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Mechanisms involved in cancer stem cell resistance in head and neck squamous cell carcinoma

Cancer Drug Resistance 2023年第1期6卷 116-137页

作者： Juliana Mota Siqueira Daniele Heguedusch Camila Oliveira Rodini Fabio Daumas Nunes maria fernanda setúbal destro rodrigues Department of Stomatology Discipline of Oral and Maxillofacial PathologySchool of DentistryUniversity of São PauloSao Paulo 05508-000Brazil Department of Biological Sciences Bauru School of DentistryUniversity of Sao PauloSão Paulo 17012-230Brazil Biophotonics Applied to Health Sciences Nove de Julho UniversityUNINOVESao Paulo 01504-001Brazil

Despite scientific advances in the Oncology field,cancer remains a leading cause of death *** and cellular heterogeneity of head and neck squamous cell carcinoma(HNSCC)is a significant contributor to the unpredictability of the clinical response and failure in cancer *** stem cells(CSCs)are recognized as a subpopulation of tumor cells that can drive and maintain tumorigenesis and metastasis,leading to poor prognosis in different types of *** exhibit a high level of plasticity,quickly adapting to the tumor microenvironment changes,and are intrinsically resistant to current chemo and *** mechanisms of CSC-mediated therapy resistance are not fully ***,they include different strategies used by CSCs to overcome challenges imposed by treatment,such as activation of DNA repair system,anti-apoptotic mechanisms,acquisition of quiescent state and Epithelial-mesenchymal transition,increased drug efflux capacity,hypoxic environment,protection by the CSC niche,overexpression of stemness related genes,and immune *** elimination of CSCs seems to be the main target for achieving tumor control and improving overall survival for cancer *** review will focus on the multi-factorial mechanisms by which CSCs are resistant to radiotherapy and chemotherapy in HNSCC,supporting the use of possible strategies to overcome therapy failure.

关键词： Head and neck squamous cell carcinoma cancer stem cell chemotherapy radiotherapy therapy resistance

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