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Low red blood cell levels of deglycating enzymes in colorectal cancer patients

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World Journal of Gastroenterology 2011年第3期17卷 329-333页

作者： maria Notarnicola maria Gabriella Caruso Valeria Tutino Vito Guerra Giovanni Misciagna Laboratory of Biochemistry National Institute for Digestive Diseases Laboratory of Epidemiology and Biostatistics National Institute for Digestive Diseases

AIM: To investigate Glyoxalase Ⅰ and fructosamine-3-kinase (FN3K) activity in red blood cells from patients with colorectal adenomas and cancer. METHODS: Thirty three consecutive subjects with one or more histologically confirmed colorectal adenomatous polyps, 16 colorectal cancer patients and a group of 11 control subjects with normal colonoscopy were included in the study. Glyoxalase Ⅰ and FN3K activities were measured in red blood cells using a spectrophotometric and radiometric assay, respectively. RESULTS: A significant reduction in both Glyoxalase Ⅰ and FN3K activity was detected in patients with tumors compared to patients with adenomas and the controls. Erythrocyte Glyoxalase Ⅰ activity in colorectal cancer was approximately 6 times lower than that detected in patients with adenoma (0.022 ± 0.01 mmol/min per milliliter vs 0.128 ± 0.19 mmol/min per milliliter of red blood cells, P = 0.003, Tukey's test). FN3K activity in red blood cells from patients with colon cancer was approximately 2 times lower than that detected in adenoma patients (19.55 ± 6.4 pmol/min per milliliter vs 38.6 ± 31.7 pmol/min per milliliter of red blood cells, P = 0.04, Tukey's test). CONCLUSION: These findings suggest that deglycating enzymes may be involved in the malignant transformation of colon mucosa.

关键词： Colorectal cancer Enzymatic activity Fructosamine-3-kinase Glycation Glyoxalase Ⅰ

Quantification of skid resistance seasonal variation in asphalt pavements

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第2期7卷 237-248页

作者： Christina Plati maria Pomoni Konstantina Georgouli Laboratory of Pavement Engineering School of Civil EngineeringNational Technical University of Athens(NTUA)Athens 15773Greece

The present study deals with the quantification of skid resistance seasonal variation in asphalt ***,skid resistance data were collected twice per year(after"wet"and"dry"seasons)along four trial sections of an urban highway with a GripTester system(during a six-year field experiment).For the estimation of a percentage reference change(%)between wet and dry skid resistance data,a methodology is developed based on distribution fitting of the percentage change of skid resistance index due to seasonal variation *** outcome of the analysis is applied and successfully validated through a set of skid resistance data collected from an interurban highway pavement section with different traffic and environmental *** such the developed methodology can be considered as a promising tool for accommodating the seasonal variation of skid ***,the resulting percentage reference change(%)enables the estimation of skid resistance level for the dry period based on the wet period ***,it seems that the proposed quantification process may constitute a practical yet efficient tool for road authorities and highway operators on how to estimate the effect of seasonal variation on skid resistance levels and schedule well-ahead necessary actions for enhancing driving safety.

关键词： Asphalt pavement Skid resistance Seasonal variation Quantification Road safety

Paleontology and evolution-part II

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Integrative Zoology 2014年第4期9卷 379-382页

作者： maria Rita PALOMBO Department of Earth Sciences Sapienza University of Rome Rome Italy

Explaining the history of life through geological deep time is undoubtedly a fascinating and challenging task that intrigued scientists even before the inception of Darwin’s *** fossil record,bearing witness to the changing of life and the continuous origination of new organisms in the course of time,on one hand represents the primary evidence for evolution,and on the other provides hints for deciphering dynamic processes and factors shaping the long,multifaceted evolutionary history of the *** at the past,therefore,is of crucial importance in the never-ending cognitive process of deciphering the way we came to be here.

关键词： doubt plain Biosphere

Differential expression of the fractalkine chemokine receptor （CX3CR 1） in human rnonocytes during differentiation

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Cellular & Molecular Immunology 2015年第6期12卷 669-680页

作者： Cecilia Analia Panek maria Victoria Ramos maria Pilar Mejias maria Iimena Abrey-Recalde Romina Iimena Fernandez-Brando maria Soledad Gori Gabriela Veronica Salamone2 Marina Sandra Palermo Laboratorio de Patogenesis e Inmunologfa de Procesos Infecciosos Instituto de Medicina Experimental (IMEX CONICET) Academia Nacional de Medicina Buenos Aires Argentina and Laboratorio de Celulas Presentadoras de Antfgeno y Respuesta Inflamatoria IMEX-CONICET Academia Nacional de Medicina Buenos Aires Argentina

Circulating monocytes （Mos） may continuously repopulate macrophage （MAC） or dendritic cell （DC） populations to maintain homeostasis. MACs and DCs are specialized cells that play different and complementary immunological functions. Accordingly, they present distinct migratory properties. Specifically, whereas MACs largely remain in tissues, DCs are capable of migrating from peripheral tissues to lymphoid organs. The aim of this work was to analyze the expression of the fractalkine receptor （CX3CR1） during the monocytic differentiation process. Freshly isolated Mos express high levels of both CX3CR1 mRNA and protein. During the Mo differentiation process, CX3CR1 is downregulated in both DCs and MACs. However, MACs showed significantly higher CX3CR1 expression levels than did DC. We also observed an antagonistic CX3CR1 regulation by interferon （IFN）-γ and interleukin （IL）-4 during MAC activation through the classical and alternative MAC pathways, respectively. IFN-γinhibited the loss of CX3CR1, but IL-4 induced it. Additionally, we demonstrated an association between CX3CR1 expression and apoptosis prevention by soluble fractalkine （sCX3CL1） in Mos, DCs and MACs. This is the first report demonstrating sequential and differential CX3CR1 modulation during Mo differentiation. Most importantly, we demonstrated a functional link between CX3CR1 expression and cell survival in the presence of sCX3CL1.

关键词： dendritic cells fractalkine receptor macrophages monocytes survival

Paleontology and evolution-part I

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Integrative Zoology 2014年第2期9卷 107-110页

作者： maria Rita Palombo Dipartimento di Scienze della Terra Sapienza Universitàdi Roma Rome Italy

Evolution is one of the central unifying concepts of natural history and modern *** it is well documented by many lines of evidence from a number of scientific disciplines(***,molecular biolo-gy,comparative anatomy,biogeography),its major sup-port indeed comes from the fossil record,where the his-tory of life can be seen unravelling through geological deep *** have modified their characteris-tics over time,and new taxa have incessantly *** mechanisms and causal factors have been shap-ing this multifaceted evolutionary history?

关键词： anatomy evolution record

Summary of Italian marine stages of the Quaternary

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Episodes 2008年第2期31卷 251-254页

作者： maria Bianca Cita Universita di Milano Dipartimento di Scienze della Terra ＂Ardito Desio＂via Mangiagalli 34 20133 Milano Italy.

Eight marine stages for the Quaternary have been defined in Italy starting from 1872 （Sicilian of Doderlein） to 1979 （Selinuntian of Ruggieri and Sprovieri）. The definition of all these stages was based essentially on invertebrate paleontology, initially from the study of pelecypods and gastropods, but also of corals, ostracods, benthic foraminifers and, more recently, on planktonic foraminifers and calcareous nannofossils. The 1948 International Geological Congress held in London decided to search for a locality in Italy to define the Neogene/Quaternary boundary in correspondence with the first appearance of the ＂northern guests＂ in the Mediterranean. The Vrica section of Calabria was selected for defining the GSSP of the Pleistocene in 1984.

关键词：地球第四纪地质时代意大利航海业

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迷失丛林 Sonora鸡尾酒吧

室内设计与装修 2025年第1期 148-149页

作者：无 Ricard Fabregat Rafaela Aranzaens Michele Soares Yesica Pena maria di Bello Adria Goula(摄影) 夏花(编译) EL EQUIPO CREATIVO 不详

Sonora鸡尾酒吧位于阿姆斯特丹Nhow酒店的顶层。其三角形的布局让空间更显紧凑,由OMA建筑事务所及建筑师RemKoolhaas设计的落地玻璃幕墙,提供了欣赏阿姆斯特丹新区壮丽景观的机会。设计师面临的挑战在于,要如何让鸡尾酒吧在与这些美景... 详细信息

Sonora鸡尾酒吧位于阿姆斯特丹Nhow酒店的顶层。其三角形的布局让空间更显紧凑,由OMA建筑事务所及建筑师RemKoolhaas设计的落地玻璃幕墙,提供了欣赏阿姆斯特丹新区壮丽景观的机会。设计师面临的挑战在于,要如何让鸡尾酒吧在与这些美景的竞争中脱颖而出。

关键词：建筑事务所玻璃幕墙阿姆斯特丹鸡尾酒建筑师三角形酒店

Growth and nutrient accumulation of Brazil nut trees(Bertholletia excelsa) in agroforestry at different fertilizer levels

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Journal of Forestry Research 2015年第2期26卷 347-353页

作者： Gotz Schroth maria do Socorro Souza da Mota maria Elizabeth de Assis Elias C.P. 513 Santarem PA 68109-971 Brazil Centro de Estudos Avanqados de Promoqao Social e Ambiental Av. Mendonqa Furtado 3979 Santarem PA 68040-050 Brazil Universidade Federal do Amazonas Manaus AM 69077-000Brazil

The Brazil nut tree（Bertholletia excelsa） is a frequent component of agroforestry systems in the Amazon because of its adaptation to nutrient-poor upland soils and multiple *** investigated the aboveground biomass production（kg dry weight）,nutrient uptake and requirements（N,P,Ca,Mg,K） of Brazil nut trees of different sizes grown under agroforestry conditions and fertilized at different *** of 70 experimental trees with different size were harvested and stem,branches and leaves were *** contents were determined for three trees of varying *** tree growth was fast,but variability was high,suggesting considerable potential for the improvement of this economically important *** trees responded to increased levels of fertilizer and lime with significantly increased foliar nutrient contents and growth,probably because of the improved availability of Mg and Ca for which the species seems to have a relatively high *** contrast to Brazil nut trees grown in forest or dense plantations,the agroforestry trees invested a substantial part of their biomass and nutrients in large branches and developed spreading *** improve stem form,reduce competition with associated crops for light and recycle nutrients,regular pruning of lower branches or planting arrangements that favor self-pruning are *** measures would also increase the recycling of Ca and Mg,large quantities of which are contained in the branches.

关键词： Allometric equation Amazon Nutrient competition Nutrient recycling Plant mineral nutrition Soil fertility Silviculture

In vitro antioxidant,antilipoxygenase and antimicrobial activities of extracts from seven climbing plants belonging to the Bignoniaceae

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Journal of Integrative Medicine 2018年第4期16卷 255-262页

作者： Carola Analla Torres Cristina Marisel Perez Zamora maria Beatriz Nunez Ana maria Gonzalez Laboratory of Microbiology and Pharmaceutical Technology Department of Basic and Applied SciencesNational University of Chaco AustralPresidencia Roque Saenz Pena 3700ChacoArgentina National Council for Scientific and Technical Research(CONICET) Godoy Cruz 2290Buenos Aires C1425FQBArgentina Institute of Botany of the Northeast(IBONE-CONICET) Sargento Juan Bautista Cabral 2131CorrientesArgentina

Objectives： This study aimed to evaluate the in vitro antioxidant capacity, to determine the anti-inflammatory effect due to lipoxygenase inhibition and to test the antimicrobial activity of ethanolic extracts from leaves of seven climbing species belonging to the Bignoniaceae family. These species are Adenocalyrnrna rnarginatum （Cham.） DC., Amphilophium vauthieri DC., Cuspidaria convoluta （VEIL） A. H. Gentry, Dolichandra dentata （K. Schum.） L. G. Lohmann, Fridericia caudigera （S. Moore） L. G. Lohmann, Fridericia chica （Bonpl.） L. G. Lohmann and Tanaecium selloi （Spreng.） L. G. Lohmann. Methods： The antioxidant activity was evaluated using three methods, 2,2＇-azino-bis（3-ethylbenzothiazo line-6-sulfonic acid）（ABTS）, 2,2-diphenyl-l-picrylhydrazyl （DPPH）, and ferric reducing antioxidant power. Lipoxygenase-inhibiting activity was assayed spectrophotometrically; the result was expressed as percent inhibition. The antimicrobial activity was assessed using the agar disk diffusion method. Minimal inhibitory concentration （MIC） and minimal bactericidal]fungicidal concentration were also determined for each extract against 12 pathogenic bacterial strains of Staphylococcus aureus and seven fungal strains of the Candida genus. The identification of the major compounds present in the most promising extract was established by high-performance liquid chromatography-tandem mass spectrometry. Results： C convoluta, F. caudigera, and F. chica exhibited the best antioxidant activity by scavenging DPPH and ABTS~ radicals and reducing Fe3＋ ion. These extracts showed a notable inhibition of lipnxygenase. F. caudigera was found to have the lower MIC value against S. aureus strains and six Candida species. The extracts of F. caudigera and C. convoluta were active even against methicillin-resistant S. aureus. C convoluta had higher total phenol content, better antioxidant activity and superior anti- inflammatory and antimicrobial activity. The main phenolic compounds found in this extract

关键词： Cuspidaria Fridericia Antioxidants Lipoxygenase Antimicrobials Herbal drugs Free radical scavengers