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Liver volumetric and anatomic assessment in living donor liver transplantation: The role of modern imaging and artificial intelligence

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World Journal of Transplantation 2023年第6期13卷 290-298页

作者： Mayara Machry Luis Fernando ferreira Angelica maria Lucchese Antonio Nocchi Kalil Flavia Heinz Feier Department of Hepato-Biliary-Pancreatic Surgery and Liver Transplantation Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Brazil Postgraduation Program in Medicine:Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Brazil

The shortage of deceased donor organs has prompted the development of alternative liver grafts for ***-donor liver transplantation(LDLT)has emerged as a viable option,expanding the donor pool and enabling timely transplantation with favorable graft function and improved long-term *** accurate evaluation of the donor liver’s volumetry(LV)and anatomical study is crucial to ensure adequate future liver remnant,graft volume and precise liver ***,ensuring donor safety and an appropriate graftto-recipient weight *** LV(MLV)using computed tomography has traditionally been considered the gold standard for assessing liver ***,the method has been limited by cost,subjectivity,and *** LV techniques employing advanced segmentation algorithms offer improved reproducibility,reduced variability,and enhanced efficiency compared to manual ***,the accuracy of automated LV requires further *** study provides a comprehensive review of traditional and emerging LV methods,including semi-automated image processing,automated LV techniques,and machine learning-based ***,the study discusses the respective strengths and weaknesses of each of the aforementioned *** use of artificial intelligence(AI)technologies,including machine learning and deep learning,is expected to become a routine part of surgical planning in the near *** implementation of AI is expected to enable faster and more accurate image study interpretations,improve workflow efficiency,and enhance the safety,speed,and cost-effectiveness of the *** preoperative assessment of the liver plays a crucial role in ensuring safe donor selection and improved outcomes in *** has inherent limitations that have led to the adoption of semi-automated and automated software ***,AI has tremendous potential for LV and segmentation;however,its widespread use is hindered

关键词： Liver transplantation Living-donor Diagnostic imaging Artificial intelligence Machine learning Deep learning

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ENERGY ESTIMATES FOR DELAY DIFFUSION-REAcTION EQUATIONS

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Journal of computational Mathematics 2008年第4期26卷 536-553页

作者： J.A.ferreira P.M.daSilva cMUc-Departamento Departamento

In this paper we consider nonlinear delay diffusion-reaction equations with initial and Dirichlet boundary conditions. The behaviour and the stability of the solution of such initial boundary value problems （IBVPs） are studied using the energy method. Simple numerical methods are considered for the computation of numerical approximations to the solution of the nonlinear IBVPs. Using the discrete energy method we study the stability and convergence of the numerical approximations. Numerical experiments are carried out to illustrate our theoretical results.

关键词： Delay diffusion reaction equation Energy method Stability convergence.

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combined Oxidative Phosphorylation Deficiency-20-Exome as a Diagnostic Implement

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Journal of Biosciences and Medicines 2024年第6期12卷 7-12页

作者： Paulo Roberto Matos-Neto Lucas Antonissen Lima Verde Airton ferreira da Ponte-Filho Luís Eduardo Oliveira Matos Amandha Espavier Trés Paulo Roberto Lacerda Leal Gerardo cristino-Filho Regina coeli de carvalho Porto carneiro Faculty of Medicine Federal University of Cear Sobral Cear Brazil Department of Neurosurgery Federal University of Cear Sobral Cear Brazil Department of Neuropediatrics Federal University of Cear Sobral Cear Brazil

Mitochondrial disorders are phenotypically varied, with serious clinical repercussions. Among them, there is the deficiency of combined oxidative phosphorylation of type 20, which occurs due to a defect in the VARS2 gene. This article presents a case of a 2-year-old female with progressive myoclonic epilepsy and psychomotor regression, with refractoriness to multiple anticonvulsants. The diagnosis was only made after the examination was carried out. Therefore, this article highlights the aspects of this rare disease and the importance of the exome for the diagnosis of rare conditions.

关键词： Oxidative Phosphorylation Epilepsy Exome Mitochondrial Defect VARS2

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Surgical and immune reconstitution murine models in bone marrow research: Potential for exploring mechanisms in sepsis, trauma and allergy

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World Journal of Experimental Medicine 2017年第3期7卷 58-77页

作者： Pedro Xavier-Elsas Renato Nunes ferreira maria Ignez c Gaspar-Elsas Department of Immunology Instituto de Microbiologia Paulo de GóesUniver-sidade Federal do Rio de Janeiro Department of Pediatrics Instituto Nacional de Saúde da Mulherda Crian?a e do Adolescente Fer-nandes FigueiraFIOCRUZ

Bone marrow, the vital organ which maintains lifelong hemopoiesis, currently receives considerable attention, as a source of multiple cell types which may play important roles in repair at distant sites. This emerging function, distinct from, but closely related to, bone marrow roles in innate immunity and inflammation, has been characterized through a number of strategies. However, the use of surgical models in this endeavour has hitherto been limited. Surgical strategies allow the experimenter to predetermine the site, timing, severity and invasiveness of injury; to add or remove aggravating factors(such as infection and defects in immunity) in controlled ways; and to manipulate the context of repair, including reconstitution with selected immune cell subpopulations. This endows surgical models overall with great potential for exploring bone marrow responses to injury, inflammation and infection, and its roles in repair and regeneration. We review three different murine surgical models, which variously combine trauma with infection, antigenic stimulation, or immune reconstitution, thereby illuminating different aspects of the bone marrow response to systemic injury in sepsis, trauma and allergy. They are:(1) cecal ligation and puncture, a versatile model of polymicrobial sepsis;(2) egg white implant, an intriguing model of eosinophilia induced by a combination of trauma and sensitization to insoluble allergen; and(3) ectopic lung tissue transplantation, which allows us to dissect afferent and efferent mechanisms leading to accumulation of hemopoietic cells in the lungs. These models highlight the gain in analytical power provided by the association of surgical and immunological strategies.

关键词： Bone-marrow Trauma Repair Transplantation Surgery

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Analysis of the impact of large scale seismic retrofitting strategies through the application of a vulnerability-based approach on traditional masonry buildings

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Earthquake Engineering and Engineering Vibration 2017年第2期16卷 329-348页

作者： Tiago Miguel ferreira Rui Maio Romeu Vicente ISISE Department of Civil EngineeringUniversity of MinhoCampus de Azurém RIScO Department of Civil EngineeringUniversity of AveiroCampus Universitário de Santiago

The buildings＇ capacity to maintain minimum structural safety levels during natural disasters, such as earthquakes, is recognisably one of the aspects that most influence urban resilience. Moreover, the public investment in risk mitigation strategies is fimdamental, not only to promote social and urban and resilience, but also to limit consequent material, human and environmental losses. Despite the growing awareness of this issue, there is still a vast number of traditional masonry buildings spread throughout many European old city centres that lacks of adequate seismic resistance, requiring therefore urgent retrofitting interventions in order to both reduce their seismic vulnerability and to cope with the increased seismic requirements of recent code standards. Thus, this paper aims at contributing to mitigate the social and economic impacts of earthquake damage scenarios through the development of vulnerability-based comparative analysis of some of the most popularretrofitting techniques applied after the 1998 Azores earthquake. The influence of each technique individually and globally studied resorting to a seismic vulnerability index methodology integrated into a GIS tool and damage and loss scenarios are constructed and critically discussed. Finally, the economic balance resulting from the implementation of that techniques are also examined.

关键词： urban resilience masonry buildings retrofitting strategies vulnerability-based approach loss estimation

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Personalized medicine:clinical oncology on molecular view of treatment

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World Journal of clinical Oncology 2024年第8期15卷 992-1001页

作者： Rafick costa dos Santos Da Silva Nathalia de Andrade Simon AndréAlves dos Santos Gabriel De Melo Olegário Jayne ferreira Da Silva Naide Oliveira Sousa Manuel Alvarez Troncoso corbacho Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória Da Conquista 45029-094BahiaBrazil

cancer,the second leading global cause of death,impacts both physically and *** treatments such as surgeries,chemotherapy,and radiotherapy have adverse effects,driving the need for more precise *** medicine enables more targeted *** mapping,alongside other molecular biology approaches,identifies specific genes,contributing to accurate *** review addresses,in clinical use,a molecular perspective on *** like alpha-fetoprotein,beta-human chorionic gonadotropin,5-hydroxyindoleacetic acid,programmed death-1,and cytotoxic T lymphocyte-associated protein 4 are explored,providing valuable ***,with an emphasis on artificial intelligence,revolutionizes the analysis of biological data,offering more accurate *** like liquid biopsy are emphasized for early *** medicine guides therapeutic strategies based on the molecular characteristics of the tumor,as evidenced in the molecular subtypes of breast *** allow personalized treatments,highlighting the role of trastuzumab and endocrine *** the benefits,challenges persist,including high costs,tumor heterogeneity,and ethical *** obstacles requires collaboration,ensuring that advances in molecular biology translate into accessible benefits for all.

关键词： Oncology Neoplasia Molecular biology Personalized medicine Molecular Markers cancer

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Physical activity and emotions in a period of social distancing due to the cOVID-19 pandemic

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Sports Medicine and Health Science 2022年第3期4卷 172-176页

作者： Raphaela Espanha corrêa Paulo Eduardo Neves ferreira Velho Rafael do Prado calazans calvino camargo Rute Estanislava Tolocka Postgraduate Program in clinical Medicine Faculty of Medical SciencesUniversidade Estadual de Campinas-UNICAMPCampinasSP13083-887Brazil Department of Dermatology Faculty of Medical SciencesUniversidade Estadual de Campinas-UNICAMPCampinasSP13083-887Brazil Postgraduate Program in Human Movement Sciences Universidade Metodista de Piracicaba-UNIMEPPiracicabaSP13390-000Brazil Health Science Graduate Program Universidade Federal de Roraima-UFRRBoa VistaRR69310-000Brazil

Social distancing(SD)to prevent SARS-coV-2(cOVID-19)transmission reduced practices of physical activities(PA)and changed emotional conditions,but the relationship between PA and the emotions has to be further *** study aimed to analyze PA and the intensity of basic emotions during a period of social distancing in the State of S~ao Paulo,*** collection was performed using the snowball system and an online survey with questions about the minimum weekly frequency of 30-min moderate and/or vigorous activities(MVPA),intensity of basic emotions,and sociodemographic profile.A total of 704 volunteers participated;mean age 38.113.4 years,67.9%female,82.0%insufficiently practiced MVPA,and 37.9%of the group reported no weekly ***/fear was the emotion with the highest intensity in the study period.A significant association was observed between PA and intensity of happiness(rho=0.125;pciation between PA practice and intensity of anxiety/fear(rho=-0.090;pciation was observed between anxiety/fear and social isolation(rho=0.082;pc policies offering PA programs and psychological care are required to improve the quality of life of the population.

关键词： Emotions expressed Physical activity Quarantine cOVID-19

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Seasonal testicular changes in Dendropsophus minutus Peters, 1872 (Anura, Hylidae)

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BIOcELL 2012年第2期36卷 57-62页

作者： ADELINA ferreira MAHMOUD MEHANNA Universidade Federal de Mato Grosso(UFMT) Instituto de BiociênciasCuiabáMTBrasil Universidade Estadual Paulista Julio de Mesquita Filho(UNESP) Laboratório de Biologia de PeixesPós-graduação em ZoologiaBotucatuSPBrasil

The reproductive cycle in anurans may be either continuous or *** differences may be connected to seasonal climate changes and/or to anthropic *** adult male individuals of the Dendropsophus minutus species were collected during one year,in the municipality of chapada dos Guimarães(Mato Grosso,Brazil).The testicles were studied under light and transmission electron *** variations were observed when the diameter of the seminiferous tubules and the thickness of the interstitial tissue were ***,changes in spermatogenesis were conspicuous and indicated that the reproductive cycle of *** in chapada dos Guimarães is discontinuous and seems related to variations in air temperature and rainfall.

关键词： spermatogenesis reproduction anura ultrastructure chapada dos Guimarães

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communicating with the non-dominant hemisphere:Implications for neurological rehabilitation

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Neural Regeneration Research 2013年第13期8卷 1236-1246页

作者： Fabricio ferreira de Oliveira Sheilla de Medeiros correia Marin Paulo Henrique ferreira Bertolucci Department of Neurology and Neurosurgery Escola Paulista de Medicina Federal University of So Paulo (UNIFESP) So Paulo SP

Aphasic syndromes usually result from injuries to the dominant hemisphere of the brain. Despite the fact that localization of language functions shows little interindividual variability, several brain areas are simultaneously activated when language tasks are undertaken. Mechanisms of language recovery after brain injury to the dominant hemisphere seem to be relatively stereotyped, including activations of perilesional areas in the acute phase and of homologues of language areas in the non-dominant hemisphere in the subacute phase, later returning to dominant hemisphere activation in the chronic phase. Plasticity mechanisms reopen the critical period of language development, more specifically in what leads to disinhibition of the non-dominant hemisphere when brain lesions affect the dominant hemisphere. The non-dominant hemisphere plays an important role during recovery from aphasia, but currently available rehabilitation therapies have shown limited results for efficient language improvement. Large-scale randomized controlled trials that evaluate well-defined interventions in patients with aphasia are needed for stimulation of neuroplasticity mechanisms that enhance the role of the non-dominant hemisphere for language recovery. Ineffective treatment approaches should be replaced by more promising ones and the latter should be evaluated for proper application. The data generated by such studies could substantiate evidence-based rehabilitation strategies for patients with aphasia.

关键词： neural regeneration reviews linguistics aphasia language speech non-dominant hemisphere disability evaluation prognosis cerebrum function grants-supported paper neuroregeneration

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Thermal and photoperiodic requirements of the seedling stage of three tropical forest species

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Journal of Forestry Research 2023年第1期34卷 209-220页

作者： Fabrina Bolzan Martins Mábele de cássia ferreira Flávia Fernanda Azevedo Fagundes Gabriel Wilson Lorena Florêncio Natural Resource Institute Federal University of ItajubáItajubáMinas Gerais 37500-903Brazil

Air temperature and photoperiod play an important role in the seedling development for tropical forest *** variables are sensitive to climate,and so evaluating thermal and photoperiodic effects on seedling development is fundamental,especially for climate change *** to quantify thermal time and the energy required for plants to reach a development stage include air temperature and cardinal *** photoperiod will also affect physiological reactions of a plant and thus its *** we evaluated the six thermal time methods widely used to compute thermal requirement,and identified the influence of the photoperiod from the 2015 and2016 growing seasons and 12 sowing dates in Itajubá,Minas Gerais state,Brazil,on seedling development of three native tropical forest species Psidium guajava L.(Myrtaceae),citharexylum myrianthum cham.(Verbenaceae),and Bixa orellana L.(Bixaceae).The method used to quantify thermal time influenced the analytical results of seedling development;the one that considered three cardinal temperatures and compared them with the mean air temperature(Method5)performed better in computing thermal *** influence of photoperiod on seedling development was inconclusive for the three species,but all three developed better in mild temperatures(between 13.3℃and 26.9℃)with a photoperiod shorter than 13 h.

关键词： Phyllochron Thermal time Day length Seedling stage Phenology

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