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What is the value of eucalyptus monocultures for the biodiversity of the Atlantic forest? A multitaxa study in southern Bahia, Brazil

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Journal of Forestry Research 2013年第2期24卷 263-272页

作者： Pedro Luís Bernardo da Rocha Blandina Felipe Viana Márcio Zikán Cardoso Amada mariana costa de Melo Misonete Gueidneli Cavalcanti costa Rodrigo Nogueira de Vasconcelos Tatiana Bichara Dantas Instituto de Biologia Universidade Federal da Bahia. Rua Bar o de Jeremoabo

Eucalyptus plantations are increasing in Brazil, frequently replacing pastures, but there is still scarce information about its capacity to maintain the fauna of neighbor forest remnants. In this study, we compared descriptors of the communities of leaf litter organisms （lizards, anurans, myriapods, arachnids, orthopterans, coleopterans, and ants） between a large remnant of primary Atlantic Forest and an adjacent eucalyptus monoculture （phase 1）. Then, we compared the same descriptors for leaf litter lizards and anurans, Euglossini bees, and frugivorous butterflies among the largest remnant, small remnants at intermediate regeneration stage, and eucalyptus monocultures that were not adjacent to the largest remnant （phase 2）. Monocultures were sampled immediately before logging. In phase 1, we detected significant differences in structure between the forest and the monoculture in six out of seven communities sampled. Ca. 81% of the species of the landscape were recorded in the forest, but only 54% of these were found also in the monoculture. In phase 2, the structure of two out of four forest communities was significantly different from the structure of small remnants and monocultures. On average, 76% of the species found in the whole landscape were sampled in the forest. Out of this subset, on average 74% of the species were also sampled in small remnants and 68% in monocultures. Findings of the present study point out a moderate capacity of eucalyptus monocultures to harbor species of the forest fauna even when fully grown but highlights the opportunity that they might offer for increasing connectivity in anthropogenic forest landscapes depending on their management.

关键词： Atlantic forest monoculture biodiversity

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Epidural Abscess Related to Brucellar Spondylodiscitis Diagnosis by Polymerase Chain Reaction(PCR)

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Advances in Infectious Diseases 2019年第3期9卷 238-242页

作者： mariana costa Marina Vitorino Beatriz Porteiro Whine Pedro Marinela Major Joao Machado Department of Internal Medicine Hospital Professor Dr.Fernando da Fonseca EPEAmadoraPortugal

The localized forms of brucellosis, particularly osteoarticular, by their symptomatology usually nonspecific, still continue to be a diagnosis challenge, being fundamental to raise a high degree of suspicion based on a careful epidemiological history. The authors describe the case of a 69 year old farmer that was admitted due to an insidious lower back pain with irradiation to the left lower limb accompanied by nocturnal sweating, anorexia and weight loss. The imaging studies revealed a spondylodiscitis in L3-L4 with an associated epidural abscess. The diagnosis of brucellosis was brought on by the occupational exposure to sheep and was confirmed by a positive PCR to Brucella in the product gathered by aspiration from the epidural abscess and also by the serology (ELISA and Rose Bengal). Despite the initial therapy with doxycycline, rifampicin and gentamycin (the last one for 1 week), the patient had a clinical and imagiologic worsening, determining surgical decompression. After the surgery, antiobiotherapy with doxycyline and rifampicin was maintained and a cycle of gentamicin was started, this time for a month, with a favorable clinical evolution.

关键词： Lower Back Pain Spondylodiscitis Brucellosis PCR

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Impact of Drug-Drug Interaction between CDK4/6 Inhibitors and Proton Pump Inhibitors on Survival Outcomes in the Treatment of Metastatic Breast Cancer—Real World Data from a Portuguese Center

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Journal of Cancer Therapy 2022年第5期13卷 266-274页

作者： Joana Reis Inês costa mariana costa Ana Valente Catarina Almeida Marta Freitas Cláudia Caeiro Catarina Fernandes Nuno Tavares Miguel Barbosa Centro Hospitalar SÃ O JOÃ O E.P.E. Porto Portugal

Introduction: Proton pump inhibitors (PPi) are widely prescribed, including in patients undergoing treatment for advanced breast cancer (ABC). Due to the pharmacokinetic characteristics of the CDK4/6 inhibitor (Ci) palbociclib a drug interaction with PPi was hypothesized. It was shown in a retrospective study that this association was an independent predictive factor for worse progression-free survival (PFS). Objective: To verify the impact of concomitant administration of PPi with Ci on overall survival (OS) and PFS. Material and Methods: This is a retrospective cohort study of patients treated with Ci for HR+HER2-ABC in the period from Feb/2017 to Aug/2020. SPSS software was used for data processing. Univariate analysis was done by the Kaplan-Meier method and log-rank test, and multivariate analysis by COX regression. P-value < 0.05 was considered significant. Results: 80 patients were included. The median age at diagnosis of ABC was 56 years (25 - 75). Treatment with Ci was 1st line for ABC in 68.8%. Choice of Ci was palbociclib in 73.8% (n = 59) and ribociclib in 26.3% (n = 21). The hormone partner was a nonsteroidal aromatase inhibitor in 45.0%, and fulvestrant in 55.0% of cases. 37.5% of patients were on PPi, and 70.0% of them were during the entire treatment (23.3% omeprazole, 73.4% pantoprazole, 3.3% others). Patients taking concomitant PPi and Ci had lower OS (OS-3 years 42.6% vs. 63.4%, p = 0.254) and PFS (PFS med 15 m. vs. 21 m., p = 0.733), although with no statistically significant difference. Discussion: In the sample, there was a numerical difference, without the statistical significance in the use of PPi in the survival of patients under Ci. This difference could be more evident with a longer follow-up and a larger sample size. This study intends to alert to the growing importance of checking for drug interactions. Polymedication, advanced age and the presence of several comorbidities are real problems in patients with ABC. Conclusion: Real-world dat

关键词： Drug Interaction Survival Impact Advanced Breast Cancer CDK4/6 Inhibitors Proton Pump Inhibitors

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Analysis of Unbalances Forces Using Methods of Identification and Finite Elements

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Journal of Mechanics Engineering and Automation 2014年第5期4卷 400-402页

作者： Lucas Rangel de Oliveira Gilberto Pechoto de Melo Tiago Bemardes Firme mariana costa Falcao Department of Mechanic Engineering Universidade Estadual Paulista Julio de Mesquita Filho Ilha Solteira 15385-000 Brazil Department of Electrical Engineering Universidade Estadual Paulista Julio de Mesquita Filho llha Solteira 15385-000 Brazil

The study of damage in rotating machineries is of fundamental interest in the fields of machine and structure design. A rotating system, supported by bearings and under some dynamic conditions, can generate a variety of problems that are encountered in many different types of rotating machines. One of these problems is the unbalance due to non-homogeneous mass distribution along the shaft. One of the techniques which are widespread today is the identification of parameters and excitation forces that may well followed by monitoring the evolution and change of possible variations of these parameters. Although several methods for the identification of unbalance excitation force are available in the literature, none of them can be considered unrestricted to be applied for all rotating systems. In this study, two methodologies to identify unknown excitations, such as unbalance, have been proposed. This project refers to the analysis of unbalanced forces from displacement parameters and speed by using methods of identification by Fourier series and Legendre polynomials together with the finite element method, state observers in reasons of the problem of absence of signs of rotational displacement, bandpass filter were used to noise suppression of the data collected from the experimental part, Quasi-Newton method to minimize a function in which the bearing stiffness and its damping are unknowns, and also the experimental verification of the methodology, using for this system owned by a rotary mechanical vibrations of the Department of Mechanical Engineering of Faculty of Engineering, campus of llha Solteira.

关键词： Unbalances forces finite element Fourier series Legendre polynomials rotate machines.

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COVID-19 mental health care toolkit:an international collaborative effort by Early Career Psychiatrists section

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General Psychiatry 2020年第5期33卷 352-355页

作者： Frances Adiukwu Laura Orsolini Drita Gashi Bytyçi Samer El Hayek Jairo M Gonzalez-Diaz Amine Larnaout Paolo Grandinetti Marwa Nofal Victor Pereira-Sanchez mariana Pinto da costa Ramdas Ransing Andre Luiz Schuh Teixeira Mohammadreza Shalbafan Joan Soler-Vidal Zulvia Syarif Ganesh Kudva Kundadak Rodrigo Ramalho Department of Neuropsychiatry University of Port Harcourt Teaching HospitalChobaRiversNigeria Department of Clinical Neurosciences/DIMSC School of MedicinePolytechnic University of MarcheAnconaMarcheItaly Mental Health Center Prizren Hospital and University Clinical Service of KosovoPrizrenKosovo Department of Psychiatry American University of BeirutBeirutLebanon CERSAME School of Medicine and Health SciencesUniversidad del Rosario-Clinica Nuestra Senora de la PazBogotaColombia Psychiatry Department D Razi Hospitalfaculty of Medicine of TunisTunis El Manar UniversityTunisTunisia Addictions Service(SerD) Department of Territorial AssistanceASL TeramoTeramoItaly Helwan Mental Health Hospital CairoEgypt Department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew YorkNew YorkUSA Unit for Social and Community Psychiatry(WHO Collaborating Centre for Mental Health Services Development) Queen Mary University of LondonLondonUK Institute of Biomedical Sciences Abel Salazar University of PortoPortoPortugal Hospital de Magalhaes Lemos PortoPortugal Department of Psychiatry BKL Walawalkar Rural Medical CollegeSawardeRatnagiriIndia Department of Childhood and Adolescent Psychiatry Universidade Federal do Rio Grande do SulPorto AlegreRSBrazil Mental Health Research Center Department of PsychiatrySchool of MedicineIran University of Medical SciencesTehranIran(the Islamic Republic of) Fidmag Research Foundation Hermanas HospitalariasBarcelonaSpain Department of Psychiatry Tarakan General HospitalJakartaIndonesia Early Psychosis Intervention Programme Institute of Mental HealthSingapore Department of Social and Community Health School of Populatin HealthUniversity of AucklandAucklandNew Zealand

The collaborative effort of an international research team from the Early Career Psychiatrists section of the World Psychiatry Association has brought about an easy-to-use,quick and stepwise mental health care toolkit for the identification and appropriate referral of those in need of mental health care during the *** simple guide can be applied in the general outpatient setting and is catered for all healthcare professionals,regardless of their expertise within the mental health field with minimal *** is our hope that by incorporating this toolkit into our daily clinical care during the pandemic for high-risk patients and patients with non-specific complaints,we will be able to bridge the mental health gap present in our society.

关键词： Psychiat section clinical

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Competition among rare earth elements on sorption onto six seaweeds

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Journal of Rare Earths 2021年第6期39卷 734-741,I0005页

作者： Joāo Pinto Marcelo costa Bruno Henriques JoséSoares mariana Dias Thainara Viana Nicole Ferreira Carlos Vale JoséPinheiro-Torres Eduarda Pereira Department of Chemistry University of Aveiro3810-193 AveiroPortugal CESAM Department of ChemistryUniversity of Aveiro3810-193 AveiroPortugal LAQV-REQUIMTE Department of Chemistry&Central Laboratory of AnalysisUniversity of Aveiro3810-193 AveiroPortugal CIIMAR一Interdisciplinary Centre of Marine and Environmental Research MatosinhosPortugal N9VE-Nature Ocean and ValueLdaPortoPortugal Central Laboratory of Analysis University of Aveiro3810-193 AveiroPortugal

Sorption has been proposed as a promising approach towards a sustainable water decontamination and recently to the recycling of rare earth elements(REE).Although living seaweed have been shown to be capable of removing REE from contaminated solutions,no studies have yet compared the effects of REE competition on sorption onto different groups of *** effects were analysed in the present study by exposing six living seaweeds(Ulva lactuca,Ulva intestinalis,Fucus spiralis,Fucus vesiculosus,Gracilaria *** Osmundea pinnatifida)(3 g/L,fresh weight) to mono-element and multi-element solutions of Y,La,Ce,Pr,Nd,Eu,Gd,Tb and Dy(1 μmol/L).Results show a preference towards light REE in mono-element solutions,which is reduced when in competition with other *** competitive effect is less pronounced in heavy REE indicating that these are still able to bind to the macroalgae despite the presence of competing *** to water content(%),seaweed specific surface area(cm^(2)/g) shows to be an important factor in the sorption of REE,since larger surface area is associated with higher removal and larger competitive effect.

关键词： Bioaccumulation Wastewater e-waste Recovery Removal Marine macroalgae

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Challenges in maintaining the probiotic potential in alcoholic beverage development

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Food Bioscience 2023年第2期52卷 133-142页

作者： Daiane costa dos Santos Josemar Goncalves de Oliveira Filho Juliana Risso Andretta Fabiano Guimaraes Silva mariana Buranelo Egea Goias Federal University(UFG) Institute of Tropical Pathology and Public HealthIPTSP-UFGStreet 235s/nEast University Sector74605-450GoianiaGOBrazil Sao Paulo State University(UNESP) Sacholo of Pharmaceutical SciencesRodovia Araraquara-Jau Km 114800-903AraraquaraSao PauloBrazil Goiano Federal Institute of Education Science and TechnologyCampus Rio VerdeRod.Sul GoianaKm 01Cx Postal 6675901-970Rio VerdeGOBrazil

The development of new functional alcoholic beverages to promote health benefits is a major challenge for current *** review presents the main applications of microorganisms with functional potential and resistant to the alcoholic environment as well as the characteristics that enable the use of alcoholic beverages as vehicles for probiotic *** our online search,it was possible to notice that the most prominent microorganisms with functional potential and that present alcohol resistance were Saccharomyces cerevisiae *** and water-kefir(composed of Saccharomyces sp.,Lactobacillus sp.,Leuconostoc sp.,Acetobacter sp.,Bifidobacterium sp.).Processing conditions,temperature,fermentation time,and raw materials used in the production of beverages are important parameters that are evaluated and are dependent on the alcohol concentration and cellular viability of the desired probiotic microorganism(s).Viability studies of probiotic microorganisms in vegetable matrices have been conducted for water-kefir and Saccharomyces *** was successfully incorporated into the developmental process of alcoholic beverages with alcohol contents ranging from 3.83 to 23%(v/v),whereas kefir beverage had an alcohol content ranging from 0.8 to 4.96%(v/v).Furthermore,to ensure the maintenance of probiotic viability in alcoholic matrices,the encapsulation technique can be used as an alternative to promote greater protection and viability of probiotics against adverse conditions.

关键词： Functional beverage Microbiological resistance Alcohol concentration

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Initial discovery of microplastic pollution in Mnemiopsis leidyi(Ctenophora:Lobata)

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Water Biology and Security 2023年第2期2卷 43-48页

作者： mariana Beatriz Paz Otegui Gabriela Carvalho Zamprogno Enrique Ronald Yapuchura Ocaris Mercia Barcellos da costa Institute of Biodiversity and Applied Experimental Biology Buenos Aires UniversityArgentina Laboratory of Coastal Biology and Microplastic Analysis/Laboratory of Research and Methodologies Development for Petroleum Analysis Chemistry DepartmentFederal University of Espírito SantoBrazil Universidad Tecnologica del Perú Peru Laboratory of Carbon and Ceramic Materials Department of PhysicsFederal University of Espírito SantoBrazil

The production of plastics has exponentially increased over time such that the observation of microplastics in the oceans has become a major concern given how frequently these particles and marine biota may *** can be ingested by diverse species,including invertebrates,which can lead to physical damage due to their small size and potentially chemical damage related to the ingestion of monomers,polymeric additives,or adsorbed *** study reports on the first evidence of microplastics in Mnemiopsis *** were described by type,quantified,and had their chemical composition *** total,328 samples of microplastic(MP)candidates were observed:blue fibers were the most abundant,followed by black,red,and green fibers as well as blue *** types of microplastics were chemically identified as polyurethane,unplasticized polyvinylchloride,and polyethylene ***,this study demonstrated that Mnemiopsis leidyi have the capacity to incorporate *** more studies are needed,Mnemiopsis leidyi is relatively abundant on the Atlantic coast and should be recommended for use as a bioindicator for microplastics.

关键词： Ctenophore Digested tissues Gelatinous zooplankton Polymers Raman spectroscopy Sea invertebrates

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Metabolomics in cancer and cancer-associated inflammatory cells

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 1-19页

作者： Gilson costa dos Santos Roberta Saldanha-Gama Natália Mesquita de Brito mariana Renovato-Martins Christina Barja-Fidalgo Department of Genetics IBRAGState University of Rio de JaneiroRio de Janeiro20551-030Brazil Department of Cell Biology IBRAGState University of Rio de JaneiroRio de Janeiro20551-030Brazil Department of Cellular and Molecular Biology IBFederal Fluminense UniversityNiterói24210-200 Brazil

Metabolomics is the last frontier of modern molecular biology,and the state-of-the-art technique for studying *** spectrometry and nuclear magnetic resonance spectroscopy are the main analytical approaches in *** metabolism plays a pivotal role during cell resting and *** cells exhibit remarkable metabolic plasticity,fundamental to support their adaptation to inflammatory environments and functional *** is a metabolic and inflammatory disease.A metabolic shift is crucial for oncogenesis,tumor cell survival,invasion,metastasis,and the associated inflammatory *** tumor microenvironment is mainly orchestrated by immune-inflammatory cells and essential for the neoplastic *** cells from tumor stroma adapt to different metabolic pathways during tumor progression,and this metabolic reprogramming affects macrophages,neutrophils,T cells,and *** the metabolism of tumor and immune cells may lead to important therapeutic implications in ***,understanding the metabolic changes that drive the interactions between tumor and stromal cells is a promising avenue advances in cancer diagnostics and therapies,leading to more accurate *** this review,we discuss the most recent metabolomics approaches in cancer studies on the tumor-associated inflammatory microenvironment.

关键词： Metabolomics cancer immunometabolism inflammation

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Beneficial effects of Pleurotus albidus supplementation on body weight and food intake in healthy C57BL/6 mice

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Journal of Future Foods 2021年第1期1卷 98-103页

作者： Paola Quevedo da costa mariana Parron Paim Eduardo Echer dos Reis Patrick Tirck Marli Camassola Paulo Cavalheiro Schenke Department of Physiology and Pharmacology Universidade Federal de PelotasCampus Capao do Leao 96900-010 Pelotas.Brazjl Department of Physiology Universidade Federal do Rio Grande do SulCampus Centro 90050-170 Porto AlegreBrazil Enzymes and Biomass Laboratory Institute of BiotechnologyUniversidade de Caxias do SulRua Francisco Getúlio Vargas 113095070-560Caxias do SulRSBrazil

The current investigation intended to check the influence of Pleurotus albidus extract supplementation on body weight,food intake,glycemia,serum lipids,and oxidative stress *** male C57BL/6 mice were partitioned into two experimental groups:control and *** supplementation was performed by gavage(500 mg/kg)for 20 uninterrupted *** this period,all animals received water and food ad libitum and they had their food ingestion and body weight monitored ***,mice underwent an insulin sensitivity test,followed by euthanasia and biochemical *** supplementation decreased the body weight and food intake,but it did not change other parameters in healthy *** work showed for the first time that the *** extract supplementation presents a promising potential on body weight and food intake control.

关键词： Blood glucose Glutathione peroxidase Insulin Pleurotus Triglycerides

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