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Assessment of a new strategy for selective phenotyping applied to complex traits in <i>Brassica napus</i>

Open j.urnal of Genetics 2012年第4期2卷 190-201页

作者： Christophe j.stin Patrick Vallée Claude Domin maria j. manzanares-dauleux Régine Delourme Agrocampus Ouest Le Rheu Cedex France INRA Le Rheu Cedex France

The accurate mapping of quantitative trait loci (QTL) depends notably on the number of recombination events occurring in the segregating population. The cost of phenotyping often limits the sample size used in QTL mapping. To get round this problem, we assessed a selective phenotyping method, called qtlRec sampling. In order to improve the accuracy of QTL mapping, a subset of individuals was selected to maximize the number of recombination events at putative QTL positions;the usefulness of this subset was compared to a selected sample built to maximize the recombination rate over the whole genome. We assessed this method on the quantitative oil content trait in Brassica napus. We showed that the qtlRec strategy could allow increasing accuracy (both support interval and position) of QTL location while it maintained a similar power of detection. We then applied this approach to the B. napus—Leptosphaeria maculans pathosystem for which resistance QTL with minor effect were previously identified. This allowed the validation of the QTL in six genomic regions. The qtlRec method is an attractive strategy for validating QTL in multiple year and/or location trials for a trait which requires costly and time-consuming phenotyping.

关键词： Selective Phenotyping QTL Brassica Napus Leptosphaeria maculans

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Resolution of metabolic syndrome after following a gluten free diet in an adult woman diagnosed with celiac disease

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World j.urnal of Gastrointestinal Pathophysiology 2011年第3期2卷 49-52页

作者： lvaro García-manzanares Alfredo j.Lucendo Sonia González-Castillo j.sús Moreno-Fernández Department of Endocrinology Hospital General de Tomellosorea de Atención especializada La Mancha Centro13700 Tomelloso(Ciudad Real)Spain Department of Gastroenterology Hospital General de Tomelloso

Adult celiac disease(CD) presents with very diverse symptoms that are clearly different from those typically seen in pediatric patients,including ferropenic anemia,dyspepsia,endocrine alterations and elevated transaminase concentration. We present the case of a 51-year-old overweight woman with altered basal blood glucose,hypercholesterolemia,hypertriglyceridemia and persisting elevated transaminase levels,who showed all the symptoms for a diagnosis of metabolic syndrome. Because she presented iron deficiency anemia,she was referred to the gastroenterology department and subsequently diagnosed with celiac disease after duodenal biopsies and detection of a compatible HLA haplotype. Gluten-free diet(GFD) was prescribed and after 6 mo the patient showed resolution of laboratory abnormalities(including recovering anemia and iron reserves,normalization of altered lipid and liver function parameters and decrease of glucose blood levels) . No changes in weight or waist circumference were observedand no significant changes in diet were documented apart from the GFD. The present case study is the first reported description of an association between CD and metabolic syndrome,and invites investigation of the metabolic changes induced by gluten in celiac patients.

关键词： Celiac disease Metabolic syndrome Glutenfree diet

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Attenuation of UV-C Solar Radiation as a Function of Altitude(0≤z≤100 km):Rayleigh Diffusion and Photo Dissociation of O_(2) Influence

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Atmospheric and Climate Sciences 2017年第4期7卷 540-553页

作者： j.se Luis Pinedo-Vega Carlos Rios-Martínez David j.cobo Navarro-Solis j.Ignacio Davila-Rangel Fernando Mireles-Garcia Sonia Azucena Saucedo-Anaya Eduardo manzanares-Acuna Valentin Badillo-Almaraz Department:UAEN Universidad Autonoma de ZacatecasZacatecasMexico

In this paper, we present an analysis of attenuation for UV-C radiation () as a function of the altitude z () by calculating the interaction ratio between the UV-C radiation and the molecular species susceptible of interact with UV-C radiation. The Rayleigh scattering spectral cross sections were calculated, the UV-C spectral cross sections of the species susceptible of interact with UV-C radiation and the UV extraterrestrial (ETR) solar spectrum were standardized with wavelength steps of 1 nm, and The International Standard Atmosphere model (ISO 1972) was adapted to calculate the molecular density. These data were utilized to calculate the photodissociation and Rayleigh scattering ratios as a function of the altitude and to determine to what measure the photodissociation and the Rayleigh diffusion were determinants of the attenuation of UV-C radiation. It became clear that the photo dissociation of O2 is the primordial mechanism of attenuation for the UV-C radiation, but the Rayleigh diffusion appears like a mechanism that encreases the photon flux, raising the performance of the O2 photodissociation. The attenuation capacities of N2O, CO2 and water vapor (H2O) over the UV-C radiation are all similar, although smaller (less than 0.6%), and this is due to their low concentration. The O3, has the theoretical greater attenuation capacity, but it is found in mid-range altitudes? (), where the residual UV-C photons has almost vanished by O2 photo dissociation or Rayleigh diffusion, so the real effect over the UV-C attenuation is minimum.

关键词： UV-C Radiation Rayleigh Scattering O_(2) Photodissociation

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