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Association between Depression, Pressure Pain Sensitivity, Stress and Autonomous Nervous System Function in Stable Ischemic Heart Disease: Impact of Beta-Adrenergic Receptor Blockade

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Journal of Behavioral and Brain Science 2016年第8期6卷 317-328页

作者： Søren Ballegaard Natasha Bergmann Benny karpatschof Jesper kristiansen Finn Gyntelberg Lars arendt-Nielsen Per Bech Åke Hjalmarson Jens Faber Department of Endocrinology Herlev Hospital Herlev Denmark Department of Psychology University of Copenhagen Copenhagen Denmark The National Research Centre for the Working Environment Copenhagen Denmark Center for Sensory-Motor Interaction Department of Health Science and Technology Aalborg University Aalborg Denmark Psychiatric Research Unit Psychiatric Centre North Zealand University of Copenhagen Hillerod Denmark Department of Cardiology Sahlgrenska University Hospital Gothenburg Sweden Faculty of Health and Medical Sciences Copenhagen University Copenhagen Denmark

Background: Depression and ischemic heart disease (IHD) are associated with persistent stress and autonomic nervous system (ANS) dysfunction. The former can be measured by pressure pain sensitivity (PPS) of the sternum, and the latter by the PPS and systolic blood pressure (SBP) response to a tilt table test (TTT). Beta-blocker treatment reduces the efferent beta-adrenergic ANS function, and thus, the physiological stress response. Objective: To test the effect of beta-blockers on changes in depression score in patients with IHD, as well as the influence on persistent stress and ANS dysfunction. Methods: Three months of non-pharmacological intervention aiming at reducing PPS and depression score in patients with stable IHD. Beta-blocker users (N = 102) were compared with non-users (N = 75), with respect to signs of depression measured by the Major Depressive Inventory questionnaire (MDI), resting PPS, and PPS and SBP response to TTT. Results: MDI score decreased 30% in non-users (p = 0.005) compared to 4% (p > 0.1) among users (between-group p = 0.003;effect size = 0.4). Resting PPS decreased in both the groups. Among most vulnerable patients with MDI ≥ 15, reductions in MDI score and resting PPS score correlated in non-users, only (r = 0.69, p = 0.007). Reduction in resting PPS correlated with an increase in PPS and SBP response to TTT. Conclusions: Stress intervention in patients with IHD was anti-depressive in non-users, only. Similarly, the association between the reduction in depression, reduction in persistent stress, and restoration of ANS dysfunction was only seen in non-users, suggesting a central role of beta-adrenergic receptors in the association between these factors.

关键词： Chronic Stress Depression Autonomic Nervous System Systolic Blood Pressure Pain Sensitivity Beta-Blockers Ischemic Heart Disease

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极权主义的起源

作者： (美)汉娜·阿伦特(Hannah arendt)

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论革命

作者： (美)汉娜·阿伦特(Hannah arendt)

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人的境况

Time Course of Postoperative Complications in Low-Risk Women after Planned Cesarean Section

作者： (美)汉娜·阿伦特(Hannah arendt)

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Open Journal of Obstetrics and Gynecology 2022年第5期12卷 394-407页

作者： Anne Raabjerg kruse Linn Håkonsen arendt Christian Erikstrup Ulrik Schiøler kesmodel Finn Friis Lauszus Niels Uldbjerg Iben Sundtoft Axel Forman Department of Obstetrics and Gynecology Regional Hospital G&oslash dstrup Herning Denmark Department of Obstetrics and Gynecology Aarhus University Hospital Aarhus Denmark Department of Clinical Immunology Aarhus University Hospital Aarhus Denmark Department of Obstetrics and Gynecology Aalborg University Hospital Aalborg Denmark

Objectives: Length of hospital stay after cesarean section is today much shorter than previously, and a stay of only 1 day is used in many departments. However, complications requiring immediate treatment must be diagnosed before leaving hospital. We assessed the time interval from planned cesarean section to diagnosis of major complications in low-risk women to estimate a safe time of discharge. Methods: We performed a retrospective observational study among 5633 women undergoing planned cesarean section from 2001-2017 at Aarhus University Hospital, Denmark. The inclusion criterion was postoperative complication graded as Clavien-Dindo ≥ II. Exclusion criteria were preoperative comorbidity or problems during surgery indicative of need for prolonged stay. Time from cesarean section to suspicion of a postoperative complication was the primary endpoint. Results: The study population consisted of 116 women with unexpected postoperative complications, 47 classified as Clavien-Dindo II and 69 as Clavien-Dindo III-IV. In 63 of the 116, the diagnoses were suspected within 24 hours (Clavien-Dindo II: 25, Clavien-Dindo III-IV: 38). These included all cases of relaparotomy and uterine atony with immediate need of medical treatment. Acute colonic pseudo-obstruction was diagnosed within 2 days, while other complications were suspected and treated 2 to 10 days postoperatively. Conclusions: Among low-risk women with a postoperative complication, all cases requiring relaparotomy and medically treated uterine atony were suspected within 24 hours after surgery. Discharge 24 hours after planned cesarean section seems safe in low-risk patients.

关键词： Cesarean Section Postoperative Complications Postoperative Hemorrhage Early Discharge Length of Hospital Stay

Hand-Sewn Running Barbed Suture versus Endoscopic Stapler Closure of the Mesenteric Defects in Retrocolic and Retrogastric RYGB: A Comparative Case-Matched Study

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Surgical Science 2015年第8期6卷 346-351页

作者： V. Simonelli G. Orlando A. Zolotas C. arendt L. Arru V. Poulain J. S. Azagra M. Goergen Centre Hospitalier de Luxembour Luxembourg Ville Luxembourg

Background: Obesity is nowadays a major health concern in Western countries and the number of bariatric surgical procedures being performed worldwide is vertiginously rising. The Laparoscopic Roux-en-Y gastric bypass (LRYGB) has become the gold standard bariatric procedure. The retrocolic retrogastric approach is closer to normal anatomy and it is associated to a lower rate of anastomotic leak, a lower rate of gastrojejunal stricture and a lower rate of marginal ulcers;therefore the problem of small bowel obstruction due to internal hernia (IH) has to be faced. The meticulous closure of all possible mesenteric defects with running, non-absorbable sutures may reduce the rate of this complication, but it can be challenging for the surgeon and it rises the operating time (OT). This study has conducted in a context of optimization of our “Fast Track-type” recovery protocol and it aims to compare the rate of early IH and the OT difference when mesenteric defects are closed using running non-absorbable barbed suture or an endoscopic stapler. Materials and Methods: From December 2014 to February 2015 a single-surgeon consecutive series of 22 patients undergoing retrocolic restrogastric LRYBP in our high volume obesity centre has been retrospectively extrapolated from our prospective longitudinal database. We recorded the overall OT and relative rate of IH in patients who received a 15-cm non-absorbable V-LocTM1 (group A, 11 patients) or EndopathTM EMS, endoscopic multifeed stapler2 (group B, 11 patients) defect. Results: The mean OT was 77.36 minutes in the group A and 60.90 minutes in the group B (P value 0.066). 0 patients (0%) in the group A versus 4 patients (36.3%) in the group B developed IH within 30 days (two-tailed P value at chi-square test: 0.02). Conclusion: Early rate of small bowel obstruction due to IH is extremely higher with the use of an endoscopic stapler instead of non-absorbable barber suture and there is not significant difference in the OT;more prosp

关键词： Laparoscopy Gastric Bypass Fastrack Internal Hernia

ApoE对诱导分化及未分化的SH-SY5Y细胞中细胞周期相关蛋白表达的影响

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ApoE对诱导分化及未分化的SH-SY5Y细胞中细胞周期相关蛋白表达的...

儿童胸部淋巴瘤的钆增强影像:是否必要静脉注射对比剂?

华东六省一市生物化学与分子生物学会2008年学术交流会

作者：李学礼 Uwe Ueberham Thomas arendt 同济大学医学院 Paul Flechsig Institute for Brain Research University of Leipzig04109 LeipzigGermany

为了探讨载脂蛋白E(apoE)对神经样细胞中细胞周期相关蛋白(包括cyclinD1,Cdk4,Cdk6,P16,P27,Cyclin A1,Cyclin E,Cyclin B1,Cyclin B2,Cdc2,P21 and Cdk5)表达的影响,本实验采用实时定量RT-PCR,Western blot and FACS方法分析经不同多态性ApoE处理的诱导分化及未分化SY5Y细胞系中细胞周期相关蛋白表达的变化。各ApoE多态性为重组的人apoE2,apoE3,apoE4,以及从人血浆中抽提的apoE多态性混合物。结果显示,经apoE处理后,在未分化SY5Y细胞,多数细胞周期相关蛋白(cyclinD1,Cdk4,Cdk6,P16,P21除外)表达下降,提示在体外apoE阻断未分化细胞的细胞周期进程;而对于分化细胞,绝大多数细胞周期相关蛋白(仅Cdk6和Cdk5除外)表达上调,提示在ApoE有利于分化细胞的细胞周期进程。其作用效果由高到低依次为apoE2,apoE3,apoE4 and apoEm。FACS方法检测各组细胞S期细胞数进一步证实各apoE多态性对细胞周期的影响。

关键词：载脂蛋白E 细胞周期细胞周期相关蛋白 SH-SY5Y细胞系

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国际医学放射学杂志 2019年第4期 496-497页

作者：任彦 C.T.arendt M.Beeres D.Leithner P.Tischendorf M.Langenbach B.kaltenbach Department of Diagnostic and Interventional Radiology University Hospital Frankfurt

摘要目的随着对钆对比剂潜在副作用关注度提高,非对比剂MR成像日益受到重视。最近的诸多文献评估了潜在的对比剂脑沉积的风险,促使研究焦点向非对比剂增强替代

关键词：对比剂淋巴瘤静脉注射

直接导入神经细胞的钙调神经磷酸酶(PP2B)对tau蛋白的脱磷酸化作用

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直接导入神经细胞的钙调神经磷酸酶(PP2B)对tau蛋白的脱磷酸化作用