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Climate change and human health: Last call to arms for us

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World Journal of Clinical Cases 2024年第11期12卷 1870-1874页

作者： Antonio Corrente maria Caterina pace Marco Fiore Department of Anaesthesiology and Intensive Care Medicine The Anastasia Guerriero HospitalMarcianise 81025CasertaItaly Department of Women Child and General and Specialized SurgeryUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy

Climate change,now the foremost global health hazard,poses multifaceted challenges to human *** editorial elucidates the extensive impact of climate change on health,emphasising the increasing burden of diseases and the exacerbation of health *** highlights the critical role of the healthcare sector,particularly anaesthesia,in both contributing to and mitigating climate *** is a call to action for the medical community to recognise and respond to the health challenges posed by climate change.

关键词： Climate change Carbon footprint Sustainability Greenhouse gases Anaesthetic gases Environmental impact Disposable laryngoscope blades

Burden of severe infections due to carbapenem-resistant pathogens in intensive care unit

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World Journal of Clinical Cases 2023年第13期11卷 2874-2889页

作者： maria Caterina pace Antonio Corrente maria Beatrice Passavanti Pasquale Sansone Stephen Petrou Sebastiano Leone Marco Fiore Department of Women Child and General and Specialized SurgeryUniversity of Campania"Luigi Vanvitelli"Naples 80138Italy Department of Emergency Medicine University of California San FranciscoSan FranciscoCA 94143United States Division of Infectious Diseases “San Giuseppe Moscati”HospitalAvellino 83100Italy

Intensive care units(ICU)for various reasons,including the increasing age of admitted patients,comorbidities,and increasingly complex surgical procedures(e.g.,transplants),have become"the epicenter"of nosocomial infections,these are characterized by the presence of multidrug-resistant organisms(MDROs)as the cause of ***,the perfect match of fragile patients and MDROs,as the cause of infection,makes ICU mortality very ***,carbapenems were considered for years as last-resort antibiotics for the treatment of infections caused by MDROs;unfortunately,nowadays carbapenem resistance,mainly among Gram-negative pathogens,is a matter of the highest concern for worldwide public *** comprehensive review aims to outline the problem from the intensivist's perspective,focusing on the new definition and epidemiology of the most common carbapenem-resistant MDROs(Acinetobacter baumannii,Pseudomonas aeruginosa and Enterobacterales)to emphasize the importance of the problem that must be permeating clinicians dealing with these diseases.

关键词： Antimicrobial resistance Multidrug-resistant PDR Carbapenem-resistance Multidisciplinary critical care Intensive care unit

The Solution of the Einstein’s Equations in the Vacuum Region Surrounding a Spherically Symmetric Mass Distribution

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Journal of Modern Physics 2024年第9期15卷 1353-1374页

作者： Carlo maria pace ICRANet Pescara Italy

In this article, we address the solution of the Einstein’s equations in the vacuum region surrounding a spherically symmetric mass distribution. There are two different types of mathematical solutions, depending on the value of a constant of integration. These two types of solutions are analysed from a physical point of view. The comparison with the linear theory limit is also considered. This leads to a new solution, different from the well known one. If one considers the observational data in the weak field limit this new solution is in agreement with the available data. While the traditional Schwarzschild solution is characterized by a horizon at r=2GM/c2, no horizon exists in this new solution.

关键词： General Theory of Relativity Schwarzschild Solution Event Horizon Black Hole

The Gravitational Potential and the Gravitational Force According to the Correct Schwarzschild Metric

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Journal of Modern Physics 2024年第12期15卷 2256-2273页

作者： Carlo maria pace ICRANet Piazza della Repubblica Pescara Italy

In a recent article, we have corrected the traditional derivation of the Schwarzschild metric, thus obtaining the formulation of the correct Schwarzschild metric, which is different from the traditional Schwarzschild metric. In this article, by starting from this correct Schwarzschild metric, we obtain the formulas of the correct gravitational potential and of the correct gravitational force in the case described by this metric. Moreover, we analyse these correct results and their consequences. Finally, we propose some possible crucial experiments between the commonly accepted theory and the same theory corrected according to this article.

关键词： General Theory of Relativity Schwarzschild Metric Gravitational Potential Gravitational Force Stable Circular Orbital Motion

The Correct Reissner-Nordstrøm, Kerr and Kerr-Newman Metrics

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Journal of Modern Physics 2024年第10期15卷 1502-1522页

作者： Carlo maria pace ICRANet Pescara Italy

In a very recent article of mine I have corrected the traditional derivation of the Schwarzschild metric thus arriving to formulate a correct Schwarzschild metric different from the traditional Schwarzschild metric. In this article, starting from this correct Schwarzschild metric, I also propose corrections to the other traditional Reissner-Nordstrøm, Kerr and Kerr-Newman metrics on the basis of the fact that these metrics should be equal to the correct Schwarzschild metric in the borderline case in which they reduce to the case described by this metric. In this way, we see that, like the correct Schwarzschild metric, also the correct Reissner-Nordstrøm, Kerr and Kerr-Newman metrics do not present any event horizon (and therefore do not present any black hole) unlike the traditional Reissner-Nordstrøm, Kerr and Kerr-Newman metrics.

关键词： General Theory of Relativity Schwarzschild Reissner-Nordstrøm Kerr Kerr-Newman Metric Event Horizon Black Hole

Nosocomial spontaneous bacterial peritonitis antibiotic treatment in the era of multi-drug resistance pathogens: A systematic review

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World Journal of Gastroenterology 2017年第25期23卷 4654-4660页

作者： Marco Fiore Alberto Enrico Maraolo Ivan Gentile Guglielmo Borgia Sebastiano Leone Pasquale Sansone maria Beatrice Passavanti Caterina Aurilio maria Caterina pace Department of Anaesthesiological Surgical and Emergency SciencesUniversity of Campania“Luigi Vanvitelli” Department of Clinical Medicine and Surgery Section of Infectious DiseasesUniversity of Naples Federico II Division of Infectious Diseases “San Giuseppe Moscati”Hospital

To systematically review literature upon aetiology of nosocomial spontaneous bacterial peritonitis (N-SBP) given the rising importance of multidrug-resistant (MDR) bacteria. METHODSA literature search was performed on MEDLINE and Google Scholar databases from 2000 to 15th of November 2016, using the following search strategy: “spontaneous” AND “peritonitis”. RESULTSThe initial search through electronic databases retrieved 2556 records. After removing duplicates, 1958 records remained. One thousand seven hundred and thirty-five of them were excluded on the basis of the screening of titles and abstract, and the ensuing number of remaining articles was 223. Of these records, after careful evaluation, only 9 were included in the qualitative analysis. The overall proportion of MDR bacteria turned out to be from 22% to 73% of cases across the studies. CONCLUSIONN-SBP is caused, in a remarkable proportion, by MDR pathogens. This should prompt a careful re-assessment of guidelines addressing the treatment of this clinical entity.

关键词： Hospital-acquired infections Nosocomial spontaneous bacterial peritonitis Multidrug resistant bacteria Cirrhosis Critically ill patient

Medicinal cannabis products for the treatment of acute pain

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World Journal of Clinical Cases 2023年第12期11卷 2670-2676页

作者： Marco Fiore Aniello Alfieri Sveva Di Franco Stephen Petrou Giovanni Damiani maria Caterina pace Department of Women Child and General and Specialized SurgeryUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy Department of Emergency Medicine University of California San FranciscoSan FranciscoCA 94143United States Department of Biomedical Surgicaland Dental SciencesUniversity of MilanMilan 20122Italy

For thousands of years,medicinal cannabis has been used for pain treatment,but its use for pain management is still ***-analysis of the literature has shown contrasting results on the addition of cannabinoids to opioids compared with placebo/other active agents to reduce *** studies are mainly focused on medicinal cannabis use in chronic pain management,for which the analgesic effect has been proven in many *** review focuses on the potential use of medical cannabis for acute pain management in preclinical studies,studies on healthy subjects and the few pioneering studies in the clinical setting.

关键词： Cannabis Cannabinoids Endocannabinoid system 2-arachidonoylglycerol Anandamide Analgesia Acute pain

Spontaneous bacterial peritonitis due to carbapenemase-producing Enterobacteriaceae:Etiology and antibiotic treatment

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World Journal of Hepatology 2020年第12期12卷 1136-1147页

作者： Marco Fiore Sveva Di Franco Aniello Alfieri maria Beatrice Passavanti maria Caterina pace Stephen Petrou Francesca Martora Sebastiano Leone Department of Women Child and General and Specialized SurgeryUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy Department of Emergency Medicine Good Samaritan Hospital Medical CenterNY 11795United States Department of Experimental Medicine University of Campania“Luigi Vanvitelli”Naples 80138Italy Division of Infectious Diseases “San Giuseppe Moscati”HospitalAvellino 83100Italy

Carbapenem antibiotics were first introduced in the 1980s and have long been considered the most active agents for the treatment of multidrug-resistant gramnegative *** the last decade,carbapenem-resistant Enterobacteriaceae(CRE)have emerged as organisms causing spontaneous bacterial *** caused by CRE have shown a higher mortality rate than those caused by bacteria sensitive to carbapenem *** antibiotic guidelines for the treatment of spontaneous bacterial peritonitis are insufficient,and rapid deescalation of empiric antibiotic treatment is not widely *** review summarizes the molecular characteristics,epidemiology and possible treatment of spontaneous bacterial peritonitis caused by CRE.

关键词： Spontaneous bacterial peritonitis Carbapenem-resistant Enterobacteriaceae Carbapenem-resistant Klebsiella pneumoniae Cirrhosis

First Italian outbreak of VIM-producing Serratia marcescens in an adult polyvalent intensive care unit, August-October 2018: A case report and literature review

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World Journal of Clinical Cases 2019年第21期7卷 3535-3548页

作者： maria Rosaria Iovene Vincenzo Pota Massimiliano Galdiero Giusy Corvino Federica maria Di Lella Debora Stelitano maria Beatrice Passavanti maria Caterina pace Aniello Alfieri Sveva Di Franco Caterina Aurilio Pasquale Sansone Vettakkara Kandy Muhammed Niyas Marco Fiore Department of Experimental Medicine University of Campania"Luigi Vanvitelli"Naples 80138Italy Department of Women Child and General and Specialized SurgeryUniversity of Campania"Luigi Vanvitelli"Naples 80138Italy Department of Medicine All India Institute of Medical SciencesNew Delhi 110029India

BACKGROUND Carbapenem-resistant Enterobacteriaceae has become a significant public health concern as hospital outbreaks are now being frequently reported and these organisms are becoming difficult to treat with the available *** SUMMARY An outbreak of VIM-producing Serratia marcescens occurred over a period of 11 wk(August,1 to October,18)in patients admitted to the adult polyvalent intensive care unit of the University of Campania“Luigi Vanvitelli”located in *** episodes occurred in three patients(two patients infected,and one patient colonized).All the strains revealed the production of *** After three decades of carbapenem antibiotics use,the emergence of carbapenemresistance in Enterobacteriaceae has become a significant concern and a stricter control to preserve its clinical application is *** is,to our knowledge,the first outbreak of VIM-producing Serratia marcescens in *** policies must be implemented to avoid future outbreaks.

关键词： Serratia marcescens Carbapenamase VIM Intensive care unit Outbreak Case report