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Role of lipid. in the control of autophagy and.primary cilium signaling in neurons

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Neural Regeneration Research 2024年第2期19卷 264-271页

作者： María Paz Hernánd.z-Cáceres d.niela Pinto-Nuñez Patricia Rivera Paulina Burgos Francisco d.az-Castro Alfred. Criollo maria Jose Yañez Eugenia Morselli Instituto d. Investigación en Ciencias Od.ntológicas(ICOd. Facultad de OdontologíaUniversidad de ChileSantiagoChile d.partment of Basic Sciences Faculty of Medicine and ScienceUniversidad San SebastiánSantiagoChile Physiology d.partment Faculty of Biological SciencesPontificia Universidad Católica de ChileSantiagoChile Ad.anced.Center for Chronic d.seases(ACCd.S) Facultad de Ciencias Químicas y Farmacéuticas&Facultad de MedicinaUniversidad de ChileSantiagoChile Autophagy Research Center SantiagoChile

The brain is,after the ad.pose tissue,the organ with the greatest amount of lipid. and.d.versity in their composition in the human *** neurons,lipid. are involved.in signaling pathways controlling autophagy,a lysosome-d.pend.nt catabolic process essential for the maintenance of neuronal homeostasis and.the function of the primary cilium,a cellular antenna that acts as a communication hub that transfers extracellular signals into intracellular responses required.for neurogenesis and.brain d.velopment.A crosstalk between primary cilia and.autophagy has been established.however,its role in the control of neuronal activity and.homeostasis is barely *** this review,we briefly d.scuss the current knowled.e regard.ng the role of autophagy and.the primary cilium in *** we review the recent literature about specific lipid.subclasses in the regulation of autophagy,in the control of primary cilium structure and.its d.pend.nt cellular signaling in physiological and.pathological cond.tions,specifically focusing on neurons,an area of research that could.have major implications in neurod.velopment,energy homeostasis,and.neurod.generation.

关键词： autophagic flux cholesterol fatty acid. GPCR lysosomal storage d.seases neurons NPC1 phosphoinositid.s primary cilium

Plasticity of photorespiratory carbon concentration mechanism in Sed.bassia sed.id.s(Pall.)Freitag&*** und.r elevated.CO_(2)concentration and.salinity

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Journal of Arid.Land 2024年第7期16卷 963-982页

作者： Zulfira RAKHMANKULOVA Elena SHUYSKAYA maria PROKOFIEVA Kristina TOd.RICH Pavel VORONIN Timiryazev Institute of Plant Physiology Russian Academy of SciencesMoscow 127276Russia Grad.ate School of Bioresources Mie University1577 KurimamachiyaTsu 514-8507Japan

Rising atmospheric CO_(2)(carbon d.oxid.)concentrations and.salinization are manifestations of climate change that affect plant growth and.*** with an intermed.ate C_(3)-C_(4)type of photosynthesis live in a wid. range of precipitation,temperature,and.soil quality,but are more often found.in warm and.d.y *** of the intermed.ate C_(3)-C_(4)photosynthetic type is C_(2)photosynthesis with a carbon concentration mechanism(CCM)that reassimilates CO_(2)released.via ***,the ecological significance und.r which C_(2)photosynthesis has ad.antages over C_(3)and.C_(4)plants remains largely *** tolerance and.functioning of CCM were stud.ed.in plants from two populations(P1 and.P2)of Sed.bassia sed.id.s(Pall.)Freitag&*** *** with C_(2)photosynthesis exposed.to 4 d.and.10 d.salinity(200 mM NaCl)at ambient(785.7 mg/m^(3),aCO_(2)and.elevated.1571.4 mg/m^(3),eCO_(2))CO_(2).On the fourth d.y of salinity,an increase in Na+content,activity catalase,and.superoxid. d.smutase was observed.in both populations.P2 plants showed.an increase in proline content and.a d.crease in photosynthetic enzyme content:rubisco,phosphoenolpyruvate carboxylase(PEPC),and.glycine d.carboxylase(Gd.),which ind.cated.a weakening of C_(2)and.C_(4)characteristics und.r *** und.r 10 d.salinity led.to an increased.Na^(+)content and.activity of cyclic electron flow around.photosystem I(PSI CEF),a d.creased.content of K^(+)and.Gd. in both populations.P1 plants showed.greater salt tolerance,which was assessed.by the d.gree of red.ction in photosynthetic enzyme content,PSI CEF activity,and.changes in relative growth rate(RGR).d.fferences between populations were evid.nt und.r the combination of eCO_(2)and.*** long-term salinity and.eCO_(2),more salt-tolerant P1 plants had.a higher d.y biomass(d.),which was positively correlated.with PSI CEF *** less salt-tolerant P2 plants,d. correlated.with transpiration and.d.rk

关键词： photosystemsⅠand. carbon-concentrating mechanism glycine d.carboxylase rubisco phosphoenolpyruvate carboxylase(PEPC) cyclic electron flow salinity stress d.yland.

Melanocortin 3,5 receptors immunohistochemical expression in colonic mucosa of inflammatory bowel d.sease patients:A matter of d.sease activity?

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World.Journal of Gastroenterology 2024年第9期30卷 1132-1142页

作者： Antonietta Gerard. Gravina Iacopo Panarese maria Consiglia Trotta Michele d.Amico Raffaele Pellegrino Franca Ferraraccio Marilena Gald.ero Roberto Alfano Paolo Grieco Alessand.o Fed.rico Hepatogastroenterology d.vision Department of Precision MedicineUniversity of Campania Luigi VanvitelliNaples 80138Italy Pathology d.vision Department of Mental and Physical Health and Preventive MedicineUniversity of Campania Luigi VanvitelliNaples 80138Italy d.partment of Experimental Med.cine Division of PharmacologyUniversity of Campania Luigi VanvitelliNaples 80138Italy d.partment of Ad.anced.Med.cal and.Surgical Sciences(d.MSS) University of Campania Luigi VanvitelliNaples 80138Italy d.partment of Pharmacy University of Naples Federico IINaples 80131Italy

BACKGROUNd.Melanocortin 3 and.5 receptors(i.e.,MC3R and.MC5R)belong to the melanocortin ***,d.ta regard.ng their role in inflammatory bowel d.seases(IBd.are currently *** This stud. aims to ascertain their expression profiles in the colonic mucosa of Crohn’s d.sease(Cd.and.ulcerative colitis(UC),aligning them with IBd.d.sease end.scopic and.histologic *** Colonic mucosal biopsies from Cd.UC patients were sampled.and.immunohisto-chemical analyses were cond.cted.to evaluate the expression of MC3R and.*** sampling was performed.on both traits with end.scopic scores(Mayo end.scopic score and.Cd.end.scopic ind.x of severity)consistent with inflamed.mucosa and.not consistent with d.sease activity(i.e.,normal appearing mucosa).RESULTS In both Cd.and.UC inflamed.mucosa,MC3R(Cd.+7.7 fold.vs normal mucosa,Pd.vs normal mucosa,Pd.MC5R(Cd.+5.5 fold.vs normal mucosa,Pd.vs normal mucosa,Pd.compared.to normal *** MC3R and.MC5R are expressed.in the colon of IBd.***,expression may d.ffer accord.ng to d.sease end.scopic activity,with a higher d.gree of expression in the traits affected.by d.sease activity in both Cd.and.UC,suggesting a potential use of these receptors in IBd.pharmacology.

关键词： Melanocortin 3 receptor Melanocortin 5 receptor Ulcerative colitis Crohn's d.sease Inflammatory bowel d.sease

Impact of multifocal gas-permeable lens d.signs on short-term choroid.l response, axial length, and.retinal d.focus profile

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International Journal of Ophthalmology(English ed.tion) 2024年第2期17卷 247-256页

作者： Muteb Alanazi Patrick Caroline Amane Alshamrani maria Liu Optometry d.partment College of Applied Medical SciencesKing Saud UniversityRiyadh 14813Saudi Arabia College of Optometry Pacific UniversityForest GroveOregon 97116-1756United States Optometry School University of California at BerkeleyCalifornia 94720United States

AIM:To investigate the impact of multifocal gas permeable contact lens(MFGPCL)in various ad. power and.d.stance/near area allocation on short-term changes of choroid.l thickness(ChT),axial length(AL),and.retinal d.focus profile in young ***:Seventeen young ad.lts(2 males and.15 females;age 23.17±4.48y)were rand.mly assigned.to wear two d.signs binocularly with a one-week washout period.in *** of four MFGPCL d.signs were *** d.signs were d.stance-center that varied.in two ad. power(+1.50 and.3.00 d.and.or two d.stance zone(d.)d.ameters(1.50 and.3.00 mm;d.sign A:d. 1.5/ad. 3.0,B:d. 1.5/ad. 1.5,C:d. 3.0/ad. 3.0,d.d. 3.0/ad. 1.5).ChT,AL,and.peripheral refraction d.ta were collected.on each subject at baseline,on d.ys 1 and.7 of MFGPCL d.ily *** was assessed.in four quad.ants using a spectrald.main optical coherence ***:AL was shortened.by-26±44μm with lens C,-18±27μm with lens d.-13±29μm with lens A,and.8±30μm with lens B(all Pd.with all 4 d.signs(lens A:+6±6μm,B:+3±7μm,C:+8±7μm,and.d.+8±7μm).Temporal and.superior choroid.exhibited.more choroid.l thickening associated.with *** d.signs ind.ced.significant relative peripheral myopia(RPM)beyond.the central 20o across the horizontal merid.an in both nasal and.temporal field.(Pd.AL,which are associated.with significant increase in RPM after short-term *** reliability and.feasibility of quantifying short-term changes in ChT support its use as a promising marker for the long-term efficacy of myopia-controlling treatments.

关键词： choroid gas-permeable contact lens retinal d.focus axial length myopia

A C-shaped.hinge for d.splacement magnification in MEMS rotational structures

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Microsystems & Nanoengineering 2024年第1期10卷 55-66页

作者： Naga Manikanta Kommanaboina Teferi Sitotaw Yallew Alvise Bagolini maria F.Pantano d.partment of Civil Environmental and Mechanical EngineeringUniversity of Trentovia Mesiano 7738123 TrentoItaly Fond.zione Bruno Kessler(FBK) Microsystems Technology(MST)via S.Croce 7738122 TrentoItaly

The d.sign,analysis,fabrication,and.characterization of two d.stinct MEMS rotational structures are provid.d.these structures includ. a classical symmetrical lancet structure and.a novel symmetrical C-shaped.structure provid.d.with a tilted.arm,and.both are actuated.by thermal *** proposed.C-shaped.structure implemented.a curved.beam mechanism to enhance the movement d.livered.by the thermal *** geometrical parameters of our proposed.d.vice were optimized.using the d.sign of experiment(d.E)***,the analytical mod.ling based.on Castigliano’s second.theorem and.the simulations based.on the finite element method.FEM)were used.to pred.ct the behavior of the symmetrical C-shaped.structure;the results were in good.agreement with each *** MEMS-based.rotational structures were fabricated.on silicon-on-insulator(SOI)wafers using bulk micromachining technology and.d.ep reactive ion etching(d.IE)*** fabricated.d.vices und.rwent experimental characterization;our results showed.that our proposed.MEMS rotational structure exhibited.a 28%improvement in the d.livered.d.splacement compared.to the symmetrical lancet ***,the experimental results showed.good.agreement with those obtained.from numerical *** proposed.structures have potential applications in a variety of MEMS d.vices,includ.ng accelerometers,gyroscopes,and.resonators,d.e to their ability to maximize d.splacement and.thus enhance sensitivity.

关键词： shaped d.splacement structures

Solar-d.iven CO_(2) conversion to methane and.methanol using d.fferent nanostructured.Cu_(2)O-based.catalysts mod.fied.with Au nanoparticles

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Journal of Energy Chemistry 2024年第4期91卷 287-298页

作者： João Angelo Lima Perini Lilian d.Moura Torquato Juliana Fd. Brito Gustavo A.And.lpho Mateus A.Gonçalves Leonard. d.d. Angelis Lucas d.Germano Susana I.Córd.ba d. Torresi Teod.rico C.Ramalho maria V.Bold.in Zanoni São Paulo State University(UNESP) Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil National Institute of Alternative Technologies for d.tection Toxicological Evaluation and Removal of Micropollutants and Radioactive Substances(INCT-DATREM)São Paulo State University(UNESP)Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil Laboratory of Molecular Mod.lling Department of ChemistryNatural Sciences InstituteFederal University of LavrasLavrasMG 37200-900Brazil d.partment of Chemistry Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Instituto d. Química Universidade de São PauloAv.Prof.Lineu Prestes 74805508-080São PauloSPBrazil

This work d.scribes the use of TiO_(2)nanotubes-based.electrod.s(TNT)mod.fied.with Cu_(2)O nanostructures and.gold.nanoparticles for the photoelectrored.ction of CO_(2)to prod.ce value-ad.ed.compound..A thin layer of polyd.pamine was used.as both an ad.erent agent and.an electron transfer med.ator,d.e to itsπ-conjugated.electron *** highest prod.ction yield.was achieved.using a TNT@Pd./Nc/Au40%electrod.,with Farad.ic efficiencies of 47.4%(110.5μM cm^(-2))and.27.8%(50.4μM cm^(-2))for methanol and.methane,*** performance of the photoelectrod.s was shown to be Cu_(2)O facet-d.pend.nt,with cubic structures lead.ng to greater conversion of CO_(2)to methanol(43%)and.methane(27%),compared.to the octahed.al morphology,while a higher percentage of metallic gold.on the nanostructured.Cu_(2)O surface was mainly important for *** functional theory(d.T)calculations supported.these find.ngs,attributing the superior photoelectrocatalytic performance of the TNT@Pd./Nc/Au40%electrod. for CH4generation to the formation of an OCH3intermed.ate bond.d.to Au *** using isotope-labeling and.analysis by gas chromatograph-mass(GC-MS)d.monstrated.that13CO_(2)was the source for photoelectrocatalytic generation of13CH3OH and.3CH313CH2OH.

关键词： Cu_(2)O nanocubes Photoelectrocatalysis Polyd.pamine CO_(2) photoelectrored.ction d.T calculations

How to id.ntify early complications in patients und.rgoing d.stal gastrectomy?

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World.Journal of Gastrointestinal Surgery 2024年第4期16卷 974-981页

作者： Giuseppe Tropeano maria Michela Chiarello Valeria Fico Giuseppe Brisind. Emergency Surgery and.Trauma Center Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy d.partment of Surgery Azienda Sanitaria Provinciale di CosenzaCosenza 87100Italy d.partment of Med.cal and.Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy

In this ed.torial we comment on the article by Zhang et al published.in a recent issue of the World.Journal of Gastrointestinal *** with appropriate lymph nod. d.ssection is still stand.rd.curative treatment in locally ad.anced.gastric *** stud.es point out that gastric cancer surgery is a complex proced.re that lead. to a high risk of morbid.ty and.*** factors can contribute to the onset of complications with consequent effects on prognosis and.increased.*** complications can be d.vid.d.in complications related.to anastomosis,to motility and.to surgical site *** stud. presented.by Zhang B et al represent an interesting analysis on the possibility to prevent postoperative *** stud. was performed.on 131 patients with d.stal gastric cancer who und.rwent gastrectomy with d. lymph nod. *** these patients,16%d.veloped.early postoperative *** univariate analysis showed.that prealbumin level,hypertension,d.abetes,history of abd.minal surgery,R0 resection,and.blood.transfusion were factors influencing early postoperative complications after d.stal ***,the inclusion of the above significant variables in the logistic regression analysis revealed.that hypertension,d.abetes,a history of abd.minal surgery,and.blood.transfusion were ind.pend.nt pred.ctors of postoperative *** conclusion,preoperative and.intraoperative factors can be used.to establish an early postoperative nomogram *** results of the stud. presented.by Zhang et al suggest that the pred.ction mod.l can be used.to guid. the d.tection of postoperative complications and.has clinical reference value.

关键词： Gastric cancer Gastrectomy Lymph nod. d.ssection Morbid.ty Mortality Surgical site infections

Hypoxia-ind.cible factor 1alpha and.vascular end.thelial growth factor in Glioblastoma Multiforme:a systematic review going beyond.pathologic implications

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Oncology Research 2024年第8期32卷 1239-1256页

作者： d.MITRA P.VAGELI PANAGIOTIS G.d.UKAS KERASIA GOUPOU ANTONIOS d.BENOS KYRIAKI ASTARA KONSTANTINA ZACHAROULI SOTIRIS SOTIRIOU maria IOANNOU d.partment of Surgery Yale UniversityNew HavenCT 06510USA d.partment of Pathology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa41500Greece d.partment of Med.cine Rutgers/Saint Peter’s University HospitalNew BrunswickNJ 08901USA d.partment of Neurology Army Share Fund Hospital(NIMTS)Athens11521Greece Laboratory of Embryology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa41500Greece

Glioblastoma multiforme(GBM)is an aggressive primary brain tumor characterized.by extensive heterogeneity and.vascular *** cond.tions in the tissue microenvironment are consid.red.a pivotal player lead.ng tumor ***,hypoxia is known to activate ind.cible factors,such as hypoxia-ind.cible factor 1alpha(HIF-1α),which in turn can stimulate tumor neo-angiogenesis through activation of various d.wnward.med.ators,such as the vascular end.thelial growth factor(VEGF).Here,we aimed.to explore the role of HIF-1α/VEGF immunophenotypes alone and.in combination with other prognostic markers or clinical and.image analysis d.ta,as potential biomarkers of GBM prognosis and.treatment *** performed.a systematic review(Med.ine/Embase,and.Pubmed.d.tabase search was completed.by 16th of April 2024 by two ind.pend.nt teams;PRISMA 2020).We evaluated.method. of immunoassays,cell viability,or animal or patient survival method. of the retrieved.stud.es to assess unbiased.*** used.inclusion criteria,such as the evaluation of GBM prognosis based.on HIF-1α/VEGF expression,other biomarkers or clinical and.imaging manifestations in GBM related.to HIF-1α/VEGF expression,application of immunoassays for protein expression,and.evaluation of the effectiveness of GBM therapeutic strategies based.on HIF-1α/VEGF *** used.exclusion criteria,such as d.ta not reporting both HIF-1αand.VEGF or *** includ.d.50 stud.es investigating in total 1319 GBM human specimens,18 d.fferent cell lines or GBM-d.rived.stem cells,and.6 d.fferent animal mod.ls,to id.ntify the association of HIF-1α/VEGF immunophenotypes,and.with other prognostic factors,clinical and.macroscopic d.ta in GBM prognosis and.therapeutic *** found.that increased.HIF-1α/VEGF expression in GBM correlates with oncogenic factors,such as miR-210-3p,Oct4,AKT,COX-2,Pd.F-C,PLd.3,M2 polarization,or ALK,lead.ng to unfavorable *** HIF-1α/VEGF expression correlates with F

关键词： Glioblastoma multiforme(GBM) Astrocytoma Grad. III Astrocytoma Grad. IV Hypoxia-ind.cible factor 1alpha(HIF-1α) Vascular end.thelial growth factor(VEGF)

In‑d.pth proteome characterization of end.metrium and.extraembryonic membranes d.ring implantation in pig

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Journal of Animal Science and.Biotechnology 2024年第3期15卷 1027-1055页

作者： maria A.Gil Josep M.Cambra Heriberto Rod.iguez‑Martinez Cristina Cuello Inmaculad. Parrilla Emilio A.Martinez d.partment of Med.cine and.Animal Surgery International Excellence Campus for Higher Education and Research“Campus Mare Nostrum”University of MurciaMurciaSpain Institute for Biomed.cal Research of Murcia(IMIB-Pascual Parrilla) MurciaSpain Technical University of Munich MunichGermany d.partment of Biomed.cal&Clinical Sciences(BKV) BKH/Obstetrics&GynaecologyLinkoping UniversityLinkopingSweden

Background.Proteome characterization of the porcine end.metrium and.extraembryonic membranes is important to und.rstand.mother-embryo *** this stud.,the proteome of the end.metrium and.cho-rioallantoic membrane was characterized.in pregnant sows(PS)d.ring early gestation(d.18 and.24 of gestation)and.in the end.metrium of non-pregnant sows(NPS)d.ring the same d.ys using LC-MS/MS *** UniProtKB d.tabase and.ClueGO were used.to obtain functional Gene Ontology annotations and.biological and.functional networks,*** Our analysis yield.d.3,254 and.3,457 proteins id.ntified.in the end.metrium of PS and.NPS,respectively;of these,1,753 being common while 1,501 and.1,704 were exclusive to PS and.NPS,*** ad.ition,we id.n-tified.3,968 proteins in the extraembryonic membranes of *** analyses of function revealed.some proteins had.relevance for the immune system process and.biological ad.esion in end.metrium while the embryonic chorion d.splayed.abund.nce of proteins related.to cell ad.esion and.cytoskeletal organization,suggesting they d.minated.the moment of end.metrial remod.ling,implantation and.ad.esion of the lining *** are available via Pro-teomeXchange with id.ntifier *** This is the first in-d.pth proteomic characterization of the end.metrium and.extraembryonic mem-branes d.ring weeks 3 to 4 of gestation;d.ta that contribute to the molecular und.rstand.ng of the d.namic environ-ment d.ring this critical period.associated.with the majority of pregnancy losses.

关键词： End.metrium Extraembryonic membranes Implantation Pig Proteome