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Climate change impacts on eutrophication in the Po River(Italy):Temperature-mediated reduction in nitrogen export but no effect on phosphorus

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Journal of Environmental Sciences 2024年第9期143卷 148-163页

作者： Elisa Soana maria pia Gervasio Tommaso Granata Daniela Colombo Giuseppe Castaldelli Department of Environmental and Prevention Sciences University of FerraraVia Luigi Borsari 4644121 FerraraItaly CESI-Italian Electrical and Technical Experimental Center via Rubattino 5420134MilanoItaly

Rivers worldwide are under stress from eutrophication and nitrate pollution,but the ecological consequences overlap with climate change,and the resulting interactions may be unexpected and still *** Po River basin(northern Italy)is one of the most agriculturally productive and densely populated areas in *** remains unclear whether the climate change impacts on the thermal and hydrological regimes are already affecting nutrient dynamics and transport to coastal *** present work addresses the long-term trends(1992-2020)of nitrogen and phosphorus export by investigating both the annual magnitude and the seasonal patterns and their relationship with water temperature and discharge *** the constant diffuse and point sources in the basin,a marked decrease(-20%)in nitrogen export,mostly as nitrate,was recorded in the last decade compared to the 1990 s,while no significant downward trend was observed for *** water temperature of the Po River has warmed,with the most pronounced signals in summer(+0.13℃/year)and autumn(+0.16℃/year),together with the strongest increase in the number of warm days(+70%-80%).An extended seasonal window of warm temperatures and the persistence of low flow periods are likely to create favorable conditions for permanent nitrate removal via denitrification,resulting in a lower delivery of reactive nitrogen to the *** present results show that climate change-driven warming may enhance nitrogen processing by increasing respiratory river metabolism,thereby reducing export from spring to early autumn,when the risk of eutrophication in coastal zones is higher.

关键词： Nutrient export Eutrophication Climate change Water temperature Denitrification Po River

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Management of hepatic metastases of well/moderately differentiated neuroendocrine tumors of the digestive tract

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 294-303页

作者： Anna La Salvia Stefano Partelli Marco Tampellini Domenico Tamburrino Massimo Falconi Giorgio V.Scagliotti maria pia brizzi Division of Medical Oncology Department of OncologyUniversity of TurinSan Luigi Gonzaga HospitalRegione Gonzole 1010043 OrbassanoItaly Pancreatic Surgery Unit San Raffaele HospitalVita-Salute San Raffaele University20132 MilanItaly HPB Unit Royal Free HospitalLondon NW32QGUK

In neuroendocrine tumors(NETs),liver metastases(LM)represent the most crucial prognostic factor,irrespective of the primary tumor *** diagnosis,about 65-95%of gastroenteropancreatic neuroendocrine tumors(GEP-NETs)show hepatic *** strategies of LM are heterogeneous and range from systemic therapy to liver-directed *** type of systemic therapy used is dependent on the grade and proliferation of the tumor and includes somatostatin analogues,interferon,m-Tor and tyrosine kinase inhibitors,and *** liver-directed techniques,such as transarterial embolization/chemoembolization and selective internal radiation therapy,offer excellent palliation for patients with liver-predominant *** highly selected cases,liver transplantation and peptide receptor radionuclide therapy are *** relatively low disease incidence and the diversity of presentation have led to a lack of well-conducted randomized controlled trials comparing the efficacy of different treatment *** indicates that surgery is the only treatment that offers potential for *** unresectable lesions,the absence of data from rigorous trials limits the validity of many publications that detail *** this review we will discuss the existing approaches for hepatic metastases from GEP-NETs.

关键词： Gastroenteropancreatic carcinoids metastases systemic treatment

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MIS 5e sea surface temperature estimation;a multi-proxy approach using a marine macrofossil assemblage(Mar Piccolo,Gulf of Taranto,Southern Italy)

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Journal of Palaeogeography 2024年第2期13卷 327-350页

作者： Pierluigi Santagati Edoardo Perri maria pia Bernasconi Mario Borrelli Salvatore Guerrieri Salvatore Critelli Dipartimento di Biologia Ecologia e Scienze della TerraUniversita della Calabriavia Pietro Bucci87036 Arcavacata di RendeCosenzaItaly Dipartimento di Ingegneria Ambientale Universita della Calabriavia Pietro Bucci87036 Arcavacata di RendeCosenzaItaly

It is reported a multi-proxy palaeoclimatic study conducted on a MIS 5e calcarenite from the Mar Piccolo Basin(MP),Gulf of Taranto(GT)(Central Mediterranean).The calcarenite returned a rich malacofauna consisting of 120 extant species,including four of the tropical Senegalese Fauna,today absent in the *** biogeographic-climatic affinity of the assemblage shows,compared to today,a double percentage of warm affinity species,while the cold affinity species are nearly equally represented,indicating a warmer but not strictly tropical *** is confirmed by the most recurring preferred SST ranges of the assemblage,indicating an average of 20℃.The skeletal compositions of five well-preserved molluscan and coral specimens were analyzed for trace elements and stable isotopes for further mean SST *** the comparison of the results of several equations available in literature,it appears that only some SST estimations are realistic,converging into similar values of,on average,20.8±0.9℃.Considering all the used proxies,the MIS 5e SST difference compared to today falls in the range 1.2—2.0℃for the GT(being a more reasonable scenario)and 2.0—2.8℃for the *** is not a firmly tropical-like SST setting as suggested by the sole Senegalese fauna,indicating at least 2.7℃—3.5℃more than today’s GT and MP,*** approximations and assumptions made for obtaining SST values with any single proxy indicate the need of a multi-proxy approach to define the best SST estimation.

关键词： MiS 5e Sea surface temperature Palaeoclimate proxy Fossil fauna Gulf of Taranto

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Weathering and accumulation of trace elements in the soils of the Porali Plain, Balochistan: repercussions in agriculture

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Acta Geochimica 2024年第2期43卷 214-234页

作者： maria Kaleem Erum Bashir Shahid Naseem Tahir Rafique Bushra Shahab Department of Geology University of KarachiKarachi 75270Pakistan Applied Chemistry Research Centre PCSIR Laboratories ComplexKarachi 75280Pakistan

This study is theﬁrst attempt to assess the nature of the soil,especially on the western side of the Porali Plain in Balochistan;a new emerging agriculture hub,using weathering and pollution indices supplemented by multi-variate analysis based on geochemical *** outcomes of this study are expected to help farmers in soil manage-ment and selecting suitable crops for the ***-ﬁve soil samples were collected,mainly from the arable land of the Porali *** drying and coning-quarter-ing,soil samples were analyzed for major and trace ele-ments using the XRF technique;sieving and hydrometric methods were employed for granulometric ***-mated data were analyzed using Excel,SPSS,and Surfer software to calculate various indices,correlation matrix,and spatial *** granulometric analysis showed that 76%of the samples belonged to loam types of soil,12%to sand type,and 8%to silt *** indices:CIA,CIW,pia,PWI,WIP,CIX,and ICV were calculated to infer the level of *** indices reﬂect mod-erate to intense weathering;supported by K_(2)O/AI_(2)O_(3),Rb/K_(2)O,Rb/Ti,and Rb/Sr *** of the geo-ac-cumulation and Nemerow Pollution indices pinpoint rela-tively high concentrations of Pb,Ni,and Cr concentration in the *** correlation matrix and Principal Compo-nent Analysis show that the soil in this study area is mainly derived from the weathering of igneous rocks of Bela Ophiolite(Cretaceous age)and Jurassic sedimentary rocks of Mor Range having SEDEX/MVT type *** may result in the undesirable accumulation of certain trace elements which adversely affects crops.

关键词： Weathering indices Pollution indices Accumulation Repercussions Trace elements Multivariate analyses Porali Plain Balochistan

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Maximizing Convergence Speed for Second Order Consensus in Leaderless Multi-Agent Systems

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IEEE/CAA Journal of Automatica Sinica 2022年第2期9卷 259-269页

作者： Gianvito Difilippo maria pia Fanti Agostino Marcello Mangini Department of Electrical and Information Engineering Polytechnic University of BariBari 70125Italy IEEE

The paper deals with the consensus problem in a leaderless network of agents that have to reach a common velocity while forming a uniformly spaced ***,the final common velocity(reference velocity)is determined by the agents in a distributed and leaderless ***,the consensus protocol parameters are optimized for networks characterized by a communication topology described by a class of directed graphs having a directed spanning tree,in order to maximize the convergence rate and avoid *** advantages of the optimized consensus protocol are enlightened by some simulation results and comparison with a protocol proposed in the related *** presented protocol can be applied to coordinate agents such as mobile robots,automated guided vehicles(AGVs)and autonomous vehicles that have to move with the same velocity and a common inter-space gap.

关键词： Consensus protocols directed spanning tree multiagent systems networked systems second-order consensus

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An Eco-Route Planner for Heavy Duty Vehicles

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IEEE/CAA Journal of Automatica Sinica 2021年第1期8卷 37-51页

作者： maria pia Fanti Agostino Marcello Mangini Alfredo Favenza Gianvito Difilippo the Department of Electric and Information Engineering University Polytechnic of BariBariItaly Links Foundation TurinItaly the company AutoLogS BariItaly

Driving style,traffic and weather conditions have a significant impact on vehicle fuel consumption and in particular,the road freight traffic significantly contributes to the CO2 increase in *** paper proposes an Eco-Route Planner devoted to determine and communicate to the drivers of Heavy-Duty Vehicles(HDVs)the eco-route that guarantees the minimum fuel consumption by respecting the travel time established by the freight *** proposed eco-route is the optimal route from origin to destination and includes the optimized speed and gear *** this aim,the Cloud Computing System architecture is composed of two main components:the Data Management System that collects,fuses and integrates the raw external sources data and the Cloud Optimizer that builds the route network,selects the eco-route and determines the optimal speed and gear ***,a real case study is discussed by showing the benefit of the proposed Eco-Route planner.

关键词： profile An Eco-Route Planner for Heavy Duty Vehicles

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The measure of friction angles for different types of granular material

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Journal of Mountain Science 2019年第4期16卷 769-777页

作者： DEGANUTTI Andrea maria TECCA pia Rosella GENEVOIS Rinaldo CNR-IRPI Department of Geosciences University of Padova

The aim of this research is to deepen the knowledge of the role of friction on the dynamics of granular media; in particular the friction angle is taken into consideration as the physical parameter that drives stability, motion and deposition of a set of grains of any nature and size. The idea behind this work is a question: is the friction angle really that fundamental and obvious physical parameter which rules stability and motion of granular media as it seems from most works which deal with particle dynamics? The experimental study tries to answer this question with a series of laboratory tests, in which different natural and artificial granular materials have been investigated in dry condition by means of a tilting flume. The characteristic friction angles, both in deposition(repose) and stability limit(critical) conditions, were measured and checked against size, shape, density and roughness of the considered granular material. The flume tests have been preferred to "classical" geotechnical apparatuses(e.g. shear box) since the flume experimental conditions appear closer to the natural ones of many situations of slope stability interest(e.g. a scree slope). The results reveal that characteristic friction angles depend on size and shape of grains while mixtures of granules of different size show some sorting mechanism with less clear behaviour.

关键词： Rheology Granular material Friction angle Deposition process Yielding process

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Economic analysis of atmospheric mercury emission control for coal-fired power plants in China

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Journal of Environmental Sciences 2015年第7期27卷 125-134页

作者： maria pia Ancora Lei Zhang Shuxiao Wang Jeremy Schreifels Jiming Hao State Key Joint Laboratory of Environment Simulation and Pollution Control School of Environment Tsinghua University Collaborative Innovation Center for Regional Environmental Quality Tsinghua University State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex

Coal combustion and mercury pollution are closely linked, and this relationship is particularly relevant in China, the world＇s largest coal consumer. This paper begins with a summary of recent China-specific studies on mercury removal by air pollution control technologies and then provides an economic analysis of mercury abatement from these emission control technologies at coal-fired power plants in China. This includes a cost-effectiveness analysis at the enterprise and sector level in China using 2010 as a baseline and projecting out to 2020 and2030. Of the control technologies evaluated, the most cost-effective is a fabric filter installed upstream of the wet flue gas desulfurization system（FF ＋ WFGD）. Halogen injection（HI） is also a cost-effective mercury-specific control strategy, although it has not yet reached commercial maturity. The sector-level analysis shows that 193 tons of mercury was removed in 2010 in China＇s coal-fired power sector, with annualized mercury emission control costs of 2.7 billion Chinese Yuan. Under a projected 2030 Emission Control（EC） scenario with stringent mercury limits compared to Business As Usual（BAU） scenario, the increase of selective catalytic reduction systems（SCR） and the use of HI could contribute to 39 tons of mercury removal at a cost of 3.8 billion CNY. The economic analysis presented in this paper offers insights on air pollution control technologies and practices for enhancing atmospheric mercury control that can aid decision-making in policy design and private-sector investments.

关键词： Atmospheric mercury Coal-fired power plants China Cost-effectiveness Activated carbon and halogen injection

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Role of lipids in the control of autophagy and primary cilium signaling in neurons

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Neural Regeneration Research 2024年第2期19卷 264-271页

作者： María Paz Hernández-Cáceres Daniela Pinto-Nuñez Patricia Rivera Paulina Burgos Francisco Díaz-Castro Alfredo Criollo maria Jose Yañez Eugenia Morselli Instituto de Investigación en Ciencias Odontológicas(ICOD) Facultad de OdontologíaUniversidad de ChileSantiagoChile Department of Basic Sciences Faculty of Medicine and ScienceUniversidad San SebastiánSantiagoChile Physiology Department Faculty of Biological SciencesPontificia Universidad Católica de ChileSantiagoChile Advanced Center for Chronic Diseases(ACCDiS) Facultad de Ciencias Químicas y Farmacéuticas&Facultad de MedicinaUniversidad de ChileSantiagoChile Autophagy Research Center SantiagoChile

The brain is,after the adipose tissue,the organ with the greatest amount of lipids and diversity in their composition in the human *** neurons,lipids are involved in signaling pathways controlling autophagy,a lysosome-dependent catabolic process essential for the maintenance of neuronal homeostasis and the function of the primary cilium,a cellular antenna that acts as a communication hub that transfers extracellular signals into intracellular responses required for neurogenesis and brain development.A crosstalk between primary cilia and autophagy has been established;however,its role in the control of neuronal activity and homeostasis is barely *** this review,we briefly discuss the current knowledge regarding the role of autophagy and the primary cilium in *** we review the recent literature about specific lipid subclasses in the regulation of autophagy,in the control of primary cilium structure and its dependent cellular signaling in physiological and pathological conditions,specifically focusing on neurons,an area of research that could have major implications in neurodevelopment,energy homeostasis,and neurodegeneration.

关键词： autophagic flux cholesterol fatty acids GPCR lysosomal storage diseases neurons NPC1 phosphoinositides primary cilium

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Reduction in sperm aneuploidy levels in severe oligoasthenoteratospermic patients after medical therapy： a preliminary report

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Asian Journal of Andrology 2012年第4期14卷 591-598页

作者： Giorgio Cavallini maria Cristina Magli Andor Crippa Anna pia Ferraretti Luca Gianaroli Medicitalia Andrological Section Outpatient Clinic of Ferrara Ferrara 44100 Italy Laboratory of Assisted Reproduction Societa Italiana di Medicina della Riproduzione (SISMER) Bologna 40138 Italy Operative Unit of Assisted Reproduction Societa Italiana di Medicina della Riproduzione (SISMER) Bologna 40138 Italy

The objective of this study was to investigate whether medical therapy can reduce sperm aneuploidy levels and irfiprove the results of intracytoplasmic sperm injection （ICSI） in patients with severe idiopathic oligoasthenoteratospermia （OAT）. Thirty-three infertile couples requiring ICSI because of severe idiopathic OAT after at least one unsuccessful ICSI cycle were considered. Semen parameters （concentration, motility and morphology）, the percentage of aneuploid sperm and the results of ICSI （the number of oocytes fertilized, embryos transferred, biochemical pregnancies, clinical pregnancies and live births） were compared before and after a 3-month course of treatment with L-carnitine 1 g given twice per day＋acetyI-L-carnitine 500 mg given twice per day＋one 30-mg cinnoxicam tablet every 4 days. Aneuploidy was assessed using fluorescent in situ hybridisation （FISH） performed on chromosomes X, Y, 13, 15, 16, 17, 18, 21 and 22. The results showed that 22 of the 33 patients had a reduced frequency of aneuploid sperm and improved sperm morphology after treatment （group 1）, and 11 showed no change （group 2）. The numbers of biochemical pregnancies, clinical pregnancies and live births were significantly higher in group I than in group 2. No significant difference was found between the groups regarding the numbers of oocytes fertilized and embryos transferred. The side effects were negligible. The numbers of ICSI pregnancies and live births in severe idiopathic OAT patients improved with a course of L-carnitine, acetyI-L-carnitine and cinnoxicam.

关键词： acetyI-L-carnitine cinnoxicam ICSl L-carnitine male infertility oligoasthenoteratospermia sperm aneuploidy

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