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Ferric carboxymaltose for anemia in Crohn’s disease patients at a tertiary center:A retrospective observational cohort study

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World Journal of Clinical Cases 2023年第12期11卷 2740-2752页

作者： Natália Souza Nunes Siqueira Livia Bitencourt Pascoal Bruno Lima Rodrigues Marina Moreira de Castro Alan Sidnei Corrêa Martins Dante Orsetti Silva Araújo Luis Eduardo Miani Gomes Michel Gardere Camargo maria de lourdes setsuko ayrizono Raquel Franco Leal Inflammatory Bowel Disease Research Laboratory GastrocenterColorectal Surgery UnitSchool of Medical SciencesUniversity of Campinas(Unicamp)Campinas 13083-878São PauloBrazil

BACKGROUND Although the gastrointestinal tract is the most affected by Crohn’s disease(CD),the condition triggers other consequent manifestations,and iron deficiency anemia(IDA)is one of the most ***(IV)iron replacement is currently available through several drugs,such as ferric hydroxide sucrose and ferric carboxymaltose(FCM).However,the clinical management of these conditions can be *** To elucidate the drug’s effectiveness,the present study analyzed,through medical records,the clinical and epidemiological data of a cohort of patients with active CD who received IV FCM for the IDA *** This retrospective observational study included 25 patients with active CD,severe anemia,and refractory to previous conventional *** were evaluated two times:During the last treatment with ferric hydroxide sucrose and treatment with *** After treatment with FCM,parameters of IDA assessment significantly improved,serum hemoglobin(Hb)levels increased in 93%of patients(Pdeveloped CD later in life after the age of 40(A3)and with a stenosing(B2)and fistulizing(B3)*** values of Hb and hematocrit after ferric hydroxide sucrose treatment remained similar to those found before *** This study demonstrated that FCM is an important therapeutic strategy for treating IDA in CD patients,achieving satisfactory results in refractory cases.

关键词： Ferric carboxymaltose Iron deficiency anemia Crohn’s disease Inflammatory bowel disease Anemia Clinical management

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Role of diet and nutrition in inflammatory bowel disease

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World Journal of Experimental Medicine 2021年第1期11卷 1-16页

作者： Marina Moreira de Castro Lívia Bitencourt Pascoal Karine mariane Steigleder Beatriz Piatezzi Siqueira Ligiana Pires Corona maria de lourdes setsuko ayrizono Marciane Milanski Raquel Franco Leal IBD Research Laboratory Colorectal Surgery UnitSchool of Medical SciencesUniversity of Campinas(UNICAMP)Campinas 13083-878São PauloBrazil Laboratory of Metabolic Disorders School of Applied SciencesUniversity of Campinas(UNICAMP)Campinas 13083-878São PauloBrazil Laboratory of Metabolic Disorders School of Applied SciencesUniversity of Campinas(UNICAMP)Limeira 13484-350São PauloBrazil Laboratory of Nutritional Epidemiology School of Applied SciencesUniversity of Campinas(UNICAMP)Limeira 13484-350São PauloBrazil

Inflammatory bowel diseases(IBDs)are closely linked to *** latest research indicates that diet and nutrition are significantly involved in the etiopathogenesis of the disease,although their specific role throughout its clinical course still remains *** study reviewed how diet and nutrition are associated with IBD development and *** though specific diets have been shown to bring about positive outcomes,there is currently no scientific consensus regarding an appropriate diet that would benefit all IBD *** suggest that individualized dietary recommendations are of the greatest importance and that diets should be planned to provide individual IBD patients with specific nutrient requirements while keeping all the clinical aspects of the patients in *** research is clearly necessary to investigate nutritional factors involved in IBD development and,especially,to evaluate the applications of the diets during the course of the disease.

关键词： Crohn’s disease Ulcerative colitis Inflammatory bowel disease Diet Nutrition

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