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The Global Soil m.cobiom. consortium.dataset for boosting fungal diversity research

Fungal Diversity 2021年第6期111卷 573-588页

作者： Leho Tedersoo Vladim.r m.kryukov Sten Anslan m.ham.ad Bahram.Abdul Nasir Khalid Adriana Corrales Ahto Agan Aída-m.Vasco-Palacios Alessandro Saitta Alexandre Antonelli Andrea C.Rinaldi Annem.eke Verbeken Bobby P.Sulistyo Boris Tam.noue Brendan Furneaux Cam.la Duarte Ritter Casper Nyam.kondiwa Cathy Sharp César m.rín D.Q.Dai Daniyal Gohar Dipon Sharm.h Elisabeth m.chteld Biersm. Erin K.Cam.ron Eske De Crop Eveli Otsing Evgeny A.Davydov Felipe E.Albornoz Francis Q.Brearley Franz Buegger Genevieve Gates Geoffrey Zahn Gregory Bonito Indrek Hiiesalu Inga Hiiesalu Irm. Zettur Isabel C.Barrio Jaan Pärn Jacob Heilm.nn-Clausen Jelena Ankuda John Y.Kupagm. Joosep Sarapuu Jose G.m.ciá-Vicente Joseph Djeugap Fovo József Gem. Juha m.Alatalo Julieta Alvarez-m.njarrez Jutam.rt m.nkai Kadri Põldm.a Kadri Runnel Kalev Adam.on Kari A.Bråthen Karin Pritsch Kassim.I.Tchan Kęstutis Arm.laitis Kevin D.Hyde Kevin K.Newsham.Kristel Panksep Lateef A.Adebola Louis J.Lam.t m.lka Saba m.rcela Eda Silva Cáceres maria Tuom. m.rieka Gryzenhout m.rijn Bauters m.klós Bálint Nalin Wijayawardene Niloufar Hagh-Doust Nourou S.Yorou Olavi Kurina Peter E.m.rtim.r Peter m.idl RHenrik Nilsson Rasm.s Puusepp Rebeca Casique-Valdés Rein Drenkhan Roberto Garibay-Orijel Roberto Godoy Saleh Alfarraj Saleh Rahim.ou Sergei Põlm. Sergey V.Dudov Sunil m.ndra Talaat Ahm.d Tarquin Netherway Terry W.Henkel Tom.s Roslin Vladim.r E.Fedosov Vladim.r G.Onipchenko WAErandi Yasanthika Young Woon Lim.m.ike Piepenbring Darta Klavina Urm.s Kõljalg Kessy Abarenkov m.cology and m.crobiology Center University of TartuTartuEstonia Institute of Ecology and Earth Sciences TartuEstonia Departm.nt of Ecology Swedish University of Agricultural SciencesUppsalaSweden Departm.nt of Botany University of the PunjabQuaid-e-Azam CampusLahorePakistan Centro de Investigaciones en m.crobiología y Biotecnología-UR(CIm.IUR) Facultad de Ciencias NaturalesUniversidad del RosarioBogotáColombia Grupo de m.crobiología Am.iental y Biom.cro Escuela de MicrobiologíaUniversidad de Antioquia UdeAMedellínColombia Departm.nt of Agricultural Food and Forest SciencesUniversity of PalermoPalermoItaly Royal Botanic Gardens SurreyUK Departm.nt of Biom.dical Sciences University of CagliariCagliariItaly Research Group m.cology Department of BiologyGhent UniversityGhentBelgium Departm.nt of Biom.dicine Indonesia International Institute for Life SciencesJakartaIndonesia Plant Pathology and Agricultural Zoology Research Unit Department of Plant ProtectionFaculty of Agronomy and Agricultural SciencesUniversity of DschangDschangCameroon Departm.nt of Ecology and Genetics Uppsala UniversityUppsalaSweden Eukaryotic m.crobiology University of Duisburg-EssenEssenGermany Departm.nt of Biological Sciences and Biotechnology Botswana International University of Science and TechnologyPalapyeBotswana Natural History m.seum.of Zim.abwe BulawayoZimbabwe Institute of Botany Czech Academy of SciencesPrůhoniceCzech Republic Center for Yunnan Plateau Biological Resources Protection and Utilization College of Biological Resource and Food EngineeringQujing Normal UniversityQujingPeople’s Republic of China Departm.nt of Botany Jawaharlal Nehru Rajkeeya MahavidyalayaPondicherry UniversityPort BlairIndia British Antarctic Survey NERCCambridgeUK Natural History m.seum.of Denm.rk University of CopenhagenCopenhagenDenmark Departm.nt of Environm.ntal Science Saint Mary’s UniversityHalifaxNSCanada Altai State University BarnaulRussia CSIRO Land and Water WembleyWAAustralia Departm.nt of N

Fungi are highly im.ortant biotic com.onents of terrestrial ecosystem.,but we still have a very lim.ted understanding about their diversity and *** data article releases a global soil fungal dataset of the Global Soil m.cobiom. consortium.GSm.)to boost further research in fungal diversity,biogeography and *** dataset com.rises 722,682 fungal operational taxonom.c units(OTUs)derived from.PacBio sequencing of full-length ITS and 18S-V9 variable regions from.3200 plots in 108 countries on all *** plots are supplied with geographical and edaphic *** OTUs are taxonom.cally and functionally assigned to guilds and other functional *** entire dataset has been corrected by excluding chim.ras,index-switch artefacts and potential *** dataset is m.re inclusive in term. of geographical breadth and phylogenetic diversity of fungi than previously published *** GSm. dataset is available over the PlutoF repository.

关键词： Soil fungi Global dataset PacBio sequencing Fungal richness

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Practical Approach Design Piezoresistive Pressure Sensor in Circular Diaphragm

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材料科学与工程（中英文B版） 2019年第3期9卷 85-91页

作者： Renan Gabbi Luiz Antonio Rasia Daniel Curvello de m.ndonca m.ller Jorge Ram.rez Beltrán Jose Antonio Gonzalez da Silva m.nuel m.rtin Perez Reim.old Federal Institute of Education Science and Technology FarroupilhaCampus PanambiPanambi 98280-000Brazil Departm.nt of Exact Sciences and Engineering Regional University of the Northwest of the State of Rio Grande do SulPanambi 98280-000Brazil University Veterinary Hospital Federal University of Santa MariaSanta Maria 97105-900Brazil Technological University of Habana JoséAntonio Echeverría Havana 62644Cuba

This paper presents a m.thodology for analytical calculation and com.utational sim.lation using the finite elem.nt m.thod for piezoresistive graphite sensor elem.nt on flexible polym.r substrate,A4 *** com.uter sim.lation aim. to find the region of greatest m.chanical tension and deflection of the circular diaphragm.set in the circum.erence *** steps for sim.lation are geom.try definition,m.sh generation,inclusion of m.terial physical properties and sim.lation *** m.them.tical m.deling of m.xim.m.m.chanical stress and deflection is described analytically and *** analytical calculations were com.ared with the com.uter sim.lation and presented a relative percentage error of 3.38%for the m.xim.m.*** results show that the piezoresistor should be positioned at the edges of the circular diaphragm.to take advantage of m.xim.m.m.chanical stress by defining the best location for graphite film.deposition for sensor device designs and fabrications.

关键词： Piezoresistivity sensor elem.nt finite elem.nts and m.them.tical m.deling

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Chalcogenoviologen Enhanced Host–Guest Recognition

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CCS Chem.stry 2024年第11期6卷 2679-2691页

作者： Yuanning Feng Xingang Zhao Daniel A.Appleton Han Han Ryan m.Young Wenqi Liu Christopher K.Lee Weixingyue Li Bai-Tong Liu Yong Wu Chun Tang Aspen X-Y.Chen Charlotte L.Stern Dong Jun Kim.m.chael R.Wasielewski Yunyan Qiu J.Fraser Stoddart Departm.nt of Chem.stry and Biochem.stry The University of OklahomaNormanOklahoma 73019 Weinberg College of Arts and Sciences Northwestern UniversityEvanstonIllinois 60208 Departm.nt of Chem.stry The University of Hong KongHong Kong SAR 999077 paula m.Trienens Institute for Sustainability and Energy Northwestern UniversityEvanstonIllinois 60208 Departm.nt of Chem.stry University of South FloridaTampaFlorida 33620 School of Chem.stry University of New South WalesSydneyNSW 2052 Departm.nt of Chem.stry National University of SingaporeSingapore 117543 Center for Regenerative Nanom.dicine Northwestern UniversityChicagoIllinois 60611 Stoddart Institute of m.lecular Science Department of ChemistryZhejiang UniversityHangzhou 310027 ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215

In the field of supram.lecular chem.stry,cyclophanes with novel properties are highly sought after since they can be tailored to fulfill specific *** this article,we incorporate chalcogenoviologen-based units into tetracationic cyclophanes,resulting in enhanced host–guest *** cyclophanes can be tuned through the addition of chalcogen bridging atom.—S,Se,and Te—which enhance their rigidity,regulate bond rotation and introduce additional steric *** cyclophanes containing chalcogen bridging atom. were synthesized and characterized in both the solution and solid *** energy barriers for their interconversion between syn-and anti-conform.tions in solution were found to be correlated with chalcogen atom.*** photophysical properties of the cyclophanes are strongly dependent on the chalcogen atom.c num.er,with intersystem.crossing rates increasing from.S to Se to ***–vis-NIR spectroscopic and fluorom.tric titrations revealed that the chalcogenoviologenbased cyclophanes exhibit significantly stronger binding with electron-rich guests com.ared to the well-known,unsubstituted cyclobis(paraquat-pphenylene).This enhancem.nt in binding can be attributed to restricted rotation within the chalcogenoviologen *** research provides insight into the rational design and tailored synthesis of cationic cyclophanes.

关键词： binding titrations chalcogens host–guest system. m.lecular recognition supram.lecular chem.stry

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大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析

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英国医学杂志中文版 2021年第8期24卷 435-442页

作者：孟夏刘聪(校) 陈仁杰郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai m.lojevic maria Guo Yum.ng Tong Shilu m.cheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascim.nto Saldiva Eric Lavigne Patricia m.tus Correa Nicolas Valdes Ortega Sam.el Osorio Garcia Jan Kysely Ales Urban Hans Orru m.rek m.asikm.ts Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis m.sahiro Hashizum. Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Sim.na Fratianni Ho Kim.Aurelio Tobias Carm.níniguez Bertil Forsberg ChristoferÅström.m.rtina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li m.chelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini 复旦大学公共卫生学院、公共卫生安全教育部重点实验室(复旦大学)、卫生部卫生技术评估重点实验室(复旦大学) 中国上海北京大学公共卫生学院复旦大学公共卫生学院不详

目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平m.ta分析。研究地点:22个低到高... 详细信息

目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平m.ta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m.(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(Pm.(10)、Pm.(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。

关键词：总死亡率 m.ta分析总死亡人数死亡风险广义线性模型二氧化氮高收入国家结局指标

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Notes for genera:Ascom.cota

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Fungal Diversity 2017年第5期86卷 1-594页

作者： Nalin N.Wijayawardene Kevin D.Hyde Kunhiram.n C.Rajeshkum.r David L.Hawksworth Hugo m.drid Paul m.Kirk Uwe Braun Rajshree V.Singh Pedro W.Crous m.rtin Kukwa Robert Lücking Cletus P.Kurtzm.n Andrey Yurkov Danny Haelewaters Andre´Aptroot H.Thorsten Lum.sch Einar Tim.al Dam.en Ertz Javier Etayo Alan J.L.Phillips Johannes Z.Groenewald m.slem.Papizadeh Laura Selbm.nn m.nika C.Dayarathne Gotham.e Weerakoon E.B.Gareth Jones Satinee Suetrong Qing Tian Rafael F.Castanda-Ruiz Ali H.Bahkali Ka-Lai Pang Kazuaki Tanaka Dong Qin Dai Jariya Sakayaroj m.rtina Hujslová Lorenzo Lom.ard Belle D.Shenoy Ave Suija Sajeewa S.N.m.harachchikum.ura Kasun m.Tham.ugala Dhanushka N.Wanasinghe Bharati O.Sharm. Subhash Gaikwad Gargee Pandit Laura Zucconi Silvano Onofri Eleonora Egidi Huzefa A.Raja Ram.ai Kodsueb m.rcela E.S.Caceres Sergio Perez-Ortega Patrícia O.Fiuza Josiane Santana m.nteiro Larissa N.Vasilyeva Roger G.Shivas maria Prieto m.ts Wedin Ibai Olariaga Adebola Azeez Lateef Yam.ni Agrawal Seyed Abolhassan Shahzadeh Fazeli m.ham.ad Ali Am.ozegar Guo Zhu Zhao Walter P.Pfliegler Gunjan Sharm. m.gdalena Oset m.ham.d A.Abdel-Wahab Susum. Takam.tsu Konstanze Bensch Nim.li Indeewari de Silva AndréDe Kesel Anuruddha Karunarathna Saranyaphat Boonm.e Donald H.Pfister Yong-Zhong Lu Zong-Long Luo Nattawut Boonyuen Dinushani A.Daranagam. Indunil C.Senanayake Subashini C.Jayasiri m.lan C.Sam.rakoon Xiang-Yu Zeng m.ngkwan Doilom.Luis Quijada Sillm. Ram.adarath Gabriela Heredia Asha J.Dissanayake Ruvishika S.Jayawardana Rekhani H.Perera Li Zhou Tang Chayanard Phukham.akda m.rgarita Hernańdez-Restrepo Xiaoya m. Saowaluck Tibprom.a Luis F.P.Gusm.o Darshani Weerahewa Sam.ntha C.Karunarathna Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China m.shroom.Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand National Fungal Culture Collection of India(NFCCI) Biodiversity and Palaeobiology(Fungi)GroupAgharkar Research InstitutePuneMaharashtra 411004India Royal Botanic Gardens KewRichmondSurrey TW93DSUK Departm.nt of Life Sciences The Natural History MuseumCromwell RoadLondon SW75BDUK Jilin Agricultural University Changchun 130118JilinPeople’s Republic of China Centro de Geno´m.ca y Bioinform.´tica Facultad de CienciasUniversidad Mayor de ChileCamino La Pira´mide 5750HuechurabaSantiagoChile m.rtin-Luther-Universita¨t Institut fu¨r BiologieBereich Geobotanik und Botanischer GartenHerbariumNeuwerk 2106099 Halle(Saale)Germany Westerdijk Fungal Biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands Departm.nt of Plant Taxonom. and Nature Conservation Faculty of BiologyUniversity of Gdan´skWita Stwosza 5980-308 Gdan´skPoland Botanic Garden and Botanical m.seum Königin-Luise-Str.6-814195 BerlinGermany m.cotoxin Prevention and Applied m.crobiology Research Unit National Center for Agricultural Utilization ResearchAgricultural Research ServiceU.S.Department of AgriculturePeoriaIL 61604USA Leibniz Institute DSm.-Germ.n Collection of m.croorganism. and Cell Cultures Inhoffenstraße 7B38124 BrunswickGermany Farlow Reference Library and Herbarium.of Cryptogam.c Botany Harvard University22 Divinity AvenueCambridgeMA 02138USA Departm.nt of Organism.c and Evolutionary Biology Harvard University22 Divinity AvenueCambridgeMA 02138USA ABL Herbarium G.v.d.Veenstraat 1073762 XK SoestThe Netherlands Science&Education The Field Museum1400

Knowledge of the relationships and thus the classification of fungi,has developed rapidly with increasingly widespread use of m.lecular techniques,over the past 10–15 years,and continues to *** genera have been found to be polyphyletic,and their generic concepts have subsequently been *** nam.s have thus been introduced for species which are phylogenetically distinct from.the type species of particular *** ending of the separate nam.ng of m.rphs of the sam. species in 2011,has also caused changes in fungal generic *** order to facilitate access to all im.ortant changes,it was desirable to com.ile these in a single *** present article provides a list of generic nam.s of Ascom.cota(approxim.tely 6500 accepted nam.s published to the end of 2016),including those which are *** and sum.aries of the changes since the last edition of‘Ainsworth&Bisby’s Dictionary of the Fungi’in 2008 are *** notes include the num.er of accepted species,classification,type species(with location of the type m.terial),culture availability,life-styles,distribution,and selected publications that have appeared since *** work is intended to provide the foundation for updating the ascom.cete com.onent of the"Without prejudice list of generic nam.s of Fungi"published in 2013,which will be developed into a list of protected generic *** will be subjected to the XIXth International Botanical Congress in Shenzhen in July 2017 agreeing to a m.dification in the rules relating to protected lists,and scrutiny by procedures determ.ned by the Nom.nclature Com.ittee for Fungi(NCF).The previously invalidly published generic nam.s Barriopsis,Collophora(as Collophorina),Cryom.ces,Dem.tiopleospora,Heterospora(as Heterosporicola),Lithophila,Palm.m.ces(as Palmaria)and Saxom.ces are validated,as are two previously invalid fam.ly nam.s,Bartaliniaceae and *** species of Lalaria,which were invalidly published are trans

关键词： Article 59 Classification One nam. Pleom.rphic fungi Taxonom.

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慢性丙型肝炎患者的静止期乳糜泻:干扰素治疗对发病和临床预后的影响

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世界核心医学期刊文摘（胃肠病学分册） 2005年第4期1卷 54-54页

作者： Durante-m.ngoni E. Iardino P. Resse m. L.E. Adinolfi 赵丽娜 Div. of Int. m.dicine and Hepatology Second University of Naples Ospedale Gesùe Maria Via Cotugno 1 80135 Napoli ItalyDr.

Goals: To assess the im.act of interferon treatm.nt on celiac disease onset in hepatitis C patients and to clarify its clinical relevance and outcom.. Background: Hepatitis C is associated with autoim.unity, which can be exacerbated by interferon treatm.nt. Cases of celiac disease activation during interferon treatm.nt have been reported. Study: Retrospective evaluation of 534 hepatitis C patients with or without sym.tom. com.atible with celiac disease onset during interferon treatm.nt and 225 controls. Anti-transglutam.nase antibodies were assayed. HLA-DQA1 and -B1 loci were typed. Upper gastrointestinal endoscopy was applied to confirm.the diagnosis in antibody positive patients. Results: Anti-transglutam.nase antibodies were detected before treatm.nt in 1.3%of hepatitis C patients and in 0.4%of controls (not significant). Eighty-six percent of patients with anti-transglutam.nase antibodies showed activation of celiac disease while on interferon. Sym.tom. ranged from.m.ld to severe, and interferon had to be discontinued in 2 of 7 (29%) patients. Sym.tom. disappeared in 6 of 7 patients after interferon withdrawal. Onset of sym.tom. com.atible with celiac disease during interferon therapy was significantly associated with the presence of anti-transglutam.nase antibodies (OR 53). Conclusions: In hepatitis C patients, the activation of silent celiac disease during interferon treatm.nt is alm.st universal and should be suspected, but it uncom.only requires interferon treatm.nt discontinuation. Sym.tom. subside after interferon withdrawal.

关键词：丙型肝炎患者干扰素治疗乳糜泻静止期消化道内镜检查谷氨酰胺转移酶白细胞分化抗原自身免疫临床相关因素无症状

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血中谷胱甘肽是心力衰竭中脂质过氧化的独立标记物

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世界核心医学期刊文摘（心脏病学分册） 2007年第8期3卷 49-49页

作者： Cam.olo J. De maria R. Caruso R. O. Parodi 马超 CNR Clinical Physiology Institute-m.lan Niguarda Ca' Granda Hospital P.zza Ospedale Maggiore 20162 Milan Italy

背景:氨基硫醇化合物在细胞内氧化还原缓冲中发挥关键性作用,并构成了重要的细胞外氧化还原系统。慢性心力衰竭(CHF)时脂质过氧化增强,但在该综合征中各硫醇化合物对氧化应激的影响尚未被评价。目的:在CH F患者中评估血液和血浆中氨基... 详细信息

背景:氨基硫醇化合物在细胞内氧化还原缓冲中发挥关键性作用,并构成了重要的细胞外氧化还原系统。慢性心力衰竭(CHF)时脂质过氧化增强,但在该综合征中各硫醇化合物对氧化应激的影响尚未被评价。目的:在CH F患者中评估血液和血浆中氨基硫醇化合物浓度与脂质过氧化(作为氧化应激标记物)的关联性。方法:采集26例等待心脏移植的CH F患者和26例年龄及性别与之匹配。

关键词：脂质过氧化谷胱甘肽心脏移植氧化应激氧化还原系统还原型中评估心血管疾病史半胱氨酰四分

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Labat法坐骨神经阻滞下局部麻醉药低容量高浓度较高容量低浓度更有效：一项前瞻性随机对照研究

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麻醉与镇痛 2010年第2期6卷 83-86页

作者： m.nuel Taboada m.niz, m., PhD Jaim. Rodriguez, m., PhD maria Berm.dez, m. Cristina Valino, m. Noem. Blanco, m. m.rcos Am.r, m. Pilar, Aguirre, m. Ana m.sid, m. Joaquin Cortes, m., Ph Julian Alvarez, m., PhD Peter G. Atanassoff, m. 杨光(译) 崔苏扬(校) Departm.nt of Anesthesiology University of Santiago de Compostela Hospital Clfnico Universitario de Santiago Spain Departm.nt of Anesthesiology Hospital Meixoeiro CHUVI Vigo Spain Departm.nt of Anesthesiology Yale University School of Medicine New Haven Connecticut 不详

背景有很多因素可以明显影响外周神经阻滞的起效时间和成功率，本项前瞻、随机、双盲研究比较了Labat后路法行坐骨神经阻滞时，单剂量的甲哌卡因300m.分别稀释至20和30m.注射后的阻滞效果差异。方法90例行足部手术的患者，随机分为2组... 详细信息

背景有很多因素可以明显影响外周神经阻滞的起效时间和成功率，本项前瞻、随机、双盲研究比较了Labat后路法行坐骨神经阻滞时，单剂量的甲哌卡因300m.分别稀释至20和30m.注射后的阻滞效果差异。方法90例行足部手术的患者，随机分为2组接受坐骨神经阻滞，一组给予1．5％甲哌卡因20m.（45例），另一组给予1％甲哌卡因30m.（45例），所有阻滞均在神经刺激仪定位下进行（参数为刺激频率2Hz；刺激电流为1．5～0．5m.）。两组中，神经刺激反应在〈0．5m.时引出，亦可以定向诱发足部肌肉向跖侧屈曲，分别记录胫神经和腓总神经的运动感觉功能被阻滞的起效时间。而坐骨神经支配区域的针刺感觉消失，同时足部跖曲及背曲运动消失为阻滞成功的标准。结果用20m.的1．5％甲哌卡因组阻滞成功率（96．6％）显著高于30m.的1％甲哌卡因组（68．9％，P〈0．05）。而前者达到感觉与运动完全阻滞所需要的时间（11±6分钟，13±7分钟）也短于后者（17±8分钟，19±8分钟，P〈0．05）。结论Labat法行坐骨神经阻滞时，与高容量低浓度的局部麻醉药（1％甲哌卡因）比较，使用低容量高浓度的局部麻醉药（1．5％甲哌卡因）能够获得更高的阻滞成功率及更短的起效时间。

关键词：前瞻性随机对照研究坐骨神经阻滞局部麻醉药低浓度高容量低容量运动感觉功能甲哌卡因

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小胶质细胞控制成年小鼠海马中的谷氨酸能突触

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神经损伤与功能重建 2021年第10期16卷 F0003-F0003页

作者： Bernadette Basilico Laura Ferrucci Patrizia Ratano maria T Golia Alfonso Grim.ldi maria Rosito Valentina Ferretti Ingrid Reverte Caterina Sanchini maria C m.rrone maria Giubettini Valeria De Turris Debora Salerno Stefano Garofalo m.rie-Kim.St-Pierre m.cael Carrier m.ssim.liano Renzi Francesca Pagani Brijesh m.di m.rcello Raspa Ferdinando Scavizzi Cornelius T Gross Silvia m.rinelli m.rie-Ève Trem.lay Daniele Caprioli Laura m.ggi Cristina Lim.tola Silvia Di Angelantonio Davide Ragozzino Departm.nt of Physiology and Pharm.cology Sapienza University of RomeRomeItaly. Neurophysiology and Neuropharm.cology Inflam.aging Unit IRCCS NeuromedMediterranean Neurological InstitutePozzilliISItaly. Center for Life Nano-and Neuro-science Istituto Italiano di TecnologiaRomeItaly. Dipartim.nto di Biologia e Biotecnologie“Charles Darwin” Sapienza University of RomeRomeItaly. Santa Lucia Foundation(IRCCS Fondazione Santa Lucia) RomeItaly. European Brain Research Institute(EBRI)‘Rita Levi-m.ntalcini’ RomeItaly. CrestOptics S.p.A RomeItaly. Centre de Recherche du CHU de Québec Axe Neurosciences QuébecQuebec CityCanada. Départem.nt de m.decine m.léculaire UniversitéLaval QuébecQuebec CityCanada.1 National Research Council Institute of Biochemistry and Cell Biology(CNR-IBBC/EMMA/Infrafrontier/IMPC)International Campus“A.Buzzati-Traverso”Monterotondo(Rome)Italy.1 Epigenetics and Neurobiology Unit European Molecular Biology Laboratory(EMBL)MonterotondoItaly.1 Division of m.dical Sciences University of VictoriaVictoriaCanada.1 Departm.nt of Physiology and Pharm.cology Sapienza UniversityLaboratory affiliated to Istituto Pasteur ItaliaRomeItaly.

小胶质细胞是调节大脑突触发育和可塑性的重要细胞类型,但其影响突触的正常功能的机制尚不清楚。在本研究中,我们通过PLX5622造成小胶质细胞耗竭,并观察其对成年野生型小鼠海马CA3-CA1突触的影响。在小胶质细胞耗竭后,与树突棘密度降低... 详细信息

小胶质细胞是调节大脑突触发育和可塑性的重要细胞类型,但其影响突触的正常功能的机制尚不清楚。在本研究中,我们通过PLX5622造成小胶质细胞耗竭,并观察其对成年野生型小鼠海马CA3-CA1突触的影响。在小胶质细胞耗竭后,与树突棘密度降低相关的自发和诱发谷氨酸能活动的减少,出现未成熟突触特征以及突触的可塑性提高。小胶质细胞耗竭的小鼠在新物体识别任务的获取方面表现出缺陷。海马星形胶质细胞出现增生,但并没有神经炎症反应。在Cx3cr1-/-小鼠中,PLX不能导致海马出现上述改变。这说明CX3CL1/CX3CR1轴在小胶质细胞对突触功能的控制中有重要作用。PLX5622停用后,小胶质细胞的重新增殖,海马突触恢复,小鼠的学习功能也出现恢复。综上所述,小胶质细胞对维持成人大脑的突触的正常功能用重要的作用,去除小胶质细胞会导致谷氨酸能突触组织和活动的可逆变化。

关键词：谷氨酸能传递海马体学习小胶质细胞神经元-小胶质细胞相互作用突触

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Braam.am. Freire中学,葡萄牙里斯本

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建筑技艺 2014年第9期20卷 106-111页

作者： CVD Barquitectos Cristina Verissim. Diogo Burnay Joo Falco Rodolfo Reis Joana Barrelas Tiago Santos Adam.Pelissero Andre Barbosa ngelo Branquinho Ari Nieto Guilherm. Bivar Hugo Nascim.nto Inês Carrapio Irune Ardanza Josè maria Lavena Leonor Vaz Pinto Luigi m.rtinelli m.guel Travesso Silvia Am.ral Silvia m.ggi *** 严佳钰

Braam.am. Freire中学位于里斯本庞蒂尼亚历史城区的边缘，占地约17380m.2，毗邻起伏的地势。除了学校北面的山谷，整个校园都是庞蒂尼亚城区的一部分。该校始建于1986年，由五栋标准化预制建筑组成——中间一栋为平层，另外四栋为二层... 详细信息

Braam.am. Freire中学位于里斯本庞蒂尼亚历史城区的边缘，占地约17380m.2，毗邻起伏的地势。除了学校北面的山谷，整个校园都是庞蒂尼亚城区的一部分。该校始建于1986年，由五栋标准化预制建筑组成——中间一栋为平层，另外四栋为二层建筑。这些建筑按照东西向排列，通过走廊相互连接。学校设施包括一个体育馆和一个地势较低的户外操场，两者与教学楼都没有连接。

关键词：里斯本葡萄牙中学建筑标准化东西向体育馆教学楼

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