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Validation of a new scoring system: Rapid assessment faecal incontinence score

World Journal of Gastrointestinal Surgery 2015年第9期7卷 203-207页

作者： fernando de la Portilla Arantxa Calero-Lillo Rosa M Jiménez-Rodríguez maria L Reyes Manuela Segovia-González María victoria Maestre Ana M García-Cabrera Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD o Ciberehd) Instituto de Salud Carlos Ⅲ Department of General and Digestive Surgery Colorrectal Surgery Unit"Virgen del Rocío" University Hospital/IBi S/CSIC/University of Seville Department of Economics Quanti- tative MethodsUniversity Pablo Olavide of Seville

AIM: To implement a quick and simple test- rapid assessment faecal incontinence score(RAFIS) and show its reliability and validity.METHODS: From March 2008 through March 2010, we evaluated a total of 261 consecutive patients, including 53 patients with faecal incontinence. Demographic and comorbidity information was collected. In a single visit, patients were administered the RAFIS. The results obtained with the new score were compared with those of both Wexner score and faecal incontinence quality of life scale(FIQL) questionnaire. The patient withoutinfluence of the surgeon completed the test. The role of surgeon was explaining the meaning of each section and how he had to fill. Reliability of the RAFIS score was measured using intra-observer agreement and Cronbach's alpha(internal consistency) coefficient. Multivariate analysis of the main components within the different scores was performed in order to determine whether all the scores measured the same factor and to conclude whether the information could be encompassed in a single factor. A sample size of 50 patients with faecal incontinence was estimated to be enough to detect a correlation of 0.55 or better at 5% level of significance with 80% power.RESULTS: We analysed the results obtained by 53 consecutive patients with faecal incontinence(median age 61.55 ± 12.49 years) in the three scoring systems. A total of 208 healthy volunteers(median age 58.41 ± 18.41 years) without faecal incontinence were included in the study as negative controls. Pearson's correlation coefficient between "state" and "leaks" was excellent(r = 0.92, P < 0.005). Internal consistency in the comparison of "state" and "leaks" yielded also excellent correlation(Cronbach's α = 0.93). Results in each score were compared using regression analysis and a correlation value of r = 0.98 was obtained with Wexner score. As regards FIQL questionnaire, the values of "r " for the different subscales of the questionnaire were: "lifestyle" r =-0.87, "coping/behaviour" r =-0.91, "depression" r =-0.36

关键词： Faecal incontinence Measure Score Test Faecal inco

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基于LC-Q-TOF的多组织代谢组学:一种确认受富含多元酚食物影响小鼠新的代谢通路的探索工具

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营养健康新观察 2012年第1期 39-40页

作者： Mariona Jove Jose C.E.Serrano Nadia Ortega victoria Ayala Neus Angles Jordi Reguant Jose R.Morello maria Paz Romero maria Jose Motilva Joan Prat Reinald Pamplona Manuel Portero-Otin 王茂清

现在有关膳食对机体影响的代谢组学研究仅仅是研究膳食对血样和尿样的影响,而忽略了其他生物样本,例如盲肠内容物,就等于遗漏了消化系统的作用和忽略了肠道微生物菌群在代谢中的重要作用和其在生物利用率方面的影响。许多研究已经证明... 详细信息

现在有关膳食对机体影响的代谢组学研究仅仅是研究膳食对血样和尿样的影响,而忽略了其他生物样本,例如盲肠内容物,就等于遗漏了消化系统的作用和忽略了肠道微生物菌群在代谢中的重要作用和其在生物利用率方面的影响。许多研究已经证明多组织样本代谢组学在评估营养物质在机体内的代谢影响方面的重要性。然而这些研究都是以核磁共振技术为分析手段的,由于核磁共振技术的低灵敏度,限制了可检测代谢产物的数量。

关键词：代谢组学多元酚 LC-Q-TOF 生物利用率核磁共振技术生物样本盲肠内容物肠道微生物菌群

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基于LC-Q-TOF的多组织代谢组学:一种确认受富含多元酚食物影响小鼠新的代谢通路的探索工具

基于LC-Q-TOF的多组织代谢组学:一种确认受富含多元酚食物影响小...

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现在有关膳食对机体影响的代谢组学研究仅仅是研究膳食对血样和尿样的影响,而忽略了其他生物样本,例如盲肠内容物,就等于遗漏了消化系统的作用和忽略了肠道微生物菌群在代谢中的重要作用和其在生物利用率方面的影响。许多研究已经证明...

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A Laurentian affinity for the Embu Terrane,Ribeira Belt(SE Brazil),revealed by zircon provenance statistical analysis

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Geoscience Frontiers 2023年第1期14卷 149-161页

作者： Bruno V.Ribeiro Frederico M.Faleiros Ginaldo A.C.Campanha Peter A.Cawood Christopher L.Kirkland Milo Barham Erin L.Martin Marina Seraine Dina I.G.Cabrita maria T.A.G.Yogi VidyãV.Almeida Anny J.A.Forero-Ortega Elton L.Dantas Timescales of Mineral Systems Group School of Earth and Planetary SciencesCurtin UniversityPerthWA 6102Australia Isotopia Laboratory School of EarthAtmosphere and EnvironmentMonash UniversityClaytonVictoria 3800Australia Department of Mineralogy and Geotectonics University of São PauloRua do Logo 56205508-900 São PauloBrazil Department of Geological Science and Geological Engineering of Queen's University KingstonOntarioCanada Department of Earth Sciences Carleton UniversityOttawaOntarioCanada Geodynamics Division Geological Survey of Brazil(CPRM)Rua Costa 5501304-010 São PauloSPBrazil Institute for Geophysics Pontificia Universidad JaverianaBogotáColombia Institute of Geoscience University of BrasiliaCampus Universitário Darcy RibeiroAna Norte70919-900 BrasiliaDFBrazil

New and compiled detrital zircon U-Pb ages from the southern Neoproterozoic-Cambrian Ribeira Belt,SE Brazil,demonstrate Laurentian affinity of the Embu Terrane which is statistically distinct from the adjoining Apiaíand São Roque terranes with cratonic affinity(e.g.,São Francisco Craton).Zircon provenance results indicate that the type-area of the Embu Terrane is dominated by detrital zircon age modes at ca.1200 Ma,1400 Ma,and 1800 Ma,with maximum depositional age of ca.1000 Ma.In contrast,the Apiaíand São Roque terranes are dominated by Paleoproterozoic detrital zircon ages(ca.2200-2000 Ma age dominant component),with maximum depositional ages of ca.1400 Ma and 1750 Ma,respectively.Multidimensional scaling(MDS)analysis of non-parametric similarity measurements on zircon age populations indicates for the first time that the Embu Terrane encompass two statistically distinct detrital zircon age spectra,which is also reflected in the metamorphic zircon age record.The statistical characterization of the Embu Terrane through populational metrics allow a quantitative comparison with surrounding tectonic domains and rock samples classified such as Embu-type.Our results clearly highlight the distinction between the statistically differentiated Embu Terrane from the Apiaíand São Roque terranes,supporting an allochthonous interpretation.In addition,we demonstrate that rocks samples previously classified as Embu-type are significantly dissimilar to the definition of Embu Terrane,failing to support alternative tectonic models(e.g.,intracontinental evolution).Detrital zircon age spectra reveal that the Apiaíand São Roque terranes have similar zircon provenance to domains sourced from the São Francisco Craton,whereas detrital zircon populations from the Embu Terrane have greater affinity with SW Laurentia basins(and their inferred sediment sources),consistent with previous findings.Therefore,we interpret the Embu Terrane as a Rodinia descendant developed along the active margin of the SW Laurentia that collided with the Ribeir

关键词： Ribeira belt Embu terrane Detrital zircon Multidimensional scaling Rodinia and gondwana Paleogeography

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Wireless Sensor Networks for Water Quality Monitoring and Control within Lake victoria Basin: Prototype Development

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Wireless Sensor Network 2014年第12期6卷 281-290页

作者： Anthony Faustine Aloys N. Mvuma Hector J. Mongi maria C. Gabriel Albino J. Tenge Samuel B. Kucel The University of Dodoma Dodoma Tanzania Busitema University Tororo Uganda

The need for effective and efficient monitoring, evaluation and control of water quality in Lake victoria Basin (LVB) has become more demanding in this era of urbanization, population growth and climate change and variability. Traditional methods that rely on collecting water samples, testing and analyses in water laboratories are not only costly but also lack capability for real-time data capture, analyses and fast dissemination of information to relevant stakeholders for making timely and informed decisions. In this paper, a Water Sensor Network (WSN) system prototype developed for water quality monitoring in LVB is presented. The development was preceded by evaluation of prevailing environment including availability of cellular network coverage at the site of operation. The system consists of an Arduino microcontroller, water quality sensors, and a wireless network connection module. It detects water temperature, dissolved oxygen, pH, and electrical conductivity in real-time and disseminates the information in graphical and tabular formats to relevant stakeholders through a web-based portal and mobile phone platforms. The experimental results show that the system has great prospect and can be used to operate in real world environment for optimum control and protection of water resources by providing key actors with relevant and timely information to facilitate quick action taking.

关键词： Wireless Sensor Networks Lake victoria Basin Gateway Sensor Nodes

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Morphological Characterization of Agave tequilana Weber Variety azul(Asparagaceae)under Cultivation in the Municipality of Llera,Tamaulipas,Mexico

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Open Journal of Forestry 2020年第2期10卷 264-275页

作者： Alejandra Vázquez-Acosta Jacinto Trevino-Carreon Benigno Estrada-Drouaillet Martha Lucrecia Garcia-Alanis maria Concepcion Herrera-Monsiváis Virginia Vargas Tristán Instituto Tecnologico de Ciudad victoria Boulevard Emilio Portes Gilnumero 1301 pteVictoriaTamaulipasMéxico Facultad de Ingeniería y Ciencias-Universidad Autonoma de Tamaulipas Centro Universitario Adolfo Lopez MateosVictoriaTamaulipasMéxico

The blue agave (Agave tequilana Weber variety azul) is a species that is widely used to produce tequila. For this reason, in the last decade, large extensions of terrain have been established for its cultivation. However, much of this land has been abandoned in a short time because at the beginning it was not known that at least six years were needed before the agave could be harvested. However, when the growers wanted to reintegrate some of these crops into the productive process, their exact age and the cultural activities needed for harvesting the agave were unknown because information regarding its vegetative development relative to its age was lacking. The hypothesis of this work was: If the morphological properties reflect the development state of the population individuals, then the properties height, basal area, rosette diameter, the north, south, east and west leaf, leaves number and foliar verticil will help to characterize the age categories in Agave tequilana Weber variety azul population under cultivated conditions. To this end, six plots with plants of different ages (one to six years) were selected in the municipality of Llera, Tamaulipas, Mexico. In each plot, 60 individuals were selected at random, and their morphological properties (height, basal area, rosette diameter, northern leaf, southern leaf, eastern leaf, western leaf;number of leaves and leaf whorl) were measured. With these data, a principal component analysis was performed to determine which of these properties explains the most variation of the data. The results indicate that height and basal area are the properties that are most closely associated with plant age. It is also for the first time demonstrated that harvest time can be reduced by one or two years, which favors producers economically because it could generate savings in production costs.

关键词： Morphological Properties Vegetative Development Principal Components Blue Agave

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哥伦比亚大学的公司治理

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国际行政科学评论（中文版） 2019年第3期85卷 161-182页

作者：杰森斯·马里奥·弗洛瑞·帕拉玛丽亚·维多利亚·洛佩斯·佩雷斯安东尼奥·曼努埃尔·洛佩斯·赫尔南德斯丁晶晶(译) 王秋蕾(审校) 格拉纳达大学不详

在对问责制和管理透明度提出更高要求的背景下,我们分析了公司治理(CG)机制的采用程度,并定义了哥伦比亚所有大学的治理模型。在高等教育领域,通常没有与公司治理相关的强制性要求。然而,如今治理机制对于确定大学的目标、策略和方向至... 详细信息

在对问责制和管理透明度提出更高要求的背景下,我们分析了公司治理(CG)机制的采用程度,并定义了哥伦比亚所有大学的治理模型。在高等教育领域,通常没有与公司治理相关的强制性要求。然而,如今治理机制对于确定大学的目标、策略和方向至关重要。基于对哥伦比亚81个高等教育机构校长的调查,我们分析了它们所采用的公司治理模式(管理模式和利益相关者模式)。这个结果有助于更好地理解大学中的关键公司治理概念。

关键词：哥伦比亚公司治理管理教育校长大学

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Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)

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Science China(Physics,Mechanics & Astronomy) 2016年第4期59卷 1-7页

作者： WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou Department of Nuclear Physics China Institute of Atomic Energy Beijing 102413 China Institute of Modern Physics Lanzhou 730000 China College of Nuclear Science and Engineering Sichuan University Chengdu 610065 China Department of Engineering Physics Tsinghua University Beijing 100084 China Department of Physics and Astronomy Shanghai Jiaotong University Shanghai 200240 China School of Physics and Astronomy Monash University Melbourne Victoria 3800 Australia Center for Nuclear Study University of Tokyo Wako Saitama 351-0198 Japan Konkoly Observatory of the Hungarian Academy of Sciences 1121 Budapest Konkoly-Thege Miklos u. 13-17 Hungary Department of Physics University of South Dakota Vermillion SD 57069 United States School of Physics and Astronomy University of Minnesota Minneapolis MN 55455 United States Department of Physics University of Notre Dame Notre Dame IN 46556 Unites States Research Center for Nuclear Physics Osaka University Suita Osaka 565-0871 Japan School of Space Science and Physics Shandong University Weihai Campus Weihai 264209 China

Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given.

关键词：核天体物理学地下实验室强流加速器流体静压演化过程高灵敏度 ECR源直接测量

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β-淀粉样蛋白损害星形胶质细胞在阿尔茨海默病中对营养不良突触的吞噬作用

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神经损伤与功能重建 2021年第5期16卷 F0003-F0003页

作者： maria V Sanchez-Mico Sebastian Jimenez Angela Gomez-Arboledas Clara Muñoz-Castro Carmen Romero-Molina victoria Navarro Elisabeth Sanchez-Mejias Cristina Nuñez-Diaz Raquel Sanchez-Varo Elena Galea JoséC Davila Marisa Vizuete Antonia Gutierrez Javier Vitorica 杜一星(编译) Dpto.Bioquimica y Biologia Molecular Facultad de FarmaciaUniversidad de SevillaSevillaSpain Instituto de Biomedicina de Sevilla(IBiS)-Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla SevillaSpain Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas(CIBERNED) MadridSpain Department of Neurology Massachusetts General Hospital and Harvard Medical SchoolCharlestownMassachusettsUSA Dpto.Biologia Celular Genetica y FisiologiaInstituto de Investigación Biomedica de Malaga-IBIMAFacultad de CienciasUniversidad de MalagaMalagaSpain Institut de Neurociències and Departament de Bioquímica i Biologia Molecular Unitat de Bioquímica de MedicinaUniversitat Autònoma de BarcelonaBarcelonaSpain ICREA BarcelonaSpain. 不详

摘要在阿尔茨海默病(AD)中,在β-淀粉样蛋白斑块周围发现了反应性星形胶质细胞和营养不良的神经突(异常的突触前元件)。笔者的前期研究已经表明,反应性星形胶质细胞会包裹、吞噬和降解APP小鼠以及AD患者海马中营养不良的突触,但仅波及不... 详细信息

摘要在阿尔茨海默病(AD)中,在β-淀粉样蛋白斑块周围发现了反应性星形胶质细胞和营养不良的神经突(异常的突触前元件)。笔者的前期研究已经表明,反应性星形胶质细胞会包裹、吞噬和降解APP小鼠以及AD患者海马中营养不良的突触,但仅波及不到7%的营养不良神经突,这表明星形胶质细胞在AD中的吞噬能力降低。本研究旨在通过分析原代星形胶质细胞培养物对分离突触(突触神经小体,SNs)吞噬和降解的能力来深入了解其潜在机制。SNs分别来自APP(包含营养不良性突触和β淀粉样肽)小鼠、Tau(包含AT8-和AT100-阳性磷酸化Tau)小鼠以及WT(对照)小鼠。我们发现与SNs-WT相比,星形胶质细胞的吞噬和降解能力在SNs-APP大大降低,但在AT8/AT100阳性的SNs-Tau却没有。在12月大的APP小鼠的海马中证实了星形胶质细胞吞噬能力的降低,因为只有(1.60±3.81)%的斑块状星形胶质细胞具有吞噬结构。

关键词：老年痴呆 β-淀粉样蛋白星形胶质细胞营养不良性突触小胶质细胞病理吞噬作用

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小胶质细胞在光/暗周期过程中调节海马突触传递和睡眠持续时间

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神经损伤与功能重建 2022年第5期17卷 310-310页

作者：杜一星(编译) The Department of Biochemistry and Molecular Biology The University of British Columbia Department of Physiology and Pharmacology Sapienza University Laboratory affiliated to Istituto Pasteur Italia Department of Neurophysiology Neuropharmacology Inflammaging IRCCS Neuromed Department of Physiology and Pharmacology Sapienza University of Rome Axe Neurosciences Centre de Recherche du CHU de Québec Université Laval Quebec City Department of Neurology San Raffaele of Cassino 4. National Research Council Institute of Biochemistry and Cell Biology (EMMA/Infrafrontier/IMPC ) International Campus "A. Buzzati-Traverso" INRAE Bordeaux INP NutriNeuro UMR 1286 Bordeaux University Tecniplast S.P.A. Buguggiate Department of Molecular Medicine Sapienza University INSERM Neurocentre Magendie Physiopathologie de la Plasticité Neuronale Division of Medical Sciences University of Victoria

小胶质细胞是大脑的常驻巨噬细胞,通过感知神经元活动并支持突触重塑和可塑性积极促进脑实质的稳态。虽然已有研究表明星形胶质细胞在睡眠中的不同作用,但小胶质细胞在调节睡眠/觉醒周期和白天不同阶段调节突触活动中的作用尚未深入研... 详细信息

小胶质细胞是大脑的常驻巨噬细胞,通过感知神经元活动并支持突触重塑和可塑性积极促进脑实质的稳态。虽然已有研究表明星形胶质细胞在睡眠中的不同作用,但小胶质细胞在调节睡眠/觉醒周期和白天不同阶段调节突触活动中的作用尚未深入研究。以光作为授时提示,我们研究了用集落刺激因子-1受体拮抗剂PLX5622消除小胶质细胞对雄性小鼠睡眠/觉醒周期和海马突触传递的影响。我们的数据表明,小胶质细胞几乎完全的耗竭会增加NREM睡眠的持续时间并减少海马兴奋性神经传递。由于cx3cr1GFP/GFP小鼠显现与PLX5622处理的小鼠中发现的相同情况,趋化因子fractalkine受体CX3CR1在这些效应中起相关作用。此外,在光照阶段小胶质细胞表达较低水平的cx3cr1;当培养的小胶质细胞受到ATP(一种在睡眠期间释放的嘌呤能分子)的刺激时其cx3cr1表达降低。我们的研究结果表明,小胶质细胞参与调节睡眠,调整其cx3cr1表达以响应光/暗阶段,并以时相依赖性方式调节突触活动。

关键词： cx3cr1 脑电图长期增强小胶质细胞耗竭微型兴奋性突触后电流睡觉眠自发兴奋性突触后电流

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