检索结果-南通市图书馆

基于3D打印技术的侧脑室穿刺模型制造及其在医学培训中的应用研究

在线全文

学校读者我要写书评

暂无评论

创伤与急诊电子杂志 2018年第1期6卷 7-11页

作者：廖正俭刘宇清何炳蔚黄绳跃陈寿吕翱杨智坤洪文瑶福建省立医院神经外科福州350001 福建医科大学省立临床学院福州350001 福州大学机械工程及自动化学院福州350116

目的研究基于3D打印技术的侧脑室穿刺训练模型在年轻医生培训中的应用。方法选取2016年8月至2017年8月在本科室学习的年轻医师60名作为研究对象(每人学习时间为1个月),分为A、B两组,A组为常规培训组,B组为模拟穿刺培训组,每组30人。利用... 详细信息

目的研究基于3D打印技术的侧脑室穿刺训练模型在年轻医生培训中的应用。方法选取2016年8月至2017年8月在本科室学习的年轻医师60名作为研究对象(每人学习时间为1个月),分为A、B两组,A组为常规培训组,B组为模拟穿刺培训组,每组30人。利用1例侧脑室轻度扩大患者颅脑CT、MRI扫描所得的DICOM数据,经计算机图像数据处理、原始3D虚拟模型制作、正向设计及3D打印,制作出A、B两种实体训练模型用于B组年轻医生培训。2组医生进行问卷调查及模拟手术操作成功率统计。结果 B组医生经模拟穿刺训练后,对侧脑室解剖的掌握、穿刺方法的了解、自信心均较常规培训组明显增加,在模拟穿刺手术时,第一次穿刺的成功率明显高于A组(P均<0.05)。结论利用侧脑室穿刺训练模型培训具有显著效果,可使年轻医生快速熟练掌握穿刺技术、提高手术成功率与自信心。

关键词： 3D打印技术侧脑室穿刺训练三维虚拟模型实体模型

HPLC-DAD analysis and antifungal effect of Hyptis martiusii Benth(Lamiaceae) against Candida strains

在线全文

学校读者我要写书评

暂无评论

Asian Pacific journal of Tropical Biomedicine 2019年第3期9卷 123-128页

作者： janaína Esmeraldo Rocha Henrique Douglas Melo Coutinho Cícero Roberto Nascimento Saraiva Antonia Thassya Lucas dos Santos Ant?nio judson Targino Machado jo?o Tavares Calixto júnior Irwin Rose Alencar Menezes josé Galberto Martins da Costa jaime Ribeiro-Filho Aracelio Viana Colares Laboratory of Microbiology and Biology Molecular Department of Biological Chemistry Regional University of Cariri Leao Sampaio University Center Department of Biological Sciences Regional University of Cariri Laboratory of Pharmacology and Molecular Chemistry Department of Biological Chemistry Regional University of Cariri Laboratory of Natural Product Research Department of Biological Chemistry Regional University of Cariri

Objective: To evaluate the anti Candida activity of Hyptis martiusii decoction and its major compound, caffeic acid alone or in the presence of fluconazole, as well as their cytotoxic effect. Methods: The decoction was characterized using high performance liquid chromatography coupled with diode array detector. For the antifungal activity, the minimum inhibitory concentration(MIC) and the potential effect of the decoction with the fluconazole were evaluated by microdilution method using 96-well microtiter trays. The osmotic fragility test was performed using erythrocytes under saline stress. All tests were performed in triplicate. Results: The chemical characterization of the decoction was performed by high performance liquid chromatography and revealed the presence of seven compounds, including caffeic acid as major constituent. The antifungal tests demonstrated that both decoction(DHm) and caffeic acid obtained from Hyptis martiusii presented MIC and MFC ≥4096 μg/mL against Candida albicans and Candida tropicalis strains. However, in the presence of fluconazole, DHm and caffeic acid presented IC_(50) of 2.60 and 2.53 μg/mL respectively, demonstrating significant synergistic effects against Candida strains. The modulator activity of DHm might be due to the presence of caffeic acid. Moreover, DHm and caffeic acid did not cause significant hemolytic effects, indicating that they present low cytotoxicity. Conclusions: These data indicate that DHm potentiates the activity of the fluconazole, without enhancement of the toxicity, encouraging further toxicological, pharmacological and phytochemical studies to provide consistent evidence of the potential of this plant to be used in drug development.

关键词： Hyptis martiusii Caffeic acid Candida albicans Candida tropicalis Antifungal properties

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

平面心肌灌注成像评价急性胸痛患者的价值

世界核心医学期刊文摘（心脏病学分册） 2005年第5期1卷 44-45页

作者： Yamada A.T. Soares jr. j. Meneghetti j.C. 郝广华 Heart Institute (InCor) Univ. of S. Paulo Medical School Av. Dr. Eneas Carvalho A. S. ao Paulo Brazil

Background: Rest single-photon emission computed tomographic(SPECT) perfusion imaging identifies acute myocardial ischemia in patients with chest pain in the emergency department; however, the costs are high and radioisotopic services are usually not available 24 h a day. Planar imaging through a portable gamma camera may be useful in this setting. However, planar imaging might be associated with less predictive values in comparison with a gated SPECT imaging. We sought to evaluate rest planar myocardial perfusion imaging for evaluation and triage of patients with suspected acute cardiac ischemia. Methods: Patients within 6 h of chest pain onset and nondiagnostic electrocardiograms(ECGs) underwent planar myocardial perfusion imaging. Studies showing perfusion defects were considered suggestive of acute coronary syndromes. The results of planar scintigraphy were compared with the clinical diagnosis and outcomes. All patients were followed up and monitored for the occurrence of major cardiac events 120 days after hospital discharge. Results: 71 patients underwent scintigraphy. Twenty-one(30%) patients had acute coronary syndromes, 15(21%) had major cardiac events(8 had myocardial infarction and 7 underwent myocardial revascularization). Planar scintigraphy demonstrated perfusion defects in 21 patients, 16 (76%) patients with acute coronary syndromes, 12(80%) patients who had major cardiac events and in 7(88%) patients with myocardial infarction. The negative predictive value of planar scintigraphy was 90%for diagnosis of acute coronary syndromes and 94%for detecting major cardiac events. Conclusion: Early planar myocardial perfusion imaging allowed rapid and accurate risk stratification of emergency departments patients with possible myocardial ischemia and nondiagnostic ECGs.

关键词：急性胸痛灌注成像灌注缺损心脏事件急性心肌缺血急诊科阴性预测值门控检查费用风险度

海军潜艇某部艇员下腰痛的脊柱功能调查与分析

在线全文

学校读者我要写书评

暂无评论

转化医学杂志 2018年第2期7卷 114-117页

作者：费奥赵宏张新京宋修林张杨甘维军王丽华海军机关门诊部理疗科解放军92730部队医院海军后勤保障部卫生局海军总医院心内科

目的了解潜艇艇员下腰痛的患病及其脊柱功能状况,并分析相关影响因素。方法通过问卷调查海军某潜艇基地现役艇员的一般情况、职业、生活习惯和下腰痛等情况。按照纳入标准确定143例下腰痛艇员,入选者采用疼痛视觉模拟评分法、专项体格... 详细信息

目的了解潜艇艇员下腰痛的患病及其脊柱功能状况,并分析相关影响因素。方法通过问卷调查海军某潜艇基地现役艇员的一般情况、职业、生活习惯和下腰痛等情况。按照纳入标准确定143例下腰痛艇员,入选者采用疼痛视觉模拟评分法、专项体格检查及改良Oswestry功能障碍指数进行评估。结果所选取的423例艇员中下腰痛143例,占33.81%,腰部疼痛视觉模拟评分法评分以服役年限≥9年组(8.52±0.68)最高,与其他服役年限组比较差异有统计学意义(P<0.05)。下腰痛艇员Oswestry功能障碍指数总分(37.92±3.22)分,其影响因素与从事专业、服役年限、病程时间、外伤史有关。结论现役艇员中下腰痛发病率较高,脊柱功能状况差,不适症状明显,应积极开展健康教育,提高艇员对疾病的认知能力,建立健康生活习惯。

关键词：海军医学潜艇艇员下腰痛脊柱功能

新型磷酸二酯酶5抑制剂CPD1对单侧输尿管梗阻引起的肾间质纤维化小鼠治疗作用

在线全文

学校读者我要写书评

暂无评论

中国药理学通报 2023年第1期39卷 147-152页

作者：刘傲璐任倩封文斌李斌陈心慧李思蓉赵子建穆云萍李芳红广东工业大学生物医药学院广东广州510006 南方医科大学南方医院肾内科器官衰竭防治国家重点实验室国家肾脏病临床医学研究中心广东广州510515

目的探讨新型磷酸二酯酶5抑制剂CPD1对单侧输尿管梗阻(unilateral ureteric obstruction,UUO)诱导的肾纤维化小鼠肾脏组织结构损伤及间质纤维化的影响。方法8周龄♂C57BL/6 j小鼠随机分为假手术组、模型组、CPD1治疗组,手术结扎模型组... 详细信息

目的探讨新型磷酸二酯酶5抑制剂CPD1对单侧输尿管梗阻(unilateral ureteric obstruction,UUO)诱导的肾纤维化小鼠肾脏组织结构损伤及间质纤维化的影响。方法8周龄♂C57BL/6 j小鼠随机分为假手术组、模型组、CPD1治疗组,手术结扎模型组和治疗组小鼠左侧输尿管,假手术组仅分离输尿管而不结扎。造模2 h后,给予CPD1(5 mg·kg^(-1)·d^(-1))灌胃治疗,持续7 d。通过组织病理学染色和Western blot,观察CPD1治疗对UUO小鼠患侧肾脏组织结构病变和纤维化标志蛋白:纤维连接蛋白(fibronectin,FN)、α平滑肌肌动蛋白(α-SMA)、Ⅰ型胶原(collagen-Ⅰ)、肾损伤分子-1(kidney injury molecule 1,Kim-1)表达及分布的影响。结果与假手术组相比,UUO组小鼠患侧肾组织中肾小管扩张,可见明显空泡变性,炎症浸润增加,FN、α-SMA、collagen-I及Kim-1蛋白的表达明显增加(P<0.05);CPD1可明显改善UUO模型小鼠患侧肾脏的结构,降低胶原纤维蛋白的沉积,纤维化标志蛋白FN、α-SMA、collagen-I及Kim-1的表达均得到明显抑制(P<0.05)。结论磷酸二酯酶5抑制剂CPD1通过下调细胞外基质ECM的沉积,减少Kim-1介导的肾损伤,改善输尿管梗阻诱导的肾间质纤维化,其具体的作用机制还有待进一步研究。

关键词：磷酸二酯酶5抑制剂 CPD1 肾间质纤维化单侧输尿管梗阻胶原沉积肾损伤

强脉冲光治疗面部痤疮后红斑及炎性色素沉着236例疗效观察

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

中国美容医学 2012年第10期21卷 1791-1792页

作者：陈勇军王辉黄莉宁许云静敖贤邢丽娟李慧忠杨斌广东省皮肤性病防治中心广东广州510091

目的:观察强脉冲光(I PL)治疗面部痤疮后红斑及炎性色素沉着的临床疗效。方法:采用皇后光子嫩肤仪对有面部痤疮红斑及炎性色素沉着的患者进行治疗,波长560～1200nm,能量密度16～28j/cm2,治疗3～5次为1个疗程,每次治疗间隔时间为4周,1个... 详细信息

目的:观察强脉冲光(I PL)治疗面部痤疮后红斑及炎性色素沉着的临床疗效。方法:采用皇后光子嫩肤仪对有面部痤疮红斑及炎性色素沉着的患者进行治疗,波长560～1200nm,能量密度16～28j/cm2,治疗3～5次为1个疗程,每次治疗间隔时间为4周,1个疗程后观察疗效。结果:236例患者中褐黑色炎性色素沉着51例,红斑137例,红斑加色素沉着48例,其中111例痊愈,显效101例,有效24例,总有效率达100%。结论:I PL治疗痤疮后红斑及炎性色素沉着无创、有效,可临床推广应用。

关键词：强脉冲光痤疮红斑色素沉着治疗

在线全文

学校读者我要写书评

暂无评论

赤道太平洋强迫对北极涛动的影响(英文)

赤道太平洋强迫对北极涛动的影响(英文)

第26届中国气象学会年会季风动力学论坛分会场

作者：贾晓静 Derome j Department of Earth Sciences ZheJiang University Department of Atmospheric and Oceanic Sciences McGill University

The potential role of tropical Pacific forcing in driving the seasonal variability of the Arctic Oscillation （ao） is explored using both observational data and as imple general circulation model （SGCM）. Alead-lag regression technique is first applied to the monthly a veraged sea surface temperature （SST） and the ao index. The ao maximum is found to be related to an egative SST anomaly over the tropical Pacific three months earlier. I dealized thermal forcings are then designed based on the regression of the seasonally averaged tropical Pacific precipitation against the ao index. Results indicate that forcing a nomalies over the western tropical Pacific are more effective in generating an ao-like response while those over the eastern tropical Pacific tend to produce a Pacific-North American （PNA）-like response. The physical mechanisms responsible for the energy transport from the tropical Pacific to the extratropical N orth Atlantic are investigated using wave activity flux and vorticity forcing formalisms. The energy from the western tropical Pacific forcing tends to propagate zonally to the North Atlantic because of the jets tream waveguide effect while the transport of the energy from the eastern tropical Pacific forcing mostly concentrates over the PNA area.

关键词： Arctic Oscillation western tropical Pacific seasonal variability

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

废旧塑料混合物浮选分离综合研究型实验设计

广东化工 2023年第21期50卷 157-160,168页

作者：王建超王春辉石彦利石奥王会姣卜庆伟侯嫔王建兵王春荣中国矿业大学(北京)化学与环境工程学院北京100083

针对环保领域“废旧塑料循环利用”及“微塑料污染源头控制”热点,该文设计了高铁酸钾表面预处理结合浮选分离聚碳酸酯(PC)与聚甲基丙烯酸甲酯(PMMA)的综合研究型实验。实验主要开展了表面预处理、浮选因素影响研究及分离效率评价,并结... 详细信息

针对环保领域“废旧塑料循环利用”及“微塑料污染源头控制”热点,该文设计了高铁酸钾表面预处理结合浮选分离聚碳酸酯(PC)与聚甲基丙烯酸甲酯(PMMA)的综合研究型实验。实验主要开展了表面预处理、浮选因素影响研究及分离效率评价,并结合分析表征、数值模拟等方法对机理进行了探究。结果显示,预处理能选择性地降低PC的上浮率,结合浮选能实现PC与PMMA废旧塑料混合物的高效分离,纯度和回收率均达到100%。该实验针对环境领域热点,结合实验研究、材料表征、数值模拟等不同知识,能培养学生知识融合能力、科学创新思维。

关键词：综合研究型实验废旧塑料浮选分离表面预处理数值模拟

在线全文

学校读者我要写书评

暂无评论

WN/W难熔栅自对准增强型n沟道HFET

功能材料与器件学报 2000年第3期6卷 190-192页

作者：刘伟吉曾庆明李献杰敖金平赵永林郭建魁徐晓春信息产业部电子第十三研究所石家庄050051

发展了WN/W难熔栅自对准工艺。WN/W栅在850oC下退火，保持了较好的形貌。在此工艺基础上研制出了适用于互补逻辑电路的增强型n沟道异质结场效应晶体管。在1×50μm的HFET中，实现了最大跨导约为56mS/mm，阈值电压为3.5V。与p型HFET的－3... 详细信息

发展了WN/W难熔栅自对准工艺。WN/W栅在850oC下退火，保持了较好的形貌。在此工艺基础上研制出了适用于互补逻辑电路的增强型n沟道异质结场效应晶体管。在1×50μm的HFET中，实现了最大跨导约为56mS/mm，阈值电压为3.5V。与p型HFET的－3V的阈值基本对称。反向击穿电压为4～5V。

关键词： WN/W 难熔栅 CHFET HIGFET 场效应晶体管