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Could mammalian inorganic polyphosphate.be.a crucial signaling mole.ule.in ne.rological disorde.s?

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Ne.ral Re.e.e.ation Re.e.rch 2024年第4期19卷 701-702页

作者： Re.ata Torre. Da Costa maria e.Sole.io Rutge.s Unive.sity Department of BiologyCamdenNJUSA

Since.the.e.rly stage. of life.on e.rth,ce.lular me.abolism has e.olve. to adapt to fluctuations in nutrie.t and oxyge. *** this conte.t,mammals,which are.probably the.organisms that show one.of the.highe.t le.e.s of me.abolic comple.ity,have.de.e.ope. an e.e.ant syste. that use. constant and re.harge.ble.e.e.gy source. of modulate.the.r *** home.stasis is e.pe.ially important in the.ce.tral ne.vous syste.,as ne.rons and othe. ce.ls in the.brain are.highly susce.tible.to fluctuations in nutrie.ts and oxyge. availability.

关键词： me.abolism home.stasis ne.rological

Carbon se.ue.tration in a bamboo plantation:a case.study in a Me.ite.rane.n are.

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Journal of Fore.try Re.e.rch 2024年第3期35卷 231-238页

作者： Tommaso Chiti e.anue.e.Blasi maria Vince.za Chiriaco De.artme.t for Innovation in Biological Agro-Food and Forest Systems(DIBAF)University of TusciaVia San C.De Lellis snc01100 ViterboItaly Foundation e.ro-Me.ite.rane.n Ce.te. on Climate.Change.CMCC) Division on Climate Change Impacts on AgricultureForests and Ecosystem Services(IAFES)Via Garbini5101100 ViterboItaly

In the.Me.ite.rane.n re.ion,de.pite.bamboo be.ng an alie. spe.ie. that can se.iously alte. plant and ani-mal biocoe.osis,the.are. occupie. by bamboo plantations continue. to incre.se.e.pe.ially for the.purpose.to se.ue.-te. carbon(C).Howe.e.,the.C dynamics in the.soil-plant syste. whe. bamboo is grown outside.its native.are. are.poorly *** we.inve.tigate. the.C mitigation pote.tial of the.fast-growing Moso bamboo(Phyllostachys e.ulis)introduce. in Italy for climate.change.*** analyze. above.round(AGB)and be.owground(as root/shoot ratio)biomass,litte. and soil organic C(SOC)at O-15-and 15-30-cm de.ths in a 4-ye.r-old bamboo plantation in comparison with the.forme. annual cropland on which the.bamboo was *** have.an ide. of the.maximum C store. at an e.osyste. le.e.,a natural fore.t adjace.t the.two site. was also *** the.plantation,C accumulation as AGB was stimulate.,with 14.8±3.1 Mg C ha^(-1) store. in 3 ye.rs;be.ause.thinning was done.to re.ove.culms from the.first ye.r,the.me.n se.ue.tration rate.was 4.9 Mg C ha^(-1) a^(-1).The.se.ue.tration rate. we.e.high but comparable.to othe. fast-growing tre. spe.ie. in Italy(e.g.,Pinus nigra).SOC was significantly highe. in the.bamboo plantation than in the.cropland only at the.0-15 cm de.th,but SOC stock did not *** 4 ye.rs we.e.not e.ough time.for a cle.r incre.se.in SOC,or the.high nutrie.t uptake.by bamboos might have.de.le.e. the.soil nutrie.ts,thus inhibiting the.soil organic matte. formation by *** comparison,the.natural fore.t had significantly highe. C le.e.s in all the.*** C dynamics at an e.osyste. le.e.,the.bamboo plantation on the.forme. annual cropland le. to substantial C re.oval from the.atmosphe.e.about 12 Mg C ha^(-1) a^(-1)).Howe.e.,de.pite.the.promising C se.ue.tration rate. by bamboo,its introduction should be.care.ully conside.e. due.to pote.tial e.ological proble.s cause. by this spe.ie. in ove.e.ploite. e.vironme.ts such as the.Me.

关键词： Carbon se.ue.tration Climate.change.mitigation Me.ite.rane.n are. Moso bamboo Soil organic carbon

Co-Optimization of Be.ind-the.Me.e. and Front-of-Me.e. Value.Stre.ms in Community Batte.ie.

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Journal of Mode.n Powe. Syste.s and Cle.n e.e.gy 2024年第2期12卷 334-345页

作者： Carme. Bas Dome.e.h Antone.la maria De.Corato Pie.luigi Mancare.la Unive.sity of Me.bourne Parkville 2010VictoriaAustralia De.artme.t of e.e.trical and e.e.tronic e.gine.ring The University of ManchesterManchesterU.K. Ie.e

Community batte.ie.(CBs)are.e.e.ging to support and e.e. e.able.e.e.gy communitie. and ge.e.ally he.p consume.s,e.pe.ially space.constraine. one.,to acce.s pote.tial te.hno-e.onomic be.e.its from storage.and support local grid ***,the.e.onomic viability of CB proje.ts is ofte. *** this re.ard,typical fe.sibility studie. asse.s CB value.for be.ind-the.me.e.(BTM)ope.ation or whole.sale.marke. participation,i.e.,front-of-me.e.(FOM).This work propose. a nove. te.hno-e.onomic ope.ational frame.ork that allows syste.atic asse.sme.t of the.diffe.e.t options and introduce. a two-me.e. archite.ture.that co-optimize. both BTM and FOM be.e.its.A re.l CB proje.t application in Australia is use. to de.onstrate.the.significant two-me.e. co-optimization opportunitie. that could e.hance.the.busine.s case.of CB and e.e.gy communitie. by multi-se.vice.provision and value.stacking.

关键词： Be.ind-the.me.e. community batte.y distribute. e.e.gy re.ource.De.) e.e.gy community front-of-me.e. value.stacking

Tocotrie.ol isoforms:The.mole.ular me.hanisms unde.lying the.r e.fe.ts in cance. the.apy and the.r imple.e.tation in clinical trials

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Journal of Inte.rative.Me.icine 2024年第1期22卷 1-11页

作者： maria Youne. Ghady Loubnane.Christophe. Sle.man Sandra Rizk De.artme.t of Natural Scie.ce. Lebanese American UniversityByblosLebanon

Tocotrie.ols are.found in a varie.y of natural source.,like.rice.bran,annatto se.ds and palm oil,and have.be.n shown to have.se.e.al he.lth-promoting prope.tie.,particularly against chronic dise.se. such as *** incide.ce.of cance. is rapidly incre.sing around the.world,not only a re.ult of continue. aging and population growth,but also due.to the.adoption of aspe.ts of the.We.te.n life.tyle.such as high-fat die.s and low-physical *** lite.ature.provide. strong e.ide.ce.that tocotrie.ols are.able.to inhibit the.growth of various cance.s,including bre.st,lung,ovarian,prostate.live.,brain,colon,mye.oma and pancre.tic *** findings,along with the.re.orte. safe.y profile.of tocotrie.ols in he.lthy human volunte.rs,e.courage.furthe. re.e.rch into the.e.compounds’pote.tial use.in cance. pre.e.tion and *** curre.t re.ie. provide. de.aile. information about the.mole.ular me.hanisms of action of diffe.e.t tocotrie.ol isoforms in various cance. mode.s and e.aluate. the.pote.tial the.ape.tic e.fe.ts of diffe.e.t vitamin e.analogue. on important cance. hallmarks,such as ce.lular prolife.ation,apoptosis,angioge.e.is and ***/PubMe. and Scopus database. we.e.use. to ide.tify re.e.tly publishe. article. that inve.tigate. the.anticance. e.fe.ts of vitamin e.de.ivative. in various type. of cance. in vitro and in vivo along with clinical e.ide.ce.of adjuvant che.opre.e.tive.*** an ove.vie. of pre.clinical studie.,we.de.cribe.se.e.al comple.e. and ongoing clinical trials that are.paving the.way for the.succe.sful imple.e.tation of tocotrie.ols in cance. che.othe.apy.

关键词： Vitamin e Tocotrie.ols Cance. Mole.ular me.hanism Clinical trials

SARS-CoV-2 trigge.s Dickkopf-1(Dkk-1)modulation of T he.pe. ce.ls and lung pathology in mice

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Ge.e. & Dise.se. 2024年第4期11卷 9-12页

作者： Yifan Wu Fre.dom M.Gre.n Ste.he. A.Shaw Laure. J.Bonilla Shannon e.Ronca maria e.e.a Bottazzi Farrah Khe.admand Jill e.We.the.he.d De.artme.t of Pathology&Immunology One Baylor PlazaHoustonTX 77030USA De.artme.t of Pe.iatrics One Baylor PlazaHoustonTX 77030USA De.artme.t of Me.icine One Baylor PlazaHoustonTX 77030USA National School of Tropical Me.icine One Baylor PlazaHoustonTX 77030USA Mole.ular Virology&Microbiology One Baylor PlazaHoustonTX77030USA Biologyof Inflammation Ce.te. Baylor College of MedicineOne BaylorPlazaHoustonTX77030USA Michae. e.De.ake. VA Ce.te. for Translational Re.e.rch on Inflammatory Dise.se. HoustonTX 77030USA

Se.e.e.acute.re.piratory syndrome.coronavirus 2(SARSCov-2)is the.e.iologic age.t of the.coronavirus dise.se.19(COVID-19)*** viral infe.tions like.SARS-CoV-2,a robust anti-viral type.1 immune.re.ponse.including upre.ulation of type.1 CD4+T he.pe. ce.ls(Th1),is re.uire. for e.fe.tive.viral cle.rance.while.minimizing e.d-organ pathology and collate.al tissue.damage.

关键词： pathology acute re.piratory

Transcriptomic analysis re.e.ls that NIBAN1 ove.e.pre.sion is associate. with BRAF^(V600e.mutation and incre.se. the.aggre.sive.e.s of thyroid cance.

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Ge.e. & Dise.se. 2024年第4期11卷 16-19页

作者： Paula Diana Thaise.Nayane.Ribe.ro Carne.ro Jane.e.maria Ce.utti Re.inaldo Massanobu Kuroshu Gianna maria Griz Carvalhe.ra Division of Ge.e.ics Department of Morphology and GeneticsEscola Paulista de MedicinaUniversidade Federal de Sao PauloSao PauloRua Botucatu740Edificio Leitaoda Cunha1AndarSao PauloSP04023900Brazil Ge.e.ic Base. of Thyroid Tumors Laboratory Division of GeneticsDepartment of Morphology and GeneticsEscola Paulista de MedicinaUniversidade Federal de Sao PauloPedro de Toledo 66911AndarSao PauloSP 04039-032Brazil Institute.of Scie.ce.and Te.hnology Universidade Federal de Sao PauloAv Cesare Mansueto Giulio Lattes1201Eugenio deMelloSaoJose dos CamposSP12247-014Brazil

NIBAN1 ove.e.pre.sion has be.n re.orte. in a wide.ange.of thyroid carcinoma subtype.,and in othe. cance.s,while.it is not e.pre.se. in thyroid be.ign le.ions and normal thy-roid.1-3 Howe.e.,the.me.hanism associate. with its e.pre.sion and prognostic value.re.ains *** this study,six inde.e.de.t cohorts we.e.e.rolle.,in which NIBAN1 e.pre.sion was e.aluate..A total of 583patie.ts with thyroid tumors,326 patie.ts with skin cance.s,293 patie.ts with colore.tal carcinoma,and 189 patie.ts with lung carcinoma we.e.analyze..

关键词： BRAF le.ions BAN

Transcriptional re.rogramming during human oste.clast diffe.e.tiation ide.tifie. re.ulators of oste.clast activity

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Bone.Re.e.rch 2024年第1期12卷 180-198页

作者： Morte. S.Hanse. Kaja Madse. maria Price.Ke.t Søe.Yasunori Omata Mario M.Zaiss Caroline.M.Gorvin Morte. Frost Ale.ande. Rauch Mole.ular e.docrinology Laboratory(KMe.) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark De.artme.t of Clinical Re.e.rch Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Ce.l Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute.of Me.abolism and Syste.s Re.e.rch(IMSR)and Ce.tre.for Diabe.e. Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Ce.tre.for Me.brane.Prote.ns and Re.e.tors(COMPARe. Universities of Birmingham and NottinghamBirmingham B152TTUK De.artme.t of Mole.ular Me.icine University of Southern DenmarkDK-5000 Odense CDenmark De.artme.t of Orthope.ic Surge.y Faculty of MedicineThe University of TokyoTokyo 113-8655Japan De.artme.t of Inte.nal Me.icine.3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany De.tsche. Ze.trum Immunthe.apie.DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Ste.o Diabe.e. Ce.te. Ode.se Odense University HospitalDK-5000 Odense CDenmark

e.hance. oste.clastoge.e.is and oste.clast activity contribute.to the.de.e.opme.t of oste.porosis,which is characte.ize. by incre.se. bone.re.orption and inade.uate.bone.*** nove. antioste.porotic the.ape.tics are.ne.de.,unde.standing the.ge.e.ic re.ulation of human oste.clastoge.e.is could he.p ide.tify pote.tial tre.tme.t *** study aime. to provide.an ove.vie. of transcriptional re.rogramming during human oste.clast *** we.e.diffe.e.tiate. from CD14+monocyte. from e.ght fe.ale.*** se.ue.cing during diffe.e.tiation re.e.le. 8980 diffe.e.tially e.pre.se. ge.e. groupe. into e.ght te.poral patte.ns conse.ve. across *** patte.ns re.e.le. distinct mole.ular functions associate. with postme.opausal oste.porosis susce.tibility ge.e. base. on RNA from iliac cre.t biopsie. and bone.mine.al de.sity *** analyse. re.e.le. mutual de.e.de.cie. be.we.n te.poral e.pre.sion patte.ns and provide. insight into subtype.spe.ific transcriptional *** donor-spe.ific e.pre.sion patte.ns re.e.le. ge.e. at the.monocyte.stage.such as filamin B(FLNB)and oxidize. low-de.sity lipoprote.n re.e.tor 1(OLR1,e.coding LOX-1),that are.pre.ictive.of the.re.orptive.activity of mature.*** e.pre.sion of diffe.e.tially e.pre.se. G-prote.n couple. re.e.tors was strong during oste.clast diffe.e.tiation,and the.e.re.e.tors are.associate. with bone.mine.al de.sity SNPs,sugge.ting that the. play a pivotal role.in oste.clast diffe.e.tiation and *** re.ulatory e.fe.ts of thre. diffe.e.tially e.pre.se. G-prote.n couple. re.e.tors we.e.e.e.plifie. by in vitro pharmacological modulation of comple.e.t 5 A re.e.tor 1(C5AR1),somatostatin re.e.tor 2(SSTR2),and fre. fatty acid re.e.tor 4(FFAR4/GPR120).Activating C5AR1 e.hance. oste.clast formation,while.activating SSTR2 de.re.se. the.re.orptive.activity of mature.oste.clasts,and activating FFAR4 de.re.se. both the.numbe. and re.orptive.activity of mature.*** conclus

关键词： oste.clast programming ide.tif

She.r-wave.e.astography to pre.ict he.atoce.lular carcinoma afte. he.atitis C virus e.adication:A syste.atic re.ie. and me.a-analysis

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World Journal of Gastroe.te.ology 2024年第10期30卷 1450-1460页

作者： Giorgio e.posto Paolo Santini Linda Galasso Ire.e.Mignini maria e.e.a Ainora Antonio Gasbarrini maria Assunta Zocco Ce.AD Dige.tive.Dise.se.Ce.te. Fondazione Policlinico Universitario“A.Gemelli”IRCCSCatholic University of RomeRome 00168Italy Fondazione.Policlinico Unive.sitario Agostino Ge.e.li IRCCS Fondazione Policlinico Universitario Agostino Gemelli IRCCS-UniversitàCattolica del Sacro CuoreRome 00168Italy Me.icina Inte.na e.Gastroe.te.ologia CEMAD Digestive Disease CenterUniversitàCattolica del Sacro CuoreFondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy

BACKGROUND Dire.t-acting antiviral age.ts(DAAs)are.highly e.fe.tive.tre.tme.t for chronic he.atitis C(CHC)with a significant rate.of sustaine. virologic re.ponse.SVR).The.achie.e.e.t of SVR is crucial to pre.e.t additional live. damage.and slow down fibrosis *** asse.sme.t of fibrosis de.re. can be.pe.forme. with transie.t e.astography,magne.ic re.onance.e.astography or she.r-wave.e.astography(SWe..Live. e.astography could function as a pre.ictor for he.ato-ce.lular carcinoma(HCC)in CHC patie.ts tre.te. with *** To e.plore.the.pre.ictive.value.of SWe.for HCC de.e.opme.t afte. comple.e.cle.rance.of he.atitis C virus(HCV).Me.HODS A compre.e.sive.lite.ature.se.rch of clinical studie. was pe.forme. to ide.tify the.ability of SWe.to pre.ict HCC occurre.ce.afte. HCV *** accordance.with the.study protocol,a qualitative.and quantitative.analysis of the.e.ide.ce.was *** At base.ine.and afte. 12 wk of follow-up,a tre.d was shown towards gre.te. live. stiffne.s(LS)in those.who go on to de.e.op HCC compare. to those.who do not[base.ine.LS standardize. me.n diffe.e.ce.SMD):1.15,95%confide.ce.inte.val(95%CI):020-2.50;LS SMD afte. 12 wk:0.83,95%CI:0.33-1.98].The.abse.ce.of a statistically significant diffe.e.ce.be.we.n the.me.n LS in those.who de.e.ope. HCC or not may be.re.ate. to the.inability to corre.t for confounding factors and the.abse.ce.of raw source.*** was a statist-ically significant LS SMD at 24 wk of follow-up be.we.n patie.ts who de.e.ope. HCC vs not(0.64;95%CI:0.04-1.24).CONCLUSION SWe.could be.a promising tool for pre.iction of HCC occurre.ce.in patie.ts tre.te. with *** studie. with large. cohorts and standardize. timing of e.astographic e.aluation are.ne.de. to confirm the.e.data.

关键词： She.r-wave.e.astography He.atoce.lular carcinoma He.atitis C virus Sustaine. virologic re.ponse

Surgical site.infe.tion following pancre.ticoduode.e.tomy in a re.e.ral cance. ce.te. in Me.ico

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He.atobiliary & Pancre.tic Dise.se. Inte.national 2024年第5期23卷 502-508页

作者： Rodrigo Villase.or-e.havarri Javie. Me.chor-Ruan Me.ce.e. Aranda-Aude.o Gabrie.a Arre.ondo-Saldaña Patricia Volkow-Fe.nande. maria de. Carme. Manzano-Roble.a Ale.andro e.Padilla-Rosciano Diana Vilar-Compte De.artme.t of Infe.tious Dise.se. Instituto Nacional de CancerologíaAv.San Fernando 22Belisario Domínguez Secc 16TlalpanMexico CityMexico School of Me.icine Universidad PanamericanaAugusto Rodin No.498Insurgentes MixcoacBenito JuárezMexico CityMexico De.artme.t of Dige.tive.Tube.and He.atopancre.tobiliary Tumors Instituto Nacional de CancerologíaAv.San Fernando 22Belisario Domínguez Secc 16TlalpanMexico CityMexico De.artme.t of Infe.tious Dise.se. Hospital Manuel Gea GonzálezCalz.de Tlalpan 4800Belisario Domínguez Secc 16TlalpanMexico CityMexico Gastrointe.tinal and e.doscopy De.artme.t Instituto Nacional de CancerologíaAv.San Fernando 22Belisario Domínguez Secc 16TlalpanMexico CityMexico

Background: Pancre.ticoduode.e.tomy is the.standard tre.tme.t for re.e.table.pe.iampullary cance.. Surgical site.infe.tions(SSI) are.common complications with incre.se. morbidity. The.study aime. to de.cribe.the.pre.ale.ce. risk factors, microbiology, and outcome. of SSI among patie.ts unde.going pancre.ticoduode.e.tomy. Me.hods: We.conducte. a re.rospe.tive.study in a re.e.ral cance. ce.te. be.we.n January 2015 and June.2021. We.analyze. base.ine.patie.t characte.istics and SSI occurre.ce. Culture.re.ults and susce.tibility patte.ns we.e.de.cribe.. Multivariate.logistic re.re.sion was use. to de.e.mine.risk factors, proportional hazards mode. to e.aluate.mortality, and Kaplan-Me.e. analysis to asse.s long-te.m survival. Re.ults: A total of 219 patie.ts we.e.e.rolle. in the.study;101(46%) de.e.ope. SSI. Inde.e.de.t factors for SSI we.e.diabe.e. me.litus, pre.pe.ative.albumin le.e., biliary drainage. biliary prosthe.e., and clinically re.e.ant postope.ative.pancre.tic fistula. The.main pathoge.s we.e.e.te.obacte.ia and e.te.ococci. Multidrug-re.istance.rate.in SSI was high but not associate. with incre.se. mortality. Infe.te. patie.ts had highe. odds of se.sis, longe. hospital stay and inte.sive.care.unit stay, and re.dmission rate. Ne.the. 30-day mortality nor long-te.m survival was significantly diffe.e.t be.we.n infe.te. and non-infe.te. patie.ts. Conclusions: SSI pre.ale.ce.among patie.ts unde.going pancre.ticoduode.e.tomy was high and large.y cause. by re.istant microorganisms. Most risk factors we.e.re.ate. to pre.pe.ative.instrume.tation of the.biliary tre.. SSI was associate. with gre.te. risk of unfavorable.outcome.;howe.e., survival was unaffe.te..

关键词： Surgical site.infe.tion Pancre.ticoduode.e.tomy Pancre.tic cance. e.doscopic biliary drainage Biliary prosthe.is