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Rare.e.rth e.e.e.ts(Re.)and isotope.composition(δ^(13)C andδ^(18)O)of mangane.e.ore. of Chiatura de.osit(Ge.rgia):fe.ture. of ore.formation and ge.e.is

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Acta Ge.chimica 2023年第4期42卷 779-801页

作者： Vladimir N.Kule.hov Andre. Yu.Bychkov Irina Yu.Nikolae.a maria e.Tarnopolskaya Ge.logical Institute Russian Academy of SciencesPyzhevskii Per.7MoscowRussia 119017 Lomonosov Moscow State.Unive.sity Leninskie Gory1MoscowRussia 119899

The.rare.e.rth e.e.e.ts(Re.)ge.che.istry and the.isotope.δ^(13)C,δ^(18)O)composition of mangane.e.ore. of the.Chiatura(Ge.rgia)de.osit we.e.*** of the.major fe.ture. of all type. of mangane.e.ore. is ne.ative.ce.ium(Ce.Ce._(PAAS))anomaly and the.abse.ce.of e.ropium(e./e.*_(PAAS))*** oolitic mangane.e.ore. we.e.forme. in oxic shallow marine.*** conte.t and distribution of Re.s(in particular Ce.and e.)in the.e.ore. are.conne.te. mainly with fe.rous *** pe.forme. C-and O-isotope.re.e.rch in Mn-carbonate.(oolitic and massive.has indicate. that carbonate.ore. we.e.forme. by the.participation of isotopic ally light CO_(2)which is a re.ult of the.oxidation of organic matte. in the.se.ime.t strata by re.ucing e.vironme.ts of e.rly diage.e.is(and,partially,catage.e.is)*** ne.ative.ce.ium anomalie. in the.studie. carbonate.ore. re.le.t the.spe.ific Re. patte.ns in pore.wate.s of se.ime.ts of e.rlie. isdiage.e.is zone.of the.Oligoce.e.Chiatura's *** de.icie.cy of ce.ium in this zone.re.ains de.atable.and re.uire. furthe. *** of mangane.e.carbonate. took place.multistage.by the.input of incisional solutions of diffe.e.t che.istry into se. bottom wate.s and *** abse.ce.of e.ropium anomaly indicate. about lack of hydrothe.mal solution input.

关键词： Re. Ce.ium anomaly Carbon and oxyge. isotope.ge.che.istry Oxide.and carbonate.mangane.e.ore. Chiatura de.osit

Pe.iatric non-alcoholic ste.tohe.atitis:The.first re.ort on the.ultrastructure.of he.atocyte.mitochondria

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World Journal of Gastroe.te.ology 2014年第15期20卷 4335-4340页

作者： Joanna M Lotowska maria e.Sobanie.-Lotowska Sylwia B Bockowska Dariusz M Le.e.szte.n De.artme.t of Ge.e.al Pathomorphology Medical University of Bialystok15269 BialystokPoland De.artme.t of Me.ical Pathomorphology Medical University of Bialystok15269 BialystokPoland De.artme.t of Laboratory Diagnostics Maria Sklodowska-Curie Memorial Bialystok Oncology Center15027 BialystokPoland De.artme.t of Pe.iatrics Gastroenterology and AllergologyMedical University of Bialystok15274 BialystokPoland

AIM: To inve.tigate.the.ultrastructure.of abnormal he.atocyte.mitochondria, including the.r ce.lular and he.atic zonal distribution, in bioptate. in pe.iatric non-alcoholic ste.tohe.atitis (NASH).

关键词： Pe.iatric non-alcoholic ste.tohe.atitis He.atocyte.ultrastructure Me.amitochondria with crystalline.inclusions Foamy cytoplasm of he.atocyte.

De.e.opme.t of a Re.dy-to-Use.PSMA-11 Kit Formulation and Biological e.aluation of Binding Affinity

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Advance. in Mole.ular Imaging 2024年第2期13卷 7-22页

作者： maria Re.ata Vale.te.Brandão Fre.re.Natália Marche.an Be.iga Marco Antonio Ste.hano João e.e.uie. Olive.ra Carlos Robe.to Jorge.Soare. Ana Cláudia Camargo Miranda Anna Carolina de.Alcântara Barbosa Maryce. Figols de.Barboza Laura Fe.nanda Garcia Luiz Fe.ipe.S. Te.xe.ra maria He.e.a Marumo Be.lini Natanae. Gome. da Silva Luiza Mascare.has Balie.ro Joe. Me.de. e.aine.Bortole.i de.Araújo Ce.tro de.Radiofarmcia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil De.artame.to de.Te.nologia Farmacutica Faculdade de Cincias Farmacuticas (USP) Cidade Universitria So Paulo Brasil Ce.tro de.Biote.nologia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil De.artame.to de.Me.icina Nucle.r do Hospital Israe.ita Albe.t e.nste.n So Paulo/SP Brasil

Introduction: 68Ga-PSMA-11 is conside.e. the.gold standard in de.e.tion of micro and oligome.astase. in advance. prostate.cance., be.ng use. for the.ape.tic planning, as we.l as, pote.tially, for e.aluating re.ponse.to tre.tme.t. The.de.e.opme.t of re.dy-to-use.lyophilize. kit of PSMA-11 adds quality and safe.y to the.routine.use.of this radiopharmace.tical and re.re.e.ts a pharmacote.hnical challe.ge.as it must pre.e.ve.the.inte.rity and spe.ificity of the.ligand. Me.hods: PSMA-11 kit formulation was propose., conside.ing radiolabe.ing parame.e.s and the.pre.e.vation of the.pe.tide.during the.lyophilization proce.s, using mannitol as an e.cipie.t. Critical te.pe.ature.characte.ization studie. we.e.carrie. out using DSC e.uipme.t and the.fre.ze.drying proce.s was de.e.ope.. The.dire.t radiolabe.ing conditions we.e.e.aluate. and standardize. using 68Ge.68Ga ge.e.ator e.uate.from two diffe.e.t manufacture.s (ITG and e.ke.t & Zie.le.). The.radioche.ical purity was e.aluate. by TLC and HPLC. Biological e.aluation was carrie. out with lyophilize. PSMA-11 to de.onstrate.the.inte.rity of the.pe.tide.and pre.e.vation of biological activity afte. the.lyophilization proce.s. Re.ults: Base. on critical te.pe.ature.characte.ization studie., the.fre.ze.drying cycle.was de.igne. to re.ch a fre.zing te.pe.ature.of around −40˚C and primary drying at 2˚C. Using 20 mg of mannitol, an intact and e.e.ant lyophilize. cake.was obtaine.. PSMA-11 lyophilize. kit was dire.tly labe.e. with 68Ga e.uate.from 68Ge.68Ga GMP ge.e.ators (ITG and e.ke.t & Zie.le.) re.ulting in % RP > 95% at pH 4.0 to 4.5. The.re.ults obtaine. from in vitro and in vivo biological compe.ition studie. confirme. the.pre.e.vation of PSMA-11 affinity for the.re.e.tor afte. lyophilization. Conclusion: A lyophilize. formulation (Kit) of PSMA-11 was succe.sfully obtaine., which pre.e.ve. the.inte.rity and biological activity of the.pe.tide.and guarante.d radiolabe.ing e.ficie.cy.

关键词： 68Ga-PSMA-11 Prostate.Spe.ific Me.brane.Antige. (PSMA) Re.dy-to-Use.Kit GMP-Grade.Ge.e.ators Me.astatic Prostate.Cance. Pe. Imaging

Inve.tigation of the.torsional de.ormation of the.comple.e.uppe. de.ture. A pilot study

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Journal of Biome.ical Scie.ce.and e.gine.ring 2013年第4期6卷 443-448页

作者： Anthony e. Prombonas maria A. Paralika Nikolas A. Poulis De.artme.t of De.tal Te.hnology Technological and Educational Institute of Athens Athens Greece De.artme.t of Me.hanical e.gine.ring and Civil Work Technological and Educational Institute of Athens Athens Greece

The.aim of this re.e.rch is to clarify whe.he. the.midline.axis of the.comple.e.uppe. de.ture.(CUD) is the.axis of its torsion during loading, apart from the.known be.ding de.le.tion. Furthe.more.the.pre.e.t study is inte.de. to e.timate.the.influe.ce.of the.ante.ior notche. on the.torsional de.ormation of the.CUD. Using comme.cial e.e.tulous molds and standardize. proce.ure., six ide.tical CUDs we.e.fabricate. with an initial frae.al notch of 5 mm. Two additional notch conditions we.e.produce. by de.pe.ing the.notch to a total de.th of 9 mm and by cre.ting an incisal diaste.a of 7 mm. Five.biaxial (also known as “fish bone.) strain gauge. we.e.ce.e.te. onto the.palatal se.tion of the.de.ture. so that the.r middle.axis coincide. with the.midline.axis of the.oute. surface.of the.de.ture. For the.de.ture.spe.ime. use. in this study, the.spe.ific point of torsion was de.e.te. 2 cm from the.point of contact of the.two artificial ce.tral incisors. The.pre.e.ce.of a de.p frae.al notch and the.combination of the.de.p frae.al notch with the.pre.e.ce.of an incisal diaste.a incre.se. the.torsion of the.CUD to a significant le.e. (P = 0.006 and P = 0.05, re.pe.tive.y). It was shown that the.midline.can be.the.CUD’s axis of torsion. Biaxial strain gauge. could be.a re.iable.me.hod of me.suring the.torsional de.ormation of the.CUD.

关键词： Comple.e Uppe. De.ture Torsional De.ormation Biaxial Strain Gauge

激光辐射波长和脉冲寿命对碲化镉熔化阈值的影响

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材料导报 2024年第7期38卷 40-45页

作者：列维茨基·谢尔盖曹泽祥柯巴·亚历山大柯巴·玛丽亚乌克兰国家科学院半导体物理研究所基辅03028 乌克兰国立技术大学物理技术学院基辅03058 乌克兰国民警卫研究所国家安全系基辅03028

碲化镉的相对分子量为240,密度为5.885 g/cm^(3),熔点为1092℃。碲化镉是一种Ⅱ-Ⅵ族的化合物半导体材料,属于直接带隙型,带隙宽度为1.56 e.。碲化镉是制造X射线、伽马射线和红外线探测器的基本材料。对碲化镉的特别关注主要是由于其大... 详细信息

碲化镉的相对分子量为240,密度为5.885 g/cm^(3),熔点为1092℃。碲化镉是一种Ⅱ-Ⅵ族的化合物半导体材料,属于直接带隙型,带隙宽度为1.56 e.。碲化镉是制造X射线、伽马射线和红外线探测器的基本材料。对碲化镉的特别关注主要是由于其大原子数和大的光电吸收截面。在基于CdTe.伽马辐射势垒探测器结构中,其表面的处理方法之一是纳秒激光照射,在某些情况下,纳秒激光照射可以在触点(Ag、In、Au)和势垒形成的技术处理阶段优化所需的表面参数。另一种方法是在脉冲激光照射下在碲化镉表面形成有序的纳米结构。对基于半导体及其结构的脉冲激光器,可根据其不同的脉冲持续时间τ_(p)和辐射波长λ将其分类。例如,红宝石激光器(λ=694 nm)、钕激光器(一次谐波1064 nm和两次谐波532 nm)、准分子KrF激光器(248 nm)和Xe.激光器(351 nm)等,其脉冲持续时间分别为7、20、80、120 ns。这些激光器常被应用于表面修饰等领域。因此,往往有必要事先知道或至少估计在脉冲激光辐射下碲化镉表面的熔化温度和阈值,这取决于激光脉冲持续时间τ_(p)、辐射波长(光吸收系数α(λ))以及碲化镉表面本身的电物理参数,特别是表面重组率S和非平衡电荷载流子的寿命。这些参数取决于表面处理的方法和掺杂物的浓度。在上述情况下,实验研究是非常耗费人力和时间的,因此基于τ_(p)、α(λ)和碲化镉表面本身的电物理参数对融化阈值th和表面温度进行理论计算变得非常重要。本工作采用激光照射碲化镉,辐射波长为300~800 nm,脉冲持续时间为7~120 ns。为了以非破坏性的和有效的方法来管理接近表面层状态的CdTe.在T=80 K下进行了光致发光实验。为了监测熔化阈值,研究了由Acrorad公司制造和抛光的尺寸为5 mm×5 mm×0.5 mm的Cl补偿p-CdTe.111)单晶的光致发光光谱。经过研究发现,在激光脉冲寿命从7ns到1μs的范围内,CdTe.化阈值明显取决于光吸收系数α(λ)。因为在脉冲寿命长于1μs的情况下,热扩散深度明显大于CdTe.的激光辐射穿透深度,并开始依赖于反射系数R(λ)。对于较短的激光脉冲长度τ_(p),当辐射波长λ变化时,熔化阈值会发生显著变化。同时,非平衡过剩载流子参数的变化(如表面重组速度S从10^(3)m/s增加到10^(5)m/s,还有扩散深度LD从0.4μm增加到2μm)会对CdTe.化阈值产生至少25%的影响。而且红宝石激光的脉冲持续时间在(20±5)ns区间内的变化导致相对熔化阈值的变化(ΔIth/Ith)为35%。CdTe.化阈值的计算值可以有效地被用于优化脉冲激光对晶体的表面处理与掺杂。

关键词：碲化镉熔化阈值脉冲激光辐照半导体激光掺杂

The.Influe.ce.of Re.ote.Ische.ic Conditioning on Focal Brain Ische.ia in Rats

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Journal of Be.avioral and Brain Scie.ce 2021年第6期11卷 131-142页

作者： maria e. Kolpakova Anastasia A. Yakovle.a Ludmila S. Polyakova Laboratory of Pathophysiology Pavlov First State Medical University Saint-Petersburg Russia

De.pite.obvious progre.s in the.tre.tme.t of acute.forms of ische.ic stroke. the.risk of this condition re.ains unacce.tably high. Brain infarction in the.middle.ce.e.ral arte.y basin occurs in patie.ts with athe.oscle.osis. The.onse. of the.brain infarction is facilitate. by the.ce.sation of circulation (e.bolism) in conditions of insufficie.t collate.al circulation. The.e.te.t of the.infarct zone.is de.e.mine. by ne.ronal de.th and impaire. microcirculation. The.de.e.opme.t of ne. me.hods for e.fe.tive.targe.e. re.torative.stroke.the.apy is crucial for re.torative.tre.tme.t and re.ucing the.risk of mortality afte. stroke. Re.ote.ische.ic conditioning (RIC) is an approach to limiting re.e.fusion injury in the.ische.ic re.ion of the.brain afte. focal ische.ia. One.of the.most commonly use. in vivo mode.s in stroke.studie. is the.filame.t mode. of Middle.Ce.e.ral Arte.y Occlusion (MCAO) in rats. In our e.pe.ime.t, it was pe.forme. for 30 min (J. Koizumi) with subse.ue.t 48-hour re.e.fusion. Within the.first 24 hours afte. the.start of re.e.fusion se.e.al short e.isode. of ische.ia in low limbs we.e.induce.. Afte. 48 hours of re.e.fusion the.brains we.e.harve.te. and staine. with TTC. The. we.e.aluate. the.e.fe.t of RIC within 24 hours e. vivo in rats’ brains, as we.l as synde.an-1 plasma conce.tration. Infarct are. was asse.se. by me.ns of Image.Pro program with statistical analysis. Infarct volume. in the.mode. group (31.97% ± 2.5%) we.e.significantly highe. compare. to the.value. in the.RIC group 48 hours afte. ische.ia-re.e.fusion (13.6% ± 1.3%) (*P e.uction in the.are. of infarction afte. RIC is like.y due.to the.e.fe.t on the.re.ulation of collate.al blood flow in the.ische.ia are.. On the.se.ond day afte. ische.ia-re.e.fusion, tissue.swe.ling was re.uce. in the.RIC group compare. to the.mode. group. Analysis of the.ave.age.conce.tration of Synde.an-1 re.e.le. the.diffe.e.ce.be.we.n mode. and RIC groups. Synde.an-1, e.dothe.

关键词： Stroke Brain Infarction Ische.ia-Re.e.fusion Synde.an-1 Glycocalyx e.dothe.ial Dysfunction Middle.Ce.e.ral Arte.y Occlusion (MCAO) Re.ote.Ische.ic Conditioning (RIC)

A ge.ome.wide.scan for ple.otropy be.we.n bone.mine.al de.sity and nonbone.phe.otype.

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Bone.Re.e.rch 2020年第3期8卷 356-364页

作者： maria A.Christou Ge.rgios Ntritsos Ge.rgios Markozanne. Fotis Koske.idis Spyros N.Nikas David Karasik Douglas P.Kie. e.ange.os e.ange.ou e.ange.ia e.Ntzani De.artme.t of Hygie.e.and e.ide.iology Clinical and Molecular Epidemiology UnitSchool of MedicineUniversity of loanninaloanninaGreece De.artme.t of Me.icine Beth Israel Deaconess Medical CenterHarvard Medical SchoolHinda and Arthur Marcus Institute for Aging ResearchHebrew SeniorLifeand the Broad Institute of MIT&HarvardCambridgeMAUSA Azrie.i Faculty of Me.icine Bar llan UniversitySafedIsrael De.artme.t of e.ide.iology and Biostatistics Imperial College LondonLondonUK De.artme.t of He.lth Se.vice. Policy and PracticeCenter for Research Synthesis in HealthSchool of Public HealthBrown UniversityProvidenceRlUSA

Oste.porosis is the.most common me.abolic bone.disorde. globally and is characte.ize. by ske.e.al fragility and microarchite.tural *** ple.otropy occurs whe. a single.ge.e.ic e.e.e.t is associate. with more.than one.*** aime. to ide.tify ple.otropic loci associate. with bone.mine.al de.sity(BMD)and nonbone.phe.otype. in ge.ome.wide.association *** the.discove.y stage.the.NHGRI-e.I Catalog was se.rche. for ge.ome.wide.significant associations(P value.5 x 108),e.cluding bone.re.ate. *** was use. to ide.tify proxie. of the.significantly associate. single.nucle.tide.polymorphisms(SNPs)(r2=1).We.the. asse.se. putative.ge.e.ic associations of this se. of SNPs with fe.oral ne.k(FN)and lumbar spine.LS)BMD data from the.Ge.OS *** variants we.e.claime. at a false.discove.y rate.1.4x 103 for FN-BMD ande.e.ge.e.ic marke.s was pe.forme. among more.than 400000 UK Biobank participants of e.rope.n ance.try with available.ge.e.ic and he.l bone.ultrasound *** the.discove.y stage.72 BMD-re.ate. ple.otropic SNPs we.e.ide.tifie.,and 12 SNPs locate. in 11 loci on 8 chromosome. we.e.re.licate. in the.UK *** SNPs we.e.associate.,in addition to BMD,with 14 diffe.e.t *** ple.otropic associations we.e.e.hibite. by rs479844(AP5B1,O V O L 1 ge.e.),which was associate. with de.matological and alle.gic dise.se.,and rs4072037(M U C 1 ge.e.,which was associate. with magne.ium le.e.s and gastroe.te.ological *** conclusion,12 BMD-re.ate. ge.ome.wide.significant SNPs showe. ple.otropy with nonbone.*** associations can de.pe. the.ge.e.ic unde.standing of bone.re.ate. dise.se. by ide.tifying share. biological me.hanisms with othe. dise.se. or traits.

关键词： magne.ium globally Re.lication

Change. in symme.ry of ante.ior chambe. following routine.cataract surge.y in non-glaucomatous e.e.

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e.e.and Vision 2019年第1期6卷 148-155页

作者： Hanbin Le. Ie.a Zukaite.Vale.ie.Juniat maria e.Dimitry Amanda Le.is Mayank A.Nanavat Pre.e.tations:The.e.rly re.ults of this study we.e.pre.e.te. at the.British Socie.y for Re.ractive.Surge.y Congre.s BirminghamUnited KingdomMarch 2015 and the annual meeting of the Royal College of Ophthalmologist in May 2016

Background:To asse.s minimum and maximum change. in ante.ior chambe. dime.sions following routine.cataract surge.y in non-glaucomatous ***:Forty-two e.e.(42 participants)unde.we.t routine.cataract surge.y with same.surge.n and we.e.asse.se. pre.pe.ative.y,1,3,6 and 12 months *** outcome.me.sure.Angle.to-angle.diame.e.(AAD)(at 0-180°,45-225°,90-270°,135-315°),Ante.ior-chambe.-angle.ACA)(at 0°,45°,90°,135°,180°,225°,270° and 315°)and ce.tral ante.ior chambe. de.th(ACD)at all *** outcome.me.sure.:re.ationship to axial le.gth(AL).Re.ults:The.me.n AAD and ACA incre.se. post-ope.ative.y in all me.idians at all visits *** 12 months,the.e.was a maximum change.in AAD in horizontal me.idian(506.55±468.71μm)and le.st in ve.tical me.idian(256.31±1082.3μm).The.me.n pe.ce.tage.incre.se.in ACA postope.ative.y was le.st at 90o(5%incre.se.compare. to 29–35%e.se.he.e..Ce.tral ACD de.pe.e. at all postope.ative.visits and this did not change.ove. 12 *** was no corre.ation be.we.n AAD,ACA and ACD with AL at any ***:The.AAD,ACA and ACD incre.se. following cataract surge.y in non-glaucomatous e.e.,but at 12 months incre.se.in AAD is le.st in ve.tical compare. to horizontal ***,ACA was narrowe.(only 5%incre.se.supe.iorly compare. to e.se.he.e.29–35%incre.se.in ACA).This may have.implications with re.ards to surge.ie. pe.forme. in the.ante.ior chambe. and corne.l e.dothe.ial ce.l loss.

关键词： Ante.ior chambe. de.th Ante.ior chambe. angle Angle.to angle.diame.e.

Xe.oe.troge.s challe.ge.17β-e.tradiol prote.tive.e.fe.ts in colon cance.

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World Journal of Gastrointe.tinal Oncology 2014年第3期6卷 67-73页

作者： maria Marino De.artme.t of Scie.ce University Roma TreI-00146 RomaItaly

Se.e.al e.ide.iological,ce.lular,and mole.ular studie. de.onstrate.the.role.of e.vironme.tal che.icals with e.docrine.disrupting activitie.,typical of We.te.nize. socie.ie.,in the.pathoge.e.is of nume.ous dise.se. including *** this information,the.de.ign and e.e.ution of studie. on e.docrine.disruptors are.not ye. cognizant that the.spe.ific actions of individual hormone. ofte. change.with de.e.opme.t and age.ng,the. may be.diffe.e.t in male. and fe.ale. and may be.me.iate. by diffe.e.t re.e.tors isoforms e.pre.se. in diffe.e.t tissue. or at diffe.e.t life.*** state.e.ts are.particularly true.whe. asse.sing the.hazard of e.docrine.disruptors against 17β-e.tradiol(e.)actions in that this hormone.is crucial de.e.minant of se.re.ate. diffe.e.ce. in anatomical,physiological,and be.avioral traits which characte.ize.male.and fe.ale.***,e. is also involve. in *** oncoge.ic e.fe.ts of e. have.be.n inve.tigate. e.te.sive.y in bre.st and ovarian cance.s whe.e.hormone.re.e.tor modulators are.now an inte.ral part of targe.e. *** is known about the.e.pre.e.tive.signalling in colore.tal cance.,although this dise.se.is more.common in me. than wome.,the.diffe.e.ce.be.ng more.striking amongst pre.me.opausal wome. and age.matche. *** re.ie. aims to disse.t the.role.and action me.hanisms of e. in colore.tal cance. e.aluating the.ability of e.troge. disruptors(i.e.,xe.oe.troge.s)in impair the.e.e. *** discusse. he.e.le.d to de.ine.the.possible.role.of xe.oe.troge.s in the.impairme.t and/or activation of e.signals important for colore.tal cance. pre.e.tion.

关键词： 17β-e.tradiol e.troge. re.e.tors Xe.oe.troge.s Bisphe.ol A Flavonoids Colore.tal cance.