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Tissue-source effect on mesenchymal stem cells as living biodrugs for heart failure:Systematic review and meta-analysis

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World Journal of Cardiology 2024年第8期16卷 469-483页

作者： Moaz safwan mariam safwan bourgleh Mohamed Aldoush Khawaja Husnain Haider Department of Basic Sciences Sulaiman Al Rajhi UniversityAl Bukairiyah 51941Saudi Arabia

BACKGROUND Mesenchymal stem cells(MSCs),as living biodrugs,have entered advanced phases of clinical assessment for cardiac function restoration in patients with myocardial infarction and heart *** MSCs are available from diverse tissue sources,bone-marrow-derived MSCs(BM-MSCs)remain the most wellstudied cell type,besides umbilical-cord-derived MSCs(UC-MSCs).The latter offers advantages,including noninvasive availability without ethical *** To compare the safety and efficacy of BM-MSCs and UC-MSCs in terms of left ventricular ejection fraction(LVEF),6-min walking distance(6MWD),and major adverse cardiac events(MACEs).METHODS Five databases were systematically searched to identify randomized controlled trials(RCTs).Thirteen RCTs(693 patients)were included using predefined eligibility *** mean differences and odds ratio(OR)for the changes in the estimated treatment *** UC-MSCs significantly improved LVEF vs controls by 5.08%[95%confidence interval(CI):2.20%-7.95%]at 6 mo and 2.78%(95%CI:0.86%-4.70%)at 12 ***,no significant effect was observed for BM-MSCs vs *** significant changes were observed in the 6MWD with either of the two cell ***,no differences were observed for MACEs,except rehospitalization rates,which were lower only with BM-MSCs(odds ratio 0.48,95%CI:0.24-0.97)vs *** UC-MSCs significantly improved LVEF compared with *** advant-safwan M et ***-source and MSCs as living biodrugs ageous characteristics position them as a promising alternative to MSC-based therapy.

关键词： Cardiovascular disease Heart disease Mesenchymal stem cells Umbilical cord stem cells

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Evaluation of groundwater quality in the Dibdibba aquifer using hydrogeochemical and isotope techniques(Basrah Province,Iraq)

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Acta Geochimica 2022年第5期41卷 823-838页

作者： Inass A.Al-Mallah Wasan S.Al-Qurnawi Hussein B.Ghalib Adnan B.Al Hawash mariam H.Abdulameer Geology Department College of ScienceUniversity of BasrahBasrahIraq Director of the Scholarships and Cultural Relations Department Ministry of Higher Education and Scientific ResearchBaghdadIraq Department of Marine Chemistry and Environmental Pollution Marine Science CenterUniversity of BasrahBasrahIraq Biology Department College of Education-QurnaUniversity of BasrahBasrahIraq

The Dibdibba aquifer is considered to be the main source in the Al-Zubair area because agriculture depends on it to provide grazing water in the *** groundwater well samples were collected from the shallow Dibdibba Aquifer in Basra Province,southern Iraq,through the dry and wet period for 37 water samples were collected,to investigate the water quality deterioration,which is a hydrogeochemical modeling study where used to represent the groundwater mixing *** physicochemical parameter results show the spatial and temporal variations along the groundwater flow path.A Durov diagram of the studied samples shows water type Na-SO_(4),which is represented by mixing waters that may be affected by *** geochemical model ratio results of the groundwater well samples have shown high mixing ratios in the east and southeast regions of the study *** stable isotope composition of groundwater samples indicated that the recharge source of the Dibdibba aquifer is meteoric water influenced by vapor water from the Arabian *** stable isotope results have shown that the enrichment ofδO values is relatively linked with high salinity concentration and indicated the mixing between the upper unconfined and the lower confined,especially in the eastern and southern parts of the study *** findings of geochemical modeling and isotopes indicated an increasing groundwater quality ***,we recommended avoiding these areas for intensive extraction of groundwater.

关键词： safwan–Zubair Dibdibba formation Geochemical modeling Mixing Stable isotopes Basra

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