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Autoimmune hepatitis in human immunodeficiency virus infection: Case report and literature review

World Journal of Clinical Infectious Diseases 2017年第4期7卷 50-57页

作者： Ivan Nore?a Jairo A Morantes-caballero Andrés Garcés Brian José Gómez Gabriel Rodríguez Carlos Saavedra William Otero Infectious Diseases Section Department of Internal Medicine Universidad Nacional de Colombia and Hospital Universitario Nacional de Colombia Department of Internal Medicine Universidad Nacional de Colombia and Hospital Universitario Nacional de Colombia Gastroenterology Section Department of Internal Medicine Universidad Nacional de Colombia and Hospital Universitario Nacional de Colombia

The infection due to human immunodeficiency virus(HIV) is characterized by the progressive reduction of CD4+ T lymphocytes and the compromise of other cell lines of the immune system, resulting in immunosuppression. In this context, autoimmune diseases could be considered contradictory, however, cases of autoimmune diseases during this infection have been described, including autoimmune hepatitis(AIH), which is uncommon and has few case reports within medical literature, none of them from Latin America. In this case report where a patient with an HIV infection on combined antiretroviral treatment developed acute elevation of transaminases, hyperbilirubinemia, and deterioration in hepatic synthetic function. Although initially an antiretroviral drug-induced liver injury was suspected, during the study a diagnosis of autoimmune hepatitis was proven, which required treatment with corticosteroid and azathioprine, obtaining a satisfactory response and managing to continue the antiretroviral therapy. Autoimmune diseases in HIV infection must be taken into account. In the case of hepatitis in patients with HIV on antiretroviral treatment, the differentiation between viral hepatitis caused by autoimmune diseases or medications is essential to establish an adequate treatment, and avoid the suspension of the antiretroviral therapy.

关键词： Autoimmunity Autoimmune hepatitis Human immunodeficiency virus Anti-human immunodeficiency virus agents Drug-induced liver injury

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如果中国好智利会更受益 006

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中国社会科学报

作者： Gina caballero 褚国飞

路易斯·施密特·蒙特斯(Luis Schmidt Montes)，现任智利驻华大使。毕业于智利天主教大学(Uni versi dadCatoli ca de Chile)。曾先后担任全国水果产品工商联主席、国家农业协会(Nati onalSoci ety of Agri cul ture，SNA)主席等多项...

路易斯·施密特·蒙特斯(Luis Schmidt Montes)，现任智利驻华大使。毕业于智利天主教大学(Uni versi dadCatoli ca de Chile)。曾先后担任全国水果产品工商联主席、国家农业协会(Nati onalSoci ety of Agri cul ture，SNA)主席等多项职务，SNA是智利农业领域最著名的协会。

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世界是银沉默是金 016

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中国社会科学报

作者： Gina caballero 褚国飞

卡洛斯·莫塔(Carlos Malta)是目前巴西乐坛最伟大的代表人物之一，被称为“七乐器大师”。他和其乐队Pife Mudemo，在巴西、美国、委内瑞拉、日本、摩洛哥、法国和中国的表演及音乐节中多次赢得观众的站立喝彩。2011年9月，这个天才乐...

卡洛斯·莫塔(Carlos Malta)是目前巴西乐坛最伟大的代表人物之一，被称为“七乐器大师”。他和其乐队Pife Mudemo，在巴西、美国、委内瑞拉、日本、摩洛哥、法国和中国的表演及音乐节中多次赢得观众的站立喝彩。2011年9月，这个天才乐团来到北京，首次为中国观众演奏，和谐地?

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Searching for the Nano-Hertz Stochastic Gravitational Wave Background with the Chinese Pulsar Timing Array Data ReleaseⅠ

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Research in Astronomy and Astrophysics 2023年第7期23卷 300-311页

作者： Heng Xu Siyuan Chen Yanjun Guo Jinchen Jiang Bojun Wang Jiangwei Xu Zihan Xue RNicolas caballero Jianping Yuan Yonghua Xu Jingbo Wang Longfei Hao Jingtao Luo Kejia Lee Jinlin Han Peng Jiang Zhiqiang Shen Min Wang Na Wang Renxin Xu Xiangping Wu Richard Manchester Lei Qian Xin Guan Menglin Huang Chun Sun Yan Zhu National Astronomical Observatory Chinse Academy of SciencesBeijing 100101China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China Max-Planck institut fúr Radioastronomie Auf Dem HúgelBonnD-53121Germany Hellenic Open University School of Science and Technology26335 PatrasGreece Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Yunnan Astronomical Observatories Chinese Academy of SciencesKunming 650216China Institute of Optoelectronic Technology Lishui UniversityLishui 323000China National Time Service Center Chinese Academy Of SciencesXi'an 710600China Key Laboratory of Radio Astronomy and Technology Chinese Academy of SciencesBeijing 100101China Beijing Laser Acceleration Innovation Center HuairouBeijing 101400China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Australia Telescope National Facility CSIRO Space and AstronomyP.O.Box 76Epping NSW 1710Australia

Observing and timing a group of millisecond pulsars with high rotational stability enables the direct detection of gravitational waves(GWs).The GW signals can be identified from the spatial correlations encoded in the times-of-arrival of widely spaced *** Chinese Pulsar Timing Array(CPTA)is a collaboration aiming at the direct GW detection with observations carried out using Chinese radio *** short article serves as a“table of contents”for a forthcoming series of papers related to the CPTA Data Release 1(CPTA DR1)which uses observations from the Five-hundred-meter Aperture Spherical radio ***,after summarizing the time span and accuracy of CPTA DR1,we report the key results of our statistical inference finding a correlated signal with amplitude logA_(c)=-14.4_(-2.8)^(+1.0)for spectral index in the range ofα∈[-1.8,1.5]assuming a GW background(GWB)induced quadrupolar *** search for the Hellings–Downs(HD)correlation curve is also presented,where some evidence for the HD correlation has been found that a 4.6σstatistical significance is achieved using the discrete frequency method around the frequency of 14 n *** expect that the future International Pulsar Timing Array data analysis and the next CPTA data release will be more sensitive to the n Hz GWB,which could verify the current results.

关键词： (stars:)pulsars:general gravitational waves methods:statistical methods:observational

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反思“西化” 体现民族自我意识 006

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中国社会科学报

作者： Gina caballero 褚国飞

随着经济与社会的发展，文化不可避免地会随之发展变化。这是一个自然过程，也是文化之所以保持生机与活力的重要标志。文化的发展难免会带来一些负面的因素，这需要我们理性看待，并尽量寻找有效的解决方案，但绝不可因此而固步自封。...

随着经济与社会的发展，文化不可避免地会随之发展变化。这是一个自然过程，也是文化之所以保持生机与活力的重要标志。文化的发展难免会带来一些负面的因素，这需要我们理性看待，并尽量寻找有效的解决方案，但绝不可因此而固步自封。中国在发展中遇到不少困惑，比如

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农牧业合作:推进中阿双边关系发展的引擎 006

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中国社会科学报

作者： Gina caballero 褚国飞

付拓哲(Arturo Videla) ，现任阿根廷农牧渔业部乳业副国务秘书，此前曾担任阿根廷科尔多瓦(Cordoba)省畜牧业副秘书长、维拉玛丽娅(Villa Maria)中小乳品企业协会(the Associations of small and medium dairy private ente rprises)...

付拓哲(Arturo Videla) ，现任阿根廷农牧渔业部乳业副国务秘书，此前曾担任阿根廷科尔多瓦(Cordoba)省畜牧业副秘书长、维拉玛丽娅(Villa Maria)中小乳品企业协会(the Associations of small and medium dairy private ente rprises)顾问以及城市间区域发展机构(the Intermnic

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使用异维A酸治疗1例13岁色素性水疱型痒疹患者疗效显著

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世界核心医学期刊文摘（皮肤病学分册） 2006年第1期2卷 19-20页

作者： Requena caballero C Nagore E Sanmartn O 王琼 Servicio de Dermatologa Instituto Valenciano de Oncologa C/P Beltran Baguena no 8 y 19 46009 Valencia Spain

Prurigo pigmentosa is a rare inflammatory disease of unknown origin, first reported from Japan, with only 33 cases described in non-Japanese patients. We describe a 13-year-old girl with a pruriginous symmetrical eruption of papules and vesicles affecting her back, neck and chest of 1 month duration. She remembered a similar, but lighter eruption, 2 months before. As the initial diagnosis was of a vesiculobullous form of Darier disease, treatment with isotretinoin 40 mg/day was started with good response. Histological study showed a superficial perivascular and interstitial dermatitis composed predominantly of lymphocytes. The epidermiswas spongiotic,with exocytosis of lymphocytes and some neutrophils and necrotic keratinocytes. All these findings were consist ent with prurigo pigmentosa. The lesions resolved leaving a light brown reticulate hyperpigmentation. Prurigo pigmentosa has never been reported in prepubescent patients, the vesiculobullous forms are unusual, and the only treatments used previously are sulphonamides, tetracyclines and macrolides. We report a 13-year -old Caucasian girl with vesiculobullous prurigo pigmentosa successfully treated with isotretinoin.

关键词：色素性痒疹首例报道角质形成细胞组织学检查表皮棘层大疱青春期前大环内酯类药物海绵样变

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Acute and Long-Lasting Neurological Symptoms in SARS CoV-2 Infected Patients

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Journal of Behavioral and Brain Science 2021年第3期11卷 73-81页

作者： Gabriel Salazar Tortolero Cherifa Nechat Marta Fragoso Martinez Beatriz Chavarria Javier Emilio Codas Iolanda caballero Saez Hector Cruz Tabuenca Consuelo Martinez Marta Andrés Consorci Sanitari de Terrassa (CST) Barcelona Spain HM Delfos Barcelona Spain

There have been reported a large number of neurological symptoms in CoV-2 infected patients after the COVID-19 outbreak was declared in January 2020. Cases reports as well as series of COVID-19 patients have shown a wide variety of neurological symptoms such as stroke, encephalomyelitis, polyradiculoneuropathy and other neurological conditions. Despite the fact, a high incidence of neurological symptoms have been reported during the COVID-19 pandemic, the proportion of them in acute and in a more chronic phase has not been exactly described in most of the papers published until now. We described in this article the neurological symptoms in a series of COVID-19 patients during the acute phase of infection while they were admitted into the hospital and subsequently the persisting neurological symptoms showed in the following 6 months in the outpatients’ evaluation once they were discharged from the hospital in the province of Catalonia-Spain from January to June of 2020.

关键词： CoV-2 Neurological Symptoms CoV-2 Europe Neurological Sequeles

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Lens Capsule HSPG-Perlecan Regulates Lens Fibre Differentiation during Chick Embryo Development

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Open Journal of Veterinary Medicine 2017年第2期7卷 9-22页

作者： Cristina Martín María I. Alonso Francisco Lamus José A. Moro A. De la Mano José M. fernandez Alberto caballero ángel Gato Departamento de Anatomía y Radiología Laboratorio de Desarrollo y Teratología del Sistema Nervioso. Instituto de Neurociencias de Castilla y León (INCYL) Facultad de Medicina Universidad de Valladolid Valladolid Espa&#241a Departamento de Biología Celular Histología y Farmacología Facultad de Medicina Universidad de Valladolid Valladolid Spain

Lens fibre differentiation is a life-long process related with lens transparency, and is particularly intense during development, being related with an FGF-2 antero-posterior gradient at the equator level as the main growth factor involved which has been related with the basal membrane of the lens anlagen known as “Lens capsule”. However the lens fibre differentiation induced by FGF2 depends, as in other biological systems, on the local bioavailability of FGF-2 regulated by their relationship with extracellular matrix molecules as Heparan Sulphate Proteoglycans. Here, we try to clarify how Perlecan (a heparan sulphate proteoglycan specific from basement membranes) is involved in lens fibre differentiation at earliest stages of eye development. Our results show that Perlecan, is a major component in the lens capsule during the earliest stages of lens development in chick embryos being present during lens plate induction, lens vesicle stage and the onset of lens fibre differentiation. In order to demonstrate a direct involvement of HSPG-Perlecan in lens fibre differentiation, we generate depleted lenses by HSPG-Perlecan synthesis disruption and specific enzymatic digestion. The HSPG-Perlecan depleted lens show a significant delay or abolition in the lens fibre differentiation which remains in an immature cells displaying DNA synthesis in the posterior epithelium and a decrease in FGF2 lens expression. These data support the hypothesis that lens capsule HSPG-Perlecan is a key molecule involved in lens fibre differentiation during development, probably by involvement in FGF-2 biodisponibility.

关键词： Eye Development Lens Fibre Differentiation HSPG-Perlecan FGF-2 Chick Embryo

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Branched Polyamines Functionalized with Proposed Reaction Pathways Based on <sup>1</sup>H-NMR, Atomic Absorption and IR Spectroscopies

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American Journal of Analytical Chemistry 2014年第16期5卷 1090-1101页

作者： Vicente Cervantes-Mejía Elizabeth Baca-Solis Judith caballero-Jiménez Rosario Merino-García Jesús Cruz-Gatica Gabriela Moreno-Martínez Yasmi Reyes-Ortega Chemical Center Sciences Institute Autonomous University of Puebla Puebla México

Three novel branched polyamines N,N,N’,N’-tetrakis-[3((pyridine-2-methyl)-amine) propyl]-1,4- butanediamine (1), N,N,N’,N’-tetrakis-[N-((2-methylpyridine)ethyl)propanamide]ethylenediamine (2) and N,N,N’,N’-tetrakis-[3((2-hidroxibenziliden)-amine)propyl]-1,4-butanediamine (3), were synthesized starting from 2-pyridinecarboxaldeyde with DAB-Am-4 for 1, PAMAM G0 for 2 and from salicylaldehyde with DAB-Am-4 for 3. The pathway reactions have been proposed by 1H-NMR, IR and Atomic Absorption Spectroscopy. The optimal reaction time was set by IR spectroscopy following aldehyde? peak modification. 1 and 2 were obtained as both hydrochlorides and as free amines and 3 only as free imine. These polyamines were characterized by UV-Vis, IR, 1H-NMR and 13C-NMR and Mass Spectrometry.

关键词： Branched Polyamines Functionalization Reactions IR NMR Atomic Absorption Spectroscopy

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