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Design, Sy.thesis, <i>in Vitro</i>Antibacterial Activity. and Docking Studies of New Rhodanine Derivatives

Open Journal of Medicinal Chemistry 2020年第1期10卷 15-34页

作者： Aisha Abusetta Jowhara Alumairi mariam y. alkaabi Ruba Al Ajeil Asma Abu Shkaidim Dana Akram J. Pajak Mohammad A. Ghattas Noor Atatreh Shaikha S. AlNey.di Department of Chemistry College of Science UAE University Al-Ain UAE College of Pharmacy Al Ain University of Science and Technology Al Ain UAE

Bacterial infections present a serious challenge to healthcare practitioners due to the emergence of resistance to numerous conventional antibacterial drugs. Therefore, new bacterial targets and new antimicrobials are unmet medical needs. Rhodanine derivatives are known to possess potent antimicrobial activities. In this study. we determined the activity.spectrum of a series of new rhodanine derivatives against representative Gram-positive and Gram-negative bacterial strains. Compounds 3a and 5a had the highest activity.with minimum inhibitory.concentrations in the range of 1.12 - 2.5 μg/mL. Transmission electron microscope results confirmed that activities against bacteria occurred via rupturing of the cell wall. Molecular modeling results suggested that rhodanine derivatives have the potential to irreversibly.bind to the penicillin-binding protein (PBP) Ser62 residue in the active site. Thus, our results suggested that these rhodanine derivatives could be potential antibacterial drug candidates with strong activity.against Gram-negative bacteria.

关键词： Rhodanine Compounds PBP β-Lactamase Enzy.e Docking

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Enhancing CNN for Forensics Age Estimation Using CGAN and Pseudo-Labelling

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Computers, Materials & Continua 2023年第2期74卷 2499-2516页

作者： Sultan alkaabi Salman y.ssof Sameera Al-Mulla Institute of Informatics and Computing in Energy Universiti Tenaga NasionalMalaysia College of Engineering and IT University of DubaiUAE

Age estimation using forensics odontology.is an important process in identify.ng victims in criminal or mass disaster ***,this process is done manually.by.human ***,the speed and accuracy.may.vary.depending on the expertise level of the human expert and other human factors such as level of fatigue and *** improve the recognition speed and consistency.researchers have proposed automated age estimation using deep learning techniques such as Convolutional Neural Network(CNN).CNN requires many.training images to obtain high percentage of recognition ***,it is very.difficult to get large number of samples of dental images for training the CNN due to the need to comply.to privacy.acts.A promising solution to this problem is a technique called Generative Adversarial Network(GAN).GAN is a technique that can generate sy.thetic images that has similar statistics as the training set.A variation of GAN called Conditional GAN(CGAN)enables the generation of the sy.thetic images to be controlled more precisely.such that only.the specified ty.e of images will be *** paper proposes a CGAN for generating new dental images to increase the number of images available for training a CNN model to perform age *** also propose a pseudolabelling technique to label the generated images with proper age and *** used the combination of real and generated images to trainDentalAge and Sex Net(DASNET),which is a CNN model for dental age *** on the experiment conducted,the accuracy.coefficient of determination(R2)and Absolute Error(AE)of DASNET have improved to 87%,0.85 and 1.18 y.ars respectively.as opposed to 74%,0.72 and 3.45 y.ars when DASNET is trained using real,but smaller number of images.

关键词： Dental forensics age estimation generative adversarial network pseudo-labelling convolutional neural network

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Interleukin-28 and hepatitis C virus genoty.e-4:Treatment-induced clearance and liver fibrosis

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World Journal of Gastroenterology 2012年第47期18卷 7003-7008页

作者： Moutaz Derbala Nasser Rizk Fatima Shebl Saad alkaabi Nazeeh Eldweik Anil John Manik Sharma Rafie y.qoob Muneera Almohanadi Mohammed Butt Khaled Alejji Department of Gastroenterology.and Hepatology Hamad HospitalDoha 3050Qatar Department of Gastroenterology.and Hepatology Weill Cornell Medical CollegeDoha 3050Qatar Department of Health Sciences Qatar UniversityDoha 2713Qatar Chronic Disease Epidemiology.Division Yale School of Public HealthNew HavenCT 06520United States

AIM:To investigate the association between interleukin-28B(IL28B) genoty.e and response to treatment and hepatic fibrosis in patients with hepatitis C virus(HCV) genoty.e ***:Two hundred and one HCV-genoty.e 4 patients were *** patients were treated with Peginterferon alph2a/Ribavirin for 48 *** of treatment response(ETR) was defined as loss of detectable serum HCV RNA at the end of *** viral response(SVR) was defined as loss of detectable serum HCV RNA at the end of 24 wk follow *** of IL28B rs12979860 was performed using the TaqMan *** used logistic regression to estimate the adjusted odds ratio(aOR) and 95%***:The study.included 201 HCV-genoty.e 4 *** majority.of patients were men(89.6%),with a median age of 47 y.ars,inter-quartile range(40-51).Approximately.62.5% of patients had ETR,and 49.6% had *** who achieved SVR were more likely.to be y.unger(χ 2 = 4.91,P = 0.027),and less likely.to have fibrosis(χ 2 = 15.54,P y.e distribution of rs12979860 was 36.2%,49.0% and 14.8% for genoty.es CC,CT,and TT,*** these participants,rs12979860 genoty.e distribution did not differ by.gender(P = 0.466),pretreatment viral load(P = 0.600),inflammation(P = 0.435),or fibrosis(P = 0.291).The frequencies of IL28B rs12979860 genoty.es were TT(14.8%),CT(49.0%),and CC(36.2%).Compared to rs12979860 genoty.e TT,aORs(95%CI) for ETR and SVR were:CC genoty.e,[17.55(5.34-57.69) and 5.92(2.09-16.76),respectively.;CT genoty.e,[5.15(1.80-14.78) and 2.48(0.94-6.52),respectively..In the current study.the patients who did not achieve ETR or SVR had a lower prevalence of rs12979860 CC(17.4% and 23.3%,respectively. than individuals who had ETR or SVR(47.9% and 47.2%,respectively..Individuals with rs12979860 CC genoty.e had approximately.6 times the odds of SVR compared to individuals with TT genoty.e(aOR = 5.92;95%CI:2.09-16.76).Similarly.patients with CT

关键词： Genoty.e 4 Hepatic fibrosis Hepatitis C virus Interleukin-28B rs12979860

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阿联酋的抗击新冠疫情模式

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现代世界警察 2021年第6期 70-73页

作者： [阿联酋]哈穆德阿联酋内政部能力发展行政总局中国刑事警察学院

抗疫模式的决定因素和比较优势阿联酋采取的抗疫策略基于一系列决定因素,主要有:1.遵循世界卫生组织(WHO)的要求迅速地实施。2.遵守危机处理的透明标准,并充分及时地披露阿联酋流行病数据。3.使全社会共同参与遏制该疾病。提高人们对自... 详细信息

抗疫模式的决定因素和比较优势阿联酋采取的抗疫策略基于一系列决定因素,主要有:1.遵循世界卫生组织(WHO)的要求迅速地实施。2.遵守危机处理的透明标准,并充分及时地披露阿联酋流行病数据。3.使全社会共同参与遏制该疾病。提高人们对自身在这场危机中的作用的认识,以及采取预防措施(特别是"社会疏离")的责任感。

关键词：危机处理阿联酋流行病预防措施责任感

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