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CYP1A1,CYP2E1 and EPHX1 polymorphisms in sporadic colorectal neoplasms

World Journal of Gastroenterology 2016年第45期22卷 9974-9983页

作者： Glaucia maria M Fernandes Anelise Russo Marcela Alcantara Proenca Nathalia fernanda Gazola Gabriela Helena Rodrigues Patrícia Matos Biselli-Chicote Ana Elizabete Silva Joao Gomes Netinho érika Cristina Pavarino Eny maria Goloni-Bertollo Genetics and Molecular Biology Research Unit-UPGEM Department of Molecular Biology Sao José do Rio Preto Medical School FAMERP Departament of Biology UNESP-Sao Paulo State University Departament of Surgery and Coloproctology Service Sao José do Rio Preto Medical School FAMERP

AIM To investigate the contribution of polymorphisms in the CYP1A1, CYP2E1 and EPHX1 genes on sporadic colorectal cancer(SCRC) risk. METHODS Six hundred forty-one individuals(227 patients with SCRC and 400 controls) were enrolled in the study. The variables analyzed were age, gender, tobacco and alcohol consumption, and clinical and histopathological tumor parameters. The CYP1A1 *2A, CYP1A1 *2C CYP2E1 *5B and CYP2E1 *6 polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). The EPHX1 Tyr113 His, EPHX1 His139 Arg and CYP1A1 *2C polymorphisms were detected by real-time PCR. Chisquared test and binary logistic regression were used in the statistical analysis. Haplotype analysis was conducted using the Haploview program, version *** Age over 6 2 years was a risk factor for SCRC development(OR = 7.54, 95%CI: 4.94-11.50, P < 0.01). Male individuals were less susceptible to SCRC(OR = 0.55, 95%CI: 0.35-0.85, P < 0.01). The CYP2E1*5B polymorphism was associated with SCRC in the codominant(heterozygous genotype: OR = 2.66, 95%CI: 1.64-4.32, P < 0.01), dominant(OR = 2.82, 95%CI: 1.74-4.55, P < 0.01), overdominant(OR = 2.58, 95%CI: 1.59-4.19, P < 0.01), and log-additive models(OR = 2.84, 95%CI: 1.78-4.52, P < 0.01). The CYP2E1*6 polymorphism was associated with an increased SCRC risk in codominant(heterozygous genotype: OR = 2.81, 95%CI: 1.84-4.28, P < 0.01; homozygous polymorphic : OR = 7. 3 2, 9 5 % C I : 1.85-28.96, P < 0.01), dominant(OR = 2.97, 95%CI: 1.97-4.50, P < 0.01), recessive(OR = 5.26, 95%CI: 1.35-20.50, P = 0.016), overdominant(OR = 2.64, 95%CI: 1.74-4.01, P < 0.01), and log-additive models(OR = 2.78, 95%CI: 1.91-4.06, P < 0.01). The haplotype formed by the minor alleles of the CYP2E1*5B(C) and CYP2E1*6(A) polymorphisms was associated with SCRC(P = 0.002). However, the CYP1A1 *2A, CYP1A1 *2C, EPHX1 Tyr113 His and EPHX1 His139 Arg polymorphisms were not associated with *** In conclusion, the

关键词： Single-nucleotide polymorphisms Colorectal neoplasms Cytochrome P-450 CYP2E1 Cytochrome P-450 CYP1A1 Epoxide hydrolases 1

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Co-inoculation of selected nodule endophytic rhizobacterial strains with Rhizobium tropici promotes plant growth and controls damping off in common bean

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Pedosphere 2020年第1期30卷 98-108页

作者： Linnajara DE VASCONCELOS MARTINS FERREIRA fernanda DE CARVALHO Júlia FONSECA COLOMBO ANDRADE Damiany PáDUA OLIVEIRA Flávio Henrique VASCONCELOS DE MEDEIROS Fatima maria DE SOUZA MOREIRA Sector of Biology Microbiology and Biological ProcessesDepartment of Soil ScienceUniversidade Federal de LavrasLavras C.P.3037-37200-000(Brazil) Instituto Federal do Pará/IFPA Campus MarabáRuralMarabáC.P.041-68508-979(Brazil) Universidade Federal de Lavras Department of PhytopathologyLavras C.P.3037-37200-000(Brazil)

Production of common bean(Phaseolus vulgaris)is limited by the occurrence of damping off(rhizoctoniosis),which is caused by the fungus Rhizoctonia ***,the co-inoculation of plant growth-promoting rhizobacteria(PGPR)involved in biological control along with diatomic nitrogen(N2)-fixing rhizobia can enhance N nutrition and increase *** this context,finding microorganisms with synergistic effects that perform these two roles is of fundamental importance to ensure adequate yield *** aim of this study was to evaluate the effects of co-inoculation of nodule endophytic strains of the genera Bacillus,Paenibacillus,Burkholderia,and Pseudomonas with Rhizobium tropici CIAT 899,an N2-fixing rhizobial strain,on the biocontrol of damping off and growth promotion in common bean *** experiments were conducted under axenic conditions using the common bean cultivar Pé*** first experiment evaluated the potential of the 14 rhizobacterial strains,which were inoculated alone or in combination with CIAT 899,for the control of *** second experiment evaluated the ability of these 14 rhizobacterial strains to promote plant growth with three manners of N supply:co-inoculation with CIAT 899 at low mineral N supply(5.25 mg N mL^-1),low mineral N supply(5.25 mg N mL^-1),and high mineral N supply(52.5 mg N mL^-1).The use of rhizobacteria combined with rhizobia contributed in a synergistic manner to the promotion of growth and the control of damping off in the common ***-inoculation of the strains UFLA 02-281/03-18(Pseudomonas sp.),UFLA 02-286(Bacillus sp.),and UFLA 04-227(Burkholderia fungorum)together with CIAT 899 effectively controlled damping *** the common bean,mineral N supply can be replaced by the co-inoculation of CIAT 899 with plant growth-promoting strains UFLA 02-281/02-286/02-290/*** endophytes UFLA02-281/02-286 are promising for co-inoculation with CIAT 899 in the common bean,promoting synergy with rhizobial i

关键词： Bacillus sp. biological control Burkholderia fungorum CIAT 899 Phaseolus vulgaris plant growth-promoting rhizobacteria Pseudomonas sp. Rhizoctonia solani

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Study of Spider Silk Fibers by Raman Microscopy

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American Journal of Analytical Chemistry 2018年第10期9卷 529-545页

作者： maria fernanda Vargas-Charry Carlos Vargas-Hernández Laboratorio de Propiedades Opticas de Materiales (POM) Universidad Nacional de Colombia sede Manizales Manizales-Caldas Colombia

Spider silk fibers of species of the genera Araneus, Gasteracantha, and Linothele sericata were studied. The fibers are composed of axial threads and lateral villi, allowing adhesion to surfaces. Raman spectroscopy was used to determine the surface and internal composition of the threads forming the structure. In the three species, the characteristic amino acid peaks of the spider web were found between 2871 and 2975 cm-1, which belong to L-glycine, L-alanine, L-glutamine, and L-proline. The threads are composed of a protective layer mainly composed of amides, alanine, and glycine. The fibrils surrounding the axial fibers consist mainly of amide II (1533 cm-1), which allows adhesion between the thread and the surfaces onto which the spider weaves the web. For the genus Linothele sericata, there is a peak on the surface of this spider web located at 2145 cm-1, which is associated with isonitriles with R-N-C bonds.

关键词： Spider Silk Fibers Raman Spectroscopy

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Evaluation and Improvement of an Organizational Resource Applying Strategy Patterns

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Journal of Software Engineering and Applications 2016年第4期9卷 128-146页

作者： maria fernanda Papa Belen Rivera Pablo Becker Luis Olsina GIDIS Web School of Engineering National University of La Pampa General Pico Argentina

For any software company that frequently performs quality assurance activities devoted to measurement, evaluation (ME) and change/improvement (MEC) projects, ME and MEC strategies can be valuable organizational assets. In this paper, we analyze the improvement of a ME strategy, which can be considered an organizational resource to be applied to quality assurance activities. This resource is called the GOCAME (Goal-Oriented Context-Aware Measurement and Evaluation) strategy. AME/MEC strategy embraces the next three integrated capabilities: 1) the ME/MEC domain conceptual base and framework;2) the process perspective specifications;and, 3) the method specifications. The improvement of GOCAME was performed instantiating two strategy patterns. A strategy pattern is a reusable solution to recurrent problems in ME/MEC projects. For an improvement goal, the selected MEC strategy pattern allows instantiating in a project a set of tailored activities and methods for measurement, evaluation, analysis and change. Particularly, we instantiate the GoME_1QV (Goal-oriented Measurement and Evaluation for One Quality View) strategy pattern to understand the GOCAME current quality state and compare it with the so-called GQM+ Strategies. First, this evaluation and analysis allows us to know the GOCAME strengths and weaknesses with regard to the quality of the three capabilities. Second, we instantiate the GoMEC_1QV (Goal-oriented Measurement, Evaluation and Change for One Quality View) strategy pattern to improve the GOCAME current state, producing as result a new version of the GOCAME strategy.

关键词： Strategy Pattern Quality View Evaluation Change Improvement

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Molecular approaches for spinal cord injury treatment

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Neural Regeneration Research 2023年第1期18卷 23-30页

作者： fernanda Martins de Almeida Suelen Adriani Marques Anne Caroline Rodrigues dos Santos Caio Andrade Prins Fellipe Soares dos Santos Cardoso Luiza dos Santos Heringer Henrique Rocha Mendonça Ana maria Blanco Martinez Laboratório de Neurodegeneração e Reparo Programa de Pós-Graduação em Medicina:Anatomia PatológicaDepartamento de PatologiaFaculdade de MedicinaHospital Universitário Clementino Fraga FilhoCentro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Ciências Biomédicas Centro de Ciências da SaúdeUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Biologia Departamento de NeurobiologiaLaboratório de Regeneração Neural e FunçãoUFFRio de JaneiroBrazil Laboratório Integrado de Morfologia Instituto de Biodiversidade e Sustentabilidade NUPEMPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas-SBFisCentro Multidisciplinar UFRJ-MacaéUniversidade Federal do Rio de JaneiroMacaéBrazil

Injuries to the spinal cord result in permanent disabilities that limit daily life *** main reasons for these poor outcomes are the limited regenerative capacity of central neurons and the inhibitory milieu that is established upon traumatic *** decades of research,there is still no efficient treatment for spinal cord *** strategies are tested in preclinical studies that focus on ameliorating the functional outcomes after spinal cord *** these,molecular compounds are currently being used for neurological recovery,with promising *** molecules target the axon collapsed growth cone,the inhibitory microenvironment,the survival of neurons and glial cells,and the re-establishment of lost *** this review we focused on molecules that are being used,either in preclinical or clinical studies,to treat spinal cord injuries,such as drugs,growth and neurotrophic factors,enzymes,and *** mechanisms of action of these molecules are discussed,considering traumatic spinal cord injury in rodents and humans.

关键词： axonal regeneration drugs enzymes growth factors molecular therapy neurotrophic factors purines spinal cord injury

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Anti-Candida and anti-Cryptococcus evaluation of 15 non-alkaloidal compounds from Pterogyne nitens

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Asian Pacific Journal of Tropical Biomedicine 2016年第10期6卷 841-845页

作者： Caroline Sprengel Lima Carlos Roberto Polaquini mariana Bastos dos Santos fernanda Patricia Gullo fernanda Sangalli Leite Liliane Scorzoni Vanderlan da Silva Bolzani maria Jose Soares Mendes-Giannini Ana Marisa Fusco-Almeida Andréia Alves Rezende Luis Octavio Regasini Laboratory of Green and Medicinal Chemistry Department of Chemistry and Environmental Sciences Institute of Biosciences Letters and Exact Sciences Sao Paulo State University (UNESP) Department of Clinical Analysis School of Pharmaceutical Sciences Sao Paulo State University (UNESP) Department of Organic Chemistry Institute of Chemistry Sao Paulo State University (UNESP) Department of Biology and Animal Sciences Faculty of Engineering Sao Paulo State University (UNESP)

Objective: To evaluate anti-Candida and anti-Cryptococcus activities of 15 nonalkaloidal compounds from Pterogyne nitens Tulasne(Leguminosae), a South American medicinal ***: Compounds were submitted to antifungal assays, using microdilution method described by Clinical and Laboratory Standards Institute document, with minor modifications. Five species of Candida and two species of Cryptococcus, including clinical isolates were screened. Antifungal activity was expressed by minimum inhibitory concentration(MIC). Amphotericin B and fluconazole were used as standard antifungal ***: Among tested compounds, six substances presented fungal growth inhibition(MIC < 31.2 mg/m L) [three flavone derivatives(1–3), a glycosylated flavonol derivative(5)and two phenolic acids(10 and 12)]. Sorbifolin(1), exhibited potent antifungal activity,demonstrating MIC value of 3.90 mg/m L against Candida glabrata ATCC 90030, Cryptococcus gattii 118 and fluconazole-resistant clinical isolate of Cryptococcus neoformans var. grubii. Pedalin(2) and nitensoside B(3), two glycosylated flavone derivatives, were active against Cryptococcus neoformans ATCC 90012(MIC = 7.80 mg/m L).Conclusions: Flavone derivatives from Pterogyne nitens can serve as prototypes for the design and development of innovative anti-Candida and anti-Cryptococcus hits.

关键词： Candida Cryptococcus Antifungal Pterogyne nitens Flavonoid Opportunistic fungi

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Clinical and pathological characterization of epstein-barr virus-associated gastric carcinomas in portugal

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World Journal of Gastroenterology 2017年第40期23卷 7292-7302页

作者： Joana Ribeiro Andreia Oliveira mariana Malta Claudia Oliveira fernanda Silva Ana Galaghar Luís Pedro Afonso maria Cassiano Neves Rui Medeiros Pedro Pimentel-Nunes Hugo Sousa Molecular Oncology and Viral Pathology Group Portuguese Oncology Institute of Porto Faculty of Medicine of Porto University Department of Pathology Portuguese Oncology Institute of Porto Medical Oncology Department Portuguese Oncology Institute of Porto Instituto CUF de Oncologia Virology Service Portuguese Oncology Institute of Porto Research Department-Portuguese League Against Cancer(Liga Portuguesa Contra o Cancro-Núcleo Regional do Norte) Gastroenterology Service Portuguese Oncology Institute of Porto CINTESIS-Center for Health Technology and Services Research(Centro de Investigacao Médica Faculdade de Medicina da Universidade do Porto)

AIM To determine the prevalence of epstein-barr virus(eb V)-associated gastric carcinomas in the North Region of Portugal and to study its clinicopathological characteristics. METHODS We have performed a retrospective study including a total of 179 consecutive patients with gastric cancer(GC) submitted to gastrectomy during 2011 at the Portuguese Oncology Institute of Porto. Clinical and pathological data was collected from individual clinical records and inserted on a database with unique codification. Tumour tissues were collected from the institutional tumour bank. eb V was detected by in situ hybridization for the detection of eb V-encoded small RNAs(ebe Rs) and eb V latent proteins(LMP1 and LMP2 A) were detected by *** The analysis showed that eb V-associated gastric carcinomas(eb Va GC) represents 8.4%(15/179) of all GC cases, with a significant differential distribution among histological types(P < 0.001): 100%(3/3) of medullary carcinomas, 100%(1/1) of adenosquamous carcinoma, 8.7%(8/92) of tubular adenocarcinomas, 8.0%(2/25) of mixed carcinomas and 2%(1/51) in poorly cohesive carcinomas. The analysis revealed a higher predominance of eb Va GC in the upper third and middle(cardia, fundus and body) of the stomach(P = 0.041), a significant lower number of regional lymph nodes invasion(P = 0.025) and a tendency for better prognosis(P = 0.222). eb V latent protein expression revealed that all eb Va GC cases were LMP1-negative, nevertheless 6 cases(40%) expressed LPM2 A, which reveals that these cases show a distinct eb V-Latency profile(latency II-like).CONCLUSION eb Va GC represents 8.4% of all GC in the North Region of Portugal. The eb V-infected patients have specific clinic-pathological features that should be further explored to develop new strategies of management and treatment.

关键词： Gastric cancer Epstein-barr virus Prevalencel Epstein-barr virus-associated gastric carcinomas

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Impact Noise of Non-homogeneous Floors： Analysis of Different Input Parameters for Computational Modeling Predictions

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Journal of Civil Engineering and Architecture 2017年第3期11卷 274-281页

作者： maria fernanda de Oliveira Jorge Vicoso Patricio2 Technological Institute onCivil Construction - itt Performance Unisinos University Sao Leopoldo 93022-750 Brazil National Laboratory for Civil Engineering-LNEC Lisbon1700-066 Portugal

Floor systems with non-homogeneous slabs have more complex means of propagation than homogeneous systems, with more variables to be considered in predictions by theoretical models. For those slabs, it is necessary to understand the differences of each material composing each subsystem, and the connection types between the elements of each one of this subsystem. Some floors integrating lightweight elements without structural purposes, are broadly used in several countries in precast slabs. The predictions based on computer modelling for building systems can be influenced by the input parameters related to connections between the elements of the floor system. In building structures, the analysis of radiation due to element vibrations may be represented by wave propagation relationships as a one-dimensional system, a two-dimensional system or a three-dimensional solid. In these floors, the modelling of the interaction between elements can be basically a face, a line or a point connection. In addition, the choice of the connection type can determine the vibration transmission amongst all the floor elements. This study focuses on the differences that can be obtained in the induced vibration response due to an impact source on non-homogeneous slabs. It also presents some examples of modelling options for several floor systems, considering input parameters for different connection types.

关键词： Non-homogeneous floors vibrational response finite element analysis.

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Sequential tumor-directed and lobar radioembolization before major hepatectomy for hepatocellular carcinoma

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World Journal of Hepatology 2017年第36期9卷 1372-1377页

作者： Michael Vouche Thierry Degrez Fikri Bouazza Philippe Delatte maria gomez Galdon Alain Hendlisz Patrick Flamen Vincent Donckier Department of Radiology Institut Jules Bordet Université Libre de Bruxelles Department of Gastroenterology CHR Sambre et Meuse Department of Abdominal Surgery Institut JulesBordet Université Libre de Bruxelles Department of Pathology Institut Jules Bordet Université Libre de Bruxelles Department of Digestive Oncology Institut Jules Bordet Université Libre de Bruxelles Department of Nuclear Medicine Institut Jules Bordet Université Libre de Bruxelles Department of Abdominal Surgery Institut Jules Bordet Centre de Chirurgie Hépato-Biliaire de l’ULB (CCHB-ULB) Université Libre de Bruxelles

Preoperative radioembolization may improve the resectability of liver tumor by inducing tumor shrinkage, atrophy of the embolized liver and compensatory hypertrophy of non-embolized liver. We describe the case of a cirrhotic Child-Pugh A patient with a segment Ⅳ hepatocellular carcinoma requiring a left hepatectomy. Preoperative angiography demonstrated 2 separated left hepatic arteries, for segment Ⅳ and segments Ⅱ-Ⅲ. This anatomic variant allowed sequential radioembolizations, delivering high-dose ^(90)Yttrium(160 Gy) to the tumor, followed 28 d later by lower dose(120 Gy) to segments Ⅱ-Ⅲ. After 3 mo, significant tumor response and atrophy of the future resected liver were obtained, allowing uneventful left hepatectomy. This case illustrates that, when anatomic disposition permits it, sequential radioembolizations, delivering different ^(90)Yttrium doses to the tumor and the future resected liver, could represent a new strategy to prepare major hepatectomy in cirrhotic patients, allowing optimal tumoricidal effect while reducing the toxicity of the global procedure.

关键词： Hepatocellular carcinoma Cirrhosis Resectability Radioembolization sequential efficacy safety

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Documentary research on social innovation in health in Latin America

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Infectious Diseases of Poverty 2020年第2期9卷 92-92页

作者： Diana maria Castro-Arroyave Luisa fernanda Duque-Paz Centro Internacional de Entrenamiento e Investigaciones Medicas(CIDEIM) CaliColombia Icesi University CaliColombia

Background:Identifying social innovation in health initiatives,promoting quality of life through them,and transforming current health conditions demand the knowledge,comprehension and appropriation of the theoretical and methodological developments of this concept Academic developments in social innovation have mainly occurred in and been documented for English-speaking countries,although relevant experiences have been implemented in Latin *** this article,we describe and analyze how social innovation in health is being approached and understood in this *** text:To identify the theoretical and methodological developments of social innovation in health between 2013 and 2018,a scoping review with a mixed approach was carried *** texts in English,Spanish and Portuguese were selected for a process of reflexive analysis of intra and intertextual *** approaches identified in the studied initiatives were *** most applied approaches were innovation in health,technological innovation in health and social innovation,each with twelve publications,and social innovation in health and ecohealth with ten and seven publications *** approaches showed a general interest in reaching the goals of the Sustainable Development Goals(SDGs),the Alma Ata Declaration and the Ottawa ***:The social innovation in health approach in Latin America adopts educational strategies,identifies risk factors,optimizes resources,promotes interculturality,participation,community empowerment,and enhances intersectorality and *** an approach,process,program or solution,social innovation in health is a conceptual category under *** research provides a baseline for other systematic reviews on the subject.

关键词： Community-based health Documental research Public health Social innovation in health Social change

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