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A DNA sensor based on upconversion nanoparticles and two-dimensional dichalcogenide materials

Frontiers of Chemical Science and Engineering 2021年第4期15卷 935-943页

作者： Konstantina Alexaki Davide Giust maria-eleni kyriazi Afaf H.El-Sagheer Tom Brown Otto L.Muskens Antonios G.Kanaras School of Physics and Astronomy Faculty of Engineering and Physical SciencesUniversity of SouthamptonSouthampton SO171BJUK Department of Chemistry University of OxfordChemistry Research LaboratoryOxford OX13TAUK Chemistry Branch Department of Science and MathematicsFaculty of Petroleum and Mining EngineeringSuez UniversitySuez 43721Egypt Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK

We demonstrate the fabrication of a new DNA sensor that is based on the optical interactions occurring between oligonucleotide-coated NaYF4:Yb^(3+);Er^(3+) upconversion nanoparticles and the two-dimensional dichalcogenide materials,MoS_(2) and WS_(2).Monodisperse upconversion nanoparticles were functionalized with single-stranded DNA endowing the nanoparticles with the ability to interact with the surface of the two-dimensional materials via van der Waals interactions leading to subsequent quenching of the upconversion *** contrast,in the presence of a complementary oligonucleotide target and the formation of double-stranded DNA,the upconversion nanoparticles could not interact with MoS_(2) and WS_(2),thus retaining their inherent fluorescence *** this sensor we were able to detect target oligonucleotides with high sensitivity and specificity whilst reaching a concentration detection limit as low as 5 mol·L^(-1),within minutes.

关键词： upconversion nanoparticles DA sensor two-dimensional materials MoS_(2) WS_(2)

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Practical approaches to effective management of intestinal radiation injury:Benefit of resectional surgery

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World Journal of Gastroenterology 2011年第35期17卷 4013-4016页

作者： Nikolaos Perrakis Evangelos Athanassiou Dimitra Vamvakopoulou maria kyriazi Haris Kappos Nikolaos C Vamvakopoulos Iakovos Nomikos Department of Surgery Metaxa Cancer Memorial HospitalPiraeus 11522Greece Department of Surgery University of Thessalia Medical SchoolLarissa 41110Greece Department of Biology and Genetics University of Thessalia Medical SchoolLarissa 41110Greece

AIM:To study the outcome of patients undergoing surgical resection of the bowel for sustained radiation-induced damage intractable to conservative ***:During a 7-year period we operated on 17 cases (5 male,12 female) admitted to our surgical department with intestinal radiation injury (IRI).They were originally treated for a pelvic malignancy by surgical resection followed by postoperative *** follow-up,they developed radiation enteritis requiring surgical treatment due to failure of conservative ***:IRI was located in the terminal ileum in 12 patients,in the rectum in 2 patients,in the descending colon in 2 patients,and in the cecum in one *** patients had resection of the affected region(s).There were no postoperative deaths,while 3 cases presented with postoperative complications (17.7%).All patients remained free of symptoms without evidence of recurrence of IRI for a median follow-up period of 42 mo (range,6-96 mo).CONCLUSION:We report a favorable outcome without IRI recurrence of 17 patients treated by resection of the diseased bowel segment.

关键词： Pelvic neoplasms Bowel Radiation injuries Surgery

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Effect of Cigarette Smoke on Diabetic Skin and Protection with Topical Administration of Pinus halepensis Extract

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American Journal of Plant Sciences 2014年第26期5卷 3964-3973页

作者： Varvara Zoumpliou maria Stamatiadi Clio Vassiliadis Michail Rallis Georgios Theodoros Papaioannou Sotirios Liakos Alexandros Angelou Styliani Daskalaki maria kyriazi Vasilios Roussis Constantinos Vagias Department of Pharmaceutical Technology Faculty of Pharmacy National and Kapodistrian University of Athens Athens Greece Department of Pharmacognosy and Chemistry of Natural Products Faculty of Pharmacy National and Kapodistrian University of Athens Athens Greece

Compared to normal, diabetic skin is characterized by great sensitivity. Oxidative stress is directly involved, contributing to accelerated skin aging, xerodermia and poor wound healing. In the last 10 years, cigarette smoke (CS) exposure has been associated with several skin and dermatological conditions and is directly related to the oxidative stress affecting the skin. However, limited data exist concerning the effect of CS on diabetic skin. Some of the effects of cigarette smoke exposure on the skin of hairless diabetic mice were hereby studied and the potential skin protection by topical applications of Pinus halepensis bark extract was investigated. Female hairless SKH-2 diabetic mice were exposed for 8 days to tobacco smoke and topical applications were performed twice daily. Biophysical parameters such as transepidermal water loss (TEWL), skin elasticity and erythema were measured. In addition, the oxidative stress was evaluated. The results show that diabetes and CS have a synergistic negative action on skin condition, with the development of xerosis and high ROS levels whilst topical applications of Pinus halepensis bark extract protect efficiently the toxic effect of CS on skin, by decreasing skin dryness, oxidative stress and blood glucose levels.

关键词： Cigarette Smoke Skin Diabetes Mice Pinus halepensis Bark Extract

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优化腹部及盆腔扩散加权成像:单极与双极单次激发自旋回波回波平面序列影像处理的比较

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国际医学放射学杂志 2010年第6期 593-593页

作者： S.kyriazi M.Blackledge D.J.Collins N.M.DeSouza 李玥巍 CR-UK and EPSRC Cancer Imaging Centre Royal Marsden NHS Foundation Trust and Institute of Cancer ResearchDowns RoadSuttonSurrey SM2 5PTUK

目的比较单极和双极(双次聚焦,涡流流动补偿)腹盆部扩散加权序列扫描成像在几何变形、信噪比(SNR)、表观扩散系数(ADC)、脂肪抑制能力和伪影的存在等方面的差异。材料与方法半定量变形指数(DI)是对同一个模型行

关键词：扩散加权成像影像质量伪影涡流电流变形

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转移性卵巢癌及原发性腹膜癌:扩散加权MRI评价化疗疗效——表观扩散系数直方图的价值

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国际医学放射学杂志 2011年第6期 591-591页

作者： S.kyriazi D.J.Collins C.Messiou K.Pennert R.L.Davidson S.L.Giles 赵晓娟 Cancer Research-UK and EPSRC Cancer Imaging CentreRoyalMarsden NHS Foundation Trust and Institute of CancerResearchDowns RoadSuttonSurrey SM2 5PTEngland

目的前瞻性地评估表观扩散系数(ADC)直方图对转移性卵巢癌或原发性腹膜癌化疗疗效的预测作用。材料与方法研究获伦理委员会的批准且病人均签署知情同意书。新诊断或复发的转移性卵巢癌或原发性腹膜癌42例[平均年龄(63.0±11.4)岁]在化... 详细信息

目的前瞻性地评估表观扩散系数(ADC)直方图对转移性卵巢癌或原发性腹膜癌化疗疗效的预测作用。材料与方法研究获伦理委员会的批准且病人均签署知情同意书。新诊断或复发的转移性卵巢癌或原发性腹膜癌42例[平均年龄(63.0±11.4)岁]在化疗前及第1期和第3期化疗后均接

关键词：转移性卵巢癌化疗疗效原发性腹膜癌表观扩散系数直方图扩散加权 MRI

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