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Full-term pregnancy in breast cancer survivor with fertility preservation: A case report and review of literature

World Journal of Clinical Cases 2019年第1期7卷 58-68页

作者： marta Garrido-Marín Pedro maria Argacha Luís Fernández Florencia Molfino Fina Martínez-Soler Avelina Tortosa Pepita Gimenez-Bonafé Department of Physiological Sciences Physiology Unit Faculty of Medicine and Health Sciences Bellvitge Campus Universitat de BarcelonaIDIBELL L’Hospitalet del Llobregat Hospital Universitari General de Catalunya Servicio de Oncología Médica Consorcio Corporación Sanitaria Parc Taulí Instituto de Reproducción Cefer Department of Basic Nursing Faculty of Medicine and Health Sciences Universitat de Barcelona IDIBELL L’Hospitalet del Llobregat

A 43-year-old woman with an associated history of gynecological pathology and breast cancer with only one cryopreserved embryo wished to be a *** factors that influenced the success of the pregnancy in this case were analyzed. Favorable factors included: triple positive breast cancer [positive hormone receptors and positive human epidermal growth factor receptor 2],which is more hormosensitive and chemosensitive; absence of metastasis; correct endometrium preparation; and the patient's optimistic attitude and strict health habits. In contrast, the factors against success were: breast cancer; adjuvant breast cancer therapy gonadotoxicity; the age of the patient(> 40-year-old);endometriosis; ovarian cyst; hydrosalpinx; submucosal fibroids and the respective associated surgery done for the above-mentioned pathology(all resolved prior to the embryo transfer); and a low quantity of ovules(low ovarian reserve) after ovarian stimulation. This is a very special clinical case of a patient with theoretically low pregnancy success probability due to the consecutive accumulation of gynecological and oncological pathologies, who nonetheless became pregnant and delivered a full-term infant and was able to provide adequate breastfeeding.

关键词： Breast cancer Fertility preservation Gonadotoxicity Pregnancy In vitro fertilization Hydrosalpinx Endometriosis Case report

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磺酸多相催化剂用于二甲基亚砜中C_6-单糖脱水制5-羟甲基糠醛(英)

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催化学报 2014年第5期35卷 644-655页

作者： Gabriel Morales Juan A.Melero marta Paniagua Jose Iglesias Blanca Hernandez maria Sanz Department of Chemical and Environmental Technology Universidad Rey Juan Carlos. C/Tulipan s/n. Mostoles. E28933Madrid Spain Department of Chemical and Energy Technology Universidad Rey Juan Carlos. C/Tulipan s/n. Mostoles. E28933 Madrid Spain

Sulfonic acid-functionalized heterogeneous catalysts have been evaluated in the catalytic dehydration of C(,monosaccharides into 5-hydroxymethylfurfural(HMF) using dimethyl sulfoxide(DMSO)as *** commercial resin Amberlyst-70 was the most active catalyst,which was ascribed to its higher concentration of sulfonic acid sites as compared with the other catalysts,and it gave 93 mol%yield of HMF from fructose in 1 *** glucose as the starting material,which is a much more difficult reaction,the reaction conditions(time,temperature,and catalyst loading) were optimized for Amberlyst-70 by a response surface methodology,which gave a maximum HMF yield of 33 mol%at 147 °C with 23 wt%catalyst loading based on glucose and 24 h reaction *** promotes the dehydration of glucose into anhydroglucose,which acts as a reservoir of the substrate to facilitate the production of HMF by reducing side *** reuse without a regeneration treatment showed a gradual but not very significant decay in catalytic activity.

关键词：非均相催化剂羟甲基糠醛二甲基亚砜磺酸脱水单糖响应面分析法 DMSO

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Distribution and Prevalence of Serotypes of Group B Streptococcus Isolated from Pregnant Women in 30 Countries:A Systematic Review

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Maternal-Fetal Medicine 2023年第2期5卷 97-103页

作者： marta maria Silva Érica Alcântara Silva Caline Novais Teixeira Oliveira maria Luísa Cordeiro Santos Cláudio Lima Souza Fabrício Freire de Melo Márcio Vasconcelos Oliveira Instituto Multidisciplinar em Saúde Universidade Federal da BahiaBahia 45.029-094Brazil

Objective:This review aimed to compile scientific data on the distribution and prevalence of group BStreptococcus (GBS) serotypes isolated from pregnant women across 30 countries from 2010 to ***:This was a systematic review that addresses the distribution and prevalence of GBS in pregnant *** search included studies published between January 2010 and December 2019 in PubMed,Virtual Health Library (BVS),ScienceDirect,Scientific Electronic Library Online (SciELO),and LILACS *** also surveyed relevant articles published in English,Spanish,and Portuguese between February and April *** articles,communication,short report,theses,and dissertations were *** prevalence of GBS colonization,method for capsular serotyping,antimicrobial resistance,distribution and prevalence of serotypes were extracted from each ***:In all,795 publications were *** applying the eligibility criteria,48 articles were included for the final systematic analysis;most articles were from Asia and were published during the years 2014 to *** the identification of serotypes,most studies used the polymerase chain reaction *** were records of all 10 GBS serotypes,namely,Ia,Ib,and II–IX,among the countries *** susceptibility and resistance to antibiotics were addressed in 37.5% of the publications ***:This review showed that GBS serotypes are distributed differently in the 30 analyzed countries,with serotypes Ia,Ib,and II to V being the most ***,our results highlighted the relationship of GBS with maternal colonization,implications for neonates,and antibiotic resistance.

关键词： Streptococcus agalactiae Serotype Pregnant women

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“一带一路”倡议对国际贸易的影响

“一带一路”倡议对国际贸易的影响

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作者： marta maria Pastucha 厦门大学

学位级别：硕士

虽然相关文献众多,但较少有文献采用“双重差分”方法来研究“一带一路”倡议对不同国家经济的影响。本文基于2003年至2016年期间的88个国家的面板数据,研究了“一带一路”倡议对相关国家出口、进口和净出口的影响。实证结果表明,该倡... 详细信息

虽然相关文献众多,但较少有文献采用“双重差分”方法来研究“一带一路”倡议对不同国家经济的影响。本文基于2003年至2016年期间的88个国家的面板数据,研究了“一带一路”倡议对相关国家出口、进口和净出口的影响。实证结果表明,该倡议使得沿线国家出口增长了约10%,进口增长了4.9%,净出口了增长1.2%。本文的结果是稳健可靠的。研究结果表明,那些尚未参与“一带一路”倡议的国家和地区十分有必要积极参与该项计划。

关键词：一带一路出口进口净出口双重差分法

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Endoscopic approach to malignant strictures at the hepatic hilum

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World Journal of Gastroenterology 2007年第30期13卷 4042-4045页

作者： Giovanni D De Palma Stefania Masone maria Rega Immacolata Simeoli Francesca Salvatori Saverio Siciliano Francesco Maione Valerio Girardi marta Celiento Giovanni Persico Department of General Surgery Oncologic Surgery and Advanced Technologies Center for Technological Innovation in Surgery (ITC) University of Naples Federico Ⅱ School of Medicine Naples Italy

Hilar tumors have proven to be a challenge to treat and manage because of their poor sensitivity to conventional therapies and our inability to prevent or to detect early tumor formation. Endoscopic stent drainage has been proposed as an alternative to biliary-enteric bypass surgery and percutaneous drainage to palliate malignant biliary obstruction. Prosthetic palliation of patients with malignant hilar stenoses poses particular difficulties, especially in advanced lesions （type Ⅱ lesions or higher）. The risk of cholangitis after contrast injection into the biliary tree in cases where incomplete drainage is achieved is well known. The success rate of plastic stent insertion is around 80% in patients with proximal tumors. Relief of symptoms can be achieved in nearly all patients successfully stented.

关键词： Malignant biliary stenoses Endoscopic retrograde cholangiopancreatography Endoscopic prostheses

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Clinical relevance of the relationship between changes in gut microbiota and bile acid metabolism in patients with intrahepatic cholangiocarcinoma

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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 211-214页

作者： Elisa Herraez marta R.Romero Rocio I.R.Macias maria J.Monte Jose J.G.Marin Experimental Hepatology and Drug Targeting(HEVEFARM) IBSALUniversity of SalamancaSalamancaSpain National Institute for the Study of Liver and Gastrointestinal Diseases(CIBERehd) Carlos III National Health InstituteMadridSpain

Although only 10-15%of liver cancers are cholangiocarcinomas(CCAs),which derive from the epithelial cells of the biliary tree,these cancers constitute a serious and growing health problem *** rate of mortality due to this tumor is very high because CCA usually appears in aged people and very often,in more than 70%of cases,are diagnosed late because of:(I)their anatomical localization in a big organ like the liver;(II)the lack of specific symptoms during most time of their development;and(III)the absence of available accurate,specific and sensitive biomarkers(1).These characteristics reduce the rate of success of surgical resection,which is the only curative option for CCA patients,because the response of this aggressive cancer to the available pharmacological armamentarium is extremely feeble(2).This justifies the interest of many groups to identify non-invasive markers to achieve early diagnosis that also permit to distinguish CCA from non-malignant biliary diseases and from hepatocellular carcinoma(HCC),the most frequent liver cancer,which derives from hepatocytes(3).

关键词： metabolism patients diagnosis

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Chemical profile and antimicrobial activity of Secondatia floribunda A. DC(Apocynaceae)

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Asian Pacific Journal of Tropical Biomedicine 2017年第8期7卷 739-749页

作者： Daiany Alves Ribeiro Sarah Soares Damasceno Aline Augusti Boligon Irwin Rose Alencar de Menezes marta maria de Almeida Souza JoséGalberto Martins da Costa Programa de Pós-Graduacao em Etnobiologia e Conservacao da Natureza Universidade Regional do Cariri Departamento de Química Biológica Laboratório de Pesquisas de Produtos NaturaisUniversidade Regional do Cariri Laboratório de Fitoquímica Universidade Federal de Santa Maria Departamento de Química Biológica Laboratório de Farmacologia e Química MolecularUniversidade Regional do Cariri Departamento de Ciências Biológicas Laboratório de Ecologia VegetalUniversidade Regional do Cariri

To establish the chemical profile, and to evaluate the antibacterial and modulatory activity of the ethanolic extracts of the stalk’s inner bark and heartwood of Secondatia *** of total phenols and flavonoids was determined by the Folin-Ciocalteu method and aluminum chloride, respectively. Phenolic compounds were identified and quantified by HPLC-DAD (High Performance Liquid Chromatography-Diodearray Detector) and the Infrared Spectroscopy was performed using the measure by Attenuated Total Reflectance with Fourier Transform (ATR-FTIR). Antibacterial assays for determination of the Minimum Inhibitory Concentration (MIC) and modification of aminoglycosides were performed by *** spectra showed similar characteristics, having among its main absorption bands hydroxyl group (OH). The antibacterial activity showed clinically significant results for the strains of Staphylococcus aureus and Escherichia coli. In modulation assay, synergic and antagonistic effect for both extracts was observed. Heartwood extract in combination with antibiotics showed a significant MIC reduction at 19.8% (P < 0.000 1)-79.3% (P < 0.01).ConclusionsThis study is the first report of chemical and biological information of Secondatia floribunda suggesting that it is clinically relevant source of a new antibacterial therapy, especially due to the presence of significant levels of phenolic compounds.

关键词： Chemical composition HPLC Cinchonain Natural product Modification resistance

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Zn-Mg and Zn-Cu alloys for stenting applications:From nanoscale mechanical characterization to in vitro degradation and biocompatibility

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Bioactive Materials 2021年第12期6卷 4430-4446页

作者： Claudia García-Mintegui Laura Catalina Córdoba Judit Buxadera-Palomero Andrea Marquina Emilio Jiménez-Piqué maria-Pau Ginebra JoséLuis Cortina marta Pegueroles Biomaterials Biomechanics and Tissue Engineering GroupDepartment of Materials Science and EngineeringTechnical University of Catalonia(UPC)Barcelona East School of Engineering(EEBE)08019BarcelonaSpain Resource Recovery and Environmental Management Group UPCEEBE08019BarcelonaSpain Barcelona Research Center in Multiscale Science and Engineering UPCEEBE08019BarcelonaSpain Institute for Bioengineering of Catalonia(IBEC) 08028BarcelonaSpain Structural Integrity Micromechanics and Reliability of Materials GroupDepartment of Materials Science and EngineeringUPCEEBE08019BarcelonaSpain

In the recent decades,zinc(Zn)and its alloys have been drawing attention as promising candidates for bioresorbable cardiovascular stents due to its degradation rate more suitable than magnesium(Mg)and iron(Fe)***,its mechanical properties need to be improved in order to meet the criteria for vascular *** work investigates the mechanical properties,biodegradability and biocompatibility of Zn-Mg and Zn-Cu alloys in order to determine a proper alloy composition for optimal stent *** measurements are performed to characterize the mechanical properties at the nanoscale as a function of the Zn microstructure variations induced by *** biodegradation mechanisms are discussed and correlated to microstructure,mechanical performance and bacterial/cell *** of Mg or Cu alloying elements refined the microstructure of Zn and enhanced yield strength(YS)and ultimate tensile strength(UTS)proportional to the volume fraction of secondary ***-1Mg showed the higher YS and UTS and better performance in terms of degradation stability in Hanks’***-Cu alloys presented an antibacterial effect for *** controlled by diffusion mechanisms and by *** was dependent on the degradation rate and the nature of the corrosion products.

关键词： Zinc alloys Bioresorbable metals Galvanic corrosion Nanoindentation Biocompatibility

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Prophylaxis with ketotifen in rats with portal hypertension:involvement of mast cell and eicosanoids

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Hepatobiliary & Pancreatic Diseases International 2008年第4期7卷 383-394页

作者： Fernando Sánchez-Patán Raquel Anchuelo Elena Vara Cruz García Yolanoa Saavedra Patri Vergara Carmen Cuellar marta Rodero maria-Angeles Aller Jaime Arias Department of Surgery I School of Medicine Complutense University of MadridSpain Department of Biochemistry and Molecular Biology School of Medicine Complutense University of MadridSpain Department of Physiology Autonoma University of BarcelonaSpain Department of Parasithology School of PharmacyComplutense University of MadridSpain

BACKGROUND:Since we have previously shown an increase of mast cells in the small bowel and in the mesenteric lymph nodes in the rats with prehepatic portal hypertension,it can be hypothesized that this essential inflammatory cell would be involved in the pathogeny of the splanchnic changes related to portal hypertension. METHODS:To verify this hypothesis,we first studied mast cell infiltration in the ileum and in the mesenteric lymph nodes in sham-operated male Wistar rats(n=12) and in short-term prehepatic portal hypertensive rats (n=12),and the serum levels of rat mast cell protease Ⅱ(RMCP-Ⅱ)by *** a second set of experiments ketotifen,a mast cell stabilizer drug,was administered to sham-operated(n=10)and portal hypertensive(n=12) rats 24 hours before the intervention and prostanoids (PGE2,PGI2,TXB2)and leukotrienes(LTC4,LTB4)were assayed by RIA,mast cell infiltration in the ileum and in the mesenteric lymph nodes and the serum levels of RMCP-Ⅱwere also studied,to show its effectiveness to prevent the mesenteric alterations produced by the inflammatory mediators released by the mast cell. RESULTS:Forty-eight hours after the intervention RMCP-Ⅱ (P<0.05),PGE2(P<0.001)and LTC4 serum levels decreased and mast cell number and RMCP-Ⅱlevels increased in mesenteric lymph nodes in portal hypertensive *** administration of ketotifen reduced portal pressure(P<0.001),serum levels of PGE2(P<0.001)and RMCP-Ⅱ(P<0.001)in mesenteric lymph nodes. CONCLUSIONS:In acute portal hypertension in the rat,the mast cell translocation from intestinal mucosa to mesenteric lymph nodes,where they are activated and degranulates,would represent a defence mechanism to avoid the activation of an acute and massive inflammatory response in this *** administration of ketotifen is able to reduce the splanchnic inflammatory changes related to acute portal hypertension in the rat.

关键词： portal hypertension prostaglandins leukotrienes mast cell

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Identifying specific RGC types may shed light on their idiosyncratic responses to neuroprotection

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Neural Regeneration Research 2015年第8期10卷 1228-1230页

作者： Manuel Vidal-Sanz Francisco M.Nadal-Nicolás Francisco J.Valiente-Soriano marta Agudo-Barriuso maria P.Villegas-Pérez Departamento de Oftalmología Facultad de Medicina Universidad de Murcia and Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca) Campus de Ciencias de la Salud Carretera Buenavista s/n 30120 El Palmar Murcia Spain

Retinal ganglion cells（RGCs）are located in the innermost layer of the retina and are the only retinal output neurons,conveying light information to the main retinorecipient target regions of the brain responsible for the image-and non-image-forming visual *** are well over twenty RGC types,each with its own dendritic morphology and physiological characteristics,

关键词： RGCs retina physiological conveying ganglion glaucoma suppression neurotrophin pigmented reflex

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