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Lower and upper motor neuron involvement and their impact on disease prognosis in amyotrophic lateral sclerosis

neural Regeneration Research 2022年第1期17卷 65-73页

作者： maria n.Zakharova Anna A. Abramova Research Center of neurology MoscowRussia

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by progressive muscle wasting,breathing and swallowing difficulties resulting in patient’s death in two to five years after disease *** amyotrophic lateral sclerosis,both upper and lower motor neurons of the corticospinal tracts are involved in the process of neurodegeneration,accounting for great clinical heterogeneity of the *** phenotype has great impact on the pattern and rate of amyotrophic lateral sclerosis progression and overall survival *** more homogenous patient groups in order to study the effects of drug agents on specific manifestations of the disease is a challenging issue in amyotrophic lateral sclerosis clinical *** amyotrophic lateral sclerosis has low incidence rates,conduction of multicenter trials requires certain standardized approaches to disease diagnosis and *** review focuses on the current approaches in amyotrophic lateral sclerosis classification and staging system based on clinical examination and additional instrumental methods,highlighting the role of upper and lower motor neuron involvement in different phenotypes of the *** demonstrate that both clinical and instrumental findings can be useful in evaluating severity of upper motor neuron and lower motor neuron involvement and predicting the following course of the *** disease heterogeneity in amyotrophic lateral sclerosis clinical trials could lead to study designs that will assess drug efficacy in specific patient groups,based on the disease pathophysiology and spatiotemporal *** clinical evaluation can be a sufficient screening method for dividing amyotrophic lateral sclerosis patients into clinical subgroups,we provide proof that instrumental studies could provide valuable insights in the disease pathology.

关键词： amyotrophic lateral sclerosis biomarkers of progression classification diagnostic biomarkers disease heterogeneity electrodiagnostic medicine electromyography motor neuron disease neuroimaging

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Mind the gap among patches in arid plant communities:rapid root proliferation in response to n addition

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Journal of Plant Ecology 2019年第1期12卷 89-95页

作者： maria Fernanda Reyes Martín RAguiar Instituto de Investigaciones Fisiológicas y Ecológicas Vinculadas a la Agricultura(IFEVA)and Consejo nacional de Investigaciones Científicas y técnicas(COnICEt) Universidad de Buenos AiresAv.San Martín 4453Buenos Aires C1417DSEArgentina

Aims In arid communities,it has been proposed that individual plants can extend their roots beyond their canopy exploring neighbour-ing bare ground *** becomes relevant in systems where the vegetation is distributed in patches surrounded by bare ***,whether roots of different species may be overlapping under bare ground areas is still *** factors control-ling root responses when no plants appear to be directly influ-encing the gap among patches are still *** aim of our study was to detect perennial grasses responses to an n enrich-ment *** In a semi-arid steppe(Patagonia,Argentina),we buried root traps filled with sieved soil with and without n addition,under bare soil *** were harvested after 4 and 6 *** neighbour-hoods(30 cm in diameter)included at least three of the dominant tussock *** harvests,we identified species in the traps by root traits and quantified diversity,biomass and specific relative growth *** Findings Bare ground areas show simultaneous root growth of different *** of perennial grass roots was higher with n addition than without it in the first harvest(4 months),but this difference disappeared in the second harvest(6 months).Root biomass was maximal after 6 months in n addition *** preferred by herbivores(Bromus pictus and Poa ligularis)showed rapid growth and responses to n *** between harvests may be an indicative that n pulses interact with rising temperatures and soil water content as growing season progress.

关键词： belowground community ecology grass species roots Patagonian steppe patchiness root growth rates zone of influence

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Home range variability,spatial aggregation,and excursions of Akodon azarae and Oligoryzomys flavescens in Pampean agroecosystems

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Integrative Zoology 2020年第5期15卷 401-415页

作者： Irene GOROSItO Ailén BEnÍtEZ maria BUSCH Laboratorio de Ecología de PoblacionesFacultad de Ciencias Exactas y NaturalesUniversidad de Buenos Airesand Instituto de EcologíaGenética y Evolución de Buenos AiresConsejo Nacional de Investigaciones Científicas y TécnicasBuenos AiresArgentina Laboratorio de Ecología de Poblaciones Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresBuenos AiresArgentina Laboratorio de Ecología de Poblaciones Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos Airesand Instituto de EcologíaGenética y Evolución de Buenos AiresConsejo Nacional de Investigaciones Científicas y TécnicasBuenos AiresArgentina

Rodents are reservoirs of various types of hantavirus,some of which are agents of hantavirus pulmonary syndrome in *** hantavirus is associated with a single rodent host species but successive spill-over events may eventually lead to host-switching and new species’becoming host of a given *** study aims to gain an understanding of the spatial ecology of two hantavirus-host species,Akodon azarae,and Oligoryzomys flavescens,by identifying factors modulating their home range sizes and stability,and by evaluating intra-and interspecific spatial aggregation for these species and a third one—Oxymycterus rufus—living in *** this,eleven capture-mark-recapture surveys were carried out,spanning 22 *** found that *** males have larger and more mobile home ranges than females,independently of the ***,males could likely have a more relevant role in the transmission of hantavirus because of their greater exposure both to a higher number of contacts between individuals and viral contamination of the ***,*** individuals showed negligible displacements of their home range through time,which could limit the range of hantavirus spread in host *** *** is host to Lechiguanas hantavirus(pathogenic to humans)this result encompasses epidemiological relevance,for it may imply the existence of local foci of ***,individuals of both species performed excursions outside their home *** events could enable hantavirus spread over distances beyond the normal range of movements and lead to new hantavirus outbreaks in formerly non-infected rodent populations,favoring the persistence of the virus in nature.

关键词： hantavirus home range intra-and interspecific contact rodent spatial ecology

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Recovering noble metals from waste streams using porous organic frameworks for heterogeneous catalysis

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Science China Chemistry 2024年第11期67卷 3578-3587页

作者： Yu Pan Michelle Åhlén maria Strømme Chao Xu Division of nanotechnology and Functional Materials Department of Materials Science and EngineeringÅngström LaboratoryUppsala UniversityUppsala 75121Sweden State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350117China

Recovering noble metals from waste resources and incorporating them into catalysts stands out as a promising strategy for advancing sustainability within the catalysis field. this review provides a comprehensive overview of recent investigations into noble metal recovery from waste streams, specifically employing porous organic frameworks(POFs). Additionally, the study delves into the utilization of the resultant composites, enriched with noble metals, in heterogeneous catalysis. Moreover, we offer insights into the challenges faced and outline prospects for the practical implementation of extracting noble metal catalysts from waste streams using POFs, aiming to develop cost-effective, sustainable, and efficient heterogeneous catalysts.

关键词： porous organic frameworks noble metal recovery heterogeneous catalysis sustainability

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Spatial Variations in Particle Size and Magnetite Concentration on Cedar Beach:Implications for Grain-Sorting Processes,Western Lake Erie,Canada

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Acta Geologica Sinica(English Edition) 2010年第6期84卷 1520-1532页

作者： ZHAnG Shuwei maria t. CIOPPA ZHAnG Shihong State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences Beijing 100083 China Department of Earth and Environmental Sciences University of Windsor Windsor ON N9B 3P4 Canada College of Computer Engineering and Software Taiyuan University of Technology Taiyuan 030024 China

this study examined spatial variations in the concentration,grain size and heavy mineral assemblages on Cedar Beach（Lake Erie,Canada）.Magnetic studies of heavy mineral-enriched,dark-reddish sands present on the beach showed that magnetite（～150μm） is the dominant magnetic *** magnetic susceptibility values defined three zones：a lakeward region close to the water line（Zone 1）,the upper swash zone（Zone 2） and the region landwards of the upper swash zone （Zone 3）.Zone 2 showed the highest bulk and mass susceptibility（κ,χ） and the highest mass percentage of smaller grain-size（250μm） fractions in the bulk sand ***（i.e.κandχ） values decreased and grain size coarsened from Zone 2 lakewards（into Zone 1） and landwards （into Zone 3）,and correlated with the distribution of the heavy mineral assemblage,most probably reflecting preferential separation of large,less dense particles by waves and currents both along and across the *** eroded western section of Cedar Beach showed much higher concentrations of heavy minerals including magnetite,and finer sand grain sizes than the accreting eastern section, suggesting that magnetic techniques could be used as a rapid,cost-effective way of examining erosion along sensitive coastline areas.

关键词： magnetic susceptibility magnetite concentration grain size grain-sorting processes Cedar Beach Lake Erie

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KnowID:An Architecture for Efficient Knowledge-Driven Information and Data Access

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Data Intelligence 2020年第4期2卷 487-512页

作者： Pablo Rubén Fillottrani C.maria Keet Departamento de Ciencias e Ingeniería de la Computación Universidad Nacional del SurBahía BlancaBuenos Aires 8000Argentina Comisión de Investigaciones Científicas Provincia de Buenos AiresArgentina Department of Computer Science University of Cape TownRondebosch 7700South Africa

Modern information systems require the orchestration of ontologies,conceptual data modeling techniques,and efficient data management so as to provide a means for better informed decision-making and to keep up with new requirements in organizational needs.A major question in delivering such systems,is which components to design and put together to make up the required“knowledge to data”pipeline,as each component and process has *** this paper,we introduce a new knowledge-to-data architecture,*** pulls together both recently proposed components and we add novel transformation rules between Enhanced Entity-Relationship(EER)and the Abstract Relational Model to complete the ***’s main distinctive architectural features,compared to other ontology-based data access approaches,are that runtime use can avail of the closed world assumption commonly used in information systems and of full SQL augmented with path queries.

关键词： Extended entity-relationship diagrams Abstract relational model Ontology-based data access

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Relaxation of Mechanical Stress in Poly(vinyl alcohol) Cryogels of Different Compositions

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Chinese Journal of Polymer Science 2023年第3期41卷 442-447,I0010页

作者： Vladimir n.Manzhai maria S.Fufaeva Ekaterina S.Kashlach Institute of Petroleum Chemistry of the Siberian Branch of the Russian Academy of Sciences Tomsk 634055Russia

the study presents the experimental results of measurements of the relaxation time of cryogels formed from various colloid-dispersed systems based on a poly(vinyl alcohol) aqueous *** is shown that the value of relaxation time,which characterizes the relationship between the viscosity and elasticity of real bodies,describes the rheological properties of materials more objectively than the traditional assessment of their physical and mechanical characteristics only by the elasticity modulus of the samples.

关键词： Cryogel Relaxation processes Viscoelasticity Rheological properties

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taeniasis vs cysticercosis infection routes

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Asian Pacific Journal of tropical Medicine 2016年第6期9卷 599-600页

作者： maria teresa Galán-Puchades Department of Cell Biology and Parasitology Faculty of Pharmacy University of Valencia

Although cysticercosis caused by taenia solium(t. solium) is considered a neglected disease, its life cycle has been well known for more than two centuries. t. solium not only causes cysticercosis but also taeniasis in humans. these two diseases have totally different infection routes. to acquire taeniasis(the presence of the adult stage of t. solium in the intestine), humans have to ingest the larval stage(cysticercus) that infects a variety of organs and viscera in pigs, its intermediate hosts. therefore, taeniasis is acquired when eating raw or undercooked infected pork. the adult stage in the human intestine release eggs that contain a hexacanth embryo, the oncosphere. If humans accidentally ingest the eggs of t. solium, the released oncospheres penetrate the intestine and become cysticerci. therefore, cysticercosis is acquired by the ingestion of eggs that contaminate water, vegetables, hands etc. these facts should not be forgotten to avoid misinformation in scientific publications.

关键词： taeniasis Cysticercosis Infection routes

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Simultaneous nitrification and autotrophic denitrification in fluidized bed reactors using pyrite and elemental sulfur as electron donors

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Water Science and Engineering 2023年第2期16卷 143-153页

作者： maria F.Carboni Sonia Arriaga Piet n.L.Lens national University of Ireland Galway H91 TK33 GalwayIreland Instituto Potosino de Investigación Científica y tecnológica 78216 San Luis PotosíMexico

In this study, simultaneous nitrification and autotrophic denitrification (SnAD) with either elemental sulfur or pyrite were investigated in fluidized bed reactors in mesophilic conditions. the reactor performance was evaluated at different ammonium (12-40 mg/L of nH4+-n), nitrate (35-45 mg/L of nO3--n), and dissolved oxygen (DO) (0.1-1.5 mg/L) concentrations, with a hydraulic retention time of 12 h. the pyrite reactor supported the SnAD process with a maximum nitrogen removal efficiency of 139.5 mg/(L·d) when the DO concentration was in the range of 0.8-1.5 mg/L. this range, however, limited the denitrification efficiency of the reactor, which decreased from 90.0% ± 5.3% in phases II-V to 67.9% ± 7.2% in phases VI and VII. Sulfate precipitated as iron sulfate (FeSO4/Fe2(SO4)3) and sodium sulfate (na2SO4) minerals during the experiment. the sulfur reactor did not respond well to nitrification with a low and unstable ammonium removal efficiency, while denitrification occurred with a nitrate removal efficiency of 97.8%. In the pyrite system, the nitrifying bacterium nitrosomonas sp. was present, and its relative abundance increased from 0.1% to 1.1%, while the autotrophic denitrifying genera terrimonas, Ferruginibacter, and Denitratimonas dominated the community. thiobacillus, Sulfurovum, and trichlorobacter were the most abundant genera in the sulfur reactor during the entire experiment.

关键词： Pyrite Elemental sulfur Simultaneous nitrification and denitrification nitrogen removal 16S rRnA

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Extracts of the seaweed Bifurcaria bifurcata display antifungal activity against human dermatophyte fungi

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Journal of Oceanology and Limnology 2019年第3期37卷 848-854页

作者： CARVALHO G.Loic SILVA Raquel GOnCALVES J.maria BAtIStA t.maria PEREIRA Leonel Environmental and Biochemical Sciences Group the James Hutton InstituteDundee DD2 5DAScotlandUK Institute of Mechanical Process and Energy EngineeringSchool of Engineering and Physical SciencesHeriot Watt UniversityEdinburgh EH14 4ASScotlandUK MARE (Marine and Environmental Sciences Centre) Department of Life SciencesFaculty of Sciences and TechnologyUniversity of CoimbraCoimbra 3030-790Portugal CIEPQPF Department of Chemical EngineeringFaculty of Science and TechnologyUniversity of CoimbraCoimbra 3030-790Portugal

Bifurcaria bifurcata is a seaweed of the Order Fucales(Ochrophyta,Phaeophyceae)that can be found all year round along the Portuguese Atlantic *** it is considered edible in some countries,its biotechnological potential has not yet been assessed in detail and here we report its antimicrobial potential against human dermatophyte *** samples were harvested from Baleal Island(Peniche,Portugal)harvested in winter(BbPe);from Aguda Beach(Arcozelo,Vila nova de Gaia,Portugal),harvested in autumn(BbAg)and a sample obtained by culturing the Aguda sample under laboratory conditions(BbLC).A broth macrodilution assay was applied to determine the MIC(minimum inhibitory concentration)and MLC(minimum lethal concentration)of the *** *** show that the BbPe MeOH extracts were the most effective and had higher antifungal activity against all the tested dermatophyte strains than the BbLC and BaAg extracts[Epidermophyton floccosum FF9(100–200μg/mL MIC;200μg/mL MLC),Microsporum canis FF1(400μg/mL MIC;≥400μg/mL MLC),trichophyton mentagrophytes FF7(100μg/mL MIC;>800μg/mL MLC),*** CECt 2908(800μg/mL MIC;≥800μg/mL MLC),*** *** CECt 2958(800μg/mL MIC;≥800μg/mL MLC),*** CECt 2794(200μg/mL MIC;≥400μg/mL MLC)].In fact,only *** FF9 was sensitive to BbAg and BbLC MeOH *** our knowledge,this is the first report of antifungal activity of *** against human dermatophyte fungi.

关键词： seaweed Bifurcaria bifurcata bioactivity antifungal dermatophytes minimum inhibitory concentration minimum lethal concentration

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