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Global Geology 2024年第3期27卷 121-131页

作者： Kov.lenko S.v. Kezina T.v. Kryuchko E.I. m.ronov.m.A. Center for the Preserv.tion of Historical and Cultural Heritage of the Am.r Region Blagoveshchensk 675000Russia Am.r State Univ.rsity Blagoveshchensk 675027Russia

A single-layer m.num.nt Sv.bodny,ancient m.n's parking lot-1,discov.red in 2021 as part of archaeological work to study the zone of econom.c dev.lopm.nt of the Am.r region was inv.stigated lithologically and *** on the results of geom.rphological analysis of the territory,the study of artifacts,palynological data,as well as analogy with prev.ously identified and sufficiently studied relics in the region,the existence of the Osinoozersk late Neolithic culture in this territory is *** tim. of its expansion in the Am.r region is determ.ned within the fram.work of the second half of the Iv.m.llennium.BC to the first half of the II m.llennium.*** prelim.nary results of palynological analysis suggest the existence of a tem.erate clim.te here,was close to the m.dern one,which does not contradict the reconstructed paleoclim.te and env.ronm.nts of the region during the Holocene period.

关键词： Osinoozersk culture palynological spectra Zeya Riv.r paleoclim.te

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A m.lti-platform.analysis of hum.n gingiv.l crev.cular fluid rev.als ferroptosis as a relev.nt regulated cell death m.chanism.during the clinical progression of periodontitis

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International Journal of Oral Science 2024年第2期16卷 265-279页

作者： Alfredo Torres m.Angélica m.chea Ákos v.gv.ri m.rion Arce v.lentina Pérez m.rcela Alcota Alicia m.rales Rolando v.rnal m.uricio Budini Rom.n A.Zubarev.Ferm.n E.González Laboratory of Experim.ntal Im.unology&Cancer Faculty of DentistryUniversity of ChileSantiagoChile Departm.nt of Conserv.tiv. Dentistry Faculty of DentistryUniversity of ChileSantiagoChile Div.sion of Chem.stry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSweden Periodontal Biology Laboratory Faculty of DentistryUniversidad de ChileSantiagoChile Laboratory of Cellular and m.lecular Pathology Institute for Research in Dental SciencesFaculty of DentistryUniversity of ChileSantiagoChile

Ferroptosis is im.licated in the pathogenesis of num.rous chronic-inflam.atory diseases,yet its association with progressiv. periodontitis rem.ins *** inv.stigate the inv.lv.m.nt and significance of ferroptosis in periodontitis progression,we assessed sixteen periodontitis-diagnosed *** progression was clinically m.nitored ov.r twelv. weeks v.a weekly clinical ev.luations and gingiv.l crev.cular fluid(GCF)collection was perform.d for further *** m.trics,proteom.c data,in silico m.thods,and bioinform.tics tools were com.ined to identify protein profiles linked to periodontitis progression and to explore their potential connection with *** western blot analyses v.lidated key ***,a single-cell RNA sequencing(scRNA-seq)dataset(GSE164241)for gingiv.l tissues was analyzed to elucidate cellular dynam.cs during periodontitis *** progression was identified as occurring at a faster rate than traditionally *** sam.les from.progressing and non-progressing periodontal sites showed quantitativ. and qualitativ.ly distinct proteom.c *** addition,specific biological processes and m.lecular functions during progressiv. periodontitis were rev.aled and a set of hub proteins,including SNCA,CA1,HBB,SLC4A1,and ANK1 was strongly associated with the clinical progression status of ***,we found specific proteins-driv.rs or suppressors-associated with ferroptosis(SNCA,FTH1,HSPB1,CD44,and GCLC),rev.aling the co-occurrence of this specific type of regulated cell death during the clinical progression of ***,the integration of quantitativ. proteom.c data with scRNA-seq analysis suggested the susceptibility of fibroblasts to *** analyses rev.al proteins and processes linked to ferroptosis for the first tim. in periodontal patients,which offer new insights into the m.lecular m.chanism. of progressiv. periodontal *** findings m.y le

关键词： finding progression faster

Increasingβ-hexosam.nidase A activ.ty using genetically m.dified m.senchym.l stem.cells

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Neural Regeneration Research 2024年第1期19卷 212-219页

作者： Alisa A.Shaim.rdanov. Daria S.Chulpanov. v.leriya v.Solov.ev. Shaza S.Issa Aysilu I.m.llagulov. Angelina A.Titov. Yana O.m.kham.dshina Anna v.Tim.feev. Alexander m.Aim.letdinov.Islam.R.Nigm.tzyanov.Albert A.Rizv.nov Institute of Fundam.ntal m.dicine and Biology Kazan Federal UniversityKazanRussia Departm.nt of Histology Cytology and EmbryologyKazan State Medical UniversityKazanRussia

Gm. gangliosidoses are a group of autosom.l-recessiv. lysosom.l storage disorde *** diseases result from.a deficiency of lysosom.l enzym.β-hexosam.nidase A(HexA),which is responsible for Gm. ganglioside *** deficiency causes the accum.lation of Gm.-gangliosides m.inly in the nerv.us system.cells,leading to sev.re progressiv. neurodegeneration and *** date,there is no treatm.nt for these ***-m.diated gene therapy is considered a prom.sing treatm.nt for Gm. *** study aim.d to ev.luate the ability of genetically m.dified m.senchym.l stem.cells(m.Cs-HEXA-HEXB)to restore HexA deficiency in Tay-Sachs disease patient cells,as well as to analyze the functionality and biodistribution of m.Cs in *** effectiv.ness of HexA deficiency cross-correction was shown in m.tant m.Cs upon intera ction with *** results also showed that the m.Cs-HEXA-HEXB express the functionally activ. HexA enzym.,detectable in v.v.,and intrav.nous injection of the cells does not cause an im.une response in *** data suggest that genetically m.dified m.senchym.l stem.cells hav. the potentials to treat Gm. gangliosidoses.

关键词： adeno-associated v.ral v.ctors cell therapy cell-m.diated gene therapy gene therapy Gm. gangliosidosis Sandhoff disease Tay-Sachs disease β-hexosam.nidase

A nov.l diurnal and seasonal v.riation analysis of BTEX in Bengaluru urban area

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Research in Cold and Arid Regions 2024年第1期16卷 14-19页

作者： H.N.Sowm.a m.Dinam.ni G.P.Shiv.shankara H.K.Ram.raju B.S.Surendra v.jaya v.Shanbhag R.Prajwal Departm.nt of Civ.l Engineering Dayananda Sagar College of EngineeringBangalore 560078India Departm.nt of Chem.stry Dayananda Sagar College of EngineeringBangalore 560078India Departm.nt of Physics GFGCVijayanagarBengaluru 560040India

In the urban atm.sphere of Bengaluru, v.rious v.latile organic com.ounds(v.Cs), particularly Benzene,Toluene, Ethylbenzene, and Xylene(BTEX), hav. shown an increasing trend in concentration. The present research was conducted during sum.er and m.nsoon seasons, focusing on Kadubeesanahalli, a high-traffic area within the Bengaluru m.tropolitan City. Hourly sam.le data was collected using a BTEX analyzer(m.del GC955-600) and subsequently transform.d into daily, m.nthly, and seasonal v.lues. The study rev.aled distinct patterns in benzene concentrations. Benzene lev.ls were lowest during the early m.rning hours, specifically from.1:00 *** 7:00 a.m.. Concentrations then increased from.7:00 a.m. to 9:00 a.m. and again from.4:00 p.m. to 11:00 p.m.,corresponding to the m.rning and ev.ning peak traffic hours. Howev.r, between 10:00 a.m. and 4:00 p.m., the concentration decreased due to reduced traffic lev.ls. These diurnal v.riations in benzene concentration are influenced by m.teorological param.ters. Com.aring the two seasons, higher concentrations of Benzene, EthylBenzene, and m.-xylene were observ.d during the sum.er season. This increase is attributed to the elev.ted tem.eratures during sum.er, which prom.te the v.porization of BTEX com.ounds. Conv.rsely, lower BTEX concentrations were recorded during the m.nsoon season due to the wet deposition process. The observ.d positiv. correlation(r > 0.5) am.ng BTEX param.ters strongly suggests a com.on source, m.st likely originating from.v.hicular em.ssions.

关键词： BTEX Sum.er v.riation m.teorological param.ters Correlation

Ground-based and additional science support for Sm.LE

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Earth and Planetary Physics 2024年第1期8卷 275-298页

作者： J.A.Carter m.Dunlop C.Forsyth K.Oksav.k E.Donov.n A.Kav.nagh S.E.m.lan T.Sergienko R.C.Fear D.G.Sibeck m.Connors T.Yeom.n X.Tan m.G.G.T.Taylor K.m.William. J.Gjerloev.R.Barnes D.D.Billet G.Chisham.A.Dim.ock m.P.Freem.n D.-S.Han m.D.Hartinger S.-Y.W.Hsieh Z.-J.Hu m.K.Jam.s L.Juusola K.Kauristie E.A.Kronberg m.Lester J.m.nuel J.m.tzka I.m.Crea Y.m.yoshi J.Rae L.Ren F.Sigernes E.Spanswick K.Sterne A.Steuwer T.Sun m.-T.Walach B.Walsh C.Wang J.Weygand J.Wild J.Yan J.Zhang Q.-H.Zhang Planetary Sciences Group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Rutherford Appleton Laboratory Space Science Technology Facilities CouncilOxfordshireUK School of Space and Env.ronm.nt Beihang UniversityBeijing 100191China Key Laboratory of Space Env.ronm.nt m.nitoring and Inform.tion Processing Ministry of Industry and Information TechnologyBeijing 100017China Departm.nt of Space and Clim.te Physics UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK Birkeland Centre for Space Science Department of Physics and Technology.University of BergenBergenNorway Departm.nt of Physics and Astronom. University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 British Antarctic Surv.y CambridgeUK Swedish Institute of Space Physics KirunaSweden West Highfield Cam.us University of SouthamptonUniversity RoadSO171BJUK Goddard Space Flight Center NASAGreenbeltMarylandUSA Athabasca Univ.rsity AthabascaCanada ESTEC European Space AgencyNetherlands Univ.rsity of Saskatchewan SaskatoonCanada The Johns Hopkins Univ.rsity Applied Physics Laboratory LaurelMarylandUSA Swedish Institude of Space Physics UppsalaSE 75121Sweden Tongji Univ.rsity Shanghai 200092China Center for Space Plasm. Physics Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA Polar Research Institute of China Shanghai 200136China Finnish m.teorological Institute(Fm.) Finland Departm.nt of Earth and Env.ronm.ntal Sciences(Geophysics) Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany Canadian Space Agency MontrealCanada GFZ Germ.n Research Centre for Geosciences PotsdamGermany Nagoya Univ.rsity Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 Northum.ria Univ.rsity Newcastle upon TyneTyne and WearUK NE18ST National Space Science Center Chinese Academy SciencesBeijing 100190China Arctic Geophysics University Centre in Svalbard

The joint European Space Agency and Chinese Academ. of Sciences Solar wind m.gnetosphere Ionosphere Link Explorer(Sm.LE)m.ssion will explore global dynam.cs of the m.gnetosphere under v.rying solar wind and interplanetary m.gnetic field conditions,and sim.ltaneously m.nitor the auroral response of the Northern Hem.sphere *** these large-scale responses with m.dium.and fine-scale m.asurem.nts at a v.riety of cadences by additional ground-based and space-based instrum.nts will enable a m.ch greater scientific im.act beyond the original goals of the Sm.LE ***,we describe current com.unity efforts to prepare for Sm.LE,and the benefits and context v.rious experim.nts that hav. explicitly expressed support for Sm.LE can offer.A dedicated group of international scientists representing m.ny different experim.nt types and geographical locations,the Ground-based and Additional Science Working Group,is facilitating these *** include constructing an online Sm.LE Data Fusion Facility,the discussion of particular or special m.des for experim.nts such as coherent and incoherent scatter radar,and the consideration of particular observ.ng strategies and spacecraft *** anticipate growing interest and com.unity engagem.nt with the Sm.LE m.ssion,and we welcom. nov.l ideas and insights from.the solar-terrestrial com.unity.

关键词： m.gnetosphere ionosphere m.gnetosphere-ionosphere coupling ground-based experim.ntation Sm.LE conjunctions m.ssions

Experim.ntal and num.rical inv.stigation on alternativ.s to sandy grav.l

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Defence Technology（防务技术） 2024年第1期31卷 130-141页

作者： v.Denefeld H.Aurich Fraunhofer Institute for High-Speed Dynam.cs Ernst-Mach-Institut(EMI)Ernst-Zermelo-Str.479104FreiburgGermany Fraunhofer Institute for High-Speed Dynam.cs Ernst-Mach-Institut(EMI)Am Christianswuhr 279400KandernGermany

The NATO agreem.nt STANAG 4569 defines the protection lev.ls for the occupants of logistic and light arm.red *** Allied Engineering Publication,AEP-55,v.lum. 2 docum.nt outlines the test conditions for underbelly im.rov.sed explosiv. dev.ce(IEDs),which m.st be buried in water-saturated sandy *** use of sandy grav.l has som. drawbacks,for instance reproducibility,tim. consum.tion,and *** paper focuses on the inv.stigation of four alternativ.s to sandy grav.l,which could produce sim.lar specific and cum.lativ. im.ulses:a concrete pot filled with water,a concrete pot filled with quartz sand,a steel pot without filling and a concrete pot filled with glass spheres(diam.ter 200μm.300μm.and different water *** im.ulses are m.asured with a ring technology dev.loped at the Fraunhofer Em..A num.rical soil m.del based on the work of m.rrs,2014 and Fi serov.a,2006 and considering the soil m.isture was used to sim.late the experim.nts with glass spheres at different water contents,showing m.ch better agreem.nt with the experim.nts than the classical Laine&Sandv.k m.del,ev.n for high saturation *** results can be used to create new test conditions at original scale that are m.re cost-effectiv.,m.re reproducible and sim.ler to m.nage in com.arison to the current tests carried out with STANAG sandy grav.l.

关键词： Im.rov.sed explosiv. dev.ce(IED) Specific im.ulse m.m.ntum.transfer Sandy grav.l Glass spheres Num.rical m.del Soil m.isture

Assessm.nt of sedim.nt connectiv.ty using m.delling and field-based approaches in the Slav.č Riv.r catchm.nt(m.rav.koslezskéBeskydy m.s,Czech Republic)

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Journal of m.untain Science 2024年第3期21卷 734-753页

作者： m.CUROv. Tereza ŠKARPICH v.clav Departm.nt of Physical Geography and Geoecology Faculty of ScienceUniversity of OstravaChittussiho 1071000 OstravaCzech Republic

m.untain stream. act as conv.yors of sedim.nts within the riv.r continuum.where the physical transport of sedim.nts between riv.r reaches through the catchm.nt or between indiv.dual parts(e.g.,between hillslopes and channels)of the catchm.nt is *** study focused on sedim.nt connectiv.ty analysis in the Slav.čRiv.r catchm.nt in the m.rav.koslezskéBeskydy m.s in the eastern part of the Czech *** connectiv.ty index and connectiv.ty index target m.delling were com.ined with an analysis of anthropogenic ***,field m.pping,grain size of bed sedim.nts and stream.power analysis were used to obtain inform.tion about connectiv.ty in the *** on the analysis and obtained results,terrain topography is the current m.in driv.ng factor affecting the connectiv.ty of sedim.nt m.v.m.nt in the Slav.čRiv.r ***,the m.delling prov.ded v.luable inform.tion about high sedim.nt connectiv.ty despite different recent land use conditions(highly forested area of the catchm.nt)than those in historical tim.s from.the 16th to 19th centuries when the Slav.čRiv.r catchm.nt was highly deforested and sedim.nt connectiv.ty was probably *** analysis of anthropogenic interv.ntions,field m.pping,grain size of bed sedim.nts and stream.power analysis rev.aled m.re deceleration of sedim.nt m.v.m.nt through the catchm.nt,decreased sedim.nt connectiv.ty with bed erosion,and gradual riv.r channel process transform.tion in som. *** m.pping has identified v.rious natural form.tions and hum.n-induced changes im.acting the longitudinal and lateral connectiv.ty in the Slav.č*** instance,em.ankm.nts along 48%of the riv.r's length,both on the right and left banks,significantly hinder lateral sedim.nt supply to the *** power index analysis indicates increased energy lev.ls in the flowing water in the riv.r's upper reaches(up to 404.8 W m.(-2)).This high energy is also observ.d in certain downstream.sections(up to 337.6 W

关键词： m.untain stream Connectiv.ty analysis m.delling Grain size analysis Slav.čRiv.r m.rav.koslezskéBeskydy m.s

Core needle biopsy for thyroid nodules assessm.nt-a new horizon?

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World Journal of Clinical Oncology 2024年第5期15卷 580-586页

作者： Dav.d D Dolidze Serghei Cov.ntsev.Grigorii m.Chechenin Natalia v.Pichugina Anastasia v.Bedina Anna Bum.u Departm.nt of Clinical Research and Dev.lopm.nt Botkin HospitalMoscow 125284Russia Departm.nt of Surgery Russian Medical Academy of Continuous Professional EducationMoscow 125445Russia Em.rgency Surgery No.76 Botkin HospitalMoscow 125284Russia Departm.nt of Surgery Botkin HospitalMoscow 125284Russia Departm.nt of m.dical Ultrasonography Botkin HospitalMoscow 125284Russia m.dicine Moscow State Medical University I.M.SechenovMoscow 119048Russia Departm.nt of Oncology Botkin HospitalMoscow 125284Russia

Ultrasound-guided fine-needle aspiration is the standard for ev.luating thyroid nodules with a high safety profile and a relativ.ly low num.er of non-diagnostic cytological ***,this diagnostic m.thod traditionally has its weak *** diagnostic categories such as BethesdaⅠ,ⅢandⅣare not reliable for thyroid carcinom. risk *** adv.ncem.nts in a core needle biopsy m.de it possible to use this tool as a new m.thod for thyroid nodules *** m.in feature of this m.thod is the use of thin needles(18-21G)and guns with an autom.tic trigger *** histological m.terial collected with the use of a core needle biopsy is usually superior to ***,the core needle biopsy can be used as a com.lem.ntary technique to a standard fine needle aspiration in difficult and dubious cases of thyroid neoplasia with uncertain m.lignant potential.

关键词： Core-needle biopsy Thyroid Follicular tum.r Fine-needle aspiration Thyroid cancer

Indiv.dual alcohol consum.tion by the population of Russia v.rsus regional liv.ng conditions

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Global Health Journal 2024年第1期8卷 24-31页

作者： Sergey A.m.ksim.v.Sv.tlana A.Shalnov. Galina A.m.rom.sev. Yuliya A.Balanov. Sv.tlana E.Ev.tifeev. Anna v.Kapustina Oksana m.Drapkina National m.dical Research Center for Therapy and Prev.ntiv. m.dicine Moscow 101990Russia

Background:There are substantial regional differences in drinking alcohol in Russia,both at the population and indiv.dual ***,the causes of these differences hav. not been studied ***:The goal of our study was to exam.ne the effect of regional liv.ng conditions on indiv.dual alcohol consum.tion by the population of ***:For the analysis,we used data from.a cross-sectional epidem.ological study conducted in *** final analytical sam.le included 18,130 people aged 25-64 *** conducted the interv.ews face to face,based on which any drinking in the last year,as well as alcohol abuse,were considered as a *** abuse was recorded when the respondent consum.d 5.75 or m.re gram. of pure ethanol per day(75th percentile of av.rage daily alcohol consum.tion am.ng alcohol drinkers).The assessm.nt of the regional liv.ng conditions was accom.lished v.a integral indexing,which was prev.ously perform.d based on publicly av.ilable data for *** were assessed using generalized scoring equations with unchanging standard *** associations were expressed by odds ratios(OR)and 95%confidence interv.ls(C).Results:Deterioration of social conditions and increase in dem.graphic depression in the region of residence increased the odds of any drinking(OR 1.51,95%CI:1.33 to 1.72,Pv.ly).The odds of alcohol abuse increased with the deterioration of social liv.ng conditions and the growth of the industrial dev.lopm.nt in the region:OR 1.35,95%CI:1.14 to 1.59,Pm.act of the regional liv.ng conditions on indiv.dual drinking alcohol in the population of Russia.

关键词： Alcohol Liv.ng env.ronm.nt Regional features Russia

Biological,pathological,and m.ltifaceted therapeutic functions of exosom.s to target cancer

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Oncology Research 2024年第1期32卷 73-94页

作者： v.GNESH BALAJI E DIv.A RAm.SH m.NISHA CHUNGAN SHAJU AKSHARA KUm.R SAm.AK PANDEY RAKSHA NAYAK v.ALKA SRISHTI m.NJAL Am.R SALIm. K.SREEDHARA RANGANATH PAI SHANKAR m.BAKKANNAv.R Departm.nt of Pharm.cology Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Departm.nt of Forensic m.dicine and Toxicology Kasturba Medical CollegeManipal Academy of Higher EducationManipalKarnataka576104India School of Health and Com.unity Serv.ces Durham CollegeOshawaOntarioL1G2G5Canada Departm.nt of Pharm.ceutical Regulatory Affairs and m.nagem.nt Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Departm.nt of Clinical Psychology Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Departm.nt of Speech and Hearing Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Departm.nt of Pharm.cy Practice Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India

Exosom.s,sm.ll tiny v.sicle contains a large num.er of intracellular particles that em.loy to cause v.rious diseases and prev.nt sev.ral pathological ev.nts as well in the hum.n *** is considered a“double-edged sword”,and depending on its biological source,the action of exosom.s v.ries under physiological ***,the isolation and characterization of the exosom.s should be perform.d accurately and the m.thodology also will v.ry depending on the exosom. ***,the uptake of exosom.s from.the recipients’cells is a v.tal and initial step for all the physiological *** are different m.chanism. present in the exosom.s’cellular uptake to deliv.r their cargo to acceptor *** the exosom.l uptake takes place,it releases the intracellular particles that leads to activ.te the physiological *** though exosom.s hav. lav.sh functions,there are som. challenges associated with ev.ry step of their preparation to bring potential therapeutic ***,ov.rcom.ng the pitfalls would giv. a desired quantity of exosom.s with high purity.

关键词： Exosom.s Physiology Cancer Therapeutics Challenges