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Global Transmission Dynamics of a schistosomiasis Model and Its Optimal Control

Applied Mathematics 2019年第6期10卷 397-418页

作者： Mouhamadou Diaby mariama sène Abdou sène Laboratoire d’Analyse Numérique et d’Informatique (LANI) UFR SAT Université Gaston Berger de Saint-Louis Saint-Louis Sénégal UFR AGRO Université Gaston Berger de Saint-Louis Saint-Louis Sénégal LANI P&ocirc le sTN MAI (Mathématiques Appliquées et Informatique) Université Virtuelle du SENEGAL Dakar-Fann Sénégal

Drug treatment, snail control, cercariae control, improved sanitation and health education are the effective strategies which are used to control the schistosomiasis. In this paper, we consider a deterministic model for schistosomiasis transmission dynamics in order to explore the role of the several control strategies. The global stability of a schistosomiasis infection model that involves mating structure including male schistosomes, female schistosomes, paired schistosomes and snails is studied by constructing appropriate Lyapunov functions. We derive the basic reproduction number R0 for the deterministic model, and establish that the global dynamics are completely determined by the values of R0. We show that the disease can be eradicated when R0?≤1;otherwise, the system is persistent. In the case where ?R0?>1, we prove the existence, uniqueness and global asymptotic stability of an endemic steady state. sensitivity analysis and simulations are carried out in order to determine the relative importance of different control strategies for disease transmission and prevalence. next, optimal control theory is applied to investigate the control strategies for eliminating schistosomiasis using time dependent controls. The characterization of the optimal control is carried out via the Pontryagins Maximum Principle. The simulation results demonstrate that the insecticide is important in the control of schistosomiasis.

关键词： schistosomiasis Models Nonlinear Dynamical systems Global stability Reproduction Number Optimal Control sensitivity Analysis

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培训对员工绩效的影响分析 ——以塞拉利昂公路运输公司为例（sLRTC）

培训对员工绩效的影响分析 ——以塞拉利昂公路运输公司为例（SLR...

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作者： mariama ALIMA KAMARA 河北大学

学位级别：硕士

现代企业的成功越来越取决于其人力资源的效率和有效性。支撑组织成功的一个重要因素是拥有一支蓬勃发展、有能力、能力非凡的员工队伍,他们通过自己的技能、知识和奉献精神成为成功的支柱。本研究深入探讨了塞拉利昂公路运输公司背景... 详细信息

现代企业的成功越来越取决于其人力资源的效率和有效性。支撑组织成功的一个重要因素是拥有一支蓬勃发展、有能力、能力非凡的员工队伍,他们通过自己的技能、知识和奉献精神成为成功的支柱。本研究深入探讨了塞拉利昂公路运输公司背景下人力资源开发举措与组织绩效之间的复杂关系。本文试图严格分析各种关键假设,包括广义培训计划在多个领域提高员工绩效的程度。此外,它旨在观察和量化培训实施的频率和强度对生产力成果指标的影响。这一综合分析将涉及评估在各自行业中表现最佳的组织所影响的整体绩效效率。为了实现这些研究目标,本文采用了定量方法,通过向sLRTC的员工分发结构化问卷来收集数据。这项实证调查的结果揭示了培训和发展活动与员工绩效指标之间的强烈正相关关系,突显了人力资本投资对生产力的巨大影响。该报告强调,企业,特别是物流和运输行业的企业,迫切需要为培训和专业发展活动分配足够的资源,这些活动经过精心调整,以符合其业务的具体目标。此外,该研究强调了管理决策在设计和实施有效培训计划方面的重要作用。它表明,如果没有由各级所有者、董事和管理人员带头的战略方法,组织将缺乏从这些举措中获得最佳利益所需的实际行动步骤。最终,这项研究为实地工作做出了宝贵贡献,它将培训和组织效能作为在塞拉利昂公路运输公司动态环境中运作的相互支持的合作伙伴。这些发现对人力资源管理实践具有重要意义,并突出了未来研究工作的途径。研究结果揭示了培训和发展活动、绩效改进和组织成功之间的紧密联系。它描述了商业实体的不可或缺的因素,特别是在物流和运输方面,为与其职责相近的培训项目分配足够的资源。首先,该研究支持管理者是培训项目产出的关键决定因素。本文讨论了培训与组织绩效之间的联系,提出了一个涵盖sLRTC案例研究的战略性人力资源开发模型。通过这种方式,公司可以同时处理两个方面;培训举措和组织成功率的提高将紧密结合在一起,带来高质量的工作环境和实质性的成长和发展。

关键词：培训发展组织绩效塞拉利昂公路运输公司(sLRTC) 塞拉利昂政府人力资源-人力资源公司巴士-CB

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The Importance of Uterine Tumors in the Day-to-Day Practice of the General surgery Department of Ignace Deen National Hospital

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Open Journal of Obstetrics and Gynecology 2024年第7期14卷 1003-1009页

作者： Mamadou sakoba Barry mariama Camara Aissatou Taran Diallo Aboubacar Touré General surgery Department Ignace Deen National Hospital/Conakry University Hospital Conakry Guinea Faculty of Health sciences and Technology Gamal Abdel Nasser University of Conakry Conakry Guinea

Introduction: Uterine tumors are all abnormal cell proliferations developed at the expense of one or more tissue types, which may be located in any uterine segment and have anatomopathological characteristics of benignity or malignancy. The aim of this study was to report on the management of uterine tumors in the general surgery department of Ignace Deen Hospital in Conakry. Methodology: This was a retrospective study lasting five (5) years, from January 1, 2011 to December 31, 2015: All complete records of patients with the diagnosis of a uterine tumor managed in the department were included. Our results are presented in tables and figures. Results: 3200 patients underwent surgery. Among them, 82 cases concerned uterine tumors, i.e. 2% of the department’s overall activity. The average age of our patients was 38.5 years, with extremes of 18 and 59 years. The age group most affected was 41 - 50, with a rate of 39.02%. Housewives and married civil servants were the socio-professional strata most affected, with a predominance of married women. We estimated an increasing proportion of patients admitted to the department during the study period, proving that our study site plays a significant role in the management of uterine tumors. Conclusion: The management of uterine tumors is a major public health problem. Information, communication and education of all socio-professional groups seem necessary.

关键词： Uterine Tumors Management Conakry University Hospital

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Vulvectomy: Indications and Results in the General surgery Department of the Ignace Deen Chu Hospital in Conakry

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Open Journal of Obstetrics and Gynecology 2024年第4期14卷 560-564页

作者： Camara mariama Barry Mamadou sakoba Yattara Abdoulaye Touré Aboubacar Department of General surgery H&#244pital National Ignace Deen Conakry Guinea Faculty of Health sciences and Technology Gamal Abdel Nasser University of Conakry Conakry Guinea

Introduction: The aim of this study was to report the indications and evaluate the results of vulvectomy in the general surgery department of Ignace Deen Hospital, CHU Conakry. Materials and Methods: This was a retrospective descriptive study, conducted over a period of five (05) years from January 1, 2018 to December 31, 2022, in the general surgery department of Ignace Deen Hospital, CHU Conakry. We included in our study all patient records in whom vulvectomy was performed. Results: We recorded 15 cases of vulvectomy out of 453 perineal surgeries, i.e. 3.31%, with a mean age of 43.56 years and extremes of 35 and 69 years. Vulvar cancer was the most common diagnosis (46.67%), followed by Buschke-Lowenstein (33.33%) and anal canal cancer extending to the vulva (20%). six patients had undergone biopsy (40%). Vulvectomy with lymph node dissection was performed in only 9 patients (60%), and all surgical specimens were sent to anatomical pathology (100%). Conclusion: Vulvectomy is a surgical technique most often indicated for the treatment of vulvar cancer.

关键词： Vulvectomy Indications Results Ignace Deen Conakry University Hospital

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sustainable Management of Biodegradable Waste in Guinea: Effect of Compost on Eggplant and Chilli Crop Yields Pepper

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Agricultural sciences 2024年第9期15卷 1009-1017页

作者： Mamadou Yaya Baldé Mamadou Aliou Diallo mariama Barry Dian Foula Diallo Mamadouba Bangaly Camara Nyankoï soropogui Institut de Recherche Environnementale de Guine (IREG) Conakry Guinea Department of Chemistry Gamal Abdel Nasser University of Conakry Conakry Guinea

The fight against insalubrity in large urban and peri-urban agglomerations is a major challenge in developing countries. This problem is compounded by that of sustainable waste management mechanisms. Indeed, the current waste collection system in Guinea has proved inadequate, as moving garbage from point “A” to point “B” is tantamount to “moving the problem”. The aim of this experimental work is to demonstrate the cost-effectiveness and benefits of sustainable waste management. As part of this drive to valorize biodegradable waste, the Waste Management Research Center has undertaken a series of activities ranging from composting organic waste to testing compost on certain crop varieties. An experimental field of 8024 m2 was laid out and treated with 1500 Kg of fine compost in doses ranging from 2.5 to 5 T/ha. Two crop varieties, eggplant and chili, were tested. Compost application increased production yields: 15 to 21 tonnes of eggplant and 10.4 to 11.1 tonnes of chili per hectare. Growth rates compared with usual yields varied from 50% to 64% and from 11% to 17% for eggplant and chili, respectively. This study resulted in an optimum compost dose of 2.5 T/ha for this phase.

关键词： sustainable Waste Management Compost Eggplant Chilli Yield IREG CREGED

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Epidemiological and Hemato-Biochemical Profiles of Diabetic Patients at the Diabetology, Endocrinology, and Metabolic Diseases Department of the Alpha Oumar Diallo Regional Hospital, Kindia (Republic of Guinea)

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Journal of Diabetes Mellitus 2024年第2期14卷 108-121页

作者： Fatoumata Bah Cé Camara Ousmane sangare Elhadji saidou Balde Karamo Toure Taliby Dos Camara mariama Kourouma César Hagassou Biology Laboratory Department of Biology Faculty of Sciences Gamal Abdel Nasser University Conakry (Commune of Dixinn) Guinea Higher school of Tourism and Hospitality of Guinea Conakry Guinea Faculty of Pharmaceutical and Medical sciences Gamal Abdel Nasser University Conakry Guinea

This study aims to enhance the healthcare services for diabetic patients in the administrative region of Kindia by suggesting dietary interventions to assist diabetics in better managing their condition. Conducted over a period of six months, from February 18 to July 18, 2021, this prospective and descriptive cross-sectional study involved 220 diabetic patients. Among these, 48 patients (22%) maintained balanced glucose levels (2 g/l). Positive glycosuria was observed in 54% of the patients, whereas 46% demonstrated normal glycosuria. An analysis of urinary parameters revealed that 15% of the patients had abnormal Ketone Bodies. Normal HbA1c levels (9%) HbA1c levels. Hematological assessments indicated significant variation: 56% of the patients had low hemoglobin levels, 4% suffered from hyper-eosinophilia, and 1% each from hyper-basophilia and hyper-hemoglobinemia. The anemic profile was characterized as mild anemia in 75%, moderate anemia in 20%, and severe anemia in 5%. Furthermore, 25% of patients were affected by Microcytic anemia and 75% by Normocytic anemia. Demographically, women constituted 65% of the study group compared to 35% of men. The most represented age bracket was 41 to 60 years, accounting for 52% of the patients, while those between 61 and 80 years comprised 36%. Every district in Kindia was impacted by diabetes.

关键词： Epidemiology Diabetes Glucose Levels Glycosuria Metabolic Disorders Kindia

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Congenital Cervico-Mandibular Cystic Lymphangioma in Pediatric surgical setting in Guinea

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Open Journal of Pediatrics 2024年第1期14卷 164-173页

作者： Thierno saïdou Barry Mohamed Lamine sadou sacko Balla Keita Aissatou Bailo Balde Mamadou Alpha Diallo Moussa Conde Ibrahima Kalil Dioubate Mory sangare salamata sall mariama Dalanda Diallo Daniel Agbo-Panzo Pediatric surgery Department Donka National Hospital (HND) of Conakry University Hospital (Gamal Abdel Nasser University of Conakry (UGANC) of Guinea) Conakry Guinea Hadja Bilguissou BARRY Medical-surgical Clinic (HBB) Conakry Guinea Albert Royer Children’s service Cheikh Anta DIOP University (UCAD) Dakar Senegal surgery Department of the Regional Hospital Center of Ziguinchor (CHRZ) Ziguinchor Senegal

Introduction: Cystic lymphangiomas are rare benign malformative tumors of the lymphatic system of obscure etiopathogenesis. The cervico-facial location remains the most common (75%). Although benign, these tumors remain potentially fatal, due to possible compression of the upper aero-digestive tract. The aim of this work is to study the epidemiological, diagnostic and therapeutic characteristics of cervico-mandibular congenital cystic lymphangiomas in the pediatric surgery department of the Donka National Hospital (HND) Conakry. Patients and methods: This is a retrospective and descriptive study of 13 files lasting 7 years from January 2015 to December 31, 2021. The files of children whose age is less than or equal to 15 years operated on cervical tumor with histological evidence of cystic lymphangioma were retained. The data were analyzed using sPss statistical software 21 and anonymously. Results: The incidence of this study was 1.86 cases per year and a sex ratio of 0.62 in favor of girls. The average age was 8 months 19 days. In the antecedents, we only find poorly monitored pregnancies. The average size of the tumors was 11.85 cm. Cervical ultrasound and standard x-ray of the cervical mass were the only examinations performed. Total surgical excision of the cervical tumor was performed in all patients. The mass was polycystic on exploration. The histological examination of the surgical specimens was in favor of a cystic lymphangioma. The surgical consequences were simple in 11 patients (84.62%) and complicated by parietal suppuration in 2 cases (15.38%). There were no cases of recurrence after one year of follow-up. Conclusion: Cervico-mandibular cystic lymphangiomas are the most frequent locations of congenital lymphangiomas in children. Their severity is linked to the risk of compression of the aero-digestive tracts. Their diagnosis must be confirmed by the histology of the surgical specimen. Despite the therapeutic arsenal, excision of the cystic mass remain

关键词： Congenital Cystic Lymphangioma (LKC) Child Pediatric surgery Guinea

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Risk Factors for neonatal Mortality at the Institute of Nutrition and Child Health of the Donka/Guinea-Conakry National Hospital

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Open Journal of Pediatrics 2024年第2期14卷 327-337页

作者： Bangoura Mmah Aminata Kolié Ouo Ouo Camara salématou Hassimiou Baldé mariama Bangoura Kaba Diop Mamadou Moustapha Camara Emmanuel Diallo Fatoumata Binta Doukouré Mamadou Aliou Mamadou Mouctar sow Bémy Pé Néabey Institut de Nutrition et de santé de l’Enfant Conakry Guinea service de Pédiatrie Hô pital National Donka Conakry Guinea service de Pédiatrie Hô pital National d’Ignace Deen Conakry Guinea

Introduction: The birth of a baby is a moment of joy and celebration. However, the neonatal period is a very delicate phase of life. neonatal mortality rates remain high in low-income countries. In Guinea, after 20 years, this rate has fallen from 34.2% in 1998 to 32% in 2018. Objective: To identify the main risk factors for neonatal mortality. Methods: This was an observational, analytical case-control study, lasting 6 months from January 1 to June 30, 2019, conducted at the Institut de Nutrition et de la santé de l’Enfant (INsE) at Donka National Hospital. Results: We collected 242 cases and 242 controls, i.e. a total of 484 records. 748 patients were registered, with 32.35% deaths. 82.86% of deaths occurred in the early neonatal period. statistical analysis revealed the main risk factors: prematurity (RQ 7.39 95% CI 3.27 - 16.61 p = 0.0000003), hypothermia (RQ 2.29 95% CI 1.51 - 3.46 p = 0.0001), acute fetal distress (RQ 2.13 95% CI 1.33 - 3.43 p = 0.0016), low birth weight (QR 1.91 95% CI 1.12 - 3.24 p = 0.016), home birth (QR 3.26 95% CI 1.25 - 8.46 p = 0.015). Conclusion: neonatal mortality is a health problem in the INsE neonatology department. To reduce the mortality rate in this referral facility, it is essential to equip it and provide ongoing training for staff.

关键词： neonatal Mortality INsE Guinea-Conakry

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seroprevalence of Human Immunodeficiency Virus and Hepatitis B in Blood Donors at the N’Zérékoré Regional Blood Transfusion Centre in Guinea

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Open Journal of Immunology 2024年第2期14卷 33-45页

作者： Alimou Camara Ernest Thea Ives Nyankoye Haba Yamoussa Youla Ibrahima sory Diallo mariama sadio Diallo Djiba Kaba Jacob Camara Moussa Condé Barré soropogui Kaba Kourouma Thierno Mamadou Tounkara Babacar Mbengue Abdoulaye Touré sanaba Boumbaly Virology Research Centre Guinea Viral Haemorrhagic Fevers Laboratory Conakry Guinea Faculty of Health sciences and Techniques Gamal Abdel Nasser University Conakry Guinea National Blood Transfusion Centre Ministry of Health and Public Hygiene Conakry Guinea Institute of Health and Childhood Donka National Hospital Conakry Guinea African Centre of Excellence for the Prevention and Control of Communicable Diseases Conakry Guinea Department of Dermatology and Venereology Donka University Hospital Conakry Guine Immunology Laboratory Cheikh Anta Diop University Dakar Senegal Centre for Research and Training in Infectious Diseases of Guinea Conakry Guinea

Blood transfusion saves lives and reduces morbidity and mortality for a large number of diseases and clinical conditions, but it is not without danger. The aim of this study was to determine the seroprevalence of HIV and hepatitis B in blood donors received at the regional Blood Transfusion Centre of N’Zérékoré (Guinea). This was a 5-year retrospective analytical study. We included records of blood donors aged 18 to 60 years admitted to the N’Zérékoré Regional Blood Transfusion Centre for blood donation from January 2016 to December 2020. We performed a descriptive analysis followed by Chi-2 or Fish-er-exact tests and the student or Wilcoxon test, followed by multivariate logistic regression. In this study, donor age ranged from 18 - 60 years, with a pre-dominance of donors aged 25 - 34 (44.2%). Male donors were the most represented in our study (79.0% versus 21.0% female). More than half of the donors were blood group O (55.6%). We observed a seroprevalence of 3.6% for HIV, 13.4% for HBsAg and 0.2% for co-infection. In our series, age 25 - 34 (OR = 1.89 and P = 0.001) and 35 - 44 for HIV (OR = 2.01 and P = 0.001), HBsAgserostatus (OR = 3.04 and P = 0.001) and blood donation history (OR of 3.04 and P = 0.001) were factors associated with HIV positivity (P study, HIV serostatus (OR = 3.04 and P = 0.001) and blood donation history (OR = 0.01 and P = 0.001) were factors associated with HBsAgseropositivity. We reported a high prevalence of HIV and HBsAg. sex, serological status and blood donation history were associated factors.

关键词： seroprevalence HIV Hepatitis B Blood Donors N’Zérékoré Guinea

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Immunovirological Discordance and Associated Factors among People Living with HIV under Antiretroviral Treatment at Hôpital de Jour de Donka, Guinea

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Open Journal of Medical Microbiology 2024年第2期14卷 93-104页

作者： mariama sadjo Diallo Djiba Kaba Charles Tchibinda Delicat Issiaga Diallo Boh Fanta Diane Doufin Traore Ousmane Niabaly Oumar Mouctar Diallo Ouo-Ouo Yaramon Kolie Aly Patrice Kamano Pascal Koivogui Ahmed sékou Keita Mohamed Macire soumah Thierno Mamadou Tounkara Mohamed Cisse Facult des sciences et Techniques de la sant Universit Gamal Abdel Nasser de Conakry Conakry Guine Laboratoire de Biologie Molculaire nestor Bangoura/Helene Labrousse Hpital de Jour Donka CHU Donka Conakry Guine Centre dExcellence Africain Pour la Prvention et le Contrle des Maladies Transmissibles Conakry Guine service de Dermatologie-Vnrologie CHU Donka Conakry Guine

The antiretroviral treatment (ART) has significantly reduced the number of new HIV/AIDs infections and related deaths. However, cases of immunovirological discordance (IVD) are found in various locations. The objective of this study was to determine the profile of People living with HIV (PLHIV) with IVD and to identify associated factors. We conducted a cross-sectional study based on the records of PLHIV under ART for at least 6 months, followed at Hpital de Jour Donka from 2015 to 2017, and having both viral load (CV) and CD4 T-cell count. Prevalence of IVD was 34.57%, with 23.87% for immunological discordance (ID) and 10.7% for virological discordance (VD). Females were predominant (66.26%), and male gender influenced IVD with a statistically significant difference (p = 0.006) and was associated with VD (p = 0.007). The average age was 38.77 11.30 years. PLHIV were classified at WHO stages 3 and 4 (86.01%). The median initial haemoglobin level was 11.5 g/L [3.2 - 12]. The mean initial CD4 T-cell count was 272.84 cells/mm3 201.6. The median initial viral load (VL) was 147,337 copies/mL [1092 - 31,675,000]. The initial CD4 T-cell count 3 was associated with IVD with a statistically significant difference (p = 0.0009) and correlated with ID (p = 0.000). Prurigo was associated with IVD with a statistically significant difference (p = 0.003). Cerebral toxoplasmosis was not associated with IVD but was associated with ID (p = 0.04). This study allowed us to describe the profile of PLHIV with IVD. The main associated factors were male gender, initial CD4 T-cell count 3, toxoplasmosis, prurigo, and herpes zoster.

关键词： HIV Antiretroviral Treatment (ART) Immunovirological Discordance Donka Guinea

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