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Liver Nuclear Activation of Carbon Tetrachloride or Bromotrichloromethane to Trichloromethyl and Trichloromethylperoxyl Free *** Reactions With Lipids and Proteins

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Biomedical and Environmental Sciences 1998年第2期11卷 101-114页

作者： S. L. FANELLI G. D. castro M. E. GALELLI AND J. A. castro (Centro de Investigaciones Toxicologicas(CEITOX)-CITEFA/CONICET, Zufriategui 4380, 1603 Villa Martelli,Buenos Aires, Argentina)(Send correspondence to Dr. Jose Alberto castro, Zufriategui 4380, 1 Centro de Investígaciones Toxicológicas (CEITOX)-CITEFA/CONICET 1603 Villa Martelli Buenos Aires Zufriategui 4380 Argentina 1603 Villa Martelli Buenos Aires Zufriategui 4380 Argentina

The formation of·CCl3 radicals in liver nuclei was suggested by spin trapping of them with N-t-butyl-α-phenylnitrone followed by GC/MS detection of the resulting adduct. Comparison of its formation in microsomal biotransformation of CCl4 was made. In aerobic nuclear activation mixtures containing NADPH and CCl4, significant decrease in the arachidonic acid content of nuclear lipids was observed (27. 8%, compared to control), the intensity of this decrease was lower than that occurring in the corresponding microsomal incubation mixtures (29.1%). Significant decreases in arachidonic acid content of nuclear and endoplasmic reticulum lipids were also observed in animals at 6 hours of poisoning with the haloalkane. During aerobic nuclear metabolism of CCl4 or CBrCl3, cholesterol oxidation products were detected: a ketocholesterol, an epoxide like structure and 7-ketocholesterol. Nuclear protein carbonyl formation was not promoted during nuclear CCl4 biotransformation. NADPH by itself may lead to protein carbonyl formation during prolonged periods of incubation. CBrCl3 in contrast, led to decreased protein carbonyl formation. No increase in nuclear protein carbonyl formation was observed in CCl4 intoxicated animals during periods of time between 1 to 6 hours after treatment. The results indicate that during nuclear biotransformation of CCl4 or CBrCl3 reactive free radicals, PUFA degradation, reactive aldehydes and cholesterol oxidation products are formed, nearby DNA and regulatory proteins.

关键词： NADPH Liver Nuclear Activation of Carbon Tetrachloride or Bromotrichloromethane to Trichloromethyl and Trichloromethylperoxyl Free Radicals.Their Reactions With Lipids and Proteins Free

Gut-microbiome-brain axis:the crosstalk between the vagus nerve,alpha-synuclein and the brain in Parkinson's disease

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Neural Regeneration Research 2023年第12期18卷 2611-2614页

作者： Júlio César Claudino dos Santos Leandro Freitas Oliveira Felipe Micelli Noleto Camilla Teixeira Pinheiro Gusmão Gerly Anne de castro Brito Glauce Socorro de Barros Viana Christus University Center-UNICHRISTUS FortalezaCEBrazil Postgraduate Program in Morphofunctional Sciences Federal University of Ceará-UFCFortalezaCEBrazil Universidade Católica de Brasília-UCB BrasíliaDFBrasil Postgraduate Program in Physiology and Pharmacology department of the Federal University of Ceará-UFC FortalezaCEBrazil Physiology and Pharmacology department of the Federal University of Ceará-UFC FortalezaCEBrazil

This critical review of the literature shows that there is a close link between the microbiome,the gut,and the brain in Parkinson's *** vagus nerve,the main component of the parasympathetic nervous system,is involved in the regulation of immune response,digestion,heart rate,and control of *** can detect microbiota metabolites through its afferents,transferring this gut information to the central nervous *** and clinical studies have shown the important role played by the gut microbiome and gut-related factors in disease development and progression,as well as treatment *** findings suggest that the gut microbiome may be a valuable target for new therapeutic strategies for Parkinson's *** studies are needed to better understand the underlying biology and how this axis can be modulated for the patient's benefit.

关键词： alpha-synuclein enteric microbiota gastrointestinal tract Parkinson's disease vagus nerve

Rheumatoid arthritis: Nuclear medicine state-of-the-art imaging

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World Journal of Orthopedics 2014年第3期5卷 312-318页

作者： Paulo Henrique Rosado-de-castro Sergio Augusto Lopes de Souza Dangelo Alexandre Lea Mirian Barbosa da Fonseca Bianca Gutfilen departamento de Radiologia Hospital Universitário Clementino Fraga FilhoUniversidade Federal do Rio de JaneiroRio de Janeiro 21941-913Brazil Instituto Nacional de Traumatologia e Ortopedia Rio de Janeiro 20940-070Brazil

Rheumatoid arthritis(RA)is an autoimmune disease,which is associated with systemic and chronic inflammation of the joints,resulting in synovitis and pannus *** several decades,the assessment of RA has been limited to conventional radiography,assisting in the diagnosis and monitoring of ***,conventional radiography has poor sensitivity in the detection of the inflammatory process that happens in the initial stages of *** the past years,new drugs that significantly decrease the progression of RA have allowed a more efficient *** Medicine provides functional assessment of physiological processes and therefore has significant potential for timely diagnosis and adequate follow-up of *** single photon emission computed tomography(SPECT)and positron emission tomography(PET)radiopharmaceuti-cals have been developed and applied in this *** use of hybrid imaging,which permits computed tomography(CT)and nuclear medicine data to be acquired and fused,has increased even more the diagnostic accuracy of Nuclear Medicine by providing anatomical localization in SPECT/CT and PET/CT *** recently,fusion of PET with magnetic resonance imaging(PET/MRI)was introduced in some centers and demonstrated great *** this article,we will review studies that have been published using Nuclear Medicine for RA and examine key topics in the area.

关键词： Rheumatoid arthritis Nuclear medicine Scintigraphy Single photon emission computed tomography Positron emission tomography

Latent tuberculosis:Risk factors,screening and treatment in liver transplantation recipients from an endemic area

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World Journal of Transplantation 2021年第12期11卷 512-522页

作者： Isabela Dias Lauar Luciana Costa Faria Roberta Maia de castro Romanelli Wanessa Trindade Clemente Medicine department Universidade Josédo Rosário VellanoBelo Horizonte 31710030Minas GeraisBrazil Internal Medicine department Faculdade de MedicinaUniversidade Federal de Minas Gerais(UFMG)Belo Horizonte 30130100Minas GeraisBrazil Pediatrics department Faculdade de MedicinaUniversidade Federal de Minas Gerais(UFMG)Belo Horizonte 30130100Minas GeraisBrazil department of Laboratory Medicine Faculdade de MedicinaUniversidade Federal de Minas Gerais(UFMG)Belo Horizonte 30130100Minas GeraisBrazil

BACKGROUND Patients undergoing solid organ transplantation,particularly those who live or have lived in tuberculosis(TB)endemic areas,are at a high risk of developing *** majority of post-transplantation TB cases are associated with reactivation of latent TB infection(LTBI).Brazil is in a single position with overlapping areas of high TB endemicity and high transplant *** liver transplant(LT),one should be aware of the potential hepatotoxicity associated with the treatment regimens for *** To evaluate the frequency of LTBI in LT patients and treatment-related *** This was a retrospective analysis of a cohort of cirrhotic patients aged≥18 years,who underwent LT at a high-complexity teaching hospital from January 2005 to december *** Overall,429 patients underwent LT during the study *** these,213(49.7%)underwent the tuberculin skin test(TST)during the pre-transplant period,and 35(16.4%)of them had a positive *** treatment for LTBI was initiated after LT in 12(34.3%)of the TST-positive patients;in 3(25.0%),treatment was maintained for at least 6 *** The prevalence of LTBI was lower than *** and completion of LTBI treatment was limited by difficulties in the management of these special patients.

关键词： Latent tuberculosis Liver transplantation Tuberculosis Infection Transplantation Risk factors

Glycogenic hepatopathy:A narrative review

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World Journal of Hepatology 2018年第2期10卷 172-185页

作者： Jagannath M Sherigar Joline de castro Yong Mei Yin debra Guss Smruti R Mohanty department of Gastroenterology and Hepatology NYP-Brooklyn Methodist HospitalBrooklynNY 11215United States NYP-Brooklyn Methodist Hospital BrooklynNY 11215United States

Glycogenic hepatopathy(GH) is a rare complication of the poorly controlled diabetes mellitus characterized by the transient liver dysfunction with elevated liver enzymes and associated hepatomegaly caused by the reversible accumulation of excess glycogen in the hepatocytes. It is predominantly seen in patients with longstanding type 1 diabetes mellitus and rarely reported in association with type 2 diabetes mellitus. Although it was first observed in the pediatric population, since then, it has been reported in adolescents and adults with or without ketoacidosis. The association of GH with hyperglycemia in diabetes has not been well established. One of the essential elements in the pathophysiology of development of GH is the wide fluctuation in both glucose and insulin levels. GH and non-alcoholic fatty liver disease(NAFLD) are clinically indistinguishable, and latter is more prevalent in diabetic patients and can progress to advanced liver disease and cirrhosis. Gradient dual-echo MRI can distinguish GH from NAFLD; however, GH can reliably be diagnosed only by liver biopsy. Adequate glycemic control can result in complete remission of clinical, laboratory and histological abnormalities. There has been a recent report of varying degree of liver fibrosis identified in patients with GH. Future studies are required to understand the biochemical defects underlying GH, noninvasive, rapid diagnostic tests for GH, and to assess the consequence of the fibrosis identified as severe fibrosis may progress to cirrhosis. Awareness of this entity in the medical community including specialists is low. Here we briefly reviewed the English literature on pathogenesis involved, recent progress in the evaluation, differential diagnosis, and management.

关键词： Glycogenic hepatopathy Diabetes mellitus Hepatomegaly Mauriac syndrome Elevated liver enzymes Liver biopsy Gradient dual-echo MRI

About Drugs, Tickle and Laughter

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Psychology Research 2016年第9期6卷 491-495页

作者： Edson Olivari de castro UNESP Baum Brazil

Prevention of bile spillage during cholecystectomy: current evidences and considerations

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Hepatobiliary Surgery and Nutrition 2020年第1期9卷 109-111页

作者： Maurizio Zizzo Lorenzo Manzini Magda Zanelli Loredana de Marco Carolina castro Ruiz Antonio Manenti Valerio Annessi Surgical Oncology Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaArcispedale Santa Maria Nuova di Reggio EmiliaReggio EmiliaItaly Clinical and Experimental Medicine PhD Program University of Modena and Reggio EmiliaModenaItaly Pathology Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaArcispedale Santa Maria Nuova di Reggio EmiliaReggio EmiliaItaly General Surgery Unit Azienda UnitàSanitaria Locale-IRCCS di Reggio EmiliaOspedale Civile di GuastallaReggio EmiliaItaly department of General Surgery Azienda Ospedaliero-Universitaria-PoliclinicoModenaItaly

We really appreciated Geramizadeh, " Bile spillage and incidental gall bladder adenocarcinoma ", and Sandstrom et al. ,"Bile spillage should be avoided in elective cholecystectomy " (1,2). Both papers have been recently published in HepatoBiliary Surgery and Nutrition, 2019 (1,2). Starting from an analysis of the recent paper by Horkoff et al. "Adverse outcomes after bile spillage in incidental gall bladder cancer " in Annals of Surgery April 2019, they introduced a comprehensive discussion about epidemiology, diagnosis, therapy, prognostic factors and outcomes of incidental gallbladder cancer (1-3). They analyzed the possible risks related to bile spillage after cholecystectomy, in particular (1,2).

关键词： Surgery cholecystectomy epidemiology diagnosis

Photoconductive devices for terahertz pulsed spectroscopy:a review[Invited]

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Photonics Research 2016年第3期4卷 36-42页

作者： E.castro-Camus M.Alfaro Centro de Investigaciones en Optica A.C. departamento de Matematicas y Fisica Centro de Ciencias BasicasUniversidad Autonoma de Aguascalientes

Photoconductive switches were the key components that allowed the generation and detection of coherent broadband electromagnetic pulses at terahertz frequencies, opening the possibility for performing spectroscopy and,therefore, measuring complex dielectric properties of materials in this band, which was mostly unexplored. In this paper, we present a brief introduction to the operation principles of these devices. Subsequently, we present a review of the current state-of-the-art in this field and discuss the challenges to be faced in future development of these devices.

关键词： As Ga THz Photoconductive devices for terahertz pulsed spectroscopy:a review[Invited

PET-modified red mud as catalysts for oxidative desulfurization reactions

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Journal of Environmental Sciences 2017年第7期29卷 312-320页

作者： Nayara T.do Prado Ana P.Heitmann Herman S.Mansur Alexandra A.Mansur Luiz C.A.Oliveira Cinthia S.de castro department of Chemistry Federal University of Minas GeraisAv.Antonio Carlos 6627Campus Pampulha31270-901BH-MGBrazil department of Metallurgical and Materials Engineering Au.Antonio Carlos 6627Campus Pampulha31270-901BH-MGBrazil

This work describes the synthesis of catalysts based on red mud/polyethylene terephthalate（PET） composites and their subsequent heat treatment under N2 *** materials were characterized by scanning electron microscopy（SEM）,temperature programmed reduction（TPR）,Fourier transform infrared spectroscopy（FT–IR）,X-ray diffraction（XRD）,thermogravimetric（TG） analysis and N2adsorption/*** catalysts were evaluated in the oxidative desulfurization reaction of dibenzothiophene（DBT） in a biphasic *** results indicated that the PET impregnation on red mud increased the affinity of the catalyst with the nonpolar phase（fuel）,in which the contaminant was dissolved,allowing a higher conversion（up to 80%） and selectivity to the corresponding dibenzothiophene *** sulfone compound is more polar than DBT and diffused into the polar solvent as indicated by the data obtained via gas chromatography–mass spectrometry（GC–MS）.

关键词： Red mud PET Dibenzothiophene desulfurization Dibenzothiophene sulfone