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Chronic pelvic pain,psychiatric disorders and early emotional traumas:Results of a cross sectional case-control study

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World Journal of Psychiatry 2016年第3期6卷 339-344页

作者： flávia L Osório Ana Carolina f Carvalho mariana f donadon André L Moreno Omero Polli-Neto Medical School of Ribeir?o Preto S?o Paulo University

AIM To compare the prevalence of psychiatric disorders and early emotional traumas between women with chronic pelvic pain(CPP) and healthy *** One hundred women in reproductive age,50 of them had CPP(according to the criteria set by the International Association for Study of Pain),and 50 were considered healthy after the gynecological *** eligibility criteria were defined as follows:chronic or persistent pain perceived in the pelvis-related structures(digestive,urinary,genital,myofascial or neurological systems).Only women in reproductive age with acyclic pain for 6 mo,or more,were included in the present *** was the exclusion *** participants were grouped according to age,school level and socioeconomic status and were individually assessed through DSM-IV Structured Clinical Interview(SCID-I) and Early Trauma Inventory Self-report-short form(ETISR-Sf Brazilian version).Descriptive statistics,group comparison tests and multivariate logistics regression were used in the data *** The early emotional traumas are highly prevalent,but their prevalence did not differ between the two *** current Major Depressive Disorder was more prevalent in women with *** CPP was associatedwith endometriosis in 48% of the *** was no difference in the prevalence of disorders when endometriosis was taken into account(endometriosis vs other diseases:P > 0.29).The current Major Depressive Disorder and the Bipolar Disorder had greater occurrence likelihood in the group of women with CPP(ODDS = 5.25 and 9.0).CONCLUSION The data reinforce the link between mood disorders and *** preview evidences about the association between CPP and early traumas tended not to be significant after a stronger methodological control was implemented.

关键词： Pelvic pain Psychiatric disorder Early trauma Emotional Depression

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Reply to "Application of contrast-enhanced intraoperative ultrasonography in the decision-making about hepatocellular carcinoma operation"

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World Journal of Gastroenterology 2010年第30期16卷 3857-3858页

作者： Matteo donadon Guido Torzilli Liver Surgery Unit Third Department of SurgeryUniversity of Milan School of MedicineIRCCS Istituto Clinico HumanitasVia Manzoni 5620089RozzanoMilanItaly

The use of contrast-enhanced intraoperative ultrasound for hepatocellular carcinoma has been already proposed as a novel technique to stage the disease during surgical resection. In the herein presented "letter to the editor", the authors underline some important points, which have been raised following paper published in the January issue of World Journal of Gastroenterology.

关键词： Hepatocellular carcinoma Liver surgery Contrast-enhanced intraoperative ultrasound Cirrhosis

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Is the exposure to liver transplantation worthwhile for trainees in liver surgery?

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Hepatobiliary Surgery and Nutrition 2022年第5期11卷 746-748页

作者： Matteo donadon Paolo Baroffio Department of Health Sciences Universitàdel Piemonte OrientaleNovaraItaly Department of General Surgery University Maggiore Hospital Della CaritàNovaraItaly

In the May 2022 issue of Annals of Surgery,Albert *** and colleagues reported interesting results on the effect of liver transplantation(LT)experience in performing complex liver resection(CLR)(1).By considering 1,452 LT and 222 CLR over a period of 24 years,performed in a worldwide recognized center for LT and liver surgery,they had 25.2%major complications and 6.3%mortality after ***,they found that the more experience in LT,the less risk of postoperative complications after *** also indicated the cutoff of 95 LT;meaning that at below such number,the rate of complications after CLR significantly increased(1).

关键词： surgery Surgery liver

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Tailoring the area of hepatic resection using inflow and outflow modulation

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World Journal of Gastroenterology 2013年第7期19卷 1049-1055页

作者： Matteo donadon fabio Procopio Guido Torzilli Liver Surgery Unit Department of General SurgeryUniversity of Milan School of MedicineHumanitas Clinical and Research Center20089 MilanItaly

The performance of hepatic surgery without a parenchyma-sparing strategy carries significant risks for patient survival because of the not negligible occurrence of postoperative liver *** key factor of modern hepatic surgery is the use of the intraoperative ultrasound(IOUS),not only to stage the disease,but more importantly to guide resection with the specific aim to maximize the sparing of the functional *** in patients with hepatocellular carcinoma and underlying liver cirrhosis,or in patients with colorectal liver metastasis,IOUS allows the performance of the so-called "radical but conservative surgery",which is the pivotal factor to offer a chance of cure to an increasing proportion of patients,who until few years ago were considered only for palliative *** some new IOUS-guided surgical maneuvers,which are based on the liver inflow and outflow modulations,more precise anatomically subsegmental-and segmentaloriented resections can be effectively *** present work describes the rationale and the surgical technique for a precise tailoring of the area of hepatic resection using the most recent attainments in *** important technical achievements should be a fundamental part of the surgical armamentarium of the modern liver surgeon.

关键词： Hepatic resection Intraoperative ultrasound Liver inflow Liver outflow Resection guidance

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Parenchymal sparing anatomical liver resections for hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 706-708页

作者： Matteo donadon Guido Torzilli Department of Health Sciences University of Piemonte OrientaleNovaraItaly Department of Surgery University Maggiore Hospital della CaritàNovaraItaly Department of Biomedical Sciences Humanitas UniversityPieve EmanueleItaly Division of Hepatobiliary and General Surgery Department of SurgeryIRCCS Humanitas Research HospitalRozzanoItaly

The rationale of the performance of anatomic resection(AR)of the liver in case of hepatocellular carcinoma(HCC)is the removal of portal pedicle feeding the tumor because of the tumor’s tendency to invade the portal veins(1).This technical approach is expected to be effective from an oncological perspective for a disease such as HCC,which is associated with a high rate of intrahepatic recurrence(2,3).In the eighties,Makuuchi et *** the systematic subsegmentectomy(4)reporting excellent results(5),and later some other authors reported new techniques to identify the portal territory of a given HCC and perform a true AR of the liver(5-7).

关键词： Parenchymal sparing anatomical resections hepatocellular carcinoma(HCC) surgical margin

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Post-hepatectomy biliary fistula: from risk factors to the role of drain placement and management—still a lot to be answered

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Hepatobiliary Surgery and Nutrition 2019年第4期8卷 417-418页

作者： Guido Costa Matteo donadon Guido Torzilli Department of Hepatobiliary and General Surgery Humanitas University & Humanitas Clinical and Research Center – IRCCS Rozzano Milan Italy

Hepatic resection represents the gold-standard treatment for different liver diseases. Among postoperative complications, bile leak remains one of the most common sources of morbidity, which can lead to an increase of hospital stay, need of invasive procedure and potentially death (1). The definition and acknowledge of risk factors for the development of biliary fistula as well as its early detection and optimal management is, in this sense, of crucial importance.

关键词： fistula biliary death

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Unravel hepatic artery infusion chemotherapy in patients with resected colorectal liver metastases

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 257-260页

作者： Matteo donadon Lorenza Rimassa Guido Torzilli Department of Biomedical Sciences Humanitas UniversityPieve EmanueleMilanItaly Department of Hepatobiliary and General Surgery IRCCS Humanitas Research HospitalRozzanoMilanItaly Humanitas Cancer Center IRCCS Humanitas Research HospitalRozzanoMilanItaly

Over the past years,important progresses have been made in the treatment of patients with colorectal liver metastases(CLM).Now,5-year overall survival rate may exceed 50%by using the combination of multimodality therapies among which modern systemic chemotherapy,with or without monoclonal antibodies,and hepatic resection are the cornerstones(1,2).In such multimodality,hepatic artery infusion(HAI)has been proposed since many years with the rationale of increasing the concentration of chemotherapy agents in the liver(3).However,HAI still remains infrequently used,in particular in the adjuvant setting mainly because of the requirement of a multidisciplinary team to manage therapy,and the more widespread use of systemic chemotherapy-in particular following the perioperative“sandwich”schema(4).

关键词： infusion chemotherapy hepatic

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lmmunotherapy in hepatobiliary tumors: search for the missing pieces of the puzzle

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Hepatobiliary Surgery and Nutrition 2020年第1期9卷 86-88页

作者： Matteo donadon federica Marchesi Lorenza Rimassa Guido Torzilli Department of Hepatobiliary and General Surgery Humanitas Clinical and Research Center-IRCCSRozzanoMilanItaly Department of Biomedical Sciences Humanitas UniversityPieve EmanueleMilanItaly Department of Immunology and Inflammation Humanitas Clinical and Research Center-IRCCSRozzanoMilanItaly Department of Biotechnology and Translational Medicine University of MilanMilanItaly Humanitas Cancer Center Humanitas Clinical and Research Center-IRCCSRozzanoMilanItaly

In the current era of immunotherapy, the treatment of hepatobiliary cancers is rapidly evolving. The use of immunotherapeutic approaches, which include peptide-based vaccines, checkpoint inhibitors and antibodies, particularly applies to advanced hepatobiliary cancers, for which the availability of limited therapeutic options encourages the adoption of alternative strategies. Thanks to the published/presented, although conflicting, results of some of the clinical trials on this topic together with the incoming results of some other trials, clinicians involved in the cure of hepatobiliary cancer patients need to understand the basic and advanced applications of immunotherapies (1-6).

关键词： hepato biliary therapeutic

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Hepatobiliary surgeons meet immunologists: the case of colorectal liver metastases patients

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Hepatobiliary Surgery and Nutrition 2019年第4期8卷 370-377页

作者： Matteo donadon Nina Cortese federica Marchesi Matteo Cimino Alberto Mantovani Guido Torzilli Department of Hepatobiliary and General Surgery Humanitas UniversityPieve EmanueleItaly Department of Biomedical Sciences Humanitas UniversityPieve EmanueleItaly Department of Immunology and Inflammation Humanitas Clinical and Research CenterRozzanoMilanItaly Department of Medical Biotechnology and Translational Medicine University of MilanMilanItaly The William Harvey Research Institute Queen Mary University of LondonLondonUK

The burgeoning field of cancer immunology demands a change in the paradigm of cancer patient management. The understanding of the course of a given malignant disease should also include the host immune system as one of the key factors in determining the patient's prognosis. Surgical and medical oncologists need to understand the basic and advanced applications of immunotherapies, which are rapidly evolving, and are nowadays an integral part of the armamentarium for the treatment of cancer patients. In the present work, we review the current knowledge concerning the immune landscape of colorectal cancer (CRC) patients with liver metastases, as recently discovered.

关键词： Host immune system colorectal liver metastases (CLM) colorectal cancer liver metastases colorectal cancer (CRC) immune response immunotherapy

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Role of liver biopsy in hepatocellular carcinoma

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World Journal of Gastroenterology 2019年第40期25卷 6041-6052页

作者： Luca Di Tommaso Marco Spadaccini Matteo donadon Nicola Personeni Abubaker Elamin Alessio Aghemo Ana Lleo Pathology Unit Humanitas Clinical and Research Center IRCCSRozzano 20089Italy Department of Biomedical Sciences Humanitas UniversityPieve Emanuele 20090Italy Division of Hepatobiliary and General Surgery Department of General SurgeryHumanitas Clinical and Research Center IRCCSRozzano 20089Italy Division of Medical Oncology and Hematology Humanitas Cancer CenterHumanitas Clinical and Research Center IRCCSRozzano 20089Italy Division of Internal Medicine and Hepatology Department of GastroenterologyHumanitas Clinical and Research Center IRCCSRozzano 20089Italy

The role of liver biopsy in the diagnosis of hepatocellular carcinoma(HCC)has been challenged over time by the ability of imaging techniques to characterize liver lesions in patients with known *** fact,in the diagnostic algorithm for this tumor,histology is currently relegated to controversial ***,the risk of complications,such as tumor seeding and bleeding,as well as inadequate sampling have further limited the use of liver biopsy for HCC ***,there is growing evidence of prognostic and therapeutic information available from microscopic and molecular analysis of HCC and,as the information content of the tissue sample increases,the advantages of liver biopsy might modify the current risk/benefit *** herein review the role and potentiality of liver biopsy in the diagnosis and management of *** the potentiality of precision medicine comes to the management of HCC,it will be crucial to have rapid pathways to define prognosis,and even treatment,by identifying the patients who could most benefit from target-driven *** of the above reasons suggest that the current role of liver biopsy in the management of HCC needs substantial reconsideration.

关键词： Hepatocellular carcinoma Liver biopsy Prognostic factors Liver cancer Recurrence Liquid biopsy

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