A,fibroblast growth factor-21,follistatin,ghrelin,interleukin(IL)-6,IL-8,IL-10,IL-15,IL-18,leptin,myostatin,omentin,resistin,retinol-binding protein 4,tumor necrosis factor-α,and ***:Forty randomized controlled trials were selected for data extraction(n=2160).Exercise training induces changes in adiponectin,fetuin-A,fibroblast growth factor-21,IL-6,IL-10,leptin,resistin,and tumor necrosis factor-a levels but has no significant effects on apelin,IL-18,and ghrelin compared to *** exercise training favored large and positive changes in pooled exerkines(i.e.,an overall effect size calculated from several exerkine s)(Hedge’s g=1.02,95%confidence interval(95%CI):0.76-1.28),which in turn were related to changes in glycated hemoglobin(mean difference(MD)=-0.81%,95%CI:-0.95%to-0.67%),fasting glucose(MD=-23.43 mg/dL,95%CI:-30.07 mg/dL to-16.80 mg/dL),waist circumference(MD=-3.04 cm,95%CI:-4.02 cm to-2.07 cm),and body mass(MD=-1.93 kg,95%CI:-2.00 kg to-1.86 kg).slightly stronger effects were observed with aerobic,resistance,or high-intensity interval protocols at moderate-to vigorous-intensity and with programs longer than 24 weeks that comprise at least 3 sessions per week and more than 60 min per ***:Exercise training represents an anti-inflammatory therapy and metabolism-improving strategy with minimal side effects for patients with type 2 diabetes mellitus.

关键词： Adipokines Exercise training Hepatokines Myokines

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Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed

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Infectious Diseases of Poverty 2024年第1期13卷 85-89页

作者： Robert Colebunders Joseph Nelson siewe Fodjo Olivia Kamoen Luis-Jorge Amaral Amber Hadermann Chiara Trevisan Mark J.Taylor Julia Gauglitz Achim Hoerauf Yasuaki sato Katja Polman Maria-Gloria Basanez Dan Bhwana Thomson Lakwo Gasim Abd-Elfarag sebastien D.Pion Global Health Institute University of AntwerpAntwerpBelgium Department of Neurology Heilig Hart ZiekenhuisLierBelgium Department of Public Health Institute of Tropical MedicineAntwerpBelgium Liverpool school of Tropical Medicine LiverpoolUK Department of Computer science University of AntwerpAntwerpBelgium Institute of Medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German Center for Infection Research(DZIF) Partner Site Bonn-CologneBonnGermany school of Global Humanities and social sciences Nagasaki UniversityNagasakiJapan MRC Centre for Global Infectious Disease Analysis and London Centre for Neglected TropicalDisease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK National Institute for Medical Research TangaTanzania Vector Control Division Ministry of HealthKampalaUganda school of Public Health University of JubaJubaSouth Sudan Access for Humanity JubaSouth Sudan French National Research Institute for sustainable Development MontpellierFrance

Background There is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of onchocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an update on the new knowledge about OAE and to propose recommendations to the World Health Organization how to address this public health *** text During the 2nd International Workshop on OAE held on 19-21 september, 2023, in Antwerp, Belgium, participants recognised OAE as a substantial yet neglected public health problem, particularly in areas of sub-saharan Africa where onchocerciasis remains hyperendemic. Evidence from prospective population-based studies suggest that strengthening onchocerciasis elimination efforts leads to a significant reduction of OAE incidence. There is a need to validate an OAE case definition to estimate the burden of disease and identify onchocerciasis-endemic areas requiring intensification of onchocerciasis elimination programmes and integration of epilepsy care. It is expected that raising awareness about OAE will boost the population uptake of ivermectin. The implementation of a community-based epilepsy treatment programme offering free anti-seizure medications (AsMs) has shown high effectiveness in reducing the frequency of seizures and improving the overall quality of life of people with *** To reduce OAE burden, enhanced collaboration between onchocerciasis and mental health programmes at community, national, and international levels is required. Urgent efforts are needed to ensure the uninterrupted provision of free AsMs in onchocerciasis-endemic areas. Furthermore, OAE should be included in the quantification of the onchocerciasis disease burden.

关键词： Onchocerciasis Morbidity Burden of disease Prevention Ivermectin Epilepsy Nodding syndrome Treatment Children Policy

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Online Learning Effectiveness in Times of Covid-19 for Utesa University Undergraduate students in the Dominican Republic: A Narrative Research Approach

Online Learning Effectiveness in Times of Covid-19 for Utesa...

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作者： Luis Gabriel Pérez Báez 浙江师范大学

学位级别：硕士

Effectiveness refers to the measure of to what extent goals are accomplished,this study will focus on determining how effective online learning is,more specifically how it fares during times of COVID-19 pandemic and focused on undergraduate *** studies have been previously been made regarding online learning effectiveness,however there are not many studies referring to online learning in times of pandemic and even fewer focused on developing nations like the Dominican *** purpose of this study is to determine the effectiveness of online learning in times of COVID-19 of undergraduate students in the Dominican *** research is necessary because of how the country have switched completely,albeit temporarily to a fully online teaching modality due to COVID-19,this sudden change was done without much infrastructure,teaching materials or pacification previously adapted to this particular situation,therefore assessing how effective has online education has been during this period will contribute to the country’s current situation and any future challenge that may arrive and need a similar *** order to understand this problematic as well as to get useful information from the volunteers,undergraduate students from UTEsA University,interviews will be used to collect information which will later be analyzed using the qualitative methodology with a narrative inquiry *** conducting this study is expected to provide much needed information in this subject that may serve as guidance for a future reform of the higher education system in the country,putting special focus on the online learning modality.

关键词： Effectiveness Online learning Undergraduate students COVID-19 Dominican Republic

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Re-folded structure of syn-orogenic granitoids(Padrón dome, NW Iberia):Assessing rheological evolution of cooling continental crust in a collisional setting

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Geoscience Frontiers 2019年第2期10卷 651-669页

作者： Rubén Díez Fernández Francisco J.Rubio Pascual Luis Miguel Martín Parra Departamento de Geodinámica Estratigrafía y PaleontologíaFacultad de Ciencias GeológicasUniversidad Complutense de Madrid Instituto Geológico y Minero de Espana

This contribution discusses about the rheological, kinematic and dynamic frameworks necessary to produce recumbent and upright folds from syn-orogenic granitic massifs that were formed during an early stage of magma genesis related to the onset of a migmatitic dome. syn-kinematic granitoids occurring within the high-grade infrastructure of the Padron migmatitic dome(NW Iberia) are deformed into largescale recumbent folds(D_2) that are later affected by upright folds(D_3). Petrostructural analysis of a selected area of this dome reveals that after a period of crustal thickening(D_1), NNW-directed extensional flow gave way to recumbent folds and penetrative axial plane foliation(s_2). superimposed subhorizontal compression resulted in upright folds(D_3). A closer view into the dynamics of the dome allows exploring the factors that may condition the nucleation of folds with contrasting geometries during progressive deformation of molten continental crust. The formation of folds affecting syn-kinematic granitoids suggests a cooling metamorphic path in migmatitic domes. Active and passive folding mechanisms require a crystallizing(cooling) magma to nucleate folds. A more competent metamorphic host inhibits fold nucleation from much less competent magmas. As it crystallizes, magma becomes more rigid(competent),and approaches viscosity values of its host. Passive folding is favored when no significant competence contrast exists between magma and host, so this folding mechanism is more likely shortly after magma genesis and emplacement. In such conditions, and under dominant subhorizontal flow accompanied by flattening(D_2),passive folding would produce isoclinal recumbent geometries. Further magma cooling introduces a shift into the rheological behavior of partially molten crust. Thereon, crystallizing magma bodies would represent significant competence contrasts relative to their host. At this point, buckling is a more likely folding mechanism, and more regular, buckle fo

关键词： Recumbent folds Migmatitic domes Partial melting Crustal-derived granitoids Orogenic collapse Variscan orogen

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Evaluate More General Integrals Involving Universal Associated Legendre Polynomials via Taylor's Theorem

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Communications in Theoretical Physics 2017年第8期67卷 177-180页

作者： G.Yaez-Navarro 孙国华孙东升陈昌远董世海 EsFM Instituto Politécnico Nacional Edificio 9 Unidad Profesional ALM Catedrtica CONACyT CIC Instituto Politécnico NacionalUPALM New Energy and Electronic Engineering Yancheng Teachers University Laboratorio de Información Cuntica CIDETEC Instituto Politécnico Nacional Unidad Profesional ALM

Abstract A few important integrals involving the product of two universal associated Legendre polynomials Pl＇m＇, （x）,Pk＇n＇（x）and x2a（1-x2）-p-1,xb（1± x）-p-1and xc（1-x2）-p-1（1 ± x）axe evaluated using the operator form of Taylor＇s theorem and an integral over a single universal associated Legendre polynomial. These integrals are more general since the quantum numbers are unequal, i.e.l＇ ≠ k＇ and m＇≠ n＇ .Their selection rules are a/so given. We also verify the correctness of those integral formulas numerically.

关键词： universal associated Legendre polynomials definite integrals parity Taylor's theorem

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Novel single-ion conducting polymer electrolytes with high toughness and high resistance against lithium dendrites

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Nano Research 2023年第6期16卷 8457-8468页

作者： David Fraile-Insagurbe Nicola Boaretto Itziar Aldalur Iñigo Raposo Francisco Javier Bonilla Michel Armand María Martínez-Ibañez Centre for Cooperative Research on Alternative Energies CIC energiGUNEBasque Research and Technology Alliance(BRTA)Alava Technology ParkAlbert Einstein 48Vitoria-Gasteiz 01510Spain University of the Basque Country(UPV/EHU) Barrio Sarrienas/nLeioa 48940Spain

solid-state polymer electrolytes are considered as an alternative to classic liquid electrolytes,particularly for application in highenergy lithium metal *** respect to common dual-ion conductors,single-ion conducting polymer electrolytes(sICPEs)are less affected by lithium dendrites growth and thus are particularly interesting for application in lithium metal *** this work,novel sIC-PEs are developed,based on an ionomer having poly(ethylene-alt-maleimide)backbone and lithium phenylsulfonyl(trifluoromethanesulfonyl)imide pendant moieties,further blended with poly(ethylene oxide)(PEO)and poly(ethylene glycol)dimethyl ether(PEGDME).These sIC-PEs exhibit ionic conductivity around~7×10^(−6)s·cm^(−1) at 70℃,lithium transference number close to unity,and excellent mechanical properties,with fracture toughness over 30 J·cm^(−3).Additionally,the electrolytes show very high resistance against lithium dendrites growth,by cycling for more than 1200 h in Li°symmetric cells at a current density of 0.1 mA·cm^(−2).LiFePO4||Li°cells with these sIC-PEs were cycled at 70℃ and C/10,showing initial capacity of almost 160 mAh·g^(−1)and residual capacity of 45%after 100 *** work shows that single-ion conducting polymer electrolytes based on poly(ethylene-alt-maleimide)backbone are promising materials for application as electrolytes or catholytes in lithium metal polymer batteries.

关键词： single-ion conductors solid-state Li metal batteries polymer electrolytes lithium dendrites transference number mechanical properties

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Genetic variants involved in gallstone formation and capsaicin metabolism,and the risk of gallbladder cancer in Chilean women

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World Journal of Gastroenterology 2010年第3期16卷 372-378页

作者： sergio Báez Yasuo Tsuchiya Alfonso Calvo Martha Pruyas Kazutoshi Nakamura Chikako Kiyohara Mari Oyama Masaharu Yamamoto Department of surgery Sótero del Río Hospital Department of Community Preventive Medicine Niigata University Graduate School of Medical and Dental Sciences Department of Anatomic Pathology Sótero del Río Hospital Department of Preventive Medicine Graduate School of Medical SciencesKyushu University Faculty of Health sciences Niigata University of Health and Welfare

AIM:To determine the effects of genetic variants associated with gallstone formation and capsaicin (a pungent component of chili pepper) metabolism on the risk of gallbladder cancer (GBC).METHODs: A total of 57 patients with GBC, 119 patients with gallstones, and 70 controls were enrolled in this study. DNA was extracted from their blood or paraffi n block sample using standard commercial kits. The statuses of the genetic variants were assayed using Taqman sNP Genotyping Assays or Custom Taqman sNP Genotyping ***:The non-ancestral T/T genotype of apolipoprotein B rs693 polymorphism was associated with a decreased risk of GBC (OR:0.14,95% CI:0.03-0.63). The T/T genotype of cholesteryl ester transfer protein (CETP) rs708272 polymorphism was associated with an increased risk of GBC (OR:5.04,95% CI:1.43-17.8).CONCLUsION: Genetic variants involved in gallstone formation such as the apolipoprotein B rs693 and CETP rs 708272 polymorphisms may be related to the risk of developing GBC in Chilean women.

关键词： Genetic risk factor Gallbladder cancer Gallstone Genetic polymorphism Apolipoprotein B Cholesteryl ester transfer protein

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c-Abl kinase at the crossroads of healthy synaptic remodeling and synaptic dysfunction in neurodegenerative diseases

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Neural Regeneration Research 2023年第2期18卷 237-243页

作者： Daniela A.Gutiérrez América Chandía-Cristi María JoséYáñez silvana Zanlungo Alejandra R.Alvarez Cell signaling Laboratory Department of Cellular and Molecular BiologyCenter for Aging and Regeneration(CARE)Millennium Institute on Immunology and ImmunotherapyBiological Sciences FacultyPontificia Universidad Católica de ChileSantiagoChile school of Medical Technology Health Sciences FacultyUniversidad San SebastianSede Los LeonesSantiagoChile Department of Gastroenterology Faculty of MedicinePontificia Universidad Católica de ChileSantiagoChile

Our ability to learn and remember depends on the active formation,remodeling,and elimination of ***,the development and growth of synapses as well as their weakening and elimination are essential for neuronal *** structural reorganization of synaptic complexes,changes in actin cytos keleton and organelle dynamics,as well as modulation of gene expression,determine synaptic *** has been proposed that dys regulation of these key synaptic homeostatic processes underlies the synaptic dysfunction observed in many neurodegenerative *** is known about downstream signaling of activated N-methyl-D-aspartate andα-amino-3-hydroxy-5-methyl-4-isoazolepro pionate receptors;howeve r,other signaling pathways can also contribute to synaptic plasticity and long-lasting changes in learning and *** non-receptor tyrosine kinase c-Abl(ABL1)is a key signal transducer of intra and extracellular signals,and it shuttles between the cyto plasm and the *** review focuses on c-Abl and its synaptic and neuronal ***,we discuss the evidence showing that the activation of c-Abl can be detrimental to neurons,promoting the development of neurodegenerative ***,c-Abl activity seems to be in a pivotal balance between healthy synaptic plasticity,regulating dendritic spines remodeling and gene expression after cognitive training,and synaptic dysfunction and loss in neurodegenerative ***,c-Abl genetic ablation not only improves learning and memory and modulates the brain genetic program of trained mice,but its absence provides dendritic spines resiliency against *** re,the present review has been designed to elu cidate the common links between c-Abl regulation of structural changes that involve the actin cytos keleton and organelles dynamics,and the transc riptional program activated during synaptic *** summarizing the recent discove ries on c-Abl functions,we aim to provide an overview of how

关键词： actin cytoskeleton activity-dependent plasticity Alzheimer's disease c-Abl dendritic spines learning synapse synaptic plasticity transcription tyrosine kinase

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Design and Evaluation of a Vision-Based UI for People with Large Cognitive-Motor Disabilities

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Journal of Biomedical science and Engineering 2021年第4期14卷 185-201页

作者： sergio Martínez Antonio Peñalver Juan Manuel sáez Department of Computer science and Artificial Intelligence University of Alicante Alicante Spain Center of Operations Research Miguel Hernández University Elche Spain

Recovering from multiple traumatic brain injury (TBI) is a very difficult task, depending on the severity of the lesions, the affected parts of the brain and the level of damage (locomotor, cognitive or sensory). Alt... 详细信息

style="text-align:justify;"> Recovering from multiple traumatic brain injury (TBI) is a very difficult task, depending on the severity of the lesions, the affected parts of the brain and the level of damage (locomotor, cognitive or sensory). Although there are some software platforms to help these patients to recover part of the lost capacity, the variety of existing lesions and the different degree to which they affect the patient, do not allow the generalization of the appropriate treatments and tools in each case. The aim of this work is to design and evaluate a machine vision-based UI (User Interface) allowing patients with a high level of injury to interact with a computer. This UI will be a tool for the therapy they follow and a way to communicate with their environment. The interface provides a set of specific activities, developed in collaboration with the multidisciplinary team that is currently evaluating each patient, to be used as a part of the therapy they receive. The system has been successfully tested with two patients whose degree of disability prevents them from using other types of platforms.

关键词： Brain Damage Rehabilitation Disabilities Vision-Based User Interface

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Benefits of a root fungal endophyte on physiological processes and growth of the vulnerable legume tree Prosopis chilensis(Fabaceae)

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Journal of Plant Ecology 2019年第2期12卷 264-271页

作者： Marcia González-Teuber Alejandro Urzúa Andrea Morales Cristian Ibáñez Luisa Bascuñán-Godoy Max Planck Partner Group Departamento de Ciencias del AmbienteUniversidad de Santiago de ChileAv.Libertador Bernardo O'Higgins 3363SantiagoChile Instituto de Investigación Multidisciplinario en Ciencias y Tecnología Universidad de La SerenaAv.Raúl Bitrán 1305La SerenaChile Laboratorio de Química Ecológica Universidad de Santiago de ChileAv.Libertador Bernardo O'Higgins 3363SantiagoChile Departamento de Biología Universidad de La SerenaAv.Raúl Bitrán 1305La SerenaChile Departamento de Botánica Universidad de ConcepciónBarrio Universitario s/nConcepciónChile

Aims Desertification is a major concern in arid and semi-arid regions *** interactions between vulnerable plant spe-cies and associated microbial symbionts may have important appli-cations for conservation and restoration strategies in affected *** In this study,we evaluated the root-associated fungal endophyte community in Prosopis chilensis,a vulnerable and threatened arid-adapted tree of northern *** benefits in terms of physiologi-cal performance and plant growth were also *** fungi were isolated from asymptomatic roots by the culture method for molecular identification of the 18s rRNA *** dominant fungal endophyte(Penicillium sp.)in the community was later used in inoculation experiments to assess its effect on maximum quan-tum efficiency of photosystem II(_(PsII)),(Fv/Fm)actual _(PsII) efficiency(Φ_(PsII)),and non-photochemical quenching(NPQ).Total sugars,starch content,malonaldehyde(MDA),nitrogen content(%)and growth traits were also *** Findings WhereasΦ_(PsII) increased significantly in endophyte-inoculated plants,NPQ was found to *** effect of endophyte inocula-tion on sugars and MDA was detected,but starch content,leaf nitro-gen content,number of leaves and shoot biomass were found to *** revealed that inoculation of endophytic Penicillium fungal isolate can provide significant physiological benefits to the host plant *** presence resulted in greater _(PsII) efficiency and higher leaf nitrogen and carbohydrate content,enhancing host plant *** findings highlight the importance of consider-ing the fungal endophyte community of this vulnerable species as an important tool to the design of further revegetation and conserva-tion programs.

关键词： root endophytic fungi PsII efficiency nitrogen content plant growth promotion starch accumulation arid habitats

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