检索结果-南通市图书馆

Biofabrication of nanocomposite-based scaffolds containing human bone extracellularmatrix for the differentiation of skeletal stem and progenitor cells

在线全文

学校读者我要写书评

暂无评论

Bio-Design and manufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim Janos m.Kanczler Stuart Lanham Andrew Rawlings marta Roldo Gianluca Tozzi Jonathan I.Dawson Gianluca Cidonio Richard O.C.Oreffo Faculty of medicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of Pharmacy and Biomedical Science University of PortsmouthPortsmouth PO12DTUK School of Engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK Center for Life Nano-and Neuro-Science(CLN2S) Italian Institute of Technology00161 RomeItaly

Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-ECm)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HBmSCs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(LAB)by blending human bone-ECm(B)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanoﬁller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HBmSCs viability upon *** composite of human bone-ECm-based 3D constructs containing vascular endothelial growth factor(vEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(CAm)*** inclusion of bone morphogenetic protein-2(BmP-2)with the HBmSCs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-ECm)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.

关键词： Extracellular matrix Nanoclay Bone 3D bioprinting

Porous Shish-Kebab Structure Prepared from Oriented UHmWPE Films by Processing in Supercritical CO_(2)

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第1期42卷 97-104,I0009页

作者： Sergey A.Lermontov Aleksey v.maksimkin Nataliya A.Sipyagina Tarek Dayyoub Alena N.malkova Evgeniy A.Kolesnikov Elena A.Straumal Inna O.Gozhikova Saidkhodzha G.Nematulloev Dmitry v.Telyshev Institute of Physiologically Active Compounds of the Russian Academy of Sciences Chernogolovka 142432Russia Institute for Bionic Technologies and Engineering I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 19991Russia National University of Science and Technology"mISIS"moscow 119049 Russia Institute of Biomedical Systems National Research University of Electronic TechnologyZelenogradMoscow 124498Russia

For the first time, a highly crystalline porous shish-kebab structure with a high degree of crystallinity was obtained by using a combination of two methods for the formation of porous polymeric materials. A treatment procedure using supercritical carbon dioxide(sc CO_(2))was carried out for oriented ultrahigh molecular weight polyethylene(UHmWPE) films, which provided special conditions for the crystallization of dissolved UHmWPE macromolecules on the surface of oriented UHmWPE crystals. The prepared porous materials were investigated by scanning electron microscopy(SEm) and differential scanning calorimetry(DSC). The particularity of the obtained porous shish-kebab is the absence of the amorphous phase between lamellar crystals(kebabs). The obtained pores had an oval shape, and they were oriented in the orientation direction of the UHmWPE macromolecules. The pore size ranged from 0.05 μm to 4 μm. Controlling the conditions for the crystallization of the UHmWPE macromolecules using supercritical CO_(2) gives the possibility to control the size of both lamellar disks and pores formed.

关键词： UHmWPE Supercritical CO_(2) Porous shish-kebab structure

microbial phenolic metabolites are associated with better frontal lobe cognition

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Inés Domínguez-López Isabella Parilli-moser Anna vallverdú-Queralt Anna Tresserra-Rimbau Cinta valls-Pedret Zenaida vázquez-Ruiz Olga Casta?er Ramon Estruch Emili Ros Rosa m.Lamuela-Raventós Lipid Clinic， Endocrinology and Nutrition Service， Institut d'Investigacions Biomèdiques August Pi i Sunyer， Hospital Clínic 08036 Barcelona， Spain Unit of Cardiovascular Risk and Nutrition， Institut Hospital del mar de Investigaciones médicas (ImIm) Department of Preventive medicine and Public Health， University of Navarra Departament de Nutrició， Ciències de l'Alimentació i Gastronomía， Facultat de Farmacia， Universitat de Barcelon (UB)， Av.de Joan XXII Department of Endocrinology， Hospital Clinic IDIBAPS， Barcelona， Spain Department of Internal medicine， Hospital Clinic， Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS)， University of Barcelona CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN)， Instituto de Salud Carlos III Institut de Nutrició i Seguretat Alimentària (INSA)， Universitat de Barcelona (UB)

With increasing life expectancy， neurodegenerative diseases have become one of the leading causes of ill-health in the elderly. Preventive strategies include following healthy diets， such as the mediterranean diet， which is particularly rich in polyphenols， bioactive compounds with neuroprotective properties. The aim of this study was to assess the association of microbial phenolic metabolites (mPm) with cognition. This cross-sectional analysis was performed with 200 participants of the PREDImED trial (Barcelona-Clinic recruitment center). A novel method based on liquid chromatography coupled to mass spectrometry was used to identify urinary mPm (protocatechuic acid， enterodiol glucuronide， enterolactone glucuronide， urolithin B glucuronide， and vanillic acid glucuronide)， and cognitive function was evaluated with neuropsychological tests. multivariable-adjusted ordinary least squares regression was used to assess the associations between cognitive function and mPm， and a score was calculated as the weighted sum of mPm. A higher mPm score was associated with better frontal lobe function. Among individual metabolites， vanillic acid glucuronide was correlated with frontal cognitive performance. Participants with higher concentrations of vanillic acid glucuronide and urolithin B glucuronide obtained better scores in the Color Trail Test part 2. A higher score for urinary multi-mPm was associated with better frontal cognitive performance in an older mediterranean population.

关键词：

In-situ study of the microstructure evolution during tension of a mg-Y-Zn-Al alloy processed by rapidly solidified ribbon consolidation technique

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of magnesium and Alloys 2024年第5期12卷 2024-2040页

作者： Jeno Gubicza Kristián máthis Péter Nagy Péter Jenei Zoltán Hegedus Andrea Farkas Jozef vesely Shin-ichi Inoue Daria Drozdenko Yoshihito Kawamura Department of materials Physics Faculty of ScienceEotvos Loránd UniversityPázmány P.sétány 1/ABudapest H-1117Hungary Department of Physics of materials Faculty of Mathematics and PhysicsCharles UniversityKe Karlovu 512116 Praha 2Czech Republic Deutsches Elektronen-Synchrotron DESY Notkestr.85Hamburg 22603Germany magnesium Research Center Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan

mg-Y-Zn-Al alloys processed by rapidly solidified ribbon consolidation(RSRC)technique exhibit an exceptional mechanical performance indicating promising application *** material has a bimodal microstructure consisting of fine recrystallized and coarse non-recrystallized grains with solute-rich stacking faults forming cluster arranged layers(CALs)and nanoplates(CANaPs),or complete long period stacking ordered(LPSO)*** order to reveal the deformation mechanisms,in-situ synchrotron X-ray diffraction line profile analysis was employed for a detailed study of the dislocation arrangement created during tension in mg-0.9%Zn-2.05%Y-0.15%Al(at%)*** uncovering the effect of the initial microstructure on the mechanical performance,additional samples were obtained by annealing of the as-consolidated specimen at 300 and 400℃ for 2 *** heat treatment at 300℃ had no significant effect on the initial microstructure,its evolution during tension and,thus,the overall deformation behavior under tensile *** the other hand,annealing at 400℃ resulted in a significant increase of the recrystallized grains fraction and a decrease of the dislocation density,leading to only minor degradation of the mechanical *** maximum dislocation density at the failure of the samples corresponding to the plastic strain of 10-25% was estimated to be about 16-20×10^(14)m^(-2).The diffraction profile analysis indicated that most dislocations formed during tension were of non-basal and pyramidal types,what was also in agreement with the Schmid factor values revealed independently from orientation *** was also shown that the dislocation-induced Taylor hardening was much lower below the plastic strain of 3% than above this value,which was explained by a model of the interaction between prismatic dislocations and CANaPs/LPSO plates.

关键词： mg-Zn-Y-Al alloy Long period stacking ordered(LPSO)phase Cluster arranged nanoplates(CANaPs) Annealing Tension Dislocation density Hardening

Exome sequencing identifies a likely causative variant in 53%of families with ciliopathy-related features on renal ultrasound after excluding NPHP1 deletions

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第5期11卷 40-43页

作者： Konstantin Deutsch verena Klambt Thomas m.Kitzler Tilman Jobst-Schwan Ronen Schneider Florian Buerger Steve Seltzsam Sherif El Desoky Jameela A.Kari Farkhanda Hafeez maria Szczepanska Loai A.Eid Hazem S.Awad muna Al-Saffar Neveen A.Soliman velibor Tasic Camille Nicolas-Frank Kirollos Yousef Luca m.Schierbaum Sophia Schneider Abdul Halawi Izzeldin Elmubarak Katharina Lemberg Shirlee Shril Shrikant m.mane Nancy Rodig Friedhelm Hildebrandt Division of Nephrology Department of PediatricsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Department of Pediatric Gastroenterology Nephrology and Metabolic DiseasesCharite Universitatsmedizin BerlinBerlin 13353Germany Berlin Institute of Health at Charitee Universitatsmedizin Berlin BIH Biomedical Innovation AcademyBIH Charite Clinician Scientist ProgramBerlin 10178Germany Department of Nephrology and Hypertension FriedrichAlexander-Universitat Erlangen-NurnbergErlangen 91054Germany Department of Pediatrics Faculty of Medicine King Abdulaziz UniversityPediatric Nephrology Center of ExcellenceKing Abdulaziz University HospitalJeddah 21589Saudi Arabia Department of Pediatric Nephrology The Children’s Hospital and Institute of Child HealthLahore 54000Pakistan Department of Pediatrics Faculty of Medical Sciences in ZabrzeMedical University of Silesia in KatowiceKatowice 40-752Poland Dubai Hospital and Al-Jalila Children’s Specialty Hospital Kidney Center of ExcellenceDubai 4545United Arab Emirates Department of Genetics and Genomics UAE UniversityAbu Dhabi 15551United Arab Emirates Department of Pediatrics Division of Genetics and GenomicsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Department of Pediatrics Center of Pediatric Nephrology and TransplantationKasr Al Ainy School of MedicineCairo UniversityCairo 11562Egypt Egypt Center for Research and Regenerative medicine(ECRRm) Cairo 11511Egypt medical Faculty Skopje University Children’s HospitalSkopje 1000North Macedonia Department of Genetics Yale University School of MedicineNew HavenCT 06520USA

Nephronophthisis-related ciliopathies(NPHP-RC)represent one of the most common causes of chronic kidney disease in the first three decades of life and are characterized by a broad genetic and clinical heterogeneity.1 To date,more than 90 genes have been identified that cause autosomalrecessive NPHP-RC if mutated,accounting for up to 60%of cases.1 Among these,homozygous deletions of NPHP1 are the most common *** genes localize to primary cilia,basal bodies,or the centrosome and lead to a primary ciliary disruption if mutated,thereby causing a broad phenotypical spectrum.1 Patients that suffer from NPHP-RC can either have an isolated renal phenotype,such as polyuria,polydipsia,decreased urinary concentration ability,and secondary enuresis due to loss of tubular function,or present with extrarenal symptoms including retinal degeneration,cerebellar vermis hypoplasia,or hepatic *** are often diagnosed in early adolescence,reaching end-stage renal disease before 25 years of age,but early onset and rapidly progressive forms of NPHP-RC also exist.1 Renal ultrasound indicates kidneys of normal or reduced renal length with increased echogenicity and corticomedullary cysts.

关键词： degeneration urinary likely

Global prevalence and gender inequalities in at least 60 min of self-reported moderate-to-vigorous physical activity 1 or more days per week:An analysis with 707,616 adolescents

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第5期13卷 709-716页

作者： Raphael H.O.Araujo AndrúO.Werneck Clarice L.martins Luciana L.Barboza Rafael m.Tassitano Nicolas Aguilar-Farias Gilmar m.Jesus Robinson Ramírez-véelez Riki Tesler Adewale L.Oyeyemi Ellen C.m.Silva Robert G.Weaver mark S.Tremblay Javier Brazo-Sayavera Grégore I.mielke Danilo R.P.Silva Graduation Program in Health Sciences Londrina State University(UEL)Londrina 86057-970Brazil Center for Epidemiological Research in Nutrition and Health Department of NutritionSchool of Public HealthUniversidade de Sao Paulo(USP)Sao Paulo 01246-904Brazil Department of Physical Education Federal University of ParaıbaParaıba 58051-900Brazil Research Centre of Physical Activity Health and LeisureFaculty of SportsLaboratory for Integrative and Translational Research in Population Health(ITR)University of PortoPorto 4500Portugal Postgraduate Program in Physical Education University of BrasıliaBrasılia 70910-900Brazil Department of Kinesiology and Community Health University of Illinois at Urbana-ChampaignChampaignIL 61801-3841USA Department of Physical Education Sports and RecreationUniversidad de La FronteraTemuco 4680000Chile Department of Health State University of Feira de SantanaFeira de Santana 44036-900Brazil Navarrabiomed Hospital Universitario de Navarra(HUN)Navarra Institute for Health Research(IdiSNA)Universidad Publica de Navarra(UPNA)Pamplona 31006Spain Facultad de Ciencias de la Educacion Unidad Central del Valle del Cauca(UCEVA)TuluaValle del Cauca 763022Colombia Health management Department Faculty of Heath sciencesAriel UniversityAriel 40700Israel College of Health Solutions Arizona State UniversityPhoenixAZ 85004USA Arnold School of Public Health University of South CarolinaColumbiaSC 29208USA Healthy Active Living and Obesity Research Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada Department of Pediatrics University of OttawaOttawaON K1H 8L1Canada Department of Health Sciences Carleton UniversityOttawaON K1S 5B6Canada Department of Sports and Computer Science Universidad Pablo de Olavide(UPO)Seville 41013Spain Centro Universitario Regional Noreste Universidad de la RepublicaRivera 40000Uruguay School of Public Health The University of QueenslandBrisbaneQLD 4006Australia Department of Physical Education

Background:Guidelines recommend that adolescents should accumulate an average of 60 min per day of moderate-to-vigorous physical activity(mvPA).However,using only this cut-off could hide important *** instance,from a population-level point of view,increasing physical activity for those with no or low physical activity could provide more health benefits than increasing physical activity for those with intermediate ***,including a more sensitive cut-point of≥1 days per week could be an additional strategy for identifying those with low access/opportunities for physical activity ***,the current study aims to estimate the prevalence of≥60 min of mvPA≥1 days per week among adolescents globally,and to describe any relevant gender ***:We used representative datasets from 146 countries/territories collected between 2003 and *** was *** were grouped into younger(≤14 years old)and older(>14 years old)*** Poisson regression models were used to identify the relative differences in≥60 min of mvPA≥1 days per week between boys and girls,and random-effects meta-analysis models were used to identify the pooled *** were stratified by country and ***:Approximately 80%of both younger and older adolescents reported≥60 min of mvPA≥1 days per *** prevalence was≥94%in Europe and Central Asia and North America,while the estimates for the other regions werevalence of≥60 min of mvPA≥1 days per week was higher among boys than girls,with the largest differences occurring among the oldest adolescents(Prevalence ratio_(≤14y)=1.04(95%confidence interval(95%CI)):1.03-1.04)*** ratio_(>14y)=1.09(95%CI:1.08-1.10)).Conclusion:Approximately 8 out of 10 adolescents reported accumulating≥60 min of mvPA≥1 days per week,with notable differences between *** differences were observed in several countries,especially among the oldest *** fo

关键词： Global School-based Student Health Survey Health Behaviour Among School-aged Children survey Inequality Surveillance Youth

Spouting behavior of binary particle mixtures of different densities: Fluid dynamics and particle segregation

在线全文

学校读者我要写书评

暂无评论

Particuology 2019年第1期17卷 58-66页

作者： K.G. Santos R.C. Santana D.L. souza v.v. murata m.A.S. Barrozo Federal University ofTriangulo mineiro Chemical Engineering DepartmentUniverdecidade CampusUberabaMGBrazil Federal University of Uberlandia Chemical Engineering SchoolUberlandiaMG. Brazil

Numerous industrial applications of spouted beds involve a mixture of granular particles, where differences in particle size, density, and shape can cause particle segregation, affecting the quality of flow and decreasing product homogeneity. The aim of this study was to investigate the particle segregation and fluid dynamics of a conical spouted bed operating with a binary mixture of particles of different densities. Using glass beads and polyethylene particles with a diameter of 4 mm, we determined the effects of the mass fraction of denser particles and static bed height on the minimum spouting condition and mixture index. The pressure drop and airflow in the minimum spouting condition increased with an increase in bed height or jetsam concentration. Regarding particle segregation, the jetsam particles tended to concentrate near the bottom, at the spout–annulus interface because they have a shorter trajectory than the lighter particles in the fountain region. Jetsam-rich mixtures with high initial static bed heights exhibited more efficient particle mixing, excluding those at the bottom of the bed.

关键词： Density Segregation Spouted bed Binary mixtures

A stability evaluation method for deep-seated toppling in the upper Lancang river,Southwestern China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rock mechanics and Geotechnical Engineering 2024年第7期16卷 2388-2410页

作者： Yibing Ning Huiming Tang Jianbing Peng Yanjun Shen John v.Smith Bocheng Zhang College of Geological Engineering and Geomatics Chang’an UniversityXi’an710054China Academy of Yellow River Sciences of Shaanxi Province Chang’an UniversityXi’an710054China Badong National Observation and Research Station of Geohazards China University of GeosciencesWuhan430074China School of Engineering RMIT UniversityMelbourne3001Australia

Deep-seated toppling in the upper reaches of the Lancang River,southwest China involves deformations exceeding 100 m in *** slope deformation is initiated by river downcutting and evolves distinctive characteristics with a depth of river *** this study,we propose a system for evaluating the stability of deep-seated toppled slopes in different evolutionary *** system contains identification criteria for each evolutionary stage and provides the corresponding stability evaluation *** on the mechanical and kinematic analysis of slope blocks,the specific stage of slope movement can be identified in the field through outcrop mapping,in situ tests,surface displacement monitoring,and adit and borehole *** stability evaluation methods are established based on the limiting equilibrium theory and the strain compatibility between the undisturbed zone and the toppled ***,several sample slopes in different evolution stages have been investigated to verify the applicability and accuracy of the proposed stability evaluation *** results indicate that intense tectonic activity and rapid river incision lead to a maximum principal stress ratio exceeding 10 near the slope surface,thus triggering widespread toppling deformations along the river *** considering the losses of joint cohesion during the further rotation process,the safety factor of the slope drops by 7%e28%.The self-stabilization of toppling deformation can be recognized by the layer symmetry configuration after the free rotation of the deflected *** toppled rock blocks mainly suffer sliding failures beyond the layer symmetry *** factor of safety of the K73 rockslide decreased from 1.17 to 0.87 by considering the development of the potential sliding surface and the toesaturated zone.

关键词： Stability evaluation Deep-seated toppling Evolutionary process Reservoir impoundment Rock slope

Biodiversity Assessment of Avifauna in the Forest Reservation of Aurora State College of Technology (ASCOT), Philippines

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Ecology 2024年第4期14卷 292-308页

作者： Afed S. Daiwey Heherson B. Ong Emerson v. Barcellano Edmundo C. Gumpal michelle Ann m. Calubaquib Rafael J. Padre School of Forestry and Environmental Sciences Aurora State College of Technology Baler Philippines College of Forestry and Environmental Science Isabela State University Cabagan Philippines College of Agriculture Isabela State University Cabagan Philippines College of Engineering Isabela State University Echague Philippines

The research study was conducted to assess and quantify the current status of avifauna biodiversity assets of Aurora State College of Technology’s Forest Reservation in Baler, Aurora, Philippines. Assessment of avifaunal diversity was undertaken by traversing the four established circular plots having a radius of 125 meters or 250 meters diameters each as permanent monitoring stations. Study revealed a total number of 151 Individual species, classified into 23 genera and 21 families. Eighteen of these species are endemic while the remaining five were fully migrated birds. All birds observed were classified as Least Concern (LC) species according to the International Union for Conservation of Nature’s Red List of Threatened Species and the updated list of the Birds of the World online. Its abundance, richness and diversity index were calculated using Shannon Diversity Index (H') while Pielou’s evenness (J') for distribution of species. Forest reservation of ASCOT has more even (0.756 J') and moderate diversity (2.812 H') observation on avifauna in general. However, this avian population evaluation was threatened into a verge of extinction due to natural and anthropological threats that causes forest deforestation. Such deforestation of habitat causes dwindling of wildlife territory leading to the scarcity of bird’s population. Thus, the assessment was conducted to aid ASCOT administration find significant plans to ensure sustainable conservation and protection of the remaining avifauna species in the reservation area.

关键词： Biodiversity Avifauna Abundance Species Richness Species Diversity