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同型半胱氨酸调节CD40/CD40L系统

世界核心医学期刊文摘(心脏病学分册) 2007年第9期 61-61页

作者： Prontera C. martelli N. Evangelista V. m. Romano 赵君 Laboratory of Vascular Biology and Pharmacology Consorzio Mario Negri Sud San Maria Imbaro Italy

目的:评价高同型半氨酸血症(HHcy)对体外和体内的CD40/CD40L对的影响。背景:尽管分子机制没有完全确定,HHcy与动脉粥样硬化血栓形成的高发病率相关;CD40L配对可激发血管壁细胞的炎症信号,为动

关键词：同型半胱氨酸 CD40/CD40L 对数转换

体外震波碎石成功后胆囊结石复发:一项为期10年的前瞻性研究

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世界核心医学期刊文摘（胃肠病学分册） 2006年第9期2卷 59-59页

作者： Carrilho-Ribeiro L. Pinto-Correia A. Velosa J. De moura m.C. 张欣 Centre of Gastroenterology University Hospital of Santa MariaLisbonPortugal

*** risk of recurrence has limited the acceptability of conservative therapies of gallbladder *** aim of the present study was to determine the long-term rate of stone recurrence and its risk factors after successful extracorporeal shock-wave lithotripsy(ESWL).material and *** study comprised a prospective ultrasound follow-up at yearly intervals or whenever biliary pain was reported.A total of 192 consecutive patients(primary single stones,n = 159;primary 2 or 3 stones,n = 33)were followed for up to 11.2 years after becoming stone-free and after termination of adjuvant treatment with ursodeoxycholic acid(UDCA).***-four patients developed recurrent stones after a median of 2.6 years(maximum = 8.8 years).The 108 patients without recurrence were followed for a median of 6.7 years(maximum = 11.2 years).By actuarial analysis,the cumulative recurrence rates for these 192 stone-free patients were 27%±3%,41%±4%and 54%±4%(observed ±SE)at 3,5 and 10 years,***’s regression analysis was used to identify the presence of slight calcification in the primary stone(s)as a protective feature against recurrence(p = 0.03).Conclusions.1)The risk of recurrence continues to increase over time,and although it rises less steeply after 5 years,it does not reach a plateau until at least 10 years.2)Having had slightly calcified stone(s)seems to be associated with a reduced risk of recurrence and might signal a "burnt out" lithogenic process.3)The long-term results are unsatisfactory and ESWL of gallbladder stones should be offered only in special cases.

关键词：体外震波碎石术结石复发胆囊结石前瞻性研究 Cox回归分析复发风险相关危险因素熊脱氧胆酸

慢性丙型肝炎患者的静止期乳糜泻:干扰素治疗对发病和临床预后的影响

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世界核心医学期刊文摘（胃肠病学分册） 2005年第4期1卷 54-54页

作者： Durante-mangoni E. Iardino P. Resse m. L.E. Adinolfi 赵丽娜 Div. of Int. medicine and Hepatology Second University of Naples Ospedale Gesùe Maria Via Cotugno 1 80135 Napoli ItalyDr.

Goals: To assess the impact of interferon treatment on celiac disease onset in hepatitis C patients and to clarify its clinical relevance and outcome. Background: Hepatitis C is associated with autoimmunity, which can be exacerbated by interferon treatment. Cases of celiac disease activation during interferon treatment have been reported. Study: Retrospective evaluation of 534 hepatitis C patients with or without symptoms compatible with celiac disease onset during interferon treatment and 225 controls. Anti-transglutaminase antibodies were assayed. HLA-DQA1 and -B1 loci were typed. Upper gastrointestinal endoscopy was applied to confirm the diagnosis in antibody positive patients. Results: Anti-transglutaminase antibodies were detected before treatment in 1.3%of hepatitis C patients and in 0.4%of controls (not significant). Eighty-six percent of patients with anti-transglutaminase antibodies showed activation of celiac disease while on interferon. Symptoms ranged from mild to severe, and interferon had to be discontinued in 2 of 7 (29%) patients. Symptoms disappeared in 6 of 7 patients after interferon withdrawal. Onset of symptoms compatible with celiac disease during interferon therapy was significantly associated with the presence of anti-transglutaminase antibodies (OR 53). Conclusions: In hepatitis C patients, the activation of silent celiac disease during interferon treatment is almost universal and should be suspected, but it uncommonly requires interferon treatment discontinuation. Symptoms subside after interferon withdrawal.

关键词：丙型肝炎患者干扰素治疗乳糜泻静止期消化道内镜检查谷氨酰胺转移酶白细胞分化抗原自身免疫临床相关因素无症状

2022年欧洲血管外科学会(ESVS)下肢慢性静脉疾病管理临床实践指南(全译)

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中华血管外科杂志 2023年第1期8卷 76-158页

作者： marianne G.De maeseneer Stavros K.Kakkos Thomas Aherne Niels Baekgaard Stephen Black Lena Blomgren Athanasios Giannoukas manjit Gohel Rick de Graaf Claudine Hamel-Desnos Arkadiusz Jawien Aleksandra Jaworucka-Kaczorowska Christopher R.Lattimer Giovanni mosti Thomas Noppeney marie JoseevanRijn Gerard Stansby 无 Philippe Kolh Frederico Bastos Gongalves Nabil Chakfé Raphael Coscas Gert J.deBorst Nuno V.Dias Robert J.Hinchliffe Igor B.Koncar Jes S.Lindholt Santi Trimarchi Rikka Tulamo Christopher P.Twine Frank Vermassen Anders Wanhainen martin Bjorck Nicos Labropoulos Fedor Lurie Armando mansilha Isaac K.Nyamekye marta Ramirez Ortega Jorge H.Ulloa Tomasz Urbanek Andre m.van Rij marc E.Vuylsteke 荷兰鹿特丹伊拉斯谟医疗中心皮肤科希腊帕特雷帕特雷大学血管外科爱尔兰科尔克大学医院和爱尔兰国立大学戈尔韦分校血管外科丹麦哥本哈根大学根措夫特医院和国家教学研究医院血管外科英国伦敦盖伊和圣托马斯医院及国王学院瑞典厄勒布罗大学医学院心血管和胸外科希腊塞萨利大学健康科学学院医学院拉里萨大学医院血管外科英国伦敦剑桥大学医院和帝国理工学院德国弗里德里希沙芬诊所诊断和介入放射科法国巴黎圣约瑟夫医院集团法国卡昂圣马丁私立医院血管内科波兰托伦市路德维克·赖德吉耶医学院尼古拉·哥白尼大学血管外科和血管学系波兰戈佐市静脉和美容医学中心、外科和妇科中心伦敦西北大学医疗保健NHS信托基金会英国伦敦帝国学院意大利卢卡maria Domenica Barbantini诊所血管科纽伦堡marthamaria医院血管和血管内外科德国雷根斯堡大学医院血管和内皮外科荷兰鹿特丹伊拉斯谟医疗中心血管外科英国泰恩河畔纽卡斯尔弗里曼医院纽卡斯尔大学 ESVS Guidelines Committee 比利时利日利日大学生物医学和临床前科学系葡萄牙里斯本诺瓦德里斯本大学圣玛尔塔医院里斯本中心医院和诺瓦医学院法国斯特拉斯堡大学血管外科和肾移植系巴黎援助公社(AP-HP)CHU AmbroiseParé 法国布洛涅比兰科特巴黎萨克莱大学凡尔赛大学圣昆廷分校血管外科荷兰乌得勒支大学医学中心血管外科瑞典马尔默隆德大学斯科纳大学医院血管中心和马尔默临床科学英国布里斯托尔布里斯托尔大学塞尔维亚贝尔格莱德大学医学院塞尔维亚临床中心血管和血管内外科诊所丹麦欧登塞大学医院心胸血管外科意大利米兰大学临床与社区科学系米兰IRCCS CaGranda Ospedae maggiore Policlinico基金会芬兰赫尔辛基赫尔辛基大学医院和赫尔辛基大学英国布里斯托尔北布里斯托尔NHS信托基金会布里斯托尔大学比利特根特大学医院瑞典乌普萨拉大学外科学系瑞典乌梅奥大学外科和围手术期科学系爱沙尼亚塔尔图塔尔图大学临床医学研究所外科学系美国纽约州石溪市石溪大学医学中心美国俄亥俄州托莱多普惠约布斯特血管研究所密歇根大学葡萄牙波尔图大学医学院英国伍斯特伍斯特郡皇家医院伍斯特郡急症医院NHS信托西班牙马德里La Luz Quiron Salud医院哥伦比亚波哥大安第斯大学圣菲基金会波兰卡托维兹西里西亚医科大学普通外科、血管外科、血管和静脉科新西兰达尼丁奥塔哥大学外科学系比利时Tielt圣安德列齐肯胡斯血管外科

2022年指南与2015年指南相比的新内容是什么?与2015年版《慢性静脉疾病(chronic venous disease,CVD)管理指南》1相比,该指南的总体结构做了很大修改,使其更加实用和方便。在不同章节中增加了关于管理策略的相关内容,并附有流程图。

关键词：临床实践指南血管外科学慢性静脉疾病管理指南流程图总体结构管理策略

扩散加权mRI对于检测胰腺积液合并感染的附加价值

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国际医学放射学杂志 2017年第3期 356-356页

作者： B.Borens m.Arvanitakis J.Absil S.El Bouchaibi C.matos P.Eisendrath 李安宁 Polyclinique Santa maria

摘要目的探讨扩散加权mRI对于检测胰腺积液合并感染（PFC）的附加价值。方法 48例需要内镜透壁引流的PFC病人在行内镜之前行常规mRI和DWI（b=1 000 s/mm2）。mR影像被随机分为2个系列（系列1,常规mRI;系列2,常规mRI、DW-mRI和ADC图）。... 详细信息

摘要目的探讨扩散加权mRI对于检测胰腺积液合并感染（PFC）的附加价值。方法 48例需要内镜透壁引流的PFC病人在行内镜之前行常规mRI和DWI（b=1 000 s/mm2）。mR影像被随机分为2个系列（系列1,常规mRI;系列2,常规mRI、DW-mRI和ADC图）。2位独立的影像分析者分别对影像进行定性和定量分析（ADC）。以PFC内容物的细菌学分析作为金标准。以非参数检验进行比较。2位数据分析者分别对2组数据的敏感度、特异度、阴性预测值（NPV）、阳性预测值（PPV）和准确度进行计算。绘制受试者操作特征

关键词：扩散加权 DW 常规 mRI 胰腺积液附加价值合并感染

软组织肿瘤超声成像增强后粗针活检的准确性研究

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国际医学放射学杂志 2011年第1期34卷 94-页

作者： A.De marchi E.m.Brach del Prever A.Linari S.Pozza L.Verga U.Albertini 屈谨 Department of Imaging AO CTO/Maria Adelaide

目的经皮活检对软组织肿瘤诊断价值已广为接受。当肉瘤较大时,取材较困难。研究假设超声对比剂能够辨别肿瘤中心区域,从而为粗针活检(CNB)定位。

关键词：软组织肿瘤超声对比剂活组织检查肉瘤超声成像

Sub-percent precision measurement of neutrino oscillation parameters with JUNO

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello muhammad Akram Abid Aleem 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde marcondes de André Didier Auguste 白伟东 Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna Chi Chan 常劲帆 Yun Chang 陈国明陈平平 Po-An Chen 陈少敏 Xurong Chen 陈义学陈羽陈志源陈梓康程捷程雅苹 Yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich marcos Dracos Frédéric Druillole 杜然杜书先 Stefano Dusini martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan 樊磊方建方文兴 marco Fargetta Dmitry Fedoseev 费政勇 Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男高峰 Alberto Garfagnini Arsenii Gavrikov marco Giammarchi Nunzio Giudice maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel marco Grassi Vasily Gromov 顾旻皓谷肖飞古宇关梦云管宇铎 Nunzio Guardone 郭聪郭竞渊郭万磊 Xinheng Guo 郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han 何苗 Wei He Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航 Jianrun Hu 胡俊胡守扬胡涛胡宇翔胡焯钧黄桂鸿黄翰雄黄凯旋黄文昊 Xin Huang 黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Ignacio Jeria 季筱璐贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山荆小平 Cécile Jollet Jari Joutsenvaara Leonidas Kalousis Philipp Kampmann 康丽 Rebin Karaparambil Narine Kazarian Amina Khatun Yerevan Physics Institute YerevanArmenia UniversiéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the TAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO

Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano max Buesken mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin marco Grassi Christian Grewing maxim Gromov Vasily Gromov minghao Gu Xiaofei Gu Yu Gu mengyun Guan Nunzio Guardone maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia UniversitéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChina Institute of modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina School of Physics and microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 meV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO

JUNO sensitivity on proton decay p→νK^(+)searches

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Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello muhammad Akram 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde marcondes de André Didier Auguste Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich marcos Dracos Frédéric Druillole 杜然杜书先 Stefano Dusini martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 marco Fargetta Dmitry Fedoseev Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov marco Giammarchi Agnese Giaz Nunzio Giudice maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel marco Grassi Christian Grewing Vasily Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han muhammad Sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Ka Pontificia Universidad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear Science and Technology IslamabadPakistan INFN Catania and Dipartimento di Fisica e Astronomia dell Universitàdi Catania CataniaItaly East China University of Science and Technology ShanghaiChina University of Science and Technology of China HefeiChina Joint Institute for Nuclear Research DubnaRussia INFN Sezione di milano and Dipartimento di Fisica dell Universitàdi milano MilanoItaly Department of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Physics and Earth Science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN milano Bicocca and University of milano Bicocca MilanoItaly INFN Sezione di Padova PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard Karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina SUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Physics National Taiwan UniversityTaipei Dipartimento di Fisica e Astronomia dell’Universitàdi Padova and INFN Sezione di Padova PadovaItaly University of Roma Tre and INFN Sezione Roma Tre RomaItaly Aix marseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan University WuhanChina INFN milano Bicocca and Politecnico of milano MilanoItaly National United University Miao-Li Dongguan University of Technology DongguanChina Tsinghua University BeijingChina Institute of modern Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power University BeijingChina Sun Yat-Sen University GuangzhouChina Beijing Institute of Spacecraft Environment Engineering BeijingChina Universidade Estadual de Londrina LondrinaBrazil INFN Sez

The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental *** this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNO is *** kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for ***,the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed *** on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data *** estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid scintillator detector