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Clinical characteristics and treatment outcomes in patients with liver cirrhosis and lymphoma

World Journal of Hepatology 2020年第2期12卷 34-45页

作者： JoséA González-Regueiro Astrid Ruiz-Margáin mariana cruz-contreras Ana M Montaña-Duclaud Andrea Cavazos-Gómez Roberta Demichelis-Gómez Ricardo U Macías-Rodríguez Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición SalvadorGastroenterologyInstituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránVasco de Quiroga 15Belisario Domínguez Sección XVITlalpanMexico City 14080Mexico Department of Hematology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránVasco de Quiroga 15Belisario Domínguez Sección XVITlalpanMexico City 14080Mexico

BACKGROUND A significant number of patients with liver cirrhosis concomitantly develop some type of solid or hematological cancer,including lymphoma.Treatment of patients with lymphoma and cirrhosis is challenging for physicians due to the clinical characteristics related to cirrhosis,including biochemical and functional abnormalities,as well as portal hypertension and lack of scientific evidence,limiting the use of chemotherapy.Currently,experts recommend only offering oncological treatment to patients with compensated cirrhosis.AIM To evaluate the clinical characteristics and treatment outcomes in patients with cirrhosis and lymphoma treated with chemotherapy.METHODS This was a case-control study conducted at a tertiary care center in Mexico.Data was recorded from medical files and from 8658 possible candidates with cirrhosis and/or lymphoma(2000 to 2018).Only 23 cases had both diseases concomitantly;10 patients with cirrhosis and lymphoma(cases)met the selection criteria and were included,and 20 patients with lymphoma(controls)were included and matched according to age,sex,and date of diagnosis,type and clinical stage of lymphoma.All patients received treatment with chemotherapy.For statistical analysis,descriptive statistics,Shapiro-Wilk test,Mann-Whitney U test,chisquare test and Fisher's exact test were used.Survival was evaluated using Kaplan-Meier curves and Log-rank test.RESULTS There were differences in biochemical variables inherent to liver disease and portal hypertension in patients with cirrhosis.The most frequent etiology of cirrhosis was hepatitis C virus(50%);80%were decompensated,the median Child-Turcotte-Pugh score was 7.5(6.75-9.25),and mean Model for End-stage Liver Disease was 11.5±4.50.Regarding lymphomas,non-Hodgkin's were the most common(90%),and diffuse large B cell subtype was the most frequent,with a higher International Prognostic Index in the cases(3 vs 2,P=0.049).The chemotherapy regimens had to be adjusted more frequently in the case group(50%vs 5%,P=0.009).The complications derive

关键词： Cirrhosis Cancer Lymphoma Chemotherapy Treatment Survival Toxicity Adverse events

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From prediction to prevention:Machine learning revolutionizes hepatocellular carcinoma recurrence monitoring

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World Journal of Gastroenterology 2024年第7期30卷 631-635页

作者： mariana Michelle Ramírez-Mejía Nahum Méndez-Sánchez Plan of Combined Studies in Medicine Faculty of MedicineNational Autonomous University of MexicoDistrito Federal 04510Mexico Liver Research Unit Medica Sur Clinic&FoundationDistrito Federal 14050Mexico Faculty of Medicine National Autonomous University of MexicoDistrito Federal 04510Mexico

In this editorial,we comment on the article by Zhang et al entitled Development of a machine learning-based model for predicting the risk of early postoperative recurrence of hepatocellular carcinoma.Hepatocellular carcinoma(HCC),which is characterized by high incidence and mortality rates,remains a major global health challenge primarily due to the critical issue of postoperative recurrence.Early recurrence,defined as recurrence that occurs within 2 years posttreatment,is linked to the hidden spread of the primary tumor and significantly impacts patient survival.Traditional predictive factors,including both patient-and treatment-related factors,have limited predictive ability with respect to HCC recurrence.The integration of machine learning algorithms is fueled by the exponential growth of computational power and has revolutionized HCC research.The study by Zhang et al demonstrated the use of a groundbreaking preoperative prediction model for early postoperative HCC recurrence.Challenges persist,including sample size constraints,issues with handling data,and the need for further validation and interpretability.This study emphasizes the need for collaborative efforts,multicenter studies and comparative analyses to validate and refine the model.Overcoming these challenges and exploring innovative approaches,such as multi-omics integration,will enhance personalized oncology care.This study marks a significant stride toward precise,efficient,and personalized oncology practices,thus offering hope for improved patient outcomes in the field of HCC treatment.

关键词： Hepatocellular carcinoma Early recurrence Machine learning XGBoost model Predictive precision medicine Clinical utility Personalized interventions

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Representation of three-dimensional mass distribution of the Earth's interior by biorthogonal series and its use for studying internal structure of the planet

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Geodesy and Geodynamics 2024年第3期15卷 264-275页

作者： Mykhailo Fys mariana Yurkiv Andrii Brydun Andrii Sohor Department of Cartography and Geospatial Modelling Lviv Polytechnic National UniversityLviv 79013Ukraine

This paper utilizes the mathematical concept of approximation within an ellipsoid from a single viewpoint to present the spatial mass distribution function of the Earth's interior and its internal potential.The primary focus lies in constructing the volume distribution of masses in the planet's interior, with the expansion coefficients being linear combinations of the Stokes constants. Several possible approaches are suggested for determining accurately these coefficients employing three-dimensional(biorthogonal)polynomials. By expressing the mass distribution function of the Earth's interior and its internal potential as a series, an algorithm is introduced for the calculation of gravitational energy. It allows us to estimate fluctuations in gravitational energy. The implementation of this algorithm offers the means of establishing the extent to which the Earth deviates from a state of hydrostatic equilibrium as a celestial body.Due to the aforementioned method, calculations have been conducted to validate its effectiveness and reliability. This example is given as an illustration of a given method for studying the internal structure of planets.

关键词： Mass distribution function Potential Stokes constants Biorthogonal polynomials

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Radiative loss of coherence in free electrons:a long-range quantum phenomenon

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Light(Science & Applications) 2024年第2期13卷 294-301页

作者： cruz I.Velasco Valerio Di Giulio F.Javier García de Abajo ICFO-Institut de Ciencies Fotoniques The Barcelona Institute of Science and Technology08860Castelldefels(Barcelona)Spain ICREA-InstitucióCatalana de Recerca i Estudis Avançats Passeig Lluís Companys 2308010BarcelonaSpain

Quantum physics rules the dynamics of small objects as they interact over microscopic length scales.Nevertheless,quantum correlations involving macroscopic distances can be observed between entangled photons as well as in atomic gases and matter waves at low temperatures.The long-range nature of the electromagnetic coupling between charged particles and extended objects could also trigger quantum phenomena over large distances.Here,we reveal a manifestation of quantum mechanics that involves macroscopic distances and results in a nearly complete depletion of coherence associated with which-way free-electron interference produced by electron-radiation coupling in the presence of distant extended objects.This is a ubiquitous effect that we illustrate through a rigorous theoretical analysis of a two-path electron beam interacting with a semi-infinite metallic plate and find the inter-path coherence to vanish proportionally to the path separation at zero temperature and exponentially at finite temperature.The investigated regime of large distances originates in the coupling of the electron to radiative modes assisted by diffraction at material structures but without any involvement of material excitations.Besides the fundamental interest of this macroscopic quantum phenomenon,our results suggest an approach to measuring the vacuum temperature and nondestructively sensing the presence of distant objects.

关键词： temperature quantum macroscopic

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Remediation of amide pesticide-polluted soils by combined solarization and ozonation treatment

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Pedosphere 2024年第3期34卷 641-651页

作者： Isabel GARRIDO Carmen MMARTINEZ Pilar FLORES Pilar HELLIN Fulgencio contreras Jose FENOLL Department of Sustainability and Quality Group of Fruit and Vegetable Products Instituto Murciano de Investigacion y Desarrollo Agrario y MedioambientalLa Alberca 30150(Spain)

Agriculture has a close relationship with nature,but it can also be the source of negative and permanent environmental effects.The use of pesticides in modern agriculture is a common practice,but their side effects on the environment cannot be disregarded.In this study,we evaluated a combination of solarization and ozonation techniques for the elimination of six amide pesticides(boscalid,chlorantraniliprole,cyflufenamid,fluopyram,napropamide,and propyzamide)in soil.Initial experiments were performed with four different soils to assess the efficiency of this methodology at different soil temperatures and ozone dosages under laboratory conditions,and then a greenhouse pot experiment was conducted under controlled conditions during summer.Fifty days after the onset of the experiments,higher degradation percentages of amide pesticides were observed in ozonized soils than in other treated soils,particularly when ozone was applied at 10 cm soil depth.The results show that the utilization of ozonation,along with solarization,represents a valid method for degrading residues of the studied pesticides and suggest that this combined technology may be a promising tool for remediating pesticide-polluted soils.

关键词： intermediate ozone pesticide degradation pesticide residue polyethylene film remediation technique

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Annual variation of adult survival of a south-temperate House Wren population in Argentina

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Avian Research 2024年第2期15卷 229-237页

作者： Gustavo J.Fernandez mariana E.Carro Paulo E.Llambías Grupo de Investigacion en Ecofisiología de Fauna Silvestre INIBIOMA-CONICETAsentamiento Universitario San Martín de los Andes(AUSMA)Universidad Nacional Del ComahuePasaje de la Paz 235(8370)San Martín de los AndesNeuquenArgentina Grupo de Investigacion de Biología de Aves IADIZA CCT-MendozaUniversidad Nacional de CuyoAvenida RuizLeal s/n Parque General San Martin5500MendozaArgentina

Identifying factors affecting the survival of individuals is essential for understanding the evolution of life-history traits and population dynamics.Despite numerous studies on this subject in north-temperate environments,there is a lack of equivalent studies at similar latitudes in the south.Here,we used a 14-year dataset of capture,banding,and resighting to estimate the annual variation in the apparent adult survival probability of a south-temperate population of House Wrens(Troglodytes aedon bonariae).We evaluated temporal variation in sur-vival and the effect of environmental(climatic)and demographic variables(adult abundance,total number of fledglings produced during each breeding season)on survival estimators.We found that the probability of adult survival decreased as the abundance of breeding adults increased.This density-dependent effect could be related to the resident lifestyle of southern House Wrens,which could determine an intense competition for territories and resources that ultimately would affect their survival.

关键词： Annual variation CJS Density-dependence Survival Troglodytes aedon bonariae

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Sex differences in Alzheimer's disease:an urgent research venue to follow

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Neural Regeneration Research 2024年第12期19卷 2569-2570页

作者： Raquel Jiménez-Herrera Ana contreras Juan D.Navarro-López Lydia Jiménez-Díaz Neurophysiology&Behavior Lab University of Castilla-La ManchaSchool of Medicine of Ciudad RealCiudad RealSpain

Due to increasing life expectancy,the amount of people with dementia worldwide is expected to experience a substantial rise,with estimates indicating a growth from 55 million in 2019 to a staggering 139 million by the year 2050.Among the various forms of dementia.Alzheimer's disease(AD)stands out as the predominant and most prevalent.

关键词： Alzheimer predominant estimates

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Grazing Pressure and Plant Functional Types in Puna Highlands,Northwestern Argentina

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Phyton-International Journal of Experimental Botany 2024年第5期93卷 1067-1080页

作者： Quiroga Mendiola mariana Tálamo Andrés IPAF NOA—INTA(National Institute for Agricultural Technology) Posta de HornillosJujuy4622Argentina Facultad de Ciencias Naturales Universidad Nacional de SaltaSalta4400Argentina Instituto de Bio y Geociencias del NOA(IBIGEO) UNSa-CONICET.Laboratorio de Ecología Aplicada a la Conservación(LEAC)Facultad de Ciencias NaturalesUniversidad Nacional de SaltaSalta4400Argentina Maestría en Gestión Ambiental Escuela de NegociosUniversidad Católica de Salta(UCASAL)Salta4400Argentina

The Puna grasslands support grazing systems that produce meat and wool in multi-species herds,especially from llama(Lama glama)and sheep.However,it is yet unknown whether grazing pressure can modify grassland structure and Plant Functional Types diversity and cover in Puna grasslands.We analyzed the relationship between grazing pressure and Plant Functional Types by comparing transects located near stockyards(high grazing pressure)and far from them(low pressure)and by evaluating the relationship between the Plant Functional Types cover to a Grazing Pressure Index(GPI).This index incorporates the heterogeneity of traditional pastoral management.At two ecological sites(Ciénego and Tolar),we sampled paired transects(near-far).Plots near and far from corrals were similar in all the variables measured except for plots in Tolar,which tend to have higher total cover,possibly due to fecal fertilization near stockyards.Furthermore,we recorded an increase in total cover and grass cover at higher GPI in Ciénego,while in Tolar we found lower values of total cover and herbaceous dicotyledonous cover at intermediate intensities of GPI.The only negative relationship found was the cover of clonal and non-clonal shrubs,possibly explained by the greater use of these shrubs as firewood near stockyards.In summary,our study does not show important changes in Plant Functional Types as a function of grazing pressure in the studied grasslands probably because grazing pressure is diluted or diminished when livestock rotates in different areas and grazing durations vary.Finally,the long grazing history with which the Puna has evolved could also contribute to the co-structuration between native vegetation and livestock farming.

关键词： Natural grasslands Puna herbivory ecological perturbation

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Gray Images of Constacyclic Codes over a Non-chain Extension of Z_(4)

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Algebra Colloquium 2024年第1期31卷 11-24页

作者： cruz Mohan Karthick Gowdhaman Durairajan Chinnapillai Jian Gao Department of Mathematics Bishop Heber CollegeTrichyTamil NaduIndia Presidency University BengaluruKarnatakaIndia School of Mathematics and Statistics Shandong University of Technology ZiboShandong 255000China

Let Z_(4) be the ring of integers modulo 4.We study the Λ-constacyclic and(θ,Λ)-cyclic codes over the non-chain ring R=Z_(4)[u,v]/for a unit Λ=1+2u+2v in R.We define several Gray maps and find that the respective Gray images of a quasi-cyclic code over Z_(4) are cyclic,quasi-cyclic or permutation equivalent to this code.For an odd positive integer n,we determine the generator polynomials of cyclic and Λ-constacyclic codes of length n over R.Further,we prove that a(θ,Λ)-cyclic code of length n is a Λ-constacyclic code if n is odd,and a Λ-quasi-twisted code if n is even.A few examples are also incorporated,in which two parameters are new and one is best known to date.

关键词： non-chain ring linear code Ot-cyclic code Gray map (θ_(t),Λ)-cyclic code

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Review of Networked Microgrid Protection:Architectures,Challenges,Solutions,and Future Trends

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 448-467页

作者： Jorge de la cruz Ying Wu John E.Candelo-Becerra Juan C.Vasquez Josep M.Guerrero Center for Research on Microgrids(CROM) Department of Energy TechnologyAalborg University9220 AalborgDenmark Facultad de Minas Departamento de Energia Eléctrica y AutomaticaUniversidad Nacional de ColombiaSede MedellinCarrera 80 No.65-223RobledoMedellin 050041Colombia. Center for Research on Microgrids at UPC(UPC CROM) Department of Electronic EngineeringTechnical University of Catalonia(UPC)08019 Barcelona Spain ICREA Pg.Lluis Companys 2308010 BarcelonaSpain Center for Research on Microgrids at AAU(AAU CROM) AAU EnergyAalborg University(AAU)9220 Aalborg EastDenmark

Design and selection of advanced protection schemes have become essential for reliable and secure operation of networked microgrids.Various protection schemes that allow correct operation of microgrids have been proposed for individual systems in different topologies and connections.Nevertheless,protection schemes for networked microgrids are still in devel-opment,and further research is required to design and operate advanced protection in interconnected systems.Interconnection of these microgrids in different nodes with various intercon-nection technologies increases fault occurrence and complicates protection operation.This paper aims to point out challenges in developing protection for networked microgrids,potential solutions,and research areas that need to be addressed for their development.First,this article presents a systematic analysis of different microgrid clusters proposed since 2016,including several architectures of networked microgrids,operation modes,components,and utilization of renewable sources,which have not been widely explored in previous review papers.Second,the paper presents a discussion on protection systems currently available for microgrid clusters,current challenges,and solutions that have been proposed for these systems.Finally,it discusses the trend of protection schemes in networked microgrids and presents some conclusions related to implementation.IndexTerms—Adaptive eprotection,microgrid cluster,microgrid,multiple microgrid,networked microgrid,real-time simulation,smart grid.

关键词： Adaptive eprotection microgrid cluster microgrid multiple microgrid networked microgrid real-time simulation smart grid

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