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Growing challenge of post-liver transplantation non-alcoholic fatty liver disease

World Journal of Transplantation 2022年第9期12卷 281-287页

作者： maria styliani kalogirou Olga Giouleme Gastroenterology and Hepatology Division of the Second Propedeutic Department of Internal Medicine Hippokration General HospitalMedical SchoolAristotle University of ThessalonikiThessaloniki 54642Greece

Non-alcoholic fatty liver disease(NAFLD)is one of the leading causes of chronic liver disease,cirrhosis,and hepatocellular carcinoma worldwide,with an estimated prevalence of 25%.Post-liver transplantation(LT)recurrent or de novo hepatic steatosis is a common complication in recipients,irrespective of transplantation *** factors for graft steatosis mainly include obesity,immunosuppression,donor steatosis,and genetic *** transplant recipients are at high risk of developing insulin resistance,new-onset diabetes,and posttransplantation metabolic syndrome that is highly associated with immunosuppressive ***-LT NAFLD is often underdiagnosed due to the poor sensitivity of most routine imaging *** gold standard for the diagnosis of hepatic steatosis is liver biopsy,which is,however,limited to more complex cases due to its invasive *** is no approved pharmacotherapy in *** modification remains the cornerstone in NAFLD *** treatment strategies in post-LT NAFLD include lifestyle modifications,pharmacotherapy,bariatric surgery,and tailored ***,these approaches originate from recommendations in the general population,as there is scarce data regarding the safety and efficacy of current management strategies for NAFLD in liver transplant *** prospective studies are required to achieve tailored treatment for these patients.

关键词： Non-alcoholic fatty liver disease Steatohepatitis Hepatic steatosis Liver transplantation Cirrhosis Metabolic syndrome

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Treating nonalcoholic steatohepatitis with antidiabetic drugs： Will GLP-1 agonists end the struggle？

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World Journal of Hepatology 2018年第11期10卷 790-794页

作者： maria kalogirou Emmanouil Sinakos 4th Department of Internal Medicine Hippocrates Hospital Aristotle University of Thessaloniki Thessaloniki 54642 Greece

Nonalcoholic fatty liver disease(NAFLD) is highly associated with insulin resistance(IR), type 2 diabetes mellitus and metabolic syndrome, being characterized as the hepatic component of metabolic syndrome. Despite its high prevalence, no pharmacological treatment has been established, as of yet. A growing body of evidence, however, shows that reducing IR can result in improvement of the biochemical and histological features of nonalcoholic steatohepatitis(NASH)-the aggressive form of NAFLD that can lead to cirrhosis and hepatocellular carcinoma. Unfortunately, the several trials that have assessed the effect of various antidiabetic agents to date have failed to establish an effective and safe treatment regimen for patients with NAFLD. Glucagon-like peptide-1(commonly known as GLP-1) agonists are a novel class of antidiabetic drugs that improve insulin sensitivity and promote weight loss. They also appear to have a direct effect on the lipid metabolism of hepatocytes, reducing hepatic steatosis. Several trials have demonstrated that GLP-1 agonists can reduce aminotransferase levels and improve liver histology in patients with NAFLD, suggesting that these agents could serve as an alternative treatment option for these patients. This manuscript discusses the role and potential mechanisms of GLP-1 agonists in the treatment of NASH.

关键词： Nonalcoholic steatohepatitis Cirrhosis Glucagon-like peptide-1 receptor agonists Nonalcoholic fatty liver disease

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“Sea Diamond” Wreckage—12 Years after the Fatal Maritime Accident, the Vessel Remains an Environmental Concern

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Open Journal of Ecology 2020年第8期10卷 537-570页

作者： Stephanos D. V. Giakoumatos Efstratios N. kalogirou School of Maritime and Industrial Studies University of Piraeus 80 M. Karaoli & A. Dimitriou St. 18534 Piraeus Greece

The present study was accomplished to fulfill the requisition of the Appeal Court of the city of Piraeus. According to the Court’s Decision, an environmental impact assessment should be made for the ongoing condition of the wreckage along with a study of the corrosion evolution process and a provision of the hull’s endurance should be estimated. The wreckage was sounded out, surveyed thoroughly by means of an ROV device immersed ad hoc. Extended videos and photo shots were taken and the exact position of the vessel depicted analytically on a sea contour depth chart. Hull corrosion, sea column & sea bottom sediment sampling carried out for the analysis of hazardous compounds PAHs, TPHs, PCBs and heavy metals in June and July of 2019. Fish and oyster tissues were analyzed in the lab for heavy metals’ detection. A great concern was given for (Cd) & (Pb) concentration in sea column nearby wreck. Α report of about 1000 pages of the methodology & results was handed over to the Appeal Court of which merely partial significant segments are presented herein. The technical report denotes that PCBs, PAHs, TPHs sea bed & sea column measurements nearby the wreck were, in general, low or below detectable level. As regards heavy metals concentration level in aquatic sea column, the results indicate that only in certain locations heavy metals i.e. (Pb) and (Ni) were measured above the detection limit and classified according to contamination factors from moderate to high contamination level and might attribute to the presence of the wreck in the close area. Contamination factor indices consolidate the approach that the hull presence in the bottom contributes to the environmental degradation of the “caldera” ecosystem. The vessel’s hull is expected to be wiped out in almost four hundred years period according to the applied corrosion model.

关键词： Heavy Metals Caldera Thira Island Salvage Greek Archipelago Wreckage Removal

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玻璃书店

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设计家 2009年第11期 102-105页

作者： Nicos kalogirou Evangelos Kotsioris 哈佛大学设计研究生院希腊Thessaloniki Aristotle大学

本案是由一个关闭的杀虫剂仓库改建而来的,改建后,原本的仓库将成为一个颇具吸引力的书店和小型的出版公司。这次改建也为设计师提供了一次机会,他们在可操作的尺度内,实验性地使用了多层玻璃、三角形面、翻转的几何形面等不规则建构方... 详细信息

本案是由一个关闭的杀虫剂仓库改建而来的,改建后,原本的仓库将成为一个颇具吸引力的书店和小型的出版公司。这次改建也为设计师提供了一次机会,他们在可操作的尺度内,实验性地使用了多层玻璃、三角形面、翻转的几何形面等不规则建构方式和风格。

关键词：书店杀虫剂改建几何形玻璃体三角形面多层玻璃建构方式实验性不规则

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