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Chemical composition of Rosmarinus officinalis essential oil and antioxidant action against gastric damage induced by absolute ethanol in the rat

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Asian Pacific Journal of Tropical Biomedicine 2016年第8期6卷 677-681页

作者： Christiane Takayama Felipe Meira de-Faria Ana Cristina Alves de Almeida Ricardo Jose Dunder Luis Paulo Manzo Eduardo Augusto Rabelo Socca Leonia maria Batista Marcos Jose Salvador Alba regina Monteiro Souza-Brito Anderson Luiz-Ferreira Functional and Structural Biology Department Biology Institute Campinas State University Pharmacology Department Faculty of Medical Sciences Campinas State University Department of Pharmaceutical Sciences Federal University of Paraiba Plant Physiology Department Biology Institute Campinas State University Federal University of Goias Institute of Biotechnology Nucleus of Biological Sciences Regional Catalao

Objective: To evaluate the antioxidant activity of the essential oil obtained from Rosmarinus officinalis(R. officinalis) in ethanol-induced gastric ulcer model in ***: The antioxidant properties of the essential oil obtained from R. officinalis were evaluated against gastric injury induced by absolute ethanol. Gastric tissues were prepared to enzymatic assays. The levels of glutathione, lipid peroxides, and the activities of glutathione peroxidase, superoxide dismutase and myeloperoxidase were ***: Ethanol produced severe hemorrhagic lesions in the stomach with ulcerative lesion of(140.2 ± 37.2) mm2. In animals pretreated with essential oil of R. officinalis(50 mg/kg, p.o.), a significant inhibition of mucosal injury of(21.2 ± 7.1) mm2(84%inhibition) was observed. The essential oil of R. officinalis protected the gastric mucosa probably by modulating the activities of the enzymes(superoxide dismutase and glutathione peroxidase) and increasing or maintaining the levels of glutathione. In addition,lipid peroxides levels were reduced. The essential oil of R. officinalis was analyzed by gas chromatography–mass spectrometer and the main constituents were cineole(28.5%),camphor(27.7%) and alpha-pinene(21.3%).Conclusions: We suggest that the monoterpenes present in the essential oil obtained from R. officinalis may be among the active principles responsible for the antioxidant activity shown by essential oil of R. officinalis.

关键词： Rosmarinus officinalis L. Antioxidant activity Gastric ulcer Antioxidant enzymes

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Perivascular epithelioid cell tumor of the liver coexisting with a gastrointestinal stromal tumor

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World Journal of Gastroenterology 2008年第5期14卷 800-802页

作者： Carlos Eduardo Paiva Francisco Alves Moraes Neto Abbas Agaimy maria Aparecida Custódio Domingues Silvia regina Rogatto Oncological and Hemato-oncological Center So Paulo State University Botucatu So Paulo 18610-170 Brazil Department of Pathology Amaral Carvalho Hospital Jaú So Paulo Brazil Institute of Pathology Nuremberg Clinic Center Nuremberg Germany Department of Pathology So Paulo State University Botucatu So Paulo 18610-170 Brazil Department of Urology So Paulo State University Botucatu So Paulo 18610-170 Brazil

Approximately 10% of patients with gastrointestinal stromal tumors (GIST) develop other neoplasms, either synchronously or metachronously. In this report we describe coexistence of a gastrointestinal stromal tumor and a hepatic perivascular epithelioid cell tumor (PEComa) in a 51-year-old woman with no evidence of tuberous sclerosis. A subcapsular hepatic nodule (0.8 cm in diameter) was found during surgery for symptomatic gastric neoplasm (15 cm in diameter) arising from the lesser curvature. Both tumors revealed histomorphological and immunohistochemical features confirming a diagnosis of a small incidental hepatic PEComa and a high risky extramural gastric GIST, respectively. The patient remained disease-free 25 mo after surgery with no evidence of tumor recurrence or new neoplasms. To our knowledge, this is the first report of PEComa in a patient with GIST. Hepatic lesions detected synchronously or metachronously in patients with GISTs may represent histogenetically distinct lesions and should be sampled to confirm or exclude metastatic GISTs.

关键词：胃肠肿瘤肝脏疾病症状患者

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Preliminary Tests of a Kerma-Area Product (KAP) Meter to Be Used as a Monitor Chamber in a Conventional Diagnostic X Ray System

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Journal of Modern Physics 2015年第4期6卷 483-489页

作者： Eduardo Correa regina Medeiros maria da Penha Potiens Vitor Vivolo Nathalia Costa Camila Murata Cristina Kikuti Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN) Universityof Sao Paulo (USP) Sao Paulo Brazil Federal University of Sao Paulo (UNIFESP) Sao Paulo Brazil

This study presents the results of the preliminary tests performed using a kerma-area product (KAP) meter in order to verify its usefulness as a monitor chamber in a clinical X ray system, which will be used in ionization chambers’ quality control program. The tests performed were repeatability, surface measurement uniformity, linearity with tube current, measurement variation changing the distance and field size, KAP chamber radiation attenuation, and energy dependence. The KAP meter has presented a good repeatability (a maximum variation of 0.4%);its surface has a homogeneous response (a maximum variation of 1.0% among the different irradiated regions);the response is linear with the tube current and the variation of the PKA along the distance is less than 3.43%. On the other hand, the results obtained for chamber attenuation and energy dependence show that some corrections must be applied when the measurements are made. The results have shown a good performance of the KAP meter, confirming that it is possible to use this instrument as a monitor chamber. However, it is important to highlight that some correction factors for energy dependence and chamber radiation attenuation must be considered.

关键词： KAP Meter Quality Control Diagnostic Radiology Monitor Chamber

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Pesticide Residue Control in the Years 1986-1987

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Biomedical and Environmental Sciences 1991年第4期4卷 415-422页

作者： IVANO CAMONI ALFONSO DI MUCCIO maria SANDRA BELLISAI PAOLO CITTI Istituto Superiore di Sanita' Lab. Tossicologia Applicata Viale Regina Elena 299 Rome 00161ItalyIstituto Superiore di Sanita' Lab. Tossicologia Applicata Viale Regina Elena 299 Rome 00161ItalyMinistero Della Sanita Dir. Gen. Ig. Alim. e Nutrizione Rome 00161 ItalyIstituto Superiore di Sanita' Lab. Tossicologia Applicata Viale Regina Elena 299 Rome 00161Italy

Results of analytical surveys on pesticide residue levels in foods for the years 1986-1987 are presented. Analytical data obtained from regional laboratories are tabulated in terms of various commodity groups (vegetables, fruit, cereals, processed or derived foodstuffs, other commodities, legumes, environmental samples, others) and are compared with maximum legal tolerances established by the ministerial ordinance (Italian Ministry of Health) 6.6. 1985.On a total number of 4715 determinations of classes of compounds or of single compounds made on 1601 commodities samples, only N 53 (1.1 %) violative results appeared. No residue was found at levels exceeding regulatory limits or found in commodities where a tolerance had not been established for a specific pesticide/commodity combination.

关键词： Pesticide Residue Control in the Years 1986-1987

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What have we learned about the kallikrein-kinin and renin-angiotensin systems in neurological disorders?

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World Journal of Biological Chemistry 2014年第2期5卷 130-140页

作者： maria da Graa Naffah-Mazzacoratti Telma Luciana Furtado Gouveia Priscila Santos Rodrigues Simōes Sandra regina Perosa Department de Bioquímica and Departamento de Neurologia/Neurocirurgia Universidade Federal de S?o Paulo (UNIFESP) S?o Paulo SP 4039032 Brazil

The kallikrein-kinin system(KKS) is an intricate endogenous pathway involved in several physiological and pathological cascades in the brain. Due to the pathological effects of kinins in blood vessels and tissues, their formation and degradation are tightly controlled. Their components have been related to several central nervous system diseases such as stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, epilepsy and others. Bradykinin and its receptors(B1R and B2R) may have a role in the pathophysiology of certain central nervous system diseases. It has been suggested that kinin B1R is up-regulated in pathological conditions and has a neurodegenerative pattern, while kinin B2R is constitutive and can act as a neuroprotective factor in many neurological conditions. The renin angiotensin system(RAS) is an important blood pressure regulator and controls both sodium and water intake. AngⅡ is a potent vasoconstrictor molecule and angiotensin converting enzyme is the major enzyme responsible for its release. AngⅡ acts mainly on the AT1 receptor, with involvement in several systemic and neurological disorders. Brain RAS has been associated with physiological pathways, but is also associated with brain disorders. This review describes topics relating to the involvement of both systems in several forms of brain dysfunction and indicates components of the KKS and RAS that have been used as targets in several pharmacological approaches.

关键词： Kallikrein-kinin system Renin-angiotensin system Neurological disorders Alzheimer’s disease Epilepsy Parkinson’s disease

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Photo-Induced Thermally Stimulated Depolarization Current (TSDC) in Natural and Synthetic Alexandrite (BeAl₂O₄:Cr³⁺)

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Materials Sciences and Applications 2016年第12期7卷 881-894页

作者： Neilo Marcos Trindade Ana regina Blak Elisabeth Mateus Yoshimura Luis Vicente de Andrade Scalvi Rosa maria Fernandes Scalvi Sã o Paulo Federal Institute S&atilde o Paulo Brazil Institute of Physics University of S&atilde o Paulo S&atilde o Paulo Brazil Department of Physics S&atilde o Paulo State University Bauru Brazil

The investigation of electrical properties in alexandrite (BeAl2O4:Cr3+) in synthetic and natural forms is presented in this paper. Alexandrite is a rare and precious mineral that changes color according to the light incident on it. In the synthetic form, it is used technologically as an active laser medium. The electrical characterization was obtained using the Thermally Stimulated Depolarization Current (TSDC) technique, an interesting tool to study the behavior of impurities in insulators. Alexandrite presented the electric dipole relaxation phenomenon, both in natural and in synthetic samples. It was possible to observe TSDC bands for the synthetic sample at around 170 K, and at around 175 K for the natural sample. Besides, photo-induced TSDC measurements were performed through the excitement of the samples by using a continuous wave argon laser. In addition, photoluminescence measurements were performed to verify in advance whether the laser light would be absorbed by the sample, and in order to complement the photo-induced TSDC measurements analysis. The results of photo-induced TSDC experiments have contributed to the understanding of the TSDC bands behavior: the results obtained with the technique suggest that there is an effective participation of Cr3+ ions in the formation of TSDC bands because they were more intense when the sample was exposed to the argon laser beam.

关键词： Alexandrite Chrysoberyl Thermally Stimulated Depolarization Current (TSDC) Photoluminescence Photo-Induced

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Platelet Indices in Patients with Acute Coronary Syndrome

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Journal of Biosciences and Medicines 2015年第11期3卷 71-76页

作者： Silvia Cristina Costa Carmen Guilherme de Matos Vinagre Ana Paula Marte Chacra maria regina Andrade de Azevedo Department of Health Sciences University of Santo Amaro Sao Paulo Brazil Department of Cardiology Heart Institute University of Sao Paulo Sao Paulo Brazil

The platelet indices Mean Platelet Volume (MPV), Platelet Distribution Width (PDW) and Plate-letcrit (PCT) provided by automated hematology analysis are rarely used in clinical practice. Platelets play a central role in the pathogenesis of acute coronary syndromes (ACS) and high MPV has been associated to more reactive platelets and regarded as an independent risk factor for myocardial infarction. In this study, platelet indices were evaluated in 39 patients with ACS presenting two altered biochemical parameters, C reactive protein (CRP) and creatine kinase fraction MB (CK-MB). The results obtained showed significantly higher MPV and PDW values in the group with ACS in comparison to the control group. Also observed was a weak but significant positive correlation between MPV and CK-MB. In view of findings of previous studies, which have associated macroplatelets with higher thrombotic potential our results suggest that the use of the MPV and PDW indices as additional and complementary markers may contribute to the investigation and follow-up of thrombotic risk in patients with ACS.

关键词： Platelets Platelet Indices Acute Coronary Syndrome CK-MB

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Public Participation GIS:a FOSS architecture enabling field-data collection

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International Journal of Digital Earth 2015年第5期8卷 345-363页

作者： maria Antonia Brovelli Marco Minghini Giorgio Zamboni DICA Politecnico di MilanoComoItaly

Driven by the rise of Web 2.0 and the non-stop spread of mobile device sensors,the concept of Public Participation GIS(PPGIS)is knowing a revolutionary era which perfectly fits the new vision of Digital Earth(DE).This research investigates the opportunity to build up a PPGIS prototype with completely Free and Open Source Software(FOSS)architecture,in which data directly come from field surveys carried out by users.A sample application related to urban monitoring is addressed,which concentrates on user field-collected data concerning reports of road pavement *** Data Kit suite allows users to collect geotagged multimedia information using mobile devices with onboard location sensors(e.g.a Global Positioning System receiver).On field-captured data are sent to a server and stored into a PostgreSQL database with PostGIS spatial *** then disseminates data on the *** the client-side,different solutions allow data visualization on both desktop computers and mobile *** designed architecture provided support for FOSS usage in the process of gathering,uploading,and Web publishing information collected in *** implementation of the developed PPGIS could thus substantially increase public active participation in data creation and sharing,besides enlarging DE knowledge up to the local level.

关键词： GeoWeb FOSS mobile PPGIS Web Mapping

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The Use of Solid State NMR to Evaluate the Carbohydrates in Commercial Coffee Granules

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Food and Nutrition Sciences 2011年第4期2卷 350-355页

作者： regina Freitas Nogueira Elisangela Fabiana Boffo maria Inês Bruno Tavares Leonardo AMoreira Leila Aley Tavares Antonio Gilberto Ferreira Departamento de Química da Universidade Federal de Sao CarlosSao CarlosBrasil Institutito de Macromoléculas Universidade Federal do Rio de JaneiroRio de JaneiroBrasil Escola Técnica Federal de Minas GeraisBrasil

Coffee brings many health benefits due to its chemical constituents. Based on this information, it is essential to know the main chemical compounds from coffee granules;the intermolecular interaction among the coffees compounds and the molecular components homogeneity. In this study six types of roasted commercial coffee were evaluated by solid state nuclear magnetic resonance (NMR), employing carbon-13 (13C) and hydrogen (1H) nucleus. Carbon-13 was analyzed applying high field NMR techniques, such as: magic angle spinning (MAS);magic angle spinning with cross-polariza- tion (CPMAS) and magic angle spinning with cross-polarization and dipolar dephasing (CPMASDD). The hydrogen was evaluated via relaxation times. Proton spin-lattice relaxation time in the rotating frame was deter-mined through the carbon-13 decay, during the variable contact-time experiment, using high field NMR. Proton spin-lattice relaxation time was determined through the inversion-recovery pulse sequence, using low field NMR. Considering all NMR results, it was concluded that the major coffee compounds are: a) triacilglycerides, which constitute the mobile region in the granule coffee and b) Carbohydrates such as: polysaccharides and fibers that belong to the rigid domain. These constituents belong to different molecular mobility domain, although they have strong intermolecular interactions due to the granule organization.

关键词： Solid State NMR Coffee

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The Evaluation of Polyethylene/Clay Composite from Solid State NMR

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Materials Sciences and Applications 2011年第5期2卷 453-457页

作者： regina F.Nogueira maria Ines B.Tavares Rosane A.S.San Gil Antonio G.Ferreira Departamento de Quimica Universidade Federal de Sao CarlosSao CarlosBrasil Laboratorio de Nanocompositos Polimericos Instituto de Macromoleculas Professora Eloisa Mano da Universidade Federal do Rio de JaneiroRio de JaneiroBrasil Departamento de Quimica Organica da Universidade Federal do Rio de JaneiroRio de JaneiroBrasil

Polymeric nanocomposites based on polyethylene (PE) and Brazilian natural montmorillonite clay (MN) were obtained by melt processing, using a twin-screw extruder. The main objective of this work is focusing on the characterization of composites materials by solid-state nuclear magnetic resonance (NMR). The solid-state NMR measurements were used to observe both polymer matrix (through carbon-13 and hydrogen nuclei) and the clay (silicon-29 and aluminum-27). The polymer matrix analyses were carried out applying solid state techniques, such as: cross-polarization magic angle spinning (CPMAS), variable contact time (VCT) and by the proton spin-lattice relaxation time in the rotating frame parameter (T1ρH), detected from the resolved carbon-13 decay of the VCT experiment and through the determination of spin-lattice relaxation time, T1H (using low field NMR). The clay was analyzed by 29Si and 27Al, employing MAS NMR technique. From those techniques we can have principally response on clay dispersion in the polyethylene matrix, as well as the interactions between both components in the nanostructured material. The T1H response was an important result which showed, that the materials formed, presented different molecular domains (according to the domain size that varied from 25 to 50 nm, measured by relaxation), considering the clay dispersion mode in terms of intercalation and/or exfoliation in the polymer matrix.

关键词： NMR Polymer Polyethylene Clay Montmorillonite

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