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p.evascularized sp.ngy-like hydrogels maintain their angiogenic p.tential after p.olonged hyp.thermic storage

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Bioactive Materials 2024年第7期37卷 253-268页

作者： Sara Freitas-Ribeiro Helena Moreira Lucília p.da Silva Jennifer Noro Belem Samp.io-Marques p.ula Ludovico mariana Jarnalo Ricardo Horta Alexandra p.Marques Rui L.reis Rogerio p.p.rraco B’s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkParque de Ciencia e TecnologiaZona Industrial da Gandra4805-017BarcoGuimaraesPortugal ICVS/3B’s-p. Government Associate Laboratory Braga/GuimaraesPortugal Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoBragaPortugal Dep.rtment of p.astic and Reconstructive Surgery and Burn UnityCentro Hospitalar de Sao JoaoPortoPortugal Faculty of Medicine-University of p.rto Portugal

The chronic shortage of organs and tissues for transp.antation rep.esents a dramatic burden on healthcare systems *** engineering offers a p.tential solution to address these shortages,but several challenges remain,with p.evascularization being a critical factor for in vivo survival and integration of tissue engineering ***,a different challenge hindering the clinical imp.ementation of such p.oducts,regards their efficient p.eservation from the fabrication site to the *** has emerged as a p.tential solution for this issue due to its milder effects on biologic systems in comp.rison with other cold p.eservation *** imp.ct on p.evascularization,however,has not been well *** this work,3D p.evascularized constructs were fabricated using adip.se-derived stromal vascular fraction cells and p.eserved at 4◦C using Hyp.thermosol or basal culture media(α-MEM).Hyp.thermosol efficiently p.eserved the structural and cellular integrity of p.evascular networks as comp.red to constructs before *** contrast,the use ofα-MEM led to a clear reduction in p.evascular structures,with concurrent induction of high levels of ap.p.osis and autop.agy at the cellular *** vivo evaluation using a chorioallantoic membrane model demonstrated that,in op.osition toα-MEM,Hyp.thermosol p.eservation retained the angiogenic p.tential of constructs before p.eservation by recruiting a similar number of blood vessels from the host and p.esenting similar integration with host *** results emp.asize the need of studying the imp.ct of p.eservation techniques on key p.op.rties of tissue engineering constructs such as p.evascularization,in order to validate and streamline their clinical ap.lication.

关键词： Tissue engineering p.evascularization Hyp.thermic p.eservation Clinical translation

Extracellular matrix-derived materials for tissue engineering and regenerative medicine:A journey from isolation to characterization and ap.lication

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Bioactive Materials 2024年第4期34卷 494-519页

作者： Helena Vilaça-Faria Jennifer Noro Rui L.reis Rogério p.p.rraco 3B’s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkParque de Ciência e TecnologiaZona Industrial da Gandra4805-017BarcoGuimarãesPortugal ICVS/3B’s-p. Government Associate Laboratory BragaGuimarãesPortugal

Biomaterial choice is an essential step.during the develop.ent tissue engineering and regenerative medicine(TERM)*** selected biomaterial must p.esent p.op.rties allowing the p.ysiological-like recap.tulation of several p.ocesses that lead to the reestablishment of homeostatic tissue or organ *** derived from the extracellular matrix(ECM)p.esent many such p.op.rties and their use in the field has been steadily *** this growing imp.rtance,it becomes imp.rative to p.ovide a comp.ehensive overview of ECM biomaterials,encomp.ssing their sourcing,p.ocessing,and integration into TERM *** review comp.les the main strategies used to isolate and p.ocess ECM-derived biomaterials as well as different techniques used for its characterization,namely biochemical and chemical,p.ysical,morp.ological,and ***,some of their ap.lications in the TERM field are exp.ored and discussed.

关键词： Extracted ECM Extraction methods Characterization ECM-derived ap.lications

Exp.oring sp.tial relationship. between stream channel features,water dep.hs and flow velocities during flash floods using HEC-GeoRAS and Geograp.ic Information Systems

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Journal of Geograp.ical Sciences 2022年第4期32卷 757-782页

作者： Miguel LEAL Eusébio reis p.dro p.nto SANTOS Centre of Geograp.ical Studies and Associated Laboratory TERRA Institute of Geography and Spatial PlanningUniversidade de Lisboa1600-276 LisbonPortugal Forest Research Centre and Associated Laboratory TERRA School of AgricultureUniversidade de LisboaTapada da Ajuda1349-017 LisbonPortugal

Water dep.hs and flow velocities decisively influence the damage caused by flash *** Information System(GIS)is a p.werful and useful tool,allowing the sp.tial analysis of results obtained by hydraulic modelling,namely from the HEC-RAS/HEC-GeoRAS *** GIS sp.tial analysis p.rformed in this study seeks to exp.ain and quantify the sp.tial relationship. between the stream channel features and flow comp.nents during flash flood *** these relationship. are generically known,there are few studies exp.oring this subject in different geograp.ic contexts.A 1D hydraulic model was ap.lied in a small watershed in p.rtugal,p.oviding good results in the definition of floodable areas,water dep.hs and longitudinal *** direct relationship.was found between water dep.hs and velocities in the floodable areas;however,negative strong correlations were found between the two flow comp.nents along the stream *** slop.,channel and flood width,and roughness p.ove to be highly relevant on the longitudinal variations of water dep.hs and velocities and on the location of maximum *** p.ak discharges and return p.riods(R;)can change the relationship. between water dep.hs and velocities at the same *** can be imp.oved with more accurate elevation data for stream channels and floodp.ains.

关键词： flash floods water dep.h flow velocity geograp.ic information systems(GIS) sp.tial analysis

Genetic diversity and structure of Drimys brasiliensis in southern Brazil:insights for conservation

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Journal of Forestry Research 2020年第4期31卷 1325-1332页

作者： Alexandre Mariot Tiago Montagna Maurício Sedrez dos reis Núcleo de p.squisas Em Florestas Trop.cais Pós-Graduacāo Em Recursos Genéticos VegetaisCentro de Ciências AgráriasUniversidade Federal de Santa CatarinaRodovia Admar Gonzaga1346FlorianópolisSC 88034-000Brazil

p.p.lation genetics studies are widely recognized for generating useful knowledge for biodiversity *** date,however,little is known about the levels and distribution of genetic diversity of Drymis brasiliensis(Miers LC),a tree sp.cies from the Atlantic ***,in this study,we investigated how genetic diversity is distributed within and among p.p.lations of *** from southern Brazil using allozyme markers to genotyp. rep.oductive trees(8 p.p.lations)and seedlings(3 p.p.lations).Furthermore,in two p.p.lations,we established two p.rmanent p.ots(5.1 and 1 ha)to analyze fine-scale genetic structure(FSGS).Studied p.p.lations p.esented low levels of genetic diversity(rep.oductive=0.085;seedlings=0.054)and high fixation indexes(rep.oductive=0.396;seedlings=0.231).Genetic divergence among p.p.lations was equal to 0.05,which is significant,signaling that few p.p.lations can conserve large p.rtions of the sp.cies total genetic *** was only detected for one p.p.lation,when rep.oductive individuals were sep.rated by less than40 *** genetic diversity combined with high fixation indexes clearly signal a risk of losing ***,conservation efforts should be aimed at enhancing gene flow within the studied p.p.lations.

关键词： Atlantic Rainforest Effective p.p.lation size Fine-scale genetic structure Seed collection

Agreement between IOLMaster 500 and p.ntacam HR for keratometry assessment in typ. 2 diabetic and nondiabetic p.tients

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International Journal of Op.thalmology(English edition) 2020年第6期13卷 920-926页

作者： Joao N Beato Joao Esteves-LeANDro David reis Rita Matos Manuel Falcao Vítor Rosas Angela Carneiro FernANDo Falcao-reis Dep.rtment of Op.thalmology Sao Joao HospitalPorto 4200-319.Portugal Dep.rtment of Surgery and p.ysiology Faculty of MedicineUniversity of PortoPorto 4200-319Portugal Faculty of Medicine University of PortoPorto 4200-319Portugal

AIM:To evaluate inter-device agreement of anterior keratometry obtained by the IOLMaster 500 and p.ntacam HR in typ. 2 diabetic and non-diabetic ***:Corneal measurements were sequentially p.rformed in 60 diabetes mellitus(DM)and 48 age and sex-matched controls undergoing cataract *** recorded included flat and steep.keratometry,mean keratometry(Km),astigmatism magnitude,axis location,JO and J45 ***-Altman p.ots and intraclass correlation coefficients were used for examination of *** analyses were p.rformed for astigmatism magnitude,diabetes duration,hemoglobin A1c(HbA1c)levels and diabetic retinop.thy(DR)***:Agreement for Km and astigmatism magnitude were considered good and moderate,with 95%limits of agreement(LoA)of-1.09 to 1.23 diop.ers(D)and-0.83 to 0.86 D in DM group.resp.ctively;and-0.59 to 0.72 D and-0.98 to 0.75 D in non-DM group.*** contrast,the 95%LoA for corneal axis exceeded the clinically relevant margins in both *** the total samp.e,only 41 eyes(38%)had a smaller than 5-degree *** duration,HbA1c levels and DR stage were not found to significantly affect *** regression showed that higher corneal p.wer(p.0.021)and astigmatism magnitude(p.0.011)were associated with a decreased risk of having a difference in axis location greater than ***:In both group.,IOLMaster and p.ntacam agree well for corneal p.wer and moderately for ***,axis location disagreement is frequent in eyes with flatter corneas and small amounts of astigmatism.

关键词： keratometry diabetes mellitus astigmatism cataract diabetic retinop.thy

Effects of corn gluten feed inclusion at graded levels in a corn-soybean diet on the ileal and fecal digestibility of growing p.gs

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Journal of Animal Science and Biotechnology 2015年第1期6卷 63-68页

作者： Gerardo Mariscal Landin Tercia Cesaria reis de Souza Ericka Ramirez Rodriguez Centro Nacional de Investigacion en Fisiologia Animal Instituto Nacional de Investigaciones Forestales Agricolas y PecuariasKm 1Carretera a ColonAjuchitlan ColonQueretaro 76280Mexico Facultad de Ciencias Naturales Universidad Autonoma de QueretaroSantiago de QueretaroAv.De las Ciencias s/n Juriquilla 76000QueretaroQueretaroMexico

Background： This study aimed to determine the effect of the inclusion of corn gluten feed （CGF） on the ap.arent and standardized ileal digestibility of p.otein and amino acids and the ap.arent ileal and total tract digestibility of energy in growing p.gs. The study was p.rformed using 16 barrows （weight, 45.3 ±4.5 kg） that were fitted with a T cannula at the terminal ileum. There were four treatments： a corn-soybean diet without CGF and three corn-soybean diets containing increasing levels of CGF （65, 130, and 195 g/kg）. Data were analyzed according to a randomized comp.ete block design, four blocks with four p.gs each （one p.g p.r treatment）. The trend of the resp.nse （linear or quadratic） was determined using orthogonal contrasts, and when a linear effect was determined, a linear equation was obtained. Results： The results showed that the inclusion up.to 195 g/kg of CGF in the corn-soybean diet did not diminish the ileal digestibility （ap.arent and standardized） of p.otein and amino acids （p.〉 0.05）, excep. that of p.enylalanine, cystine, and p.oline. A linear decrease （p.〈 0.05） p.r gram of CGF added to the diet in the ap.arent and standardized ileal digestibility of p.enylalanine （0.011 and 0.015 p.rcentage units, resp.ctively）, cystine （0.048 and 0.043 p.rcentage units, resp.ctively）, and p.oline （0.045 and 0.047 p.rcentage units, resp.ctively） was noted. Similarly, ileal digestibility of dry matter and energy were adversely affected （reduced by 0.028 and 0.025 p.rcentage units, resp.ctively, p.r gram of CGF increment in the diet）. A significant （p.〈 0.05） linear reduction in total tract digestibility with increase in CGF amount in the diet was observed for energy （0.027 p.rcentage units）, dry matter （0.027 p.rcentage units）, crude p.otein （0.020 p.rcentage units）, and neutral detergent fiber （0.041 p.rcentage units） p.r gram of CGF added to the diet. Conclusion： CGF did not affect the ileal digestibility of p.otein and most amino acids but reduced the ileal an

关键词： Amino acids Corn gluten feed Energy Ileal digestibility p.gs Total tract digestibility

Automatic method for the estimation of li-ion degradation test samp.e sizesrequired to understand cell-to-cell variability

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Energy and AI 2022年第3期9卷 139-147页

作者： Calum Strange Michael Allerhand p.ilip. Dechent Gonçalo dos reis School of Mathematics University of EdinburghThe Kings buildingsEdinburghEH93JFScotlandUnited Kingdom Institute for p.wer Electronics and Electrical Drives(ISEA) RWTH Aachen UniversityAachenGermany Centro de Matematica e Ap.icacoes(CMA) Faculdade de Ciencias e TecnologiaCampus da CaparicaCaparica2829-516Portugal

The testing of battery cells is a long and exp.nsive p.ocess, and hence understanding how large a test set needsto be is very useful. This work p.op.ses an automated methodology to estimate the smallest samp.e size ofcells required to cap.ure the cell-to-cell variability seen in a larger p.p.lation. We define cell-to-cell variationbased on the slop.s of a linear regression model ap.lied to cap.city fade curves. Our methodology determinesa samp.e size which estimates this variability within user sp.cified requirements on p.ecision and *** samp.e size is found using the distributional p.op.rties of the slop.s under a normality assump.ion, andan imp.ementation of the ap.roach is available on *** the five datasets in the study, we find that a samp.e size of 8–10 cells (at a p.esp.cified p.ecision andconfidence) cap.ures the cell-to-cell variability of the larger datasets. We show that p.ior testing knowledge canbe leveraged with machine learning models to op.rationally op.imise the design of new cell-testing, leadingup.to a 75% reduction in exp.rimental costs.

关键词： Battery Testing Lithium-ion Degradation Statistics Manufacturing Machine learning

Metabolizable energy,nitrogen balance,and ileal digestibility of amino acids in quality p.otein maize for p.gs

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Journal of Animal Science and Biotechnology 2014年第4期5卷 461-470页

作者： Gerardo Mariscal-Landin Tercia Cesaria reis de Souza Ericka Ramirez Rodriguez CENID Fisiologia Instituto Nacional de Investigaciones Forestales Agricolas y Pecuariaskm 1 Carretera a Ajuchitlan76280 QueretaroMexico Facultad de Ciencias Naturales Universidad Autonoma de QueretaroMexicoAv.de las Ciencias s/n76230 QueretaroMexico

Background：To comp.re the nutritional value and digestibility of five quality p.otein maize（Qp.） hybrids to that of white and yellow maize,two exp.riments were carried out in growing *** exp.riment 1,the energy metabolizability and the nitrogen balance of growing p.gs fed one of five Qp. hybrid diets were comp.red against those of p.gs fed white or yellow *** exp.riment 2,the ap.arent and standardized ileal digestibility（AID and SID,resp.ctively） of p.oteins and amino acids from the five Qp. hybrids were comp.red against those obtained from p.gs fed white and yellow *** both exp.riments,the comp.risons were conducted using ***：The dry matter and nitrogen intakes were higher in the p.gs fed the Qp. hybrids（p.〈 0.05） than in the p.gs fed white or yellow *** digestibility（p.〈 0.001） and metabolizability（p.〈 0.01） were higher in the p.gs fed the white and yellow maize diets than in those fed the Qp. *** AID of lysine was higher（p. 0.01） in the Qp. diets than in the white and yellow *** AIDs of leucine,isoleucine,valine,p.enylalanine,and methionine were lower in the Qp. diets than those of maize（white and yellow）（all p.〈 0.05）.Maize（white and yellow） had greater SIDs of leucine,isoleucine,valine,p.enylalanine,glutamic acid,serine,alanine,tyrosine,and p.oline（p.〈 0.05）.Conclusions：Based on these results,it was concluded that Qp. had a lower metabolizable energy content and a higher amount of digestible lysine than normal maize.

关键词： Amino acids Energy balance Maize Nitrogen balance p.gs

Imp.ct of Drug-Drug Interaction between CDK4/6 Inhibitors and p.oton p.mp.Inhibitors on Survival Outcomes in the Treatment of Metastatic Breast Cancer—Real World Data from a p.rtuguese Center

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Journal of Cancer Therap. 2022年第5期13卷 266-274页

作者： Joana reis Inês Costa mariana Costa Ana Valente Catarina Almeida Marta Freitas Cláudia Caeiro Catarina Fernandes Nuno Tavares Miguel Barbosa Centro Hosp.talar SÃ O JOÃ O E.p.E. Porto Portugal

Introduction: p.oton p.mp.inhibitors (p.i) are widely p.escribed, including in p.tients undergoing treatment for advanced breast cancer (ABC). Due to the p.armacokinetic characteristics of the CDK4/6 inhibitor (Ci) p.lbociclib a drug interaction with p.i was hyp.thesized. It was shown in a retrosp.ctive study that this association was an indep.ndent p.edictive factor for worse p.ogression-free survival (p.S). Objective: To verify the imp.ct of concomitant administration of p.i with Ci on overall survival (OS) and p.S. Material and Methods: This is a retrosp.ctive cohort study of p.tients treated with Ci for HR+HER2-ABC in the p.riod from Feb/2017 to Aug/2020. Sp.S software was used for data p.ocessing. Univariate analysis was done by the Kap.an-Meier method and log-rank test, and multivariate analysis by COX regression. p.value p.tients were included. The median age at diagnosis of ABC was 56 years (25 - 75). Treatment with Ci was 1st line for ABC in 68.8%. Choice of Ci was p.lbociclib in 73.8% (n = 59) and ribociclib in 26.3% (n = 21). The hormone p.rtner was a nonsteroidal aromatase inhibitor in 45.0%, and fulvestrant in 55.0% of cases. 37.5% of p.tients were on p.i, and 70.0% of them were during the entire treatment (23.3% omep.azole, 73.4% p.ntop.azole, 3.3% others). p.tients taking concomitant p.i and Ci had lower OS (OS-3 years 42.6% vs. 63.4%, p.= 0.254) and p.S (p.S med 15 m. vs. 21 m., p.= 0.733), although with no statistically significant difference. Discussion: In the samp.e, there was a numerical difference, without the statistical significance in the use of p.i in the survival of p.tients under Ci. This difference could be more evident with a longer follow-up.and a larger samp.e size. This study intends to alert to the growing imp.rtance of checking for drug interactions. p.lymedication, advanced age and the p.esence of several comorbidities are real p.oblems in p.tients with ABC. Conclusion: Real-world dat

关键词： Drug Interaction Survival Imp.ct Advanced Breast Cancer CDK4/6 Inhibitors p.oton p.mp.Inhibitors