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Maternal low protein diet induces persistent expression changes in metabolic genes in male rats

World Journal of Diabetes 2020年第5期11卷 182-192页

作者： Allan de Oliveira Lira JoséLuiz de Brito Alves mariana pinheiro fernandes Diogo Vasconcelos David Filipe Santana João Henrique da Costa-Silva Béatrice Morio Carol Góis Leandro Luciano Pirola Department of Nutrition Federal University of PernambucoVitoria de Santo AntãoPernambuco 55608680Brazil Department of Nutrition Federal University of ParaíbaJoao Pessoa 74556060Brazil Henrique da Costa-Silva Luciano PirolaDepartment of Physical Education and Sport SciencesFederal University of PernambucoVitoria de Santo AntãoPernambuco 55608680Brazil Carmen(Cardiology Metabolism and Nutrition)LaboratoryINSERM U1060Lyon-1 UniversitySouth Lyon Medical FacultyPierre Benite 69310France

BACKGROUND Perinatal exposure to a poor nutritional environment predisposes the progeny to the development of metabolic disease at the adult age,both in experimental models and *** adaptive responses to maternal protein restriction have been reported in metabolic ***,the expression of glucose/fatty acid metabolism-related genes in adipose tissue and liver needs to be *** To evaluate the metabolic impact of perinatal malnutrition,we determined malnutrition-associated gene expression alterations in liver and adipose *** In the present study,we evaluated the alterations in gene expression of glycolytic/Krebs cycle genes(Pyruvate dehydrogenase kinase 4 and citrate synthase),adipogenic and lipolytic genes and leptin in the adipose tissue of offspring rats at 30 d and 90 d of age exposed to maternal isocaloric low protein(LP)diet throughout gestation and *** also evaluated,in the livers of the same animals,the same set of genes as well as the gene expression of the transcription factors peroxisome proliferator-activated receptor gamma coactivator 1,forkhead box protein O1 and hepatocyte nuclear factor 4 and of gluconeogenic *** In the adipose tissue,we observed a transitory(i.e.,at 30 d)downregulation of pyruvate dehydrogenase kinase 4,citrate synthase and carnitine palmitoyl transferase 1b gene *** transcriptional changes did not persist in adult LP rats(90 d),but we observed a tendency towards a decreased gene expression of leptin(P=0.052).The liver featured some gene expression alterations comparable to the adipose tissue,such as pyruvate dehydrogenase kinase 4 downregulation at 30 d and displayed other tissue-specific changes,including citrate synthase and fatty acid synthase upregulation,but pyruvate kinase downregulation at 30 d in the LP group and carnitine palmitoyl transferase 1b downregulation at 90 *** gene alterations,together with previously described changes in gene expression in

关键词： Metabolic adaptation Phenotype plasticity Liver Adipose tissue Metabolism Maternal protein undernutrition Rats

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Integrating geochemical(surface waters, stream sediments)and biological(diatoms) approaches to assess AMD environmental impact in a pyritic mining area： Aljustrel(Alentejo, Portugal)

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Journal of Environmental Sciences 2016年第4期28卷 215-226页

作者： Ana Teresa Luís Nuno Duraes Saloméfernandes pinheiro de Almeida Eduardo Ferreira da Silva University of Aveiro Department of GeosciencesGeoBioTec--GeobiosciencesGeotechnologies and Geoengineering Research CenterCampus de Santiago3810-193 AveiroPortugal University of Aveiro Department of BiologyGeoBioTec--GeobiosciencesGeotechnologies and Geoengineering Research CenterCampus de Santiago3810-193 AveiroPortugal Centro de Ciencias do Mar CCMARUniversidade do AlgarveCampus de Gambelas8005-139 FaroPortugal

Aljustrel mines were classified as having high environmental hazard due to their large tailings volume and high metal concentrations in waters and *** assess acid mine drainage impacted systems whose environmental conditions change quickly,the use of biological indicators with short generation time such as diatoms is *** study combined geochemical and diatom data,whose results were highlighted in 3 groups：Group 1,with low p H（1.9–5.1）and high metal/metalloid（Al,As,Cd,Co,Cu,Fe,Mn,Ni,Pb,Zn;0.65–1032 mg/L）and SO4（405–39124 mg/L）*** acidophilic species,Pinnularia aljustrelica,was perfectly adapted to the adverse conditions;in contrast,teratological forms of Eunotia exigua were found,showing that metal toxicity affected this *** low availability of metals/metalloids in sediments of this group indicates that metals/metalloids of the exchangeable fractions had been solubilized,which in fact enables metal/metalloid diatom uptake and consequently the occurrence of teratologies;Group 2,with sites of near neutral p H（5.0–6.8）and intermediate metal/metalloid（0.002–6 mg/L）and SO4（302–2179 mg/L）concentrations;this enabled the existence of typical species of uncontaminated streams（Brachysira neglectissima,Achnanthidium minutissimum）;Group 3,with samples from unimpacted sites,showing low metal/metalloid（0–0.8 mg/L）and SO4（10–315 mg/L）concentrations,high pH（7.0–8.4）and Cl contents（10–2119 mg/L）and the presence of brackish to marine species（Entomoneis paludosa）.For similar conditions of acidity,differences in diversity,abundance and teratologies of diatoms can be explained by the levels of metals/metalloids.

关键词： Surface waters Stream sediments Diatoms Metals/metalloids AMD Teratologies

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Contraception Knowledge, Attitudes and Practices of Adolescents at Risk of Pregnancy in Northeastern Brazil

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Open Journal of Obstetrics and Gynecology 2014年第6期4卷 300-308页

作者： Gilka Paiva Oliveira Costa Giulia Paiva Oliveira Costa Monica de Paula Farias Ana Cristina pinheiro fernandes de Araújo Federal University of Paraíba Joao Pessoa(PB)Brazil Federal University of Rio Grande do Norte Joao Pessoa(PB)Brazil

Background: Contraceptive methods (CM) are important resources in the prevention of adolescent pregnancy. This study aimed to investigate adolescent knowledge, attitudes and practices related to contraception. Study Design: A cross-sectional and exploratory study was conducted with 7th to 9th grade adolescents in northeastern Brazil. Their knowledge, attitudes, and contraceptive method use were analysed by gender, age and sexual initiation groups. Results: A sexual debut had been experienced by 21% (n = 120) of all respondents (n = 570). The majority of the respondents who had experienced a sexual debut were male (73.3%, n = 88), their mean age was 15 years (SD = 1.46), and 49.3% (n = 59) never used any CM. The participants displayed low knowledge and unfavourable and ambivalent attitudes concerning contraception. Conclusion: Adolescents initiate sexual intercourse with knowledge and attitudes that limit the use of CM, which makes them more at risk of pregnancy. Further research that will be representative of the specific population in need of interventions is necessary.

关键词： Adolescent Contraception Pregnancy Attitudes

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Consequences of Different Hysterectomy Techniques in Sexual Behavior——A Systematic Review

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Open Journal of Obstetrics and Gynecology 2014年第6期4卷 333-341页

作者： Ana Fátima fernandes Ana Izabel Nicolau Camila Vasconcelos Pricilla Alves Ana Karina pinheiro Namie Sawada Cristina Maria Galvao Camila Moreira Department of Nursing Federal University of CearáFortalezaBrazil

We conducted a systematic review of the literature to determine the influence of different hysterectomy techniques in the sexual behavior of women who underwent. We searched CENTRAL (The Cochrane Library), PubMed, SCOPUS, CINAHL and LILACS for studies between the years 1998 and 2010 that prospectively examined the sexuality after hysterectomy. Those that were not randomized controlled clinical trials were excluded. It was not available electronically, it was not related with the outcomes determined, it was not research, but publications before 1998 and study which women realized chemotherapy and radiotherapy. From the 455 identified studies, 9 met inclusion criteria. There was variability in how hysterectomies influence in the sexual behavior. Most of studies considered women who underwent vaginal hysterectomy had fewer changes in sexual behavior. Sexual desire, intercourse frequency and orgasm are the sexual aspects reported by women as more changes experimented after surgery. Findings from this study have implications for healthcare providers and policymakers. Each woman needs an individualized care plan that fits within the context of her life, and there are basic interventions that every woman who underwent hysterectomy should receive. This review draws attention to the need for different care plans for women who underwent different hysterectomy techniques.

关键词： Hysterectomy Sexual Behavior Sistematic Review

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Utilized Theories by Nursing in the Care of People with an Ostomy: Integrative Review

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Open Journal of Nursing 2016年第8期6卷 600-609页

作者： Lays pinheiro de Medeiros Marjorie Dantas Medeiros Melo Bertha Cruz Enders Suenia Silva de Mesquita Xavier Julliana fernandes de Sena Gabriela de Sousa Martins Melo Jéssica Martinelli Martins de Assis Isabelle Katherinne fernandes Costa Assunção Department of Nursing Health Science Center Federal University of Rio Grande do Norte (UFRN) Central Campus Natal Brazil

Objective: To identify in the literature the theories used by nursing professionals in the care of people with an ostomy. Method: It’s about an integrative review of the literature used in the LILACS, BDENF, PubMed Central, CINAHL, Web of Science and SCOPUS database. Results: The sample was made of 18 publications. Most of them were studies published in the last five years (44.4%), international publications (72.2%), published in international periodicals (66.7%), with level IV of evidence (83.3%). It was identified in the articles that the nursing theories were shown as the most used by the nurses in the care of people with an ostomy (55.5%), followed by the theories borrowed from psychology (38.9%) and, finally, the theories borrowed from pedagogy (22.2%). Conclusion: The nurses are using the assistance nursing models with a higher frequency to subsidize their surveys, as well as borrowed theories, mostly being performed and published internationally and with a low evidence level, highlighting the need of studies with a higher stringent methodology and, beyond this, analysis research of the used theories.

关键词： Ostomy Nursing Cares Nursing Theory Nursing Models

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Immunotherapy – new perspective in lung cancer

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World Journal of Clinical Oncology 2020年第5期11卷 250-259页

作者： Fillipe Dantas pinheiro Adriano fernandes Teixeira Breno Bittencourt de Brito Filipe Antonio Franca da Silva Maria Luísa Cordeiro Santos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Lung carcinoma is associated with a high mortality worldwide,being the leading cause of cancer *** is mainly classified into squamous non-small cell lung cancer(NSCLC),non-squamous NSCLC,and small cell lung ***,such malignancy has been increasingly subdivided into histological and molecular subtypes to guide *** can be used in adjuvant and palliative *** immunotherapy,it has been widely tested in both first or subsequent palliative *** this sense,drugs such as pembrolizumab,nivolumab,atezolizumab,ipilimumab,avelumab,and durvalumab have been assessed in large *** of these trials have also studied these medicines in adjuvant and in maintenance *** recent years,advances in immunotherapy have raised the hope that the unfavorable prognosis observed in several affected individuals can be *** has increased the overall survival in squamous NSCLC,non-squamous NSCLC,and small cell lung ***,it has added to the oncology practice some side effects that are unusual in standard chemotherapy and require special clinical *** order to show how immunotherapy is being applied in the treatment of lung carcinoma,we reviewed the main studies in adjuvant and palliative *** is the better scheme?What is the better combination?What is the better dose?When should we use immunotherapy?Does programmed cell death ligand 1 expression significantly interfere in immunotherapy efficiency?Some of these questions have already been answered,while others require more investigations.

关键词： Lung cancer Treatment Immunotherapy Squamous non-small cell lung cancer Non-squamous non-small cell lung cancer Small cell lung cancer

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Bibliometric Analysis of Nursing Articles Focused on Health Education

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Open Journal of Nursing 2014年第4期4卷 223-230页

作者： Carla Monique Mourao Ana Izabel Nicolau Marília Marques Ana Fátima fernandes Maria Josefina Silva Ana Karina pinheiro Francisca Elisangela Lima Thelma Araújo Camila Moreira Department of Nursing Federal University of Ceará Fortaleza Brazil

This study aimed to analyze the references of articles with the approach to Health Education, published in Brazilian journals of nursing classified as Qualis Nursing A1 and A2. Descriptive study. Setting: SciELO library. We analyzed the references of 113 articles which were used to study the theoretical and methodological framework of bibliometrics, which aimed to promote subsidies for obtaining evaluation indicators of production, contributing to the expansion of scientific knowledge produced and disseminated among authors and researchers in nursing science. The main results showed the prevalence of article such as document most often quoted, references with 5-9 years of temporality, from Brazil and in Portuguese. The journals most frequently used were the Revista Brasileira de Enfermagem e a Revista Latino Americana de Enfermagem. Provided a vision of what is being referenced in nursing publications in Brazil, with regard to the Health Education.

关键词： Nursing Bibliometrics Scientific Health Education

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Retrospective Epidemiological Analysis of Colles’ Fracture in Patients Admitted in fernandes Távora Hospital

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Open Journal of Epidemiology 2023年第1期13卷 16-23页

作者： Yuri Borges Morais Antonio Valterno Nogueira pinheiro Antonio Valterno Nogueira pinheiro Filho Liana Alves de Freitas Soares Borges Maria Suelly Nogueira pinheiro Rian Vilar Lima Letícia pinheiro Pontes Lia Camurça Costa Igor Castelo Branco Fontenele Costa Velko Veras Pereira de Matos Filho Professor da Faculdade de Medicina Centro Universitário Christus UNICHRISTUS Fortaleza Brasil Instituto Superior de Ciências Biomédicas—ISCB Universidade Estadual do Ceará UECE Fortaleza Brasil Departamento de Cirurgia Hospital Fernandes Távora HFT Fortaleza Brasil Faculdade de Medicina Universidade de Fortaleza UNIFOR Fortaleza Brasil Faculdade de Medicina Centro Universitário Christus UNICHRISTUS Fortaleza Brasil Faculdade de Medicina Universidade Federal do Ceará UFC Fortaleza Brasi

Background: Colles’ fracture is a type of fracture of the distal third of the radius and its most common cause is falling from patient’s own height and, epidemiologically, it is more common in the elderly. Objectives: The main objective of this study is to analyze the epidemiology of Colles’ fracture retrospectively, in patients admitted to fernandes Távora Hospital. Materials and Methods: This retrospective study conducted at the fernandes Távora Hospital used 1030 radiographic images of patients with wrist fractures. Results: (After a careful analysis) It was found that this type of fracture occurred with a greater frequency in age groups of 50 to 69, 60 to 69, and 40 to 49 years old, which corresponds to 59.5% of patients and the most affected sex were females (51.1%). Conclusion: The study concluded that this type of bone injury is more common in people aged 40 to 69 years old, especially in women, because of their geometry and bone composition. It is evident that Colles’ fracture impacts the life of the affected person, therefore, an adequate diagnosis and treatment having utmost importance.

关键词： Fracture Colles’ Fracture Epidemiology

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Care Technologies in Nursing for People with Colorectal Neoplasia: Integrative Review

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Open Journal of Nursing 2016年第8期6卷 610-619页

作者： Aryele Rayana Antunes de Araújo Alexsandra Rodrigues Feijão Lays pinheiro de Medeiros Mayra Beatriz Costa Medeiros Annanda Luyza Carias Maia Ana Luiza Brandão de Carvalho Lira Isabelle Katherinne fernandes Costa Assunção Department of Nursing Health Science Center Federal University of Rio Grande do Norte (UFRN) Central Campus Natal Brazil

Objective: Identifying in the literature the care technologies used by nurses for people with colorectal neoplasia on Nietzsche’s conceptual perspective. Method: It consists in an integrative review of the literature held in the database: Latin-American Literature and Caribbean in medical health sciences Literature Analysis and Retrieval System Online, Database in Nursing, US National Library of Medicine, Cumulative Index to Nursing & Allied Health Literature, Scopus Info Site and Web of Science in December 2015. Results: 28 articles were selected to compose the final sample of this review, which were analyzed and categorized in management technology (86.20%), assistance technology (20.68%) and educational technology (10.34%). Studies published in the last five years have predominated (62.06%), in international territory (82.75%) and with evidence level IV (44.82%). Conclusion: Today the growth on the production about this theme has been highlighted, but there is an important discrepancy between the researches with high and low level of scientific evidence, showing the need of more studies about technologies that strengthen the experience of nursing.

关键词： Nursing Colorectal Neoplasia Technology Oncological Nursing

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Modeling of the Leaf Area of <i>Maytenus obtusifolia</i>Mart. from Scanned Images

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Agricultural Sciences 2019年第6期10卷 796-806页

作者： Vinicius de Souza Oliveira Karina Tiemi Hassuda dos Santos Ana Paula Braido pinheiro Gleyce Pereira Santos Jéssica Sayuri Hassuda Santos Hérica Chisté Omar Schmildt Sara Dousseau Arantes Marcio Paulo Czepak Adriano Alves fernandes Edilson Romais Schmildt Postgraduate Program in Tropical Agriculture Federal University of Espírito Santo S&#227 o Mateus ES Brazil Departament of Agrarian and Biological Sciences Federal University of Espírito Santo S&#227 o Mateus ES Brazil Capixaba Institute for Research Technical Assistance and Rural Extension Regional Center for Rural Development Linhares Brazil

The leaf has a vital role in the functions of the plant, being responsible for photosynthesis and gas exchange. Thus, the objective of this study was to fit a mathematical equation model to estimate the leaf area of Maytenus obtusifolia Mart. through the linear dimensions of the leaves. For that, six hundred and fifteen healthy leaves were collected from plants belonging to the Federal University of Espírito Santo, São Mateus Campus, in the municipality of São Mateus, located in the north of the State of Espírito Santo, Brazil. All leaves were digitized and the images processed using the ImageJ®software, obtaining the measurements of the maximum length of the main midrib (L), the maximum width of the leaf blade (W) and the real leaf area (RLA) of each sheet. Subsequently, the product of length and width multiplication (LW) was also obtained. 500 sheets were randomly separated for the generation of models of mathematical equations and their respective coefficient of determination (R2), where RLA was used as dependent variable as function of L, W or LW as independent variable. Based on the models generated, a 115 leaf sample was used for validation, where the L, W and LW values of this sample were replaced in the adjusted equations, thus obtaining the estimated leaf area (ELA). A comparison of the means of RLA and ELA was performed by Student’s t test at 5% probability. We also calculated the mean absolute error (MAE), the root mean square error (RMSE) and the Willmott index (d). The best equation was defined by the following criteria: non-significant values of RLA and ELA averages, R2 and index d closest to unit, and MAE and RMSE values with greater proximity to zero. The quadratic model equation represented by ELA=0.18122798+0.72847767(LW)+0.00002789(LW)2 generated by multiplying the length with the width (LW) is the most suitable for the estimation of the leaf area of Maytenus obtusifolia Mart., in a fast, safe and non-destructive way.

关键词： Maytenus obtusifolia Mart Non-Destructive Method Mathematical Equations

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