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Role of radiotherapy in the management of hepatocellular carcinoma:A systematic review

World Journal of Hepatology 2015年第1期7卷 101-112页

作者： maria-aggeliki kalogeridi Anna Zygogianni George Kyrgias John Kouvaris Sofia Chatziioannou Nikolaos Kelekis Vassilis Kouloulias Radiotherapy Department Larissa University Hospital41110 LarisaGreece 1~(st) Radiology Department Radiotherapy UnitAretaieion University Hospital11528 AthensGreece 2~(nd) Radiology Department Radiotherapy UnitAttikon University Hospital12642 AthensGreece

Many patients with hepatocellular carcinoma(HCC) present with advanced disease,not amenable to curative therapies such as surgery,transplantation or radiofrequency ablation. Treatment options for this group of patients include transarterial chemoembolization(TACE) and radiation therapy. Especially TACE,delivering a highly concentrated dose of chemotherapy to tumor cells while minimizing systemic toxicity of chemotherapy,has given favorable results on local control and survival. Radiotherapy,as a therapeutic modality of internal radiation therapy with radioisotopes,has also achieved efficacious tumor control in advanced disease. On the contrary,the role of external beam radiotherapy for HCC has been limited in the past,due to the low tolerance of surrounding normal liver parenchyma. However,technological innovations in the field of radiotherapy treatment planning and delivery,have provided the means of delivering radical doses to the tumor,while sparing normal tissues. Advanced and highly conformal radiotherapy approaches such as stereotactic body radiotherapy and proton therapy,evaluated for efficacy and safety for HCC,report encouraging results. In this review,we present the role of radiotherapy in hepatocellular carcinoma patients not suitable for radical treatment.

关键词： Hepatocellular carcinoma Radiotherapy Radio-embolization Hyperthermia Review

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Assessment of contralateral mammary gland dose in the treatment of breast cancer using accelerated hypofractionated radiotherapy

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World Journal of Radiology 2011年第9期3卷 233-240页

作者： maria Tolia Kalliopi Platoni Andreas Foteineas maria-aggeliki kalogeridi Anna Zygogianni Nikolaos Tsoukalas mariangela Caimi Niki Margari maria Dilvoi Panagiotis Pantelakos John Kouvaris Vassilis Kouloulias 1st and 2nd Department of Radiology Radiation Oncology UnitMedical SchoolAthens 12462Greece Oncology Clinic 401 Military HospitalAthens 11525Greece Department of Radiation Oncology San Raffaele HospitalMilan 20132Italy Department of Cytology Medical SchoolAthens 12462Greece

AIM:To measure the dose distribution,related to the treatment planning calculations,in the contralateral mammary gland of breast cancer patients treated with accelerated hypofractionated 3-dimensional conformal ***:Thirty-four prospectively selected female patients with right breast cancer (pN0,negative surgical margins) were treated with breast-conserving surgery.A total dose of 42.5 Gy (2.66 Gy/fraction) was prescribed;it was requested that planning target volumes be covered by the 95% isodose *** contralateral mam-mary gland was defined on CT *** dose received was evaluated by dose volume ***:The measured contralateral breast doses were:(1) Dose maximum:290-448 cGy [Equivalent (Eq) 337-522 cGy];(2) Mean dose:45-70 cGy (Eq 524815 cGy);and (3) Median dose:29-47 cGy (337-547 cGy) for total primary breast dose of 42.5 Gy in 16 equal *** spearman rho correlation showed statistical significance between the contralateral breast volume and maximum dose (P=0.0292),as well as mean dose (P=0.0025) and median dose (P=0.046) to the ***:Minimizing the dose to the contralateral breast has to be one of the priorities of the radiation oncologist when using short schedules because of the radiosensitivity of this organ at *** study is necessary to assess the long-term clinical impact of this schedule.

关键词： Breast cancer Hypofractionation Contralateral breast Dose calculation

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Malignant Myoepithelioma of the Parotid Gland: Literature Review on the Occasion of Our Report of a Case

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International Journal of Clinical Medicine 2012年第1期3卷 49-54页

作者： George Kyrgias Μaria-aggeliki kalogeridi John Tzitzikas Vassilios Kouloulias 不详

Malignant myoepitheliomas are rare malignant salivary gland neoplasms which usually occur in the parotid gland. Very little material on this topic has been published. This tumour represents a therapeutic challenge since there are no specific recommendations or guidelines. We present a case of malignant myoepithelioma arising de novo in the parotid gland. We discuss our therapeutic approach and considerations on appropriate post-surgical treatment. Then we provide a review of international literature on this interesting and rare oncological entity.

关键词： Malignant Myoepithelioma Parotid Radiotherapy Rare Neoplasms Review

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