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Open Journal of Rheumatology and Autoimmune Diseases 2015年第2期5卷 23-27页

作者： mohamed Diomandé Ehaulier Soh Christian Louis Kouakou Tamo Estelle Mégné mariam Gbané-Koné Abidou Kawele Coulibaly Edmond Eti Marcel N’zué Kouakou Department of Rheumatology of University Hospital Center of Cocody Abidjan C&#244te d’Ivoire Department of Rheumatology of University Hospital Center of Bouaké Bouaké C&#244te d’Ivoire

Pott’s disease usually affects two contiguous vertebrae or two spinal levels. The involvement of the three cervicothoracic and lumbar levels is rarely described. Only three cases have been described in the literature to our knowledge. The authors report three new cases of tuberculous spondylodiscitis of cervicothoracic and lumbar site. Our three cases were characterized by symptoms similar to the other topographical forms of Pott’s disease. A predisposing factor is often identified like the infection with human immunodeficiency virus. The definitive diagnosis was made in two cases by identifying acid and alcohol-fast bacilli for one case and by histology for the other case. For the third case, there was a diagnostic presumption reinforced by the satisfactory outcome on tuberculosis chemotherapy for a period of 12 months. The multilevel nature of diseases does not influence the effectiveness of treatment of this form of spinal tuberculosis.

关键词： Pott’s Disease Spondylodiscitis Bone and Joint Tuberculosis Abidjan

Epidemiological and Clinical Study of Cardiac Diseases in the Pediatric Department of the University Hospital Gabriel Touré(UH GT), Bamako (Mali)

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World Journal of Cardiovascular Diseases 2018年第7期8卷 328-336页

作者： Maiga Belco Ba Hamidou Oumar Sacko Karamoko Dembélé Adama Sanogo Nouhoum Cissé mohamed Elmouloud Togo Pierre Diakité Abdoul Aziz Dicko-Traoré Fatoumata Sylla mariam Pediatric Department UH GT Bamako Mali Cardiology UH GT Bamako Mali

Introduction: Children’s heart disease is a major public health problem in developing countries and especially in Mali. The purpose of our work was to determine frequency, different types of heart disease and their short term evolution in the pediatric department. Methods: We performed a retrospective study among children aged 0 to 15 years, hospitalized in the pediatric department from January to December 2015 and whose diagnosis was confirmed using trans-thoracic echocardiography. Results: We included 103 cases of heart disease out of a total of 8613 admissions in the pediatric department, giving an hospital prevalence of 1.2%. Mean age was 4.1 years (from 1 day to 15 years) and children under 5 years were the most affected with 73.80% of cases. Male predominance was noted (sex ratio = 1.2). Respiratory distress was the most common circumstance of discovery (93.20%). Cardiac murmur and tachycardia were the most common cardiac signs with respectively 88.35% and 83.50%. Congenital heart disease accounted for 70.87% and was dominated by ventricular septal defect (VSD) with 30.13%. Acquired heart disease (29.13% of the sample) was dominated by mitral regurgitation (MR) with 56.67%. Mortality rate was 31.9% for congenital heart disease and 11.1% for acquired heart disease. Conclusion: children’s heart disease is responsible for high mortality. Early detection improves the management of this pathology, which remains frequent.

关键词： Cardiac Disease Congenital Acquired Pediatric Bamako

Skin Cancer of the Face in Albinos: Case Management

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International Journal of Otolaryngology and Head & Neck Surgery 2022年第1期11卷 31-38页

作者： Amady Coulibaly Sibiri Traoré Sory Ibrahima Sidibé Koniba Diabaté Youssouf Sidibé Garango A. Allaye mariam G. Diallo Abdramane S. Maiga Boubacar Ba Hamady Traoré Alhousseyni Ag mohamed Department of Stomatology and Maxillofacial Surgery CHU-CNOS Bamako Mali Faculty of Medicine and Odontostomatology Bamako Mali Radiotherapy Department of the Hospital of Mali Bamako Mali Departement of Otorhinolaryngology CHU Mère-Enfant “le Luxembourg” Bamako Mali Military Hospital of Bamako Bamako Mali

Albinism represents a set of genetic abnormalities characterized by a decrease or absence of melanin. Albinism in the black subject combines white skin and other morphological characteristics of the black race. Squamous cell carcinomas of the face in albinos are a common reason for consultation. Management remains most often complex. The objective of this work was to describe the management of a case of skin cancer of the face in an albino woman. She was a 26-year-old albino woman. She is a housewife and married. She consulted on 02/04/17 for a tumor of the right side. The tumour was about 6 cm in diameter and had been growing for 7 months. There was no palpable head and neck disease. The rest of the clinical examination was normal. The biopsy concluded that there was squamous cell carcinoma. The extension assessment had not found a secondary location. She received an excision of the tumor with a margin of 10 mm and a total skin graft. The trend has been favourable after three years. No recurrence was observed. The management of facial skin cancer should be the subject of a multidisciplinary consultation. Surgery occupies an important place in the therapeutic arsenal.

关键词： Skin Cancer Face Albino Treatment

Epidemiological Profile of Newborns Who Died during Their Hospitalization in the Neonatology Unit, Mali Hospital

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Open Journal of Pediatrics 2022年第2期12卷 424-432页

作者： Korotoumou Wéllé Diallo Bourama Kané Aboubacar Sangaré Kadidiatou Touré Fatoumata Léonie François Diakité Mamadou Traoré mohamed Maba Traoré Mamadou Berthé mariam Maiga Abdoul Aziz Diakité Fatoumata Dicko Traoré Department of Pediatrics Mali Hospital Bamako Mali Department of Pediatrics Gabriel Touré University Hospital Bamako Mali Reference Health Center of Commune V Bamako Mali Department of Medical Imaging Mali Hospital Bamako Mali National Institute of Public Health Bamako Mali Reference Health Center of Commune VI Bamako Mali

Introduction: Neonatal mortality is a serious problem, particularly in developing countries. Objective: To study the epidemiological and clinical profiles of newborns who died during their hospitalization in the neonatology unit of the hospital in Mali. Methodology: This was a prospective study over a 12-month period (January 1 to December 31, 2020) including all newborns aged 0 - 28 days who died during their hospitalization. Results: A total of 424 neonates were hospitalized in neonatology, 54 died, or 12.73%. Newborns aged 0 - 7 days at admission were the most represented at 79.63% and 94.4% were full-term babies. The male gender was dominant with a ratio of 1.17. The following characteristics were frequently observed in the mothers: not educated (46.3%), poor 75.9%, living in urban areas (68%), housewives 75.4%, and having had less than 4 antenatal care visits (53.7%). For babies, respiratory distress and hyperthermia were the most common reasons for hospitalization (37% and 22.2%, respectively), with 40% being resuscitated at birth. Infection and perinatal anoxia were the most frequent diagnoses, respectively 96.3% and 37%. The death occurred within the first three days of hospitalization in 60% of cases. Conclusion: In order to reduce the mortality rate in our facilities, monitoring of pregnancy and delivery, and correct management of newborns both at birth and in the pediatric wards are important.

关键词： Newborn Death Hospital in Mali

Paraclinical, Therapeutic and Evolutionary Profile of Osteoarticular Tuberculosis: A Report about 550 Cases in Abidjan

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Open Journal of Rheumatology and Autoimmune Diseases 2015年第4期5卷 131-136页

作者： mohamed Diomandé Fulgence Kaboré Ehaulier Soh Christian Louis Kouakou mariam Gbané-Koné Abidou Kawélé Coulibaly Kouassi Jean Mermoz Djaha Baly Ouattara Edmond Eti Jean Claude Daboiko Marcel N’zué Kouakou Department of Rheumatology University Hospital Center of Cocody Abidjan C&ocircte d’Ivoire Department of Rheumatology University Hospital Center of Bouaké Bouaké C&ocircte d’Ivoire

Objective: To describe paraclinical, therapeutic and evolutionary aspects of osteoarticular tuberculosis in Abidjan. Materials and Method: We realized a descriptive retrospective study carried out in the Rheumatology Department of the University Hospital Center of Cocody in Abidjan about 550 patients over a period of 10 years from January 2004 to December 2013. The paraclinical, therapeutic and evolutionary data had interested us. Results: Osteoarticular tuberculosis represented 12.13% of 4531 rheumatic diseases identified during the study period. The tuberculin skin test was positive in 78.49% of cases. An inflammatory syndrome was present with erythrocyte sedimentation rate and C-reactive protein respectively into 69.45% and 76.54% of cases. The research of Mycobacterium tuberculosis was realized into 176 of cases which 50% was positive. Polymerase chain reaction and biopsy of tissue were performed respectively in 8 and 6 cases. Plain radiography (89.82%) and computed tomography (83.63%) were the most realized imaging. Computed tomography has contributed for the diagnostic in 99.78% of cases. The majority of our patients (82.91%) received anti-tuberculous treatment which consisted of two months of combination of rifampicin (R), isoniazid (H), pyrazinamide (Z) and Ethambutol (E) (2RHZE), followed by 10 months of rifampicin (R) and isoniazid (H) (10 RH). The outcome in patients on this treatment was favorable in 528 cases (96%). Conclusion: This study revealed that the research of Mycobacterium tuberculosis was often realized and positive. On the contrary, polymerase chain reaction and biopsy of tissue were rarely performed. The main imaging is computed tomography. Our protocol of treatment is effective.

关键词： Osteoarticular Tuberculosis Biology Imaging Abidjan

Facile, Direct Reaction of Benzaldehydes to 3-Arylprop-2-Enoic Acids and 3-Arylprop-2-Ynoic Acids in Aqueous Medium

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International Journal of Organic Chemistry 2016年第2期6卷 126-141页

作者： Thies Thiemann mohamed W. Elshorbagy Mostafa H. F. A. Salem Siraj A. N. Ahmadani Yosef Al-Jasem mariam Al Azani Mazen A. M. Al-Sulaibi Bassam Al-Hindawi Department of Chemistry United Arab Emirates University Al Ain United Arab Emirates Department of Chemical Engineering United Arab Emirates University Al Ain United Arab Emirates

Wittig reactions of benzaldehydes, alkanals, and cycloalkanals as well as of acetophenones are carried out with alkoxycarbonyl methylidenetriphenylphosphoranes in 10 w% aqueous NaOH, where the cinnamates and alkenoates produced are hydrolysed in situ and the corresponding acids are obtained after mostly simple extractive work-up, often without employing organic solvents. Under the same conditions, benzaldehydes are reacted with alkoxycarbonyl bromomethy-lidenephosphorane to produce 3-arylprop-2-ynoic acids (arylpropiolic acids).

关键词： Carboxylic Acids Arylpropiolic Acids Wittig Olefination One Pot Reaction Aqueous Reaction Medium Dehydrobromination Hydrolysis

Systemic Form of Juvenile Idiopathic Arthritis: Epidemiological, Clinical, Paraclinical and Therapeutic Aspects of 13 Cases in Abidjan

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Open Journal of Rheumatology and Autoimmune Diseases 2017年第2期7卷 103-110页

作者： mohamed Diomandé Abidou Kawélé Coulibaly Astrid Nawé Ngandeu Cyprien Kouakou Ehaulier Soh Christian Louis Kouakou Kouassi Jean Mermoz Djaha mariam Gbané-Koné Baly Ouattara Edmond Eti Jean Claude Daboiko Marcel N’zué Kouakou Department of Rheumatology University Hospital Center of Cocody Abidjan C&#244te d’Ivoire Department of Pediatrics University Hospital Center of Cocody Abidjan C&#244te d’Ivoire Department of Rheumatology University Hospital Center of Bouaké Bouaké C&#244te d’Ivoire

Objective: To describe the epidemiological, clinical, paraclinical and therapeutic aspects of systemic juvenile idiopathic arthritis observed in Abidjan. Materials and Method: This retrospective and descriptive study covered 13 children suffering from systemic juvenile idiopathic arthritis selected in the Rheumatology Department of University Hospital Center of Cocody in Abidjan (Cote d’Ivoire) from January 2005 to December 2015. We were interested to the sociodemographical, clinical, paraclinical and therapeutic aspects. Results: The systemic form of the juvenile idiopathic arthritis represented 0.2% of the 4608 rheumatologic diseases and 70.58% of the JIA. We selected 6 boys and 7 girls, with an average age of 10.8 years and mostly going to school (84.61%). The diagnostic delay was 18 months. The main clinical signs were fever and joint damage observed each in 100% of cases, impaired general condition (92.30%) and tumor syndrome (83.33%). Biological signs were characterized by hyperleukocytosis (69.20%) and the presence of a biologic inflammatory syndrome (on average, erythrocyte sedimentation rate 59.6 mm and C Reactive Protein 56.4 mg/l). The cervical damage was the essential functional complication (38.46%). The major treatment has been a therapeutic combination based on corticotherapy and methotrexate (100%) with 1 death case by macrophage activation syndrome. Conclusion: Systemic juvenile idiopathic arthritis is rarely diagnosed in the rheumatologic practice in Abidjan. It concerns children relatively big, and is characterized by a febrile polyarthritis with impaired general condition and tumor syndrome. This systemic form is treated by corticotherapy and methotrexate.

关键词： Systemic Idiopathic Juvenile Arthritis Juvenile Idiopathic Arthritis Profile Children Abidjan

Microbiological Assessment and Antimicrobials’ Use in an Infectious Diseases Department in Mali

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Advances in Microbiology 2021年第8期11卷 384-398页

作者： Mikaila Kaboré Issa Konaté Yacouba Cissoko Ibrehima Guindo Bintou Coulibaly Meli Hermine Aboubacar Alassane Oumar mariam Soumaré Assetou Fofana Abdoulaye Zaré mohamed Aly Cissé Dramane Sogoba Omar Magassouba Hama Hamidou Issa Fodé Kouyaté Sounkalo Dao Infectious Diseases Department Point “G” University Teaching Hospital Bamako Mali Faculty of Medicine and Odontostomatology University of Sciences Techniques and Technologies of Bamako (USTTB) Bamako Mali Laboratory and Biomedical Research Department National Institute of Public Health Bamako Mali Faculty of Pharmacy University of Sciences Techniques and Technologies of Bamako (USTTB) Bamako Mali Laboratory of Biomedical Analysis University Teaching Hospital of Kati Kati Mali Serefo Program University of Sciences Techniques and Technologies of Bamako (USTTB) Bamako Mali

The use of antimicrobials without microbiological proof is frequent and contributes to the emergence of resistance. The aim was to identify the organisms isolated during laboratory examinations and the type of antimicrobials consumed by patients hospitalized to Infectious Diseases’ Clinic. This is a cross-sectional and analytical study, carried out from January 1 to December 31, 2017 in the Infectious Diseases Department of Point “G” Teaching Hospital in Mali. All biological specimens from patients during the study period were analyzed. In total, 322 patients benefited from microbiological test, with a mean age of 40.9 ± 12.2 years (range 15 and 74 years) with a sex ratio of 0.93. Only 5.6% of patients were HIV negative. In all participants, a total of 658 microbiological specimen were taken, 224 (34.0%) identified at least one pathogen including bacteria in more than a half of the cases (58.5%). On the report of bacteriological analysis, the most frequently identified organisms were Mycobacterium tuberculosis (42.2%) mainly in sputum;Escherichia coli (24.2%) and Klebsiella pneumoniae (7.8%) commonly in urine and Gardnerella vaginalis (7.0%) exclusively in vaginal secretions. Candida albicans (5/8) and Cryptococcus neoformans (3/8) were the most common fungi while Plasmodium falciparum (96.4%) represented the parasite frequently found in blood. From a therapeutic standpoint, 1143 antimicrobials were prescribed to 322 admitted patients, i.e. 3.55 anti-infectives per patient. Antibiotics (excluding tuberculosis drugs), antiparasitics and antifungals represented respectively 46.2%;18.8% and 15.1% of anti-infectives. Antibiotic therapy was effective in 274 (85.1%) patients and among them, only 76 (27.7%) cases were based on microbiological evidence. Antibiotics are the most widely used antimicrobials in an infectious disease department. Empiric treatments are common but must be minimized by the search for microbiol

关键词： Antimicrobial Microbiology Infectious Diseases Mali

Influence of Age on the Clinical and Prognostic Features of Tetanus in Mali

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International Journal of Clinical Medicine 2021年第3期12卷 77-86页

作者： Mikaï la Kaboré Issa Konaté Yacouba Cissoko Jean Paul Dembélé mariam Soumaré Assetou Fofana Dramane Sogoba Oumar Magassouba Hermine Méli Abdoulaye Zaré mohamed Aly Cissé Bintou Coulibaly Hama Hamidou Issa Fodé Kouyaté Japhet Dembélé Sounkalo Dao Infectious Diseases Department Point “G” University Teaching Hospital Bamako Mali Faculty of Medicine and Odontostomatology University of Sciences Techniques and Technologies of Bamako (USTTB) Bamako Mali Serefo Program University of Sciences Techniques and Technologies of Bamako (USTTB) Bamako Mali

Background: The regression of post-vaccination immunity with age exposes elderly subjects to certain infectious diseases, in particular tetanus. The aim was to compare the clinical and prognostic features of tetanus according to the age of patients. Methodology: Analytical study of the files of patients hospitalized for tetanus in the Infectious Diseases Department at Point “G” University Teaching Hospital from 2013 to 2019 with retrospective collection. According to age, three groups of patients were formed: group I (Results: In total, 202 cases of tetanus were recorded or 7.3% of admissions. The mean age was 41.9 ± 15.6 years (range, 6 and 85 years) with a sex ratio of 19.2. According to the age grouping, group II was predominant (79.2%) followed by group III (14.9%) with respective mean ages of 39.2 ± 10.6 and 67.3 ± 6.5 and sex ratio of 39 and 29. Workers (33.3%), farmers (25.8%), traders (19.7%) and drivers (7.1%) represented the most important occupations most at risk. Clinically, bad general condition (p Conclusion: Tetanus is more prevalent in men. Complications and mortality increase with age. It is important to include booster immunization of adults in existing national programs in order to reduce disease-related morbidity and mortality in this age group.

关键词： Tetanus Elderly Clinical Prognosis Mali

Systemic Capillary Leak Syndrome Secondary to COVID-19 Infection: Case Report

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Open Journal of Nephrology 2023年第3期13卷 226-233页

作者： mariam El Galiou N’mili Manal Benamar Loubna Ouzeddoun Naima Bayahia Rabia Madani Naoufel Bouattar Tarik Department of Nephrology Dialysis and Transplantation Ibn Sina University Hospital Center Faculty of Medicine and Pharmacy Mohamed V University Rabat Morocco Department of Emergency Medicine Ibn Sina University Hospital Center Faculty of Medicine and Pharmacy Mohamed V University Rabat Morocco

Introduction: Systemic capillary leak syndrome (SCLS) is an increasingly recognized rare syndrome. Its diagnosis is suggested by the occurrence of edema with arterial hypotension, hemoconcentration, and paradoxical hypoalbuminemia. SCLS can be idiopathic (Clarkson syndrome) or secondary. Secondary SCLS (SSCLS) is mainly triggered by infections (especially viruses), drugs (antitumor therapy), malignancies, and inflammatory diseases. We report a case of systemic capillary leak syndrome secondary to the COVID-19 infection. Observation: A 74-year-old chronic smoker with no particular history was initially admitted to the intensive care unit (ICU) with a picture of respiratory distress secondary to a COVID-19 infection with favorable evolution, hence his transfer to the emergency services. On Day 8 of hospitalization, following the installation of arterial hypotension, not responding to filling, associated with hypoalbuminemia, and generalized edematous syndrome, and in the absence of any other explanation for this clinical picture, a SCLS secondary to COVID-19 infection was suggested. On the balance sheet, after the discovery of acute renal failure, serum creatinine went from 7.9 mg/l to 16.6 mg/l with microalbuminuria at 420 mg/24h and leukocyturia at 20 elements/mm3 without germ-evoked tubulointerstitial nephritis (TIN) secondary to a viral infection with COVID-19. The evolution was marked by the spontaneous regression of the edema and the normalization of the blood pressure figures. Discussion: The classic triad combining hypotension, hemoconcentration, and hypoalbuminemia suggests the diagnosis of SCLS once all other causes of shock have been ruled out. Hemoconcentration is less constant in SSCLS than in ISCLS. This is the case with our patient. The exact pathophysiological process of SCLS is largely unknown. Viral infections are the most common infectious cause of SCLS. The kidneys are the second-most common organs affected by the SARS-Cov-2 coronavirus

关键词： Hemoconcentration Low Blood Pressure COVID-19 Tubulointerstitial Nephritis