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Cardiac risk stratification of the liver transplant candidate:A comprehensive review

World Journal of Transplantation 2022年第7期12卷 142-156页

作者： Sanjana Nagraj Spyros Peppas maria gabriela rubianes guerrero Damianos G Kokkinidis Felipe I Contreras-Yametti Sandhya Murthy Ulrich P Jorde Department of Medicine Jacobi Medical Center/Albert Einstein College of MedicineNew York CityNY 10461United States Department of Gastroenterology Athens Naval HospitalAthens 11521Greece Section of Cardiovascular Medicine Yale University School of MedicineYale New Haven HospitalNew HavenCT 06510United States Department of Medicine Wellstar Atlanta Medical CenterAtlantaGA 30312United States Division of Cardiology Montefiore Medical CenterAlbert Einstein College of MedicineNew York CityNY 10467United States

Cardiovascular diseases(CVD)form a principal consideration in patients with end-stage liver disease(ESLD)undergoing evaluation for liver transplant(LT)with prognostic implications in the peri-and post-transplant *** the predominant etiology of ESLD continues to evolve,addressing CVD in these patients has become increasingly ***,as the number of LTs increase by the year,the proportion of older adults on the waiting list with competing comorbidities increase,and the demographics of LT candidates evolve with parallel increases in their CVD risk *** primary goal of cardiac risk assessment is to preemptively reduce the risk of cardiovascular morbidity and mortality that may arise from hemodynamic stress in the peri-and post-transplant *** complex hemodynamics shared by ESLD patients in the pre-transplant period with adverse cardiovascular events occurring in only some of these recipients continue to challenge currently available guidelines and their uniform *** review focusses on cardiac assessment of LT candidates in a stepwise manner with special emphasis on preoperative patient *** hope that this will reinforce the importance of cardiovascular optimization prior to LT,prevent futile LT in those with advanced CVD beyond the stage of optimization,and thereby use the finite resources prudently.

关键词： Cardiovascular risk Liver transplantation End stage liver disease Liver cirrhosis Cardiovascular diseases Cardiovascular diagnostic techniques

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Gut microbiota in a population highly affected by obesity and type 2 diabetes and susceptibility to COVID-19

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World Journal of Gastroenterology 2021年第41期27卷 7065-7079页

作者： Jaime García-Mena Karina Corona-Cervantes Daniel Cuervo-Zanatta Tizziani Benitez-guerrero JuanManuel Vélez-Ixta Norma gabriela Zavala-Torres Loan Edel Villalobos-Flores Fernando Hernández-Quiroz Claudia Perez-Cruz Selvasankar Murugesan Fernando Guadalupe Bastida-González Paola Berenice Zárate-Segura Departamento de Genética y Biología Molecular Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico City 07360CDMXMexico Departamento de Genética y Biología Molecular and Departamento de Farmacología Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico City 07360CDMXMexico Departamento de Farmacología Centro de Investigación y de Estudios Avanzados del Instituto Politécnico NacionalMexico City 07360CDMXMexico Department of Mother and Child Health SIDRA MedicineDoha 26999Qatar Laboratorio Estatal de Salud Pública del Estado de México ISEMToluca de Lerdo 50180Estado de MéxicoMexico Escuela Superior de Medicina Instituto Politécnico NacionalMexico City 11340CDMXMexico

Coronavirus disease 2019(COVID-19)is a disease produced by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and it is currently causing a catastrophic pandemic affecting humans *** disease has been lethal for approximately 3.12 million people around the world since January ***,among the most affected countries,Mexico ranks third in deaths after the United States of America and *** the high number of deceased people might also be explained by social aspects and lifestyle customs in Mexico,there is a relationship between this high proportion of deaths and comorbidities such as high blood pressure(HBP),type 2 diabetes,obesity,and metabolic *** official epidemiological figures reported by the Mexican government have indicated that 18.4%of the population suffers from HBP,close to 10.3%of adults suffer from type 2 diabetes,and approximately 36.1%of the population suffers from *** in the gut microbiota(GM)have been associated with these diseases and with COVID-19 severity,presumably due to inflammatory *** data about the association between GM dysbiosis and metabolic diseases could suggest that the high levels of susceptibility to SARSCoV-2 infection and COVID-19 morbidity in the Mexican population are primarily due to the prevalence of type 2 diabetes,obesity,and metabolic syndrome.

关键词： SARS-CoV-2 COVID-19 High blood pressure Hypertension Type 2 diabetes Obesity Metabolic syndrome Gut microbiota Immunity

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The domestication of Cucurbita argyrosperma as revealed by the genome of its wild relative

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Horticulture Research 2021年第1期8卷 1287-1300页

作者： Josue Barrera-Redondo Guillermo Sanchez-de la Vega Jonas A.Aguirre-Liguori gabriela Castellanos-Morales Yocelyn T.Gutierrez-guerrero Xitlali Aguirre-Dugua Erika Aguirre-Planter Maud I.Tenaillon Rafael Lira-Saade Luis E.Eguiarte Departamento de Ecologia Evolutiva Instituto de EcologiaUniversidad Nacional Autonoma de MexicoCircuito Exterior s/n Anexo al Jardin Botanico04510 Ciudad de MexicoMexico Department of Ecology and Evolutionary Biology University of CaliforniaIrvineCA 92697USA Departamento de Conservacion de la Biodiversidad El Colegio de la Frontera SurVillahermosaCarretera Villahermosa‐Reforma km 15.5 Rancheria El Guineo 2ªseccion86280 VillahermosaTabascoMexico Genetique Quantitative et Evolution-Le Moulon Universite Paris-SaclayInstitut National de Recherche pour l’Agriculturel’Alimentation et l’EnvironnementCentre National de la Recherche ScientifiqueAgroParisTechGif-sur-Yvette 91190France UBIPRO Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoAv.de los Barrios#1Col.Los Reyes IztacalaTlalnepantlaEdo.de Mex 54090Mexico

Despite their economic importance and well-characterized domestication syndrome,the genomic impact of domestication and the identification of variants underlying the domestication traits in Cucurbita species(pumpkins and squashes)is currently *** argyrosperma,also known as cushaw pumpkin or silver-seed gourd,is a Mexican crop consumed primarily for its seeds rather than fruit *** makes it a good model to study Cucurbita domestication,as seeds were an essential component of early Mesoamerican diet and likely the first targets of human-guided selection in pumpkins and *** obtained population-level data using tunable Genotype by Sequencing libraries for 192 individuals of the wild and domesticated subspecies of *** across *** also assembled the first high-quality wild Cucurbita *** genomic analyses revealed several structural variants and presence/absence of genes related to *** results indicate a monophyletic origin of this domesticated crop in the lowlands of *** found evidence of gene flow between the domesticated and wild subspecies,which likely alleviated the effects of the domestication *** uncovered candidate domestication genes that are involved in the regulation of growth hormones,plant defense mechanisms,seed development,and *** presence of shared selected alleles with the closely related species Cucurbita moschata suggests domestication-related introgression between both taxa.

关键词： Cucurbita likely pump

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