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Peripancreatic paraganglioma:Lesson from a round table

World Journal of Gastroenterology 2022年第21期28卷 2396-2402页

作者： Federica Petrelli Geri Fratini Andrea Sbrozzi-Vanni Andrea Giusti Raffele Manta Claudio Vignali Gabriella Nesi Andrea Amorosi Andrea Cavazzana Marco Arganini maria raffaella ambrosio Pathology Unit Azienda Sanitaria Toscana Nord OvestPisa 56121Italy Surgery Unit Azienda Sanitaria Toscana Nord OvestPisa 56121Italy Endoscopic Unit Azienda Sanitaria Toscana Nord OvestPisa 56121Italy Endoscopic Unit Santa Maria Misericordia HospitalPerugia 06122Italy Interventional Radiology Unit Azienda Sanitaria Toscana Nord OvestPisa 56121Italy Department of Health Sciences University of FlorenceFlorence 50139Italy Pathology Unit UniversitàMagna GraeciaCatanzaro 88100Italy

We described the case of a peripancreatic paraganglioma(PGL)misdiagnosed as pancreatic *** exploration revealed an unremarkable pancreas and a large well-defined cystic mass originating at the mesocolon *** enucleation of the mass was performed,preserving the pancreatic ***,a diagnosis of PGL was ***,two previously unreported mutations,one affecting the KDR gene in exon 7 and another on the JAK3 gene in exon 4 were *** mutations are known to be *** and cytologic findings were blindly reviewed by an expert panel of clinicians,radiologists,and pathologists to identify possible causes of the *** major issue was lack of evidence of a cleavage plane from the pancreas at imaging,which prompted radiologists to establish an intraparenchymal *** blinded revision shifted the diagnosis towards an extrapancreatic lesion,as the pancreatic parenchyma showed no structural alterations and no dislocation of the Wirsung *** post,the identified biases were the emergency setting of the radiologic examination and the very thin mesocolon sheet,which hindered clear definition of the lesion *** endoscopic ultrasonography diagnosis was confirmed,emphasizing the intrinsic limit of this technique in detecting large ***,pathologic review favored a diagnosis of PGL due to the morphological features and immonohistochemical *** months after tumor excision,the patient is asymptomatic with no disease relapse evident by either radiology or laboratory *** report strongly highlights the difficulties in rendering an accurate preoperative diagnosis of PGL.

关键词： Peripancreatic paraganglioma Pancreatic neuroendocrine tumor Solid pseudopapillary neoplasm S100 Succinate dehydrogenase subunit B gene and expression Fine needle biopsy

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Solvability of the Dirichlet Problem in W^(2,p )for a Class of Elliptic Equations with Singular Data

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Acta Mathematica Sinica,English Series 2014年第5期30卷 737-746页

作者： Loredana CASO Roberta D'ambrosio maria TRANSIRICO Dipartimento di Matematica Universit`a di SalernoVia Giovanni Paolo II 132I - 84084 Fisciano (SA) Italy

We prove an existence and uniqueness result for the Dirichlet problem for a class of elliptic equations with singular data in weighted Sobolev spaces.

关键词： Elliptic equations a priori estimates uniqueness and existence results weighted spaces

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Regression of liver metastases of occult carcinoid tumor with slow release Lanreotide therapy

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World Journal of Gastroenterology 2005年第13期11卷 2041-2044页

作者： Marta Bondanelli maria Rosaria ambrosio maria Chiara Zatelli Luigi Cavazzini Laura Al Jandali Rifa'y Ettore C.degli Uberti Department of Biomedical Sciences and Advanced Therapies-Section of Endocrinology Department of Experimental and Diagnostic Medicine

Few clinical studies have demonstrated an anti-proliferative activity of somatostatin (SST) analogs in carcinoids. We report the case of a woman with liver metastases of neuroendocrine tumor and no evidence of the primary tumor. The liver metastases were characterized by high proliferation index, immunoreactiviy for somatostatin receptor (SSTR)-l, 2, 3 and 5 and positive octreoscan. Urinary 5-hydroxyindolacetic acid, serum serotonin and chromogranin A were elevated. Slow release lanreotide (SR-LAN) therapy for 3 mo controlled clinical and biochemical signs of carcinoid tumor and caused a clear-cut reduction in the diameter of two liver metastases and disappearance of another lesion, with further reduction after 6 and 18 mo. We demonstrated a clear-cut long-lasting anti-proliferative effect of SR-LAN on liver metastases of occult carcinoid with high proliferation index and immunoreactivity for SSTR-1, 2, 3, and 5. Immunohistochemistry for SSTRs could be a suitable method for the selection of patients with metastatic carcinoid that may benefit from SST analog therapy.

关键词： Carcinoid Somatostatin analogs Somatostatin receptors

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Liver metastases:Contrast-enhanced ultrasound compared with computed tomography and magnetic resonance

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World Journal of Gastroenterology 2014年第29期20卷 9998-10007页

作者： Vito Cantisani Hektor Grazhdani Cristina Fioravanti maria Rosignuolo Fabrizio Calliada Daniela Messineo maria Giulia Bernieri Adriano Redler Carlo Catalano Ferdinando D’ambrosio Department of Radiology Oncology and Anatomo-Pathology "Sapienza" Medical University of Rome Department of Radiology Medical University of Pavia Department of Surgical Sciences Sapienza University of Rome

The development of ultrasound contrast agents with excellent tolerance and safety profiles has notably improved liver evaluation with ultrasound(US)for several applications,especially for the detection of *** particular,contrast enhanced ultrasonography(CEUS)allows the display of the parenchymal microvasculature,enabling the study and visualization of the enhancement patterns of liver lesions in real time and in a continuous manner in all vascular phases,which is similar to contrast-enhanced computed tomography(CT)and contrast-enhanced magnetic resonance *** studies have reported that the use of a contrast agent enables the visualization of more metastases with significantly improved sensitivity and specificity compared to ***,studies have shown that CEUS yields sensitivities comparable to *** this review,we describe the state of the art of CEUS for detecting colorectal liver metastases,the imaging features,the literature reports of metastases in CEUS as well as its technique,its clinical role and its potential ***,the updated international consensus panel guidelines are reported in this review with the inherent limitations of this technique and best practice experiences.

关键词： Ultrasound Contrast enhanced ultrasound Ultrasound contrast agent Colorectal cancer Colorectal liver metastases Magnetic resonance imaging Computed tomography 18F-fluorodeoxyglucose positron emission tomography Intraoperative ultrasound

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5Ws of Green and Sustainable Software

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Tsinghua Science and Technology 2020年第3期25卷 401-414页

作者： Coral Calero Javier Mancebo Felix Garcia maria Angeles Moraga Jose Alberto Garcia Berna Jose Luis Fernandez-Aleman ambrosio Toval the Institute of Technology and Information Systems University of Castilla-La ManchaCiudad Real 13071Spain. the Department of Informatics and Systems University of MurciaMurcia 30003Spain

Green and Sustainable Software has emerged as a new and highly active area in the software *** several years of research and work,we believe that it is now necessary to obtain a general snapshot of how the research in this area is *** do so,we have applied the 5 Ws(why,when,who,where,and what),a formula for getting the complete story on a *** have therefore carried out a study,using 542 publications related to Green and Sustainable Software research;these were recovered using *** results obtained allow us to conclude that it is important to identify key elements of the research to allow researchers be fully aware of the state of the research on Green and Sustainable Software(why);the study uses papers published between 2000 and the beginning of November 2018(when);the most prolific authors are mainly from Europe,although the USA is the most active country,Green and Sustainable Software being a very interactive area with a good number of multinational publications(who);the top five keywords related to sustainable aspects are Green Software,Green IT,Software Sustainability,Energy Consumption,and Energy Efficiency(what);finally,as regards the places authors prefer to publish in,there is almost a complete balance between conferences and journals,with a trend towards an increase in the number of publications(where).

关键词： Green Software Sustainable Software Software Engineering Software Sustainability Energy Efficiency Energy Utilization

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The role of biomaterials in burn treatment

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Burns & Trauma 2014年第4期2卷 150-152页

作者： Luigi ambrosio Department of Chemical Science and Materials Technology National Research Council00185 RomeItaly

Burns are among the most challenging injuries to *** the great advances in treatment that have been made have arguably been sufficient to address the related medical challenges of the past century,modern society now faces even greater *** are caused pre-dominantly by increase in population and lifespan,which frequently are not matched by an increased effectiveness in the maintenance of health and quality of life.

关键词： injuries treatment biomaterials

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Concerning the KIR gene frequencies reported by Dr Araujo et al.

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Cellular & Molecular Immunology 2017年第2期14卷 I0003-I0004页

作者： Hugo Vicentin Alves Eliane Papa ambrosio-Albuquerque Luciana Conci Macedo Ana maria Sell Jeane Eliete Laguila Visentainer Immunogenetics Laboratory Department of Basic Health Sciences Maringa State University CEP 87020-900 Maringa PR Brazil Department of Biotechnology Genetics and Cellular Biology Maringa State University CEP 87020-900 Maringa PR Brazil

Killer cell immtmoglobulin-like recep- tors （KIRs） are transmembraneglycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic, highly homolo- gous and found in a duster on chromo- some 19q13.4 within the 1 Mb leukocyte receptor complex. The gene content of the KIR gene cluster varies among haplotypes, although several frame- work genes are found in all haplotypes （including KIR3DL3, KIR3DP1, KIR2DL4 and KIR3DL2）. In spite of the extended diversity of the KIR genomic region, these four framework loci are nearly ubiquitous in the population, and the pseudogene （KIR3DPI） is not expressed.1

关键词： natural killer cells gene cluster T cells

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A theragenerative bio-nanocomposite consisting of black phosphorus quantum dots for bone cancer therapy and regeneration

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Bioactive Materials 2024年第5期35卷 99-121页

作者： Ashkan Bigham Ines Fasolino Silvia Borsacchi Carmen Valente Lucia Calucci Gabriele Turacchio marianna Pannico Manuel Serrano-Ruiz Luigi ambrosio maria Grazia Raucci Institute of Polymers Composites and BiomaterialsNational Research Council of Italy(IPCB-CNR)Viale John Fitzgerald Kennedy 54Mostra d’Oltremare Padiglione 2080125NaplesItaly Department of Chemical Materials and Production EngineeringUniversity of Naples Federico IIPiazzale V.Tecchio 8080125NaplesItaly Institute for the Chemistry of OrganoMetallic Compounds-ICCOM Italian National Research Council-CNRvia G.Moruzzi 156124Pis1Italy Center for Instrument Sharing of the University of Pisa(CISUP) 56126Pis1Italy Institute of Experimental Endocrinology and Oncology“G.Salvatore”(IEOS) National Research Council(CNR)Via Pietro Castellino 11180131NapoliItaly Institute of Polymers Compositesand BiomaterialsNational Research Council of Italy(IPCB-CNR)PozzuoliItaly Institute for the Chemistry of OrganoMetallic Compounds-ICCOM National Research Council-CNRSesto FiorentinoItaly Institute of Translational Pharmacology(IFT) National Research Council(CNR)Via Carducci 3267100L’Aquila(Italy).

Recently,the term theragenerative has been proposed for biomaterials capable of inducing therapeutic approaches followed by repairing/regenerating the tissue/*** study is focused on the design of a new theragenerative nanocomposite composed of an amphiphilic non-ionic surfactant(Pluronic F127),bioactive glass(BG),and black phosphorus(BP).The nanocomposite was prepared through a two-step synthetic strategy,including a microwave treatment that turned BP nanosheets(BPNS)into quantum dots(BPQDs)with 5±2 nm dimensions in *** effects of surfactant and microwave treatment were assessed in vitro:the surfactant distributes the ions homogenously throughout the composite and the microwave treatment chemically stabilizes the *** presence of BP enhanced bioactivity and promoted calcium phosphate formation in simulated body *** inherent anticancer activity of BP-containing nanocomposites was tested against osteosarcoma cells in vitro,finding that 150μg mL^(-1)was the lowest concentration which prevented the proliferation of SAOS-2 cells,while the counterpart without BP did not affect the cell growth ***,the apoptosis pathways were evaluated and a mechanism of action was *** irradiation was applied to induce further proliferation suppression on SAOS-2 cells through *** inhibitory effects of bare BP nanomaterials and nanocomposites on the migration and invasion of bone cancer,breast cancer,and prostate cancer cells were assessed in vitro to determine the anticancer potential of nanomaterials against primary and secondary bone *** regenerative behavior of the nanocomposites was tested with healthy osteoblasts and human mesenchymal stem cells;the BPQDs-incorporated nanocomposite significantly promoted the proliferation of osteoblast cells and induced the osteogenic differentiation of stem *** study introduces a new multifunctional theragenerative platform with promising potential for simultaneous bone cancer t

关键词： Bioactive glass Black phosphorus Microwave treatment Bone cancer therapy Tissue regeneration

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Nonalcoholic fatty liver disease: is the IFNL4 rs368234815 variant protective from liver damage?

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Hepatobiliary Surgery and Nutrition 2018年第3期7卷 209-211页

作者： Enrico Galmozzi Roberta D'ambrosio "A. M. and A. Migliavacca" Center for Liver Disease Division of Gastroenterology and HepatologyFondazione IRCCS Cà Granda Ospedale Maggiore PoliclinicoUniversità degli Studi di MilanoMilanItaly

Nonalcoholic fatty liver disease (NAFLD) consists of a spectrum of disorders characterized predominantly by hepatic steatosis in the absence of significant alcohol consumption, potentially evolving to nonalcoholic ste... 详细信息

关键词： damage liver NAFLD

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Conflicting Discourses on Wildfire Risk and the Role of Local Media in the Amazonian and Temperate Forests

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International Journal of Disaster Risk Science 2019年第4期10卷 529-543页

作者： Nathalia Thais Cosmo da Silva Urbano FraPaleo Jose ambrosio Ferreira Neto Departamento de Economia Rural Universidade Federal de VicosaCampus UniversitarioEdificio Edson Potsch MagalhaesVicosaMG 36570-900Brazil School of Social Sciences and Humanities University of ExtremaduraCampus of Caceres City10071 CaceresSpain

This article examines how risk is communicated by different actors,particularly local print newspapers and actors at the community level,in two different geographical contexts that are severely affected by wildfires—the Brazilian Amazon and Atlantic *** analyzed how wildfire risk is framed in local print media and local actor discourse to elucidate how wildfire risk is interpreted and aimed to identify the main priorities of these risk governance *** main findings reveal that the presentation of wildfire as a spectacle is a serious obstacle to the promotion of coherent risk governance and social learning,which involves recognizing wildfire risk as a social,political,economic,and environmental *** risk governance should communicate the multifaceted nature of risk and stimulate dialogue and negotiation among all actors to build consensus regarding land use and the creation of risk.

关键词： Discourse analysis Framing Galicia Local media Risk communication Rondonia Wildfire risk

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