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Dynamic contrast enhanced ultrasound in differential diagnosis of hepatocellular carcinoma: A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2804-2815页

作者： Giorgio Esposto Paolo Santini Fabrizio Termite Linda Galasso Irene Mignini maria Elena Ainora Antonio Gasbarrini maria Assunta Zocco Department of CEMAD Digestive Disease Center Fondazione Policlinico Universitario A Gemelli IRCCSCatholic University of RomeRome 00168Italy Department of Fondazione Policlinico Universitario Agostino Gemelli IRCCS UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Medicina Interna e Gastroenterologia CEMAD Digestive Disease CenterFondazione Policlinico Universitario A Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy

BACKGROUND Non-invasive differential diagnosis between hepatocellular carcinoma(HCC)and other liver cancer(*** or metastasis)is highly challenging and definitive diagnosis still relies on histological *** patterns of enhancement and wash-out of liver nodules can be used to stratify the risk of malignancy only in cirrhotic patients and HCC frequently shows atypical *** contrast-enhanced ultrasound(DCEUS)with standardized software could help to overcome these obstacles,providing functional and quantitative parameters and potentially improving accuracy in the evaluation of tumor *** To explore clinical evidence regarding the application of DCEUS in the differential diagnosis of liver *** A comprehensive literature search of clinical studies was performed to identify the parameters of DCEUS that could relate to histological *** accordance with the study protocol,a qualitative and quantitative analysis of the evidence was *** Rise time was significantly higher in HCC patients with a standardized mean difference(SMD)of 0.83(95%CI:0.48-1.18).Similarly,other statistically significant parameters were mean transit time local with a SMD of 0.73(95%CI:0.20-1.27),peak enhancement with a SMD of 0.37(95%CI:0.03-0.70),area wash-in area under the curve with a SMD of 0.47(95%CI:0.13-0.81),wash-out area under the curve with a SMD of 0.55(95%CI:0.21-0.89)and wash-in and wash-out area under the curve with SMD of 0.51(95%CI:0.17-0.85).SMD resulted not significant in fall time and wash-in rate,but the latter presented a trend towards greater values in HCC compared to intrahepatic *** DCEUS could improve non-invasive diagnosis of HCC,leading to less liver biopsy and early *** quantitative analysis needs to be applied on larger cohorts to confirm these preliminary results.

关键词： Dynamic contrast enhanced ultrasound Hepatocellular carcinoma Intracellular cholangiocarcinoma Quantitative ultrasound Liver cancer Time-intensity curve

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Impact of multifocal gas-permeable lens designs on short-term choroidal response, axial length, and retinal defocus profile

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 247-256页

作者： Muteb Alanazi Patrick Caroline Amane Alshamrani maria Liu Optometry Department College of Applied Medical SciencesKing Saud UniversityRiyadh 14813Saudi Arabia College of Optometry Pacific UniversityForest GroveOregon 97116-1756United States Optometry School University of California at BerkeleyCalifornia 94720United States

AIM:To investigate the impact of multifocal gas permeable contact lens(MFGPCL)in various add power and distance/near area allocation on short-term changes of choroidal thickness(ChT),axial length(AL),and retinal defocus profile in young ***:Seventeen young adults(2 males and 15 females;age 23.17±4.48y)were randomly assigned to wear two designs binocularly with a one-week washout period in *** of four MFGPCL designs were *** designs were distance-center that varied in two add power(+1.50 and 3.00 D)and/or two distance zone(DZ)diameters(1.50 and 3.00 mm;design A:DZ 1.5/add 3.0,B:DZ 1.5/add 1.5,C:DZ 3.0/add 3.0,D:DZ 3.0/add 1.5).ChT,AL,and peripheral refraction data were collected on each subject at baseline,on days 1 and 7 of MFGPCL daily *** was assessed in four quadrants using a spectraldomain optical coherence ***:AL was shortened by-26±44μm with lens C,-18±27μm with lens D,-13±29μm with lens A,and-8±30μm with lens B(all P<0.05).A significant overall increase in ChT was observed with all 4 designs(lens A:+6±6μm,B:+3±7μm,C:+8±7μm,and D:+8±7μm).Temporal and superior choroid exhibited more choroidal thickening associated with *** designs induced significant relative peripheral myopia(RPM)beyond the central 20o across the horizontal meridian in both nasal and temporal fields(P<0.05).CONCLUSION:MFGPCLs show a significant influence on ChT and AL,which are associated with significant increase in RPM after short-term *** reliability and feasibility of quantifying short-term changes in ChT support its use as a promising marker for the long-term efficacy of myopia-controlling treatments.

关键词： choroid gas-permeable contact lens retinal defocus axial length myopia

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A C-shaped hinge for displacement magnification in MEMS rotational structures

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Microsystems & Nanoengineering 2024年第1期10卷 55-66页

作者： Naga Manikanta Kommanaboina Teferi Sitotaw Yallew Alvise Bagolini maria F.Pantano Department of Civil Environmental and Mechanical EngineeringUniversity of Trentovia Mesiano 7738123 TrentoItaly Fondazione Bruno Kessler(FBK) Microsystems Technology(MST)via S.Croce 7738122 TrentoItaly

The design,analysis,fabrication,and characterization of two distinct MEMS rotational structures are provided;these structures include a classical symmetrical lancet structure and a novel symmetrical C-shaped structure provided with a tilted arm,and both are actuated by thermal *** proposed C-shaped structure implemented a curved beam mechanism to enhance the movement delivered by the thermal *** geometrical parameters of our proposed device were optimized using the design of experiment(DOE)***,the analytical modeling based on Castigliano’s second theorem and the simulations based on the finite element method(FEM)were used to predict the behavior of the symmetrical C-shaped structure;the results were in good agreement with each *** MEMS-based rotational structures were fabricated on silicon-on-insulator(SOI)wafers using bulk micromachining technology and deep reactive ion etching(DRIE)*** fabricated devices underwent experimental characterization;our results showed that our proposed MEMS rotational structure exhibited a 28%improvement in the delivered displacement compared to the symmetrical lancet ***,the experimental results showed good agreement with those obtained from numerical *** proposed structures have potential applications in a variety of MEMS devices,including accelerometers,gyroscopes,and resonators,due to their ability to maximize displacement and thus enhance sensitivity.

关键词： shaped displacement structures

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Could mammalian inorganic polyphosphate be a crucial signaling molecule in neurological disorders?

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Neural Regeneration Research 2024年第4期19卷 701-702页

作者： Renata Torres Da Costa maria E.Solesio Rutgers University Department of BiologyCamdenNJUSA

Since the early stages of life on earth,cellular metabolism has evolved to adapt to fluctuations in nutrient and oxygen *** this context,mammals,which are probably the organisms that show one of the highest levels of metabolic complexity,have developed an elegant system that uses constant and rechargeable energy sources of modulate their *** homeostasis is especially important in the central nervous system,as neurons and other cells in the brain are highly susceptible to fluctuations in nutrients and oxygen availability.

关键词： metabolism homeostasis neurological

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Efficacy of acupuncture on cancer pain:A systematic review and meta-analysis

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Journal of Integrative Medicine 2024年第3期22卷 235-244页

作者： Miguel Faria Mónica Teixeira maria João Pinto Paulo Sargento Núcleo de Investigação em Ciências e Tecnologias da Saúde Instituto Politécnico da Lusofonia1950-396 LisboaPortugal Clínica São João de Deus 1700-048 LisboaPortugal REQUIMTE/LAQV(Rede de Química e Tecnologia/Laboratório Associado para a Química Verde) Instituto Superior de EngenhariaInstituto Politécnico do Porto4051-401 PortoPortugal Hospital SOERAD 2560-312 Torres VedrasPortugal Centro de Estudos Avançados em Direito“Francisco Suarez ”1749-024 LisboaPortugal

Background:Pain associated with cancer is one of the greatest causes of reduced quality of life in *** is one of the treatments used to address this issue,with the great advantage of having little or no side effects,especially when compared with pharmacological ***:The aim of this systematic review and meta-analysis was to evaluate the current evidence regarding the efficacy of acupuncture for cancer *** strategy:Six electronic databases(PubMed,EBSCO,Cochrane Library,Scielo,b-On and Scopus)were searched for relevant articles about pain relief in cancer patients from their beginning until 2022using MeSH terms such as“acupuncture,”“electroacupuncture,”“ear acupuncture,”“acupuncture analgesia,”“oncological pain,”and“cancer pain.”Inclusion criteria:Studies included were randomized controlled trials(RCTs)where acupuncture was compared with no treatment,placebo acupuncture or usual *** extraction and analysis:Three independent reviewers participated in data extraction and evaluation of risk of bias,and a meta-analysis was *** primary outcome was pain intensity,measured with the visual analog scale,numeric rating scale,or brief pain *** outcomes also assessed were quality of life,functionality,xerostomia,pain interference,and analgesic *** were expressed as standardized mean difference(SMD)with 95%confidence interval(CI).Results:Sixteen RCTs with a total of 1124 participants were included in the meta-analysis,with the majority of the studies presenting a low or unclear risk of *** was more effective in reducing pain than no treatment(SMD=–0.90,95%CI[–1.68,–0.12]),sham acupuncture(SMD=–1.10,95%CI[–1.59,–0.61])or usual care(SMD=–1.16,95%CI[–1.38,–0.93]).Conclusion:The results of this study suggest that acupuncture may be an effective intervention to reduce pain associated with *** some limitations due to the low quality and small sample size of some included st

关键词： Acupuncture Cancer pain Meta-analysis Systematic review

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Disentangling the effects of management and climate change on habitat suitability for saproxylic species in boreal forests

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Journal of Forestry Research 2024年第2期35卷 121-133页

作者： Ellinoora Ekman María Triviño Clemens Blattert Adriano Mazziotta maria Potterf Kyle Eyvindson Department of Biological and Environmental Science University of JyvaskylaP.O.Box 3540014 JyvaskylaFinland Institute for Atmospheric and Earth System Research(INAR)/Physics Faculty of ScienceUniversity of HelsinkiP.O.Box 6800014 HelsinkiFinland School of Resource Wisdom University of JyvaskylaP.O.Box 3540014 JyvaskylaFinland Natural Resources Institute Finland(LUKE) Latokartanonkaari 900790 HelsinkiFinland Ecosystem Dynamics and Forest Management Group Technical University of MunichHans‑Carl‑Von‑Carlowitz‑Platz 285354 FreisingGermany Faculty of Environmental Sciences and Natural Resource Management Norwegian University of Life SciencesP.O.Box 50031433ÅsNorway

Forest degradation induced by intensive forest management and temperature increase by climate change are resulting in biodiversity decline in boreal *** forest management and high-end climate emission scenarios can further reduce the amount and diversity of deadwood,the limiting factor for habitats for saproxylic species in European boreal *** magnitude of their combined effects and how changes in forest management can affect deadwood diversity under a range of climate change scenarios are poorly *** used forest growth simulations to evaluate how forest management and climate change will individually and jointly affect habitats of red-listed saproxylic species in *** simulated seven forest management regimes and three climate scenarios(reference,RCP4.5 and RCP8.5)over 100 *** regimes included set aside,continuous cover forestry,business-as-usual(BAU)and four modifications of *** suitability was assessed using a speciesspecific habitat suitability index,including 21 fungal and invertebrate species groups.“Winner”and“loser”species were identified based on the modelled impacts of forest management and climate change on their habitat *** found that forest management had a major impact on habitat suitability of saproxylic species compared to climate *** suitability index varied by over 250%among management regimes,while overall change in habitat suitability index caused by climate change was on average only 2%.More species groups were identified as winners than losers from impacts of climate change(52%–95%were winners,depending on the climate change scenario and management regime).The largest increase in habitat suitability index was achieved under set aside(254%)and the climate scenario RCP8.5(>2%),while continuous cover forestry was the most suitable regime to increase habitat suitability of saproxylic species(up to+11%)across all climate change *** results show that close-to-na

关键词： Biodiversity Simulations Finland Forest planning Habitat suitability Deadwood

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Contribution of glial cells to the neuroprotective effects triggered by repetitive magnetic stimulation:a systematic review

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Neural Regeneration Research 2024年第1期19卷 116-123页

作者： Susana A.Ferreira Nuno Pinto Inês Serrenho maria Vaz Pato Graça Baltazar Centro de Investigação em Ciências da Saúde(CICS-UBI) Universidade da Beira InteriorCovilhãPortugal Faculdade de Ciências da Saúde Universidade da Beira InteriorCovilhãPortugal GRUBI-Systematic Reviews Group University of Beira InteriorCovilhãPortugal

Repetitive transcranial magnetic stimulation has been increasingly studied in different neurological diseases,and although most studies focus on its effects on neuronal cells,the contribution of nonneuronal cells to the improvement trigge red by repetitive transcranial magnetic stimulation in these diseases has been increasingly *** systematically review the effects of repetitive magnetic stimulation on non-neuronal cells two online *** of Science and PubMed were searched fo r the effects of high-frequency-repetitive transcranial magnetic stimulation,low-frequencyrepetitive transcranial magnetic stimulation,intermittent theta-bu rst stimulation,continuous thetaburst stimulation,or repetitive magnetic stimulation on non-neuronal cells in models of disease and in unlesioned animals or cells.A total of 52 studies were *** protocol more frequently used was high-frequency-repetitive magnetic stimulation,and in models of disease,most studies report that high-frequency-repetitive magnetic stimulation led to a decrease in astrocyte and mic roglial reactivity,a decrease in the release of pro-inflammatory cyto kines,and an increase of oligodendrocyte *** trend towards decreased microglial and astrocyte reactivity as well as increased oligodendrocyte proliferation occurred with intermittent theta-burst stimulation and continuous theta-burst *** papers analyzed the low-frequency-repetitive transcranial magnetic stimulation protocol,and the parameters evaluated were restricted to the study of astrocyte reactivity and release of pro-inflammatory cytokines,repo rting the absence of effects on these paramete *** what concerns the use of magnetic stimulation in unlesioned animals or cells,most articles on all four types of stimulation reported a lack of *** is also important to point out that the studies were developed mostly in male rodents,not evaluating possible diffe rential effects of repetitive transcranial magneti

关键词： astrocyte glia high-frequency repetitive magnetic stimulation inflammation low-frequency repetitive magnetic stimulation microglia neurologic disorders oligodendrocyte repetitive magnetic stimulation theta-burst stimulation

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Unveiling the silent crisis:global burden of suicide‑related deaths among children aged 10–14 years

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World Journal of Pediatrics 2024年第4期20卷 371-391页

作者： Irmina maria Michalek Pawel Koczkodaj Marzena Michalek Florentino Luciano Caetano dos Santos Department of Cancer Epidemiology and Primary Prevention Maria Sklodowska-Curie National Research Institute of Oncologyul.Wawelska 15 BWarsawPoland Private Psychiatric Practice-Marzena Michalek MDSiedlcePoland Harvard Business School Harvard UniversityBostonMAUSA

Background The rise in suicides among children aged 10–14 years demands urgent attention *** study aims to assess the global burden of suicide-related deaths in this age group from 1990 to 2019,considering factors such as sex,geography,and sociodemographics,to inform prevention strategies and *** The data from Global Burden of Disease 2019,encompassing 204 countries and territories,were analyzed to investigate deaths and years of life lost(YLLs)due to suicide among children aged 10–14 *** analyses,including mortality rates,YLLs,and the sociodemographic index(SDI),were conducted using standardized *** In 2019,a total of 8327[95%uncertainty interval(UI)=7073–9685]children aged 10–14 years died globally due to suicide,with a mortality rate of 1.30(95%UI=1.10–1.51)per 100,*** rates varied across countries/territories ranging between 0.05(95%UI=0.02–0.10)in South Africa and 7.49(95%UI=5.13–10.57)in *** contribution of suicide-related deaths to all-cause mortality ranged from 0.07%(95%UI=0.04%–0.15%)in South Africa to 33.02%(95%UI=24.36%–41.53%)in ***,there were approximately 636,196(95%UI=540,383–740,009)YLLs due to suicide,with a rate of 99.07(95%UI=84.15–115.23)per 100,*** association between SDI and suicide-related deaths was evident,with higher contributions observed in countries with higher *** This study reveals a concerning global burden of suicide-related deaths among children aged 10–14 *** progress in reducing mortality rates,suicide remains a significant *** overall rates have declined,the percentage of deaths caused by suicide in this age group is increasing.

关键词： Early adolescent Global Burden of Disease Incidence Suicide Years of life lost

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Tuning structural,electrical,dielectric and magnetic properties of Mg-Cu-Co ferrites via dysprosium(Dy^(3+))doping

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Journal of Rare Earths 2024年第1期42卷 137-146,I0005页

作者： maria Akhtar M.S.Hasan Nasir Amin N.A.Morley Muhammad Imran Arshad Department of Physics Government College UniversityFaisalabad38000Pakistan Department of Physics The University of Lahore53700Pakistan Department of Materials Science and Engineering The University of SheffieldS13JDUK Department of Physics&Astronomy University College LondonUK

In current research work,Dy3+substituted Mg0.5Cu0.25Co0.25Fe2-xDyxO4(0.0≤x≤0.04 with the step interval of 0.01)soft ferrites were synthesized by the sol-gel auto combustion *** prepared samples were characterized by the techniques using X-ray diffraction(XRD),scanning electron microscopy(SEM),energy dispersive X-ray spectroscopy(EDS),Fourier transform infrared(FTIR)spectroscopy,curre nt-voltage(Ⅰ-Ⅴ)measurement,LCR meter,vibrating sample magnetometer(VSM)and *** data reveal that the average crystallite size is 49.71 nm and the lattice constant is 0.83703 nm for sample x=*** non-uniform grain growth was demonstrated by micrographs and impurity-free elemental composition was observed from EDX *** DC resistivity has an increasing and decreasing trend in ferromagnetic and paramagnetic regions with an increase in ***,the high resistivity is observed with the order of 1010Ω·cm,and the activation energy is 0.944 eV for samples x=*** dielectric parameters including dielectric constant,dielectric losses,and impedance gradually decrease with the increase in frequency from 8 Hz to 8 *** minimum dielectric loss at high frequency is found for sample x=*** coercivity(Hc)and saturation magnetization(Ms)are found in the ranges of 520.82-544.02 Oe and 20.5841-21.1473 emu/g,*** observations confirm that dysprosium(x=0.03)doped MCC-soft ferrites may be applicable in transformer cores,microwave absorbance,and telecommunication devices.

关键词： Soft ferrites DC resistivity Dielectric loss Impedance Coercivity Rare earths

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Impact of cattle density on the structure and natural regeneration of a turkey oak stand on an agrosilvopastoral farm in central Italy

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Journal of Forestry Research 2024年第1期35卷 168-182页

作者： Alessandra Pacini Francesco Pelleri Francesco Marini Alberto Maltoni Barbara Mariotti Gianluigi Mazza maria Chiara Manetti Department of Agriculture FoodEnvironmentand ForestryUniversity of Florence50144 FlorenceItaly CREA Research Centre for Forestry and Wood 52100 ArezzoItaly PEFC Programme for the Endorsement of Forest Certification 06135 PerugiaItaly

On an agrosilvopastoral farm in central Italy where Maremmana cattle graze in Turkey oak forests,we evaluated the impact of different livestock densities on stand structure,tree diversity and natural regeneration in four types of grazed areas based on the grazing regime adopted:calf-grazed,high-intensity-grazed,low-intensity-grazed,ungrazed *** each area,we set up three permanent circular plots(radius of 15 m)to survey the structural and dasometric characteristics of the overstorey,understorey,and regeneration *** results showed that grazing negatively affected the complexity of the forest structure and its potential to regenerate and maintain a high level of *** differences in stand structure observed between the grazing areas were closely related to livestock *** most sensitive components of the system were the understorey and the regeneration ***,the current grazing management did not affect the dominant tree structure or its *** findings identified medium-term monitoring and regeneration management as the two significant aspects to consider when assessing sustainable *** forests can be established by excluding graz-ing for about 20–25 years.

关键词： Agroforestry Stand structure Regeneration Tree biodiversity Grazing intensity

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