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Social Policies in the Thirties in Europe:Crisis and Solution-The Italian Case

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International Relations and Diplomacy 2021年第4期9卷 158-165页

作者： maria teresa giusti University“G.d’Annunzio”of Chieti-Pescara AbruzzoItaly

Drawing from historiography and literature on the subject and considering the consequences produced on the European society by World War I and the 1929 Wall Street Crisis,this article aims at analysing some aspects of the fascist construction of welfare *** model suggested by the fascist regime in the thirties was a typical totalitarian welfare state,which used social policies to strengthen the home front and to build consensus for the *** the fascist regime had the war as its goal,it did not mobilize the country on the eve of World War II,but preferred to invest in social assistance and welfare,for reasons of political ***,the analysis of fascist social policy measures,such as social security,points out that some flaws in the social security system,such as excessive spending,or the categorical approach to assistance and social security typical of fascism,were borrowed from republican Italy.

关键词： World War I Fascism Propaganda Welfare State Social Policies

The plasticity of plasticity:lesson from remote microglia induced by focal central nervous system injury

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Neural Regeneration Research 2020年第1期15卷 57-58页

作者： maria teresa Viscomi Institute of Histology and Embriology Università Cattolica del S.Cuore

The last decades have represented an important season in the re-conceptualization of brain plasticity,especially in extending the concept at events occurring beyond the developmental stage and in demonstrating the profound impact of these changes on so-called spontaneous recovery after central nervous system(CNS)*** study of the cellular,molecular,functional and structural mechanisms involved in brain plasticity has clearly emphasized the multitude of players engaged in this phenomenon,leading to the conceptualization that non-neuronal cells and non-neuronal mechanisms intervene in these changes and orchestrate some of the responses observed(Werner and Stevens,2015).Among the different non-neuronal cells and non-neuronal substrates of injury-induced plasticity is becoming increasingly recognized that microglia drive a series of intrinsic CNS responses after damage(Sandvig et al.,2018;Bisicchia et al.,2019).

关键词： plasticity system injuries

Setting a highway for converting skin into neurons

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Journal of Molecular Cell Biology 2011年第6期3卷 322-323页

作者： Vania Broccoli Massimiliano Caiazzo maria teresa Dell’Anno San Raffaele Scientific Institute Via Olgettina 58Milan 20132Italy

Direct conversion of human skin fibroblasts into induced neuronal(iN)cells has been recently achieved by using different combi-nations of transcription factors eventually associated with *** findings lay the ground for a straightforward and effi-cient generation of human neurons in vitro with elaborated functional properties instrumental for disease modeling and cell-based approaches of brain repair.

关键词： eventually straight finding

Early life stress-induced neuroinflammation and neurological disorders: a novel perspective for research

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Neural Regeneration Research 2022年第9期17卷 1971-1972页

作者： Clarissa Catale Valeria Carola maria teresa Viscomi Division of Experimental Neuroscience IRCCS Santa Lucia FoundationRomeItaly Department of Dynamic and Clinical Psychology and Health StudiesSapienza University of RomeRomeItaly Department of Life Science and Public Health Section of Histology and EmbryologyUniversitàCattolica del S.CuoreRomeItaly

Childhood maltreatment(CM)has been consistently linked with numerous detrimental outcomes concerning physical and psychological ***,few studies have explored vulnerability to neurological disorders after *** life adversity,in the form of poverty,stress and abuse,has been associated with decline in cognitive function and dementia later in life(Short and Baram,2019).Robust preclinical data suggest that early life stress(ELS)may increase the risk and worsen the course of neurological disorders such as Alzheimer’s(AD)and Parkinson’s(PD)diseases,and traumatic brain injury(TBI)(Lesuis et al.,2018;Short and Baram,2019;He et al.,2020;Catale et al.,2021;Sanchez et al.,2021).

关键词： neurological disorders inflammation

Reviewing the discoverability and accessibility to data and information products linked to Essential Climate Variables

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International Journal of Digital Earth 2020年第2期13卷 236-252页

作者： maria teresa Miranda Espinosa Gregory Giuliani Nicolas Ray Institute for Environmental Sciences enviroSPACE labUniversity of GenevaGenevaSwitzerland Institute for Environmental Sciences GRID-GenevaUniversity of GenevaGenevaSwitzerland GeoHealth Group Institute of Global HealthFaculty of MedicineUniversity of GenevaGenevaSwitzerland'

Essential Climate Variables(ECVs)are geophysical records generated from systematic Earth Observations associated with climate variations,changes,and *** products support the data and information needs of international frameworks and policies such as the work of the United Nations Framework Convention on Climate Change(UNFCCC)and the Intergovernmental Panel on Climate Change(IPCC).We map the main networks and initiatives publishing ECVs,by presenting an overview of existing satellite-based ECVs,their general data creation characteristics,discoverability and accessibility methods from an end-user *** investigate key initiatives providing or coordinating access to ECV data records,such as the Global Climate Observing System(GCOS),the Committee on Earth Observation Satellites(CEOS),the Coordination Group for Meteorological Satellites(CGMS),Joint Working Group on Climate(WGClimate),the Remote Sensing Systems(REMSS),and the European Space Agency Climate Change Initiative(ESA CCI).We find that ECV data discovery and access is difficult and time consuming due to the lack of common data and metadata *** addition,the selection of fit-for-purpose data records by end-users requires the implementation of interoperable standards and scalable data infrastructures to allow the generation of tailored applications and datadriven information products in support of decision-making processes.

关键词： Essential Climate Variables Climate services discoverability accessibility usability

Nilotinib:from animal-based studies to clinical investigation in Alzheimer's disease patients

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Neural Regeneration Research 2023年第4期18卷 803-804页

作者： Annalisa Nobili Marcello D’Amelio maria teresa Viscomi Department of Medicine and Surgery University Campus Bio-MedicoDepartment of Experimental NeuroscienceIRCCS Santa Lucia FoundationRomeItaly Department of Life Science and Public Health Section of Histology and Embryology UniversitàCattolica del Sacro CuoreFondazione Policlinico Universitario“A.Gemelli”IRCCSRomeItaly

Since their first description in the brains of patients suffering from Alzheimer ’s disease(AD), more than 100 years ago, extracellular amyloid-β(Aβ) plaques and intracellular neurofibrillary tangles have been the principal focus of AD research. However, this focus has led to the failure of several long and promising clinical trials, and the efficacy of new Aβ-targeting drugs to slow down the disease progression is still controversial despite being successful in reducing the Aβ load.

关键词： Alzheimer Aβ drugs

Taeniasis vs cysticercosis infection routes

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Asian Pacific Journal of Tropical Medicine 2016年第6期9卷 599-600页

作者： maria teresa Galán-Puchades Department of Cell Biology and Parasitology Faculty of Pharmacy University of Valencia

Although cysticercosis caused by Taenia solium(T. solium) is considered a neglected disease, its life cycle has been well known for more than two centuries. T. solium not only causes cysticercosis but also taeniasis in humans. These two diseases have totally different infection routes. To acquire taeniasis(the presence of the adult stage of T. solium in the intestine), humans have to ingest the larval stage(cysticercus) that infects a variety of organs and viscera in pigs, its intermediate hosts. Therefore, taeniasis is acquired when eating raw or undercooked infected pork. The adult stage in the human intestine release eggs that contain a hexacanth embryo, the oncosphere. If humans accidentally ingest the eggs of T. solium, the released oncospheres penetrate the intestine and become cysticerci. Therefore, cysticercosis is acquired by the ingestion of eggs that contaminate water, vegetables, hands etc. These facts should not be forgotten to avoid misinformation in scientific publications.

关键词： Taeniasis Cysticercosis Infection routes

CRISPR/Cas system: An emerging technology in stem cell research

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World Journal of Stem Cells 2019年第11期11卷 937-956页

作者： maria teresa Valenti Michela Serena Luca Dalle Carbonare Donato Zipeto Department of Medicine Section of Internal Medicine DUniversity of VeronaVerona 37134Italy Department of Biochemistry University of OxfordOxford OX13QUUnited Kingdom Department of Neurosciences Biomedicine and Movement SciencesLaboratory of Molecular BiologyVerona 37134Italy

The identification of new and even more precise technologies for modifying and manipulating the genome has been a challenge since the discovery of the DNA double *** ability to modify selectively specific genes provides a powerful tool for characterizing gene functions,performing gene therapy,correcting specific genetic mutations,eradicating diseases,engineering cells and organisms to achieve new and different functions and obtaining transgenic animals as models for studying specific *** regularly interspaced short palindromic repeats(CRISPR)/Cas9 technology has recently revolutionized genome *** application of this new technology to stem cell research allows disease models to be developed to explore new therapeutic *** possibility of translating new systems of molecular knowledge to clinical research is particularly appealing for addressing degenerative *** this review,we describe several applications of CRISPR/Cas9 to stem cells related to degenerative *** addition,we address the challenges and future perspectives regarding the use of CRISPR/Cas9 as an important technology in the medical sciences.

关键词： Gene editing CRISPR/Cas9 Stem cells Degenerative diseases

The unclear role of VEGF in POEMS syndrome: therapeutic implications of neoangiogenesis in a rare plasma cell disorder

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 809-814页

作者： Gianfranco Lapietra Francesca Fazio maria teresa Petrucci Hematology Department of Translational and Precision MedicineSapienza UniversityRome 00161Italy.

POEMS syndrome is a rare paraneoplastic disorder due to an underlying clone of aberrant plasma *** name POEMS is an acronym for some of the major disease manifestations,namely polyneuropathy,organomegaly,endocrinopathy,presence of monoclonal component,and skin *** clinical presentation can be various and could lead to delayed diagnosis and *** is known about the pathogenic mechanism,although the neoangiogenesis due to overproduction of vascular endothelial growth factor(VEGF)by plasma cells seems to play a key *** latest evidence suggests that the blood concentration of this cytokine correlates with the activity of the syndrome:VEGF could then be used as a therapeutic target and a marker to monitor *** case reports have shown the efficacy of this approach,but extended studies are required to better define the use of anti VEGF in patients affected by POEMS syndrome.

关键词： POEMS syndrome VEGF anti-VEGF plasma cell disorder