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Relationship between Th17 immune response and cancer

World Journal of Clinical Oncology 2021年第10期12卷 845-867页

作者： Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus dias Fabrício Freire de Melo Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next *** has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer *** Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin *** type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor *** other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 ***(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in ***,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical *** understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets.

关键词： Cancer Immune response Th17 cells Interleukin-17 Tumor microenvironment Pathophysiology

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营养不良:一场无声的大流行健康饮食是一项人权,并且是公平、弹性社会的基础

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英国医学杂志中文版 2021年第3期24卷 121-122页

作者： Henry E Mark Glauce dias da Costa Claudia Pagliari Stefan A Unger 刘宇(译) International Development Consultant NottinghamUK Department of Nutrition and Health Federal University of VicosaVicosaBrazil Usher Institute of Population Health Sciences and Informatics University of EdinburghEdinburghUK Royal Hospital for Sick Children EdinburghUK 北京大学医学部公共卫生学院劳动与环境学系

2020年,公共卫生成为近年来最突出的问题,但早在新型冠状病毒肺炎(COVID-19)暴发之前,世界就已经目睹了一场更为安静的大流行:营养不良。受到营养不良影响的人数是惊人的。全球约1.49亿儿童发育迟缓(慢性营养不良),5000万儿童严重营养不... 详细信息

2020年,公共卫生成为近年来最突出的问题,但早在新型冠状病毒肺炎(COVID-19)暴发之前,世界就已经目睹了一场更为安静的大流行:营养不良。受到营养不良影响的人数是惊人的。全球约1.49亿儿童发育迟缓(慢性营养不良),5000万儿童严重营养不足(消瘦)1,且营养不良作为直接或根本死因占所有儿童死亡的45%2。此外,有4000万5岁以下儿童超重,6.78亿成年人肥胖1。

关键词：健康饮食公共卫生营养不良营养不足

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Unraveling oral psoriasis and its relationship with geographic tongue: A literature review

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World Journal of Dermatology 2016年第2期5卷 84-92页

作者： Bruna Lavinas Sayed Picciani Thays Teixeira-Souza áquila Almenara Curty Lívia Maria Santos Izahias Thiago Moreira Pessoa Sueli Carneiro Heron Fernando Sousa Gonzaga Eliane Pedra dias Postgraduate Program in Pathology School of MedicineFluminense Federal University Sector of Dermatology Medical Clinic DepartmentFederal of Rio de Janeiro University Department of Dermatology Medical School

Differentiating between oral psoriasis and geographic tongue is difficult and controversial because some patients with geographic tongue do not necessarily have psoriasis. Furthermore, the number of clinical studies, reporting histopathological and genetic evidence for the definitive diagnosis of oral psoriasis, is limited. The aim of this literature review was to obtain data for supporting the diagnosis of oral psoriasis with particular emphasis on the relationship between psoriasis and geographic tongue. Based on the current data, it can be concluded that geographic tongue is the most common oral lesion in psoriasis, and histopathological, immunohistochemical, and genetic similarities have been observed between the two diseases. This review also emphasizes the importance of conducting oral examinations in patients with psoriasis and skin examinations in patients with geographic tongue.

关键词： Psoriasis Geographic tongue Oral psoriasis Benign migratory glossitis

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Ballistic response of armour plates using Generative Adversarial Networks

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Defence technology 2022年第9期

作者： S.Thompson F.Teixeira-dias M.Paulino A.Hamilton

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Yield and Characterization of the Centesimal Composition of Amazonian Estuarine Fish

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Journal of Agricultural Science and Technology(B) 2019年第3期9卷 175-183页

作者： Arllon José dos Santos dias Nyelle Priscila Brito Facanha Ed Marcos Homobono da Silva Evlen Tamille Silva do Carmo Charles dos Santos Barros Gabriel Araujo da Silva Laboratory of Organic Chemistry and Biochemistry Amapá State University Macapá Amapá 68900-070 Brazil

Fish, as one of the fishery resources, is an important constituent of the diet of the Amazon population, as it is the source of several nutritional components. The present work aimed to characterize the centesimal composition of Plagioscion squamosissimus fillet (n = 10) and Macrobrachium amazonicum meat (n = 82), species acquired in the estuarine region of the state of Amapá, Brazil. Carcass yield, as well as protein, water content, lipids and ashes was determined according to the methodologies proposed by the Adolf Lutz Institute, as well as carbohydrate and caloric determinations. The analyses were performed in triplicate per sample. After comparing with the literature, it was possible to conclude that P. squamosissimus presented a fillet yield of 31.11%± 0.61%, high protein content (15.99 ± 1.26 g/100 g) and humidity (79.40 ± 1.10 g/100 g), moderate contents of mineral residues (1.10 ± 0.07 g/100 g) and carbohydrates (0.96 ± 0.90 g/100 g), low lipid contents (2.29 ± 0.65 g/100 g), as well as low caloric values (385,018.12 J/100 g) and M. amazonicum a meat yield of 44.12%± 8.34%, high levels of protein (22.81 ± 1.72 g/100 g), carbohydrates (1.92 ± 1.61 g/100 g) and mineral residues (1.76 ± 0.78 g/100 g), moderate water content (73.38 ± 0.78 g/100 g), low lipid levels (0.43 ± 0.08 g/100 g), as well as low caloric values (440,786.3 J/100 g). The results obtained in this work can serve as a subsidy in nutritional diets for humans, thus allowing an adequate dietary use of these species.

关键词： Nutritional assessment bromatological variables nutritional value chemical parameters of food

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Impact of preformed donor-specific antibodies against HLA class Ⅰ on kidney graft outcomes:Comparative analysis of exclusively anti-Cw vs anti-A and/or-B antibodies

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World Journal of Transplantation 2016年第4期6卷 689-696页

作者： Sofia Santos Jorge Malheiro Sandra Tafulo Leonídio dias Rute Carmo Susana Sampaio Marta Costa Andreia Campos Sofia Pedroso Manuela Almeida La Salete Martins Castro Henriques António Cabrita Department of Nephrology and Kidney Transplantation Centro Hospitalar do Porto Centro do Sangue e Transplanta??o do Porto Department of Nephrology Hospital Sao? Joao?

AIM To analyze the clinical impact of preformed antiH LA-Cw vs antiH LA-A and/or-B donor-specific antibodies(DSA) in kidney *** Retrospective study, comparing 12 patients transplanted with DSA exclusively antiH LA-Cw with 23 patients with preformed DSA antiH LA-A and/or *** One year after transplantation there were no differencesin terms of acute rejection between the two groups(3 and 6 cases, respectively in the DSA-Cw and the DSA-A-B groups; P = 1). At one year, eG FR was not significantly different between groups(median 59 mL /min in DSA-Cw group, compared to median 51 mL /min in DSA-A-B group, P = 0.192). Moreover, kidney graft survival was similar between groups at 5-years(100% in DSA-Cw group vs 91% in DSA-A-B group, P = 0.528). The sole independent predictor of antibody mediated rejection(AMR) incidence was DSA strength(HR = 1.07 per 1000 increase in MFI, P = 0.034). AMR was associated with shortened graft survival at 5-years, with 75% and 100% grafts surviving in patients with or without AMR, respectively(Log-rank P = 0.005).CONCLUSION Our data indicate that DSA-Cw are associated with an identical risk of AMR and impact on graft function in comparison with "classical" class I DSA.

关键词： Donor-specific antibodies Antibody-mediated rejection Anti human leukocyte antigen classⅠ AntiHLACw antibodies Graft survival Solid-phase immunoassays

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An Earth-mass planet in a time of COVID-19:KMT-2020-BLG-0414Lb

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Research in Astronomy and Astrophysics 2021年第9期21卷 243-261页

作者： Weicheng Zang Cheongho Han Iona Kondo Jennifer C.Yee Chung-Uk Lee Andrew Gould Shude Mao Leandro de Almeida Yossi Shvartzvald Xiangyu Zhang Michael D.Albrow Sun-Ju Chung Kyu-Ha Hwang Youn Kil Jung Yoon-Hyun Ryu In-Gu Shin Sang-Mok Cha Dong-Jin Kim Hyoun-Woo Kim Seung-Lee Kim Dong-Joo Lee Yongseok Lee Byeong-Gon Park Richard W.Pogge John Drummond Thiam-Guan Tan Josédias do Nascimento Júnior Dan Maoz Matthew T.Penny Wei Zhu Ian A.Bond Fumio Abe Richard Barry David P.Bennett Aparna Bhattacharya Martin Donachie Hirosane Fujii Akihiko Fukui Yuki Hirao Yoshitaka Itow Rintaro Kirikawa Naoki Koshimoto Man Cheung Alex Li Yutaka Matsubara Yasushi Muraki Shota Miyazaki Greg Olmschenk Clément Ranc Nicholas J.Rattenbury Yuki Satoh Hikaru Shoji Stela Ishitani Silva Takahiro Sumi Daisuke Suzuki Yuzuru Tanaka Paul J.Tristram Tsubasa Yamawaki Atsunori Yonehara Andreea Petric Todd Burdullis Pascal Fouqué Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Chungbuk National UniversityCheongju 28644Republic of Korea Department of Earth and Space Science Graduate School of ScienceOsaka UniversityToyonakaOsaka 560-0043Japan Center for Astrophysics j Harvard&Smithsonian 60 Garden St.CambridgeMA 02138USA Korea Astronomy and Space Science Institute Daejon 34055Republic of Korea University of Science and Technology Korea(UST)217 Gajeong-ro Yuseong-guDaejeon 34113Republic of Korea Max-Planck-Institute for Astronomy Königstuhl 1769117 HeidelbergGermany Department of Astronomy Ohio State University140 W.18th Ave.ColumbusOH 43210USA National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Universidade Federal do Rio Grande do Norte(UFRN) Departamento de F´1sica59078-970NatalRNBrazil Department of Particle Physics and Astrophysics Weizmann Institute of ScienceRehovot 76100Israel University of Canterbury Department of Physics and AstronomyPrivate Bag 4800Christchurch 8020New Zealand School of Space Research Kyung Hee UniversityYonginKyeonggi 17104Republic of Korea Possum Observatory PatutahiGisbourneNew Zealand Perth Exoplanet Survey Telescope PerthAustralia School of Physics and Astronomy Tel-Aviv UniversityTel-Aviv 6997801Israel Department of Physics and Astronomy Louisiana State UniversityBaton RougeLA 70803 USA Canadian Institute for Theoretical Astrophysics University of Toronto60 St George StreetTorontoON M5S 3H8Canada Institute of Natural and Mathematical Sciences Massey UniversityAuckland 0745New Zealand Institute for Space-Earth Environmental Research Nagoya UniversityNagoya 464-8601Japan Code 667 NASA Goddard Space Flight CenterGreenbeltMD 20771USA Department of Astronomy University of MarylandCollege ParkMD 20742USA Department of Physics University of AucklandPrivate Bag 92019AucklandNew Zealand Department of Earth and Planetary Science Graduate School of ScienceThe University of Tokyo7-3-1 Hongo

We report the discovery of KMT-2020-BLG-0414 Lb,with a planet-to-host mass ratio q2=0.9-1.2×10-5=3-4 q⊕at 1σ,which is the lowest mass-ratio microlensing planet to *** with two other recent discoveries(4?q/q⊕?6),it fills out the previous empty sector at the bottom of the triangular(log s,log q)diagram,where s is the planet-host separation in units of the angular Einstein radiusθ***,these discoveries call into question the existence,or at least the strength,of the break in the mass-ratio function that was previously suggested to account for the paucity of very low-q *** to the extreme magnification of the event,Amax~1450 for the underlying single-lens event,its light curve revealed a second companion with q3~0.05 and|log s3|~1,i.e.,a factor~10 closer to or farther from the host in *** measurements of the microlens parallaxπE and the angular Einstein radiusθE allow estimates of the host,planet and second companion masses,(M1,M2,M3)~(0.3 M⊙,1.0 M⊕,17 MJ),the planet and second companion projected separations,(a⊥,2,a⊥,3)~(1.5,0.15 or 15)au,and system distance DL~1 *** lens could account for most or all of the blended light(I~19.3)and so can be studied immediately with high-resolution photometric and spectroscopic observations that can further clarify the nature of the *** planet was found as part of a new program of high-cadence follow-up observations of high-magnification *** detection of this planet,despite the considerable difficulties imposed by COVID-19(two KMT sites and OGLE were shut down),illustrates the potential utility of this program.

关键词： gravitational lensing:micro

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