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Biliary tree gastrinomas in multiple endocrine neoplasia type 1 syndrome

World Journal of Gastroenterology 2013年第45期19卷 8312-8320页

作者： Francesco Tonelli Francesco Giudici Gabriella Nesi Giacomo Batignani maria luisa brandi Department of Surgery and Translational Medicine University of Florence50014 Florence Italy

AIM:To describe our patients affected with ectopic biliary tree gastrinoma and review the literature on this ***:Between January 1992 and June 2012,28 patients affected by duodenopancreatic endocrine tumors in multiple endocrine neoplasia type 1(MEN1)syndrome underwent surgery at our *** retrospective review article analyzes our experience regarding seventeen of these patients subjected to duodenopancreatic surgery for Zollinger-Ellison syndrome(ZES).Surgical treatment consisted of duodenopancreatectomy(DP)or total pancreatectomy(TP).Regional lymphadenectomy was always *** hepatic tumoral lesions found were removed during *** MEN1 patients,removal of duodenal lesions can sometimes lead to persistence or recurrence of *** possible explanation for this unfavorable outcome could be unrecognized ectopic localization of gastrin-secreting *** study described three cases among the seventeen patients who were found to have an ectopic gastrinoma located in the biliary ***:Seventeen MEN1 patients affected with ZES were *** mean age was 40 *** patients underwent DP and two *** histopathological examination,duodeno pancreatic endocrine tumors were found in all 17 ***-one gastrinomas were detected in the first three portions of the *** one gastrinoma was found in the *** mean number of gastrinomas per patient was 5(range 1-16).Malignancy was established in 12 patients(70.5%)after lymph node,liver and omental metastases were *** patients exhibited biliary tree gastrinomas as well as duodenal gastrinoma(s).In two cases,the ectopic gastrinoma was removed at the same time as pancreatic surgery,while in the third case,the biliary tree gastrinoma was resected one year after DP because of recurrence of ***:These findings suggest the importance of checking for the presence of ectopic gastrinomas in the biliary tree in MEN1 patients undergoing Z

关键词： Gastrinoma Multiple endocrine neoplasia type 1 Zollinger-Ellison Syndrome Ectopic gastrinoma Biliary tree Duodenopancreatectomy

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WJSC 6^(th) Anniversary Special Issues(2):Mesenchymal stem cellsAdipose mesenchymal stem cells in the field of bone tissue engineering

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World Journal of Stem Cells 2014年第2期6卷 144-152页

作者： Cecilia Romagnoli maria luisa brandi Metabolic Bone Diseases Branch Department of Surgery and Translational MedicineUniversity of Florence

Bone tissue engineering represents one of the most challenging emergent fields for scientists and *** failures of autografts and allografts in many pathological conditions have prompted researchers to find new biomaterials able to promote bone repair or regeneration with specific characteristics of biocompatibility,biodegradability and *** advancements for tissue regeneration in bone defects have occurred by following the diamond concept and combining the use of growth factors and mesenchymal stem cells(MSCs).In particular,a more abundant and easily accessible source of MSCs was recently discovered in adipose *** adipose stem cells(ASCs)can be obtained in large quantities with little donor site morbidity or patient discomfort,in contrast to the invasive and painful isolation of bone marrow *** osteogenic potential of ASCs on scaffolds has been examined in cell cultures and animal models,with only a few cases reporting the use of ASCs for successful reconstruction or accelerated healing of defects of the skull and jaw in *** these reports extend our limited knowledge concerning the use of ASCs for osseous tissue repair and regeneration,the lack of standardization in applied techniques makes the comparison between studies *** clinical trials are needed to assess ASC therapy and address potential ethical and safety concerns,which must be resolved to permit application in regenerative medicine.

关键词： Adipose-derived stem cells Bone tissue engineering Osteogenic differentiation Scaffold Regenerative medicine

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Genetic test in multiple endocrine neoplasia type 1 syndrome: An evolving story

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World Journal of Experimental Medicine 2015年第2期5卷 124-129页

作者： Francesca Marini Francesca Giusti maria luisa brandi Department of Surgery and Translational Medicine University of Florence

Multiple endocrine neoplasia type 1(MEN1) is an autosomal dominant inherited tumour syndrome expressing various endocrine and non-endocrine lesions and tumours. Since the identification of the causative gene, the oncosuppressor gene MEN1, in 1997, genetic testing has revealed an important approach for the early and differential diagnosis of the disease. The finding of a MEN1 mutation in a patient has important clinical implications for relatives since it allows very early disease diagnosis and identification of carriers, even before biochemical and/or clinical manifestation, permitting their inclusion in a specific program of surveillance and subsequent praecox therapy. Currently, genetic testing for MEN1 consists principally of the sequencing of coding regions and intron-exon junctions of the MEN1 gene. However, the recent acquisition of novel high throughput technologies will allow the design of innovative, accurate, complete and rapid genetic diagnosis. These new tools are able to increase the strength of the analysis and almost completely eliminate the possibility of false negative results. This review aims to give an overview on genetic testing of MEN1 syndrome, reporting the positive aspects of performing the analysis and the future perspectives for improving the performance of the test, as well as its application in clinical practice.

关键词： Multiple endocrine neoplasia type 1 Genetic test Clinical practice Next-generation sequencing

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Ten years of hip fractures in Italy: For the first time a decreasing trend in elderly women

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World Journal of Orthopedics 2014年第3期5卷 386-391页

作者： Prisco Piscitelli Maurizio Feola Cecilia Rao Monica Celi Elena Gasbarra Cosimo Neglia Giuseppe Quarta Federico maria Liuni Simone Parri Giovanni Iolascon maria luisa brandi Alessandro Distante Umberto Tarantino Euro Mediterranean Scientific Biomedical Institute ISBEM Research Centre72023 BrindisiItaly Department of Biological and Environmental Sciences and Technologies University of Salento73100 LecceItaly Division of Orthopaedics and Traumatology University of Tor Vergata00133 RomeItaly Department of Translational Medicine University of Florence50134 FlorenceItaly Department of Orthopaedics and Rehabilitative Medicine Second University of Naples80138 NaplesItaly

AIM:To evaluate the hospitalization rate of femoralneck fractures in the elderly Italian population over ten ***:We analyzed national hospitalizations records collected at central level by the Ministry of Health from 2000 to ***-and sex-specific rates of fractures occurred at femoral neck in people≥65 years *** performed a sub-analysis over a three-year period(2007-2009),presenting data per five-year age groups,in order to evaluate the incidence of the hip fracture in the oldest ***:We estimated a total of 839008 hospitalizations due to femoral neck fractures between 2000 and2009 in people≥65,with an overall increase of 29.8%over 10 *** incidence per 10000 inhabitants remarkably increased in people≥75,passing from158.5 to 166.8(+5.2%)and from 72.6 to 77.5(+6.8%)over the ten-year period in women and men,*** oldest age group(people>85 years old)accounted for more than 42%of total hospital admissions in 2009(n=39000),despite representing only 2.5%of the Italian ***,women aged>85accounted for 30.8%of total fractures,although they represented just 1.8%of the general *** results of this analysis indicate that the incidence of hip fractures progressively increased from 2000 to 2009,but a reduction can be observed for the first time in women≤75(-7.9%between 2004 and 2009).CONCLUSION:Incidence of hip fractures in Italy are continuously increasing,although women aged 65-74years old started showing a decreasing trend.

关键词： Femoral fractures Hip fragility fractures Osteoporosis Hospitalizations Incidence

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随机定位模拟微重力促进人前破骨细胞增殖和分化

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航天医学与医学工程 2012年第1期25卷 13-17页

作者：狄升蒙田宗成高翔骞爱荣 maria luisa brandi 商澎西北工业大学生命学院西北工业大学特殊环境生物物理学研究所空间生物实验模拟技术国防重点学科实验室陕西西安710072 佛罗伦萨大学内科学系意大利佛罗伦萨

目的观察随机定位模拟微重力对人前破骨细胞FLG29.1增殖和分化的影响。方法 FLG29.1细胞分为正常对照组与随机定位处理组,分别培养72 h后收集细胞。采用细胞计数法检测细胞总数和活细胞数;流式细胞术检测细胞周期;Griess法检测培养基中N... 详细信息

目的观察随机定位模拟微重力对人前破骨细胞FLG29.1增殖和分化的影响。方法 FLG29.1细胞分为正常对照组与随机定位处理组,分别培养72 h后收集细胞。采用细胞计数法检测细胞总数和活细胞数;流式细胞术检测细胞周期;Griess法检测培养基中NO(nitric oxide,NO)浓度;抗酒石酸盐酸性磷酸酶(TRAP)染色计算TRAP阳性细胞比例;对硝基苯磷酸(pNPP)法检测胞内TRAP活性。结果随机定位处理后,FLG29.1细胞增殖能力与活细胞比例均较对照组明显增加;细胞周期分布发生变化,处于G1期的细胞比例增加;培养基中NO浓度有增加趋势;在回转处理的同时添加诱导剂12-氧-十四烷酰佛波醋酸酯-13乙酸酯(TPA),发现TRAP阳性细胞数量增多;胞内TRAP活性较对照组明显增加。结论随机定位模拟微重力提高了FLG29.1细胞活力并促进其向破骨细胞分化。

关键词：模拟微重力破骨细胞随机定位仪

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Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra maria S.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdiSNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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Calcium-sensitive protein MLC1 as a possible modulator of the astrocyte functional state

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Neural Regeneration Research 2025年第7期20卷 2008-2010页

作者： Elena Ambrosini Angela Lanciotti maria Stefania Brignone Department of Neuroscience Istituto Superiore di SanitàRomeItaly

Astrocytes,the main population of glial cells in the central nervous system(CNS),exert essential tasks for the control of brain tissue homeostasis,supporting neuron and other glial cell activity from the developmental stage to adult *** maintain the optimal functionality of the brain,astroglial cells are particularly committed to reacting to every change in tissue homeostatic conditions,from mild modifications of the physiological environment,a process called astrocyte activation,to the more severe alterations occurring in pathological situations causing astrocyte reactivity or reactive astrogliosis(Escartin et al.,2021).During these reactive states,astrocytes mount an active,progressive response encompassing morphological,molecular,and interactional remodeling,leading to the acquisition of new functions and the loss of others,whose intensity,duration,and reversibility are dependent on the nature of the stimulus and regulated in a context-specific manner.

关键词： alterations modulator maintain

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Influence of occult hepatitis B virus infection in chronic hepatitis C outcomes

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World Journal of Gastroenterology 2011年第12期17卷 1558-1562页

作者： Conrado M Fernandez-Rodriguez maria luisa Gutierrez JoséLuis Lledó maria luisa Casas Service of Gastroenterology Hospital Universitario Fundación AlcorcónUniversity King Juan CarlosAv Budapest-128922 AlcorcónMadridSpain Service of Biochemestry Hospital Universitario Fundación AlcorcónUniversity King Juan CarlosAv Budapest-128922 AlcorcónMadridSpain

Persistence of hepatitis B virus-DNA in the sera,peripheral blood mononuclear cells or in the liver of hepatitis B surface antigen(HBsAg) -negative patients with or without serological markers of previous exposure(antibodies to HBsAg and/or to HB-core antigen) defines the entity called occult hepatitis B infection(OBI).Co-infection with hepatitis B and hepatitis C viruses is frequent in highly endemic *** this co-infection increases the risk of liver disease progression,development of cirrhosis and hepatocellular carcinoma and also increases the rate of therapeutic failure to interferon-based treatments than either virus alone,a potentially negative effect of OBI on clinical outcomes and of therapeutic response to current antiviral regimes of patients with chronic hepatitis C remains inconclusive.

关键词： Occult hepatitis B infection Chronic hepatitis C Outcomes

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Breast cancer-related lymphedema: focus on surgical treatment

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Plastic and Aesthetic Research 2020年第3期7卷 47-56页

作者： maria luisa Nardulli Department of Plastic Surgery and Burns Breast Reconstruction UnitPerrino HospitalBrindisi 72100Italy

Breast cancer-related lymphedema(BCRL)can affect breast cancer patients,especially after axillary surgery and radiation treatment,for *** line treatment is conservative and involves physical therapy and *** requires absolute,life-long compliance with treatment by the patient and,in some cases,it is *** recent years,surgery has emerged as a possible alternative or even,complementary therapy for *** most commonly reported techniques are reconstructive or debulking *** procedures are aimed at restoring the lymphatic pathways and can be effective early in the disease process,when increased arm volumes are mostly due to the accumulation of protein-rich fluid in the interstitial *** more advanced stages,where fibrotic and hypertrophic adipose tissues are dominant,debulking techniques such as liposuction can be recommended.A standard of care for the treatment of BCRL has not been ***,different techniques can be combined to optimize clinical outcomes,and the surgical approach must be individualized for each patient,based on sound clinical and imaging *** surgical treatment remains a challenging topic that requires further study before it can be standardized.

关键词： Breast cancer-related lymphedema vascularized lymph node transfer lymphaticovenous anastomosis liposuction fat grafting

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The extension of Rome＇s Capitoline Museums and the design of a new Hall on the site of the ancient ＇Giardino Romano＇

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Frontiers of Architectural Research 2015年第3期4卷 171-185页

作者： Raffaele Panella maria luisa Tugnoli Sapienza' Universitd di Roma Viale delle Medaglie d'Oro 200 Rome 00136 Italy

The new HaLL of Marcus AureLius in the CapitoLine Museums, Located within the ancient site of Giardino Romano, displays the original statue of the Roman emperor of the 2nd century AD. The idea of extending the CapitoLine Museums by incLuding this site came about in the framework of its general redevelopment.1 The new HaLL is the result of a Long and compLicated process （1988-7005） considering the exceptional importance of the site and the many changes brought to the museum programme during the said period （Figures 1 and 2）.In fact, the new HaLL was originaLLy supposed to display the marbLes of the TempLe of ApoLLo Sosianus, the foundation waLL of the TempLe of CapitoLine Jupiter, embedded within the structures of the PaLazzo CaffareLLi, opposite the Giardino Romano. However, in 1997, the plan for the CapitoLine Museum changed radicaLLy as the statue of Marcus AureLius, which had been restored foLLowing the bLast of a bomb attack in 1979, was determined to be the focus of the HALL. The project finaLLy consisted of a steeL and gLass structure on an eLLiptic plan andshaped around the foundations of the TempLe, with the statue at its center.

关键词： Capitoline Museums Temple of Apollo Sosianus Equestrian statue of Marcus Aurelius Temple of CapitolineJupiter Costantino Dardi Carlo Aymonino

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