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Differential expression of the fractalkine chemokine receptor （CX3CR 1） in human rnonocytes during differentiation

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Cellular & Molecular Immunology 2015年第6期12卷 669-680页

作者： Cecilia Analia Panek maria Victoria Ramos maria Pilar Mejias maria Iimena Abrey-Recalde Romina Iimena Fernandez-Brando maria soledad gori Gabriela Veronica Salamone2 Marina Sandra Palermo Laboratorio de Patogenesis e Inmunologfa de Procesos Infecciosos Instituto de Medicina Experimental (IMEX CONICET) Academia Nacional de Medicina Buenos Aires Argentina and Laboratorio de Celulas Presentadoras de Antfgeno y Respuesta Inflamatoria IMEX-CONICET Academia Nacional de Medicina Buenos Aires Argentina

Circulating monocytes （Mos） may continuously repopulate macrophage （MAC） or dendritic cell （DC） populations to maintain homeostasis. MACs and DCs are specialized cells that play different and complementary immunological functions. Accordingly, they present distinct migratory properties. Specifically, whereas MACs largely remain in tissues, DCs are capable of migrating from peripheral tissues to lymphoid organs. The aim of this work was to analyze the expression of the fractalkine receptor （CX3CR1） during the monocytic differentiation process. Freshly isolated Mos express high levels of both CX3CR1 mRNA and protein. During the Mo differentiation process, CX3CR1 is downregulated in both DCs and MACs. However, MACs showed significantly higher CX3CR1 expression levels than did DC. We also observed an antagonistic CX3CR1 regulation by interferon （IFN）-γ and interleukin （IL）-4 during MAC activation through the classical and alternative MAC pathways, respectively. IFN-γinhibited the loss of CX3CR1, but IL-4 induced it. Additionally, we demonstrated an association between CX3CR1 expression and apoptosis prevention by soluble fractalkine （sCX3CL1） in Mos, DCs and MACs. This is the first report demonstrating sequential and differential CX3CR1 modulation during Mo differentiation. Most importantly, we demonstrated a functional link between CX3CR1 expression and cell survival in the presence of sCX3CL1.

关键词： dendritic cells fractalkine receptor macrophages monocytes survival

Boston type I keratoprosthesis

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Annals of Eye Science 2024年第2期9卷 12-23页

作者： Karen Hu Imane Tarib maria soledad Cortina Department of Ophthalmology and Visual Sciences University of Illinois at ChicagoChicagoILUSA

Successful corneal solid tissue transplantation,beginning with penetrating keratoplasty(PKP),and evolving to include contemporary lamellar and endothelial keratoplasty,has been a tremendous advancement in the struggle to combat corneal ***,there remain patients with high-risk features predictive of transplant failure,for whom donor keratoplasty is not a viable *** corneas have therefore been developed in order to meet the needs of these *** Boston type I keratoprosthesis(BKPro)is the most widely used prosthetic cornea in the treatment of corneal *** the years since the BKPro’s introduction,refinement of surgical technique and clinical management as well as improvements in prosthetic design have contributed to promising patient outcomes,particularly in the short *** such,patients with keratoprosthesis implants continue to grow in number,and the indications for the BKPro have commensurately ***,risks of permanently blinding complications after implantation persist over all stages of *** the foreseeable future,the success of keratoprosthesis(KPro)implantation will continue to depend on refined patient selection,preoperative optimization,and incisive postoperative *** we explore indications,surgical technique and postoperative outcomes as well as several core tenants in the management of BKPro patients:limiting glaucomatous progression,controlling inflammation,and optimizing the ocular *** exquisite sensitivity of the BKPro-implanted eye to perturbations in any one of these areas showcases the intimate relationship between the prosthetic device and its surrounding environment.

关键词： Keratoprosthesis corneal transplant Boston type I keratoprosthesis(BKPro) keratoprosthesis(KPro)

Classification of anemia for gastroenterologists

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World Journal of Gastroenterology 2009年第37期15卷 4627-4637页

作者： Jose Antonio Moreno Chulilla maria soledad Romero Colás Martín Gutiérrez Martín Department of Hematology University Hospital "Lozano Blesa" University of Zaragoza C/San Juan Bosco 15 Zaragoza 50009 Spain

Most anemia is related to the digestive system by dietary deficiency, malabsorption, or chronic bleeding. We review the World Health Organization definition of anemia, its morphological classifi cation (microcytic, macrocytic and normocytic) and pathogenic classi-fication (regenerative and hypo regenerative), and integration of these classifications. Interpretation of laboratory tests is included, from the simplest (blood count, routine biochemistry) to the more specific (iron metabolism, vitamin B12, folic acid, reticulocytes, erythropoietin, bone marrow examination and Schilling test). In the text and various algorithms, we propose a hierarchical and logical way to reach a diagnosis as quickly as possible, by properly managing the medical interview, physical examination, appropriate laboratory tests, bone marrow examination, and other comple-mentary tests. The prevalence is emphasized in all sections so that the gastroenterologist can direct the diagnosis to the most common diseases, although the tables also include rare diseases. Digestive diseases potentially causing anemia have been studied in preference, but other causes of anemia have been included in the text and tables. Primitive hematological diseases that cause anemia are only listed, but are not discussed in depth. The last section is dedicated to simplifying all items discussed above, using practical rules to guide diagnosis and medical care with the greatest economy of resources and time.

关键词：形态分类贫血症胃肠病消化系统疾病网织红细胞维生素B12 红细胞生成素身体检查

Bone metastases as initial presentation of hepatocellular carcinoma

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World Journal of Hepatology 2017年第29期9卷 1158-1165页

作者： Luzdivina Monteserin Alicia Mesa maria soledad Fernandez-Garcia Arantza Gadanon-Garcia Manuel Rodriguez María Varela Department of Gastroenterology and Hepatology Complejo Asistencial Universitario de León Department of Radiology Hospital Universitario Central de Asturias Department of Pathology Hospital Universitario Central de Asturias Department of Traumatology Hospital Universitario Central de Asturias Liver Unit Hospital Uni-versitario Central de Asturias

Extra-hepatic spread is present in 5% to 15% of patients with hepatocellular carcinoma(HCC) at the time of diagnosis. The most frequent sites are lung and regional lymph nodes. Here, we report 3 cases of unsuspected HCC with symptoms due to bone lesions as initial presentation. Morphological characteristics and immunohistochemistry from the examined bone were the key data for diagnosis. None of the patients had an already known chronic liver disease. Differential diagnoses with HCC upon ectopic liver disease or hepatoid adenocarcinoma were shown. Therapy with the orally active multikinase inhibitor sorafenib plus symptomatic treatment was indicated.

关键词： Hepatocellular carcinoma Bone metastases Liver cirrhosis Sorafenib

Human sperm pattern of movement during chemotactic ＇e-orientation towards a progesterone source

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Asian Journal of Andrology 2011年第5期13卷 769-773页

作者： Cecilia soledad Blengini maria Eugenia Teves Diego Rafael Ufiates Hetor Alejandro Guidobaldi LauraVirginia Gatica Laura Cecilia Giojalas Centre for Cell and Molecular Biology National University of Cordoba Cordoba X5016GCA Argentina

Human spermatozoa may chemotactically find out the egg by following an increasing gradient of attractant molecules. Although human spermatozoa have been observed to show several of the physiological characteristics of chemotaxis, the chemotactic pattern of movement has not been easy to describe. However, it is apparent that chemotactic cells may be identified while returning to the attractant source. This study characterizes the pattern of movement of human spermatozoa during chemotactic re-orientation towards a progesterone source, which is a physiological attractant candidate. By means of videomicroscopy and image analysis, a chemotactic pattern of movement was identified as the spermatozoon returned towards the source of a chemotactic concentration of progesterone （10 pmol I^-1）. First, as a continuation of its original path, the spermatozoon swims away from the progesterone source with linear movement and then turns back with a transitional movement that can be characterized by an increased velocity and decreased linearity. This sperm behaviour may help the spermatozoon to re-orient itself towards a progesterone source and may be used to identify the few cells that are undergoing chemotaxis at a given time.

关键词： chemotaxis human spermatozoa progesterone

Implementation of a virtual multicenter gastrointestinal tumor board to reduce cancer disparities in Argentina

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World Journal of Clinical Oncology 2022年第6期13卷 423-428页

作者： Federico Esteso Natalia soledad Tissera Juan Manuel O'Connor Romina Luca Eduardo Huertas Fernando Sánchez Loria Ivana Pedraza Alejandro Pairola Fernando Brancato Lisandro Paganini mariana Kucharczyk Mora Amat maria Teresa Pombo mariana Galli Luisina Bruno Luis Caro Andrés Rodriguez Diego Enrico Federico Waisberg Matías Chacón Department of Gastrointestinal Medical Oncology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Surgery Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Radiology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Pathology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Radiation Oncology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Gastroenterology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Medical Oncology Instituto Alexander FlemingBuenos Aires 1426Argentina

Given the increasing complexity of cancer care,multidisciplinary tumor boards have become essential in daily clinical oncology *** Project Extension for Community Healthcare Outcomes(ECHO)initiative developed an innovative telementoring model using a"hub and spoke"design consisting of a team of experts(hub)that offers a full service to multiple participants(the spokes)during regularly scheduled sessions discussing patients'clinical *** Alexander Fleming Cancer Institute in Buenos Aires was the first hub in Latin America to implement Project ECHO for gastrointestinal *** our 3-year experience,80 patients from 37 centers were evaluated within Project ECHO and a range of three to five cases were discussed in each *** our perspective,the impact of this novel approach was a remarkable strategy to reduce care disparities by equalizing access to high-quality medical knowledge in a multidisciplinary environment for medical ***,it was shown to have a cost-effective impact directly on the patients and the local health system,since relevant costs were saved after unnecessary treatments,studies and travel expenses were avoided.

关键词： Tumor board Virtual Gastrointestinal Cancer disparities Oncology Extension for Community Healthcare Outcomes project

Structure of Personality at Intrapsychic and Interpersonal Levels and Depression of Caregivers of Patients Affected by Alzheimer’s Disease: Which Psychotherapeutic Approach?

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Advances in Alzheimer's Disease 2018年第4期7卷 103-118页

作者： Giulietti maria Velia Anna Vespa Stefano Berti Guido gori Marica Ottaviani Cristina Meloni Paolo Fabbietti Giuseppe Pelliccioni Lucia Paciaroni Roberta Spatuzzi Department of Research INRCA-IRCCS National Institute of Science and Health for Aging Ancona Italy Department of Research Scientific and Technological Area INRCA-IRCCS National Institute of Science and Health for Aging Anco-na Italy Health Promotion Department Ancona Alzheimer Daily Center Florence Italy Biostatistical Center INRCA-IRCCS National Institute of Health and Science on Aging Ancona Italy U.O.C. Hospice/Palliative Care Departments Potenza Italy

Background: Many studies have underlined as caregiving for people with Alzheimer’s disease (AD) is highly stressful and has significant negative consequences. Objectives: The study of the structure of personality, can help to understand the association between depression, intrapsychic and interpersonal processes of caregivers of Alzheimer’s disease patients and what kind of intervention can be planned to favor the stress burden management. Methods: Case group: Caregivers (CG) (n = 75);control group, Subjects not Caregivers (nCG) (n. 104). Tests: SASB questionnaire (Structural Analysis of Interpersonal Behavior) describing intrapsychic and interpersonal processes of the structure of personality validated on the basis of DSMIV;CDQ questionnaires—depression. Results: Intrapsychic level: From the results it emerged that CGs had lower autonomy in their choices, and lower acceptance of their own feelings, and exercised greater self-control exhausting themselves toward predetermined goals, and more depression compared to the control group. They may be not able to achieve psychic equilibrium in the presence of stress: they may likely become disoriented and engage in behaviors that may be self-defeating. SASB-Cl = Autonomy (p 0.001);SASB-Cl2-Autonomy and Love (p 0.001), SASB-CL3-Love (p 0.001);SASB-Cl4 Love and control (p 0.001), SASB-CL5-Control (p = 0.015), SASB-Cl6-Control and hate (p 0.001), SASB-Cl7-Hate (p Conclusions: Intrapsychic characteristics such as tendency to depression, inability to being in contact with their own feelings, excessive self-control may be linked to difficulties in facing burden of care and indicate serious difficulties to adaptation to burden condition. The knowledge of these modalities could allow to plan a psychotherapeutic and multidisciplinary intervention aimed at facing and overcoming the psychological distress of the caregiver.

关键词： Caregiver Alzheimer Depression Intrapsychic Behaviours Interpersonal Behaviours Personality

Sex chromosomes behavior and G-banding treatment of male meiosis in nuptial gift-giving spiders of the family Trechaleidae

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Integrative Zoology 2011年第1期6卷 56-62页

作者： maria J.ALBO Alicia POSTIGLIONI Laboratory of Ethology Ecology and EvolutionClemente Estable Biological Research InstituteMontevideoUruguay Department of Genetics and Animal Breeding Faculty of VeterinaryUniversity of the RepublicMontevideoUruguay

Preliminary genetic studies in Trechaleidae spider family show high variation in sex chromosomes and high heterocigocity,suggesting high chromatin *** trechaleids Paratrechalea ornata,Trechalea bucculenta and Trechaleoides biocellata are present in *** offering nuptial gifts during courtship have been reported in *** and *** but not in *** gifts are an inherited trait probably highly affected by environmental factors,which play an important role in gene *** hypothesize that this trait could be associated with tissue-specific genes existing in *** investigate the male meiosis in these 3 species,their sex chromosome system and the effects of G-banding on their chromosomes,and elucidate genetic differences among *** stages of the 3 species were submitted to Giemsa-staining and G-banding *** observed a haploid number of n=11 in *** and n=13 in both *** and *** from the 3 species presented an X_(1)X_(2)0 sex chromosome system,which is suggested as ancestral in *** *** and ***,both sex chromosomes were together and aligned in parallel until the segregation during anaphase *** contrast to these species,sex chromosomes of *** usually remained distant from each other until diakinesis when they were observed associated in parallel *** G-bands were similar in *** and ***,and they both differed from those in *** special behavior of sex chromosomes in *** as well as the different G-banding pattern of this species suggests the existence of novel modifications in this species.

关键词： G-banding male meiosis Neotropical spiders sex chromosomes Trechaleidae

Evaluation of Anxiety and Depression in Caregivers of Patients Affected by Alzheimer’s Disease

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Advances in Alzheimer's Disease 2015年第2期4卷 15-20页

作者： Anna Vespa maria Velia Giulietti Marica Ottaviani R. Spatuzzi F. Merico Guido gori Olimpia Claudia Rossi L. Paciaroni Giuseppe Pelliccioni Pietro Scendoni Cristina Meloni Department of Neurology INRCA-IRCCS Italian National Institute of Health and Science on Aging Ancona Italy Unity of Neurology INRCA-National Institute of Health and Science on Aging Ancona Italy Department of Neurology INRCA-IRCCS National Institute of Health and Science on Aging Ancona Italy U.O.C. Hospice/Palliative care Departments A.O.R. San Carlo di Potenza Italy Hospice Casa di Betania Palliative Care Center Lecce Italy Director Day Alzheimer Center “Le Civette” ASL-Florence Italy Department of Rheumatology INRCA-IRCCS National Institute of Health and Science on Aging Fermo Italy INRCA-IRCCS National Institute of Health and Science on Aging Ancona Italy

Background: Many studies have been underlined as care giving for people with Alzheimer’s disease (AD) is highly stressful and has significant negative consequences, such as anxiety and depression. Objective: The specific aim of our study is to establish whether a difference exists in the prevalence of depression of family caregivers of Alzheimer’s disease patients and healthy subjects not caregiver. Methods: Study group (n = 60) consists of caregivers of patients affected by Alzheimer’s disease, whereas control group (n = 120) consists of healthy individuals who are not care giving (from at least 5 years). All the subjects were subdivided on the basis of the following independent variables: sex, age, marital status and educational level. The subjects of study and control groups studied have filled in the following tests: IPAT CDQ e IPAT ASQ Tests by Cattell which describe depression and anxiety. Such tests have been validated on the adult and elderly Italian population. Statistical analysis: Student t test has been applied for the comparison between experimental and control groups. Results: The caregivers show higher levels of anxiety (medium to high, P < 0.001) and depression in comparison to the group of control (medium to high, P < 0.001). This result indicates the caregiver shows serious depression. Conclusions: The high levels of depression and anxiety suggest the following considerations: interventions of social and psychological support are fundamental not only to maintain the patient in the family nucleus but also to maintain the caregiver’s psychological health.

关键词： Caregiver Alzheimer’s Disease Anxiety Depression