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Neglected tropical diseases in Brazilian children and adolescents:data analysis from 2009 to 2013

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Infectious Diseases of Poverty 2017年第1期6卷 1369-1378页

作者： Eduardo brandao Sebastian Romero maria Almerice Lopes da Silva Fred Luciano Neves Santos National Reference Service for Filariasis Aggeu Magalhães Institute(Fiocruz-PE)RecifePernambucoBrazil Faculty of Medical Sciences National University of RosarioRosarioSanta FeArgentina Laboratory of Communicable Diseases Parasitology DepartmentAggeu Magalhaes Institute(Fiocruz-PE)RecifePernambucoBrazil Laboratory of Pathology and Bio-Intervention Goncalo Moniz Institute(Fiocruz-BA)SalvadorBahiaBrazil

Background:Neglected tropical diseases(NTDs)prevail in conditions of poverty and contribute to the maintenance of social *** of the NTDs prioritized by the Brazilian Ministry of Health,four parasitic infections require mandatory notification:acute Chagas disease,leishmaniasis,malaria,and *** on the behaviour of these NTDs in the young population are currently *** study seeks to analyse the epidemiological aspects of these parasitic infections in children and adolescents in ***:A retrospective exploratory ecological study was conducted.A spatial analysis of the cases reported between 2009 and 2013 in individuals aged between 0 and 19 years that were notified through the Health Notification Aggravation Information System(SINAN)was ***:In total,64,567 cases of cutaneous and visceral leishmaniasis,malaria,schistosomiasis,and acute Chagas disease were recorded in the SINAN database,representing a rate of 20.15 cases per 100,000 *** average age of the cases was 12.2 years and 62.32%were *** hundred and three deaths related to these obligatorily reported parasites were recorded,indicating a case fatality rate of 0.62%.Visceral leishmaniasis and acute Chagas disease had the highest rates of lethality.A heterogeneous spatial distribution of the studied parasites was ***:The number of cases and the lethality rate described in this study show that these diseases still represent a serious problem for public health in *** points to the need to encourage new research and the reformulation of social,economic,and public health policies aimed at ensuring better health and living conditions for all individuals,especially those among the populations considered vulnerable,as is the case of the young.

关键词： Parasites Visceral leishmaniasis Malaria Schistosomiasis Chagas disease Disease notification Residence characteristics Brazil

Relationship of Density of Specific Prostate Antigen (DPSA) with Prostate Histopathology: A Comparative Study of Patients Addressed in a School Hospital

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Journal of Biosciences and Medicines 2017年第3期5卷 105-111页

作者： Marcos Benedito Figueiredo brandã o maria Benedita Figueiredo brandã o Elias Sobreira Sathler Richard Raphael Borges Tavares Vieira Carolina Cadinelli Vieira Pedro Kozlowsky de Alencar Marcus Vinicius de Mello Pinto Lamara Laguardia Valente Rocha Lina Claudia Pereira Lopes Daniel Almeida da Costa Carlos Henrique Diniz Branco Luiz Gioseffi Jannuzzi School Hospital of the Dom Andre Arcoverde Foundation Valen&ccedil a Brazil Universidade Está cio de Sá Rio de Janeiro Brazil The Medical School at the Center of Higher Education of Valenç a Valen&ccedil a Brazil The Cellurare Institute Center of Laser Treatment and Cell Therapy Petr&oacute polis Brazil The Medical School at the Health Sciences Institute of the University Center of Caratinga Caratinga Brazil

Background: The prostate is the site of problems that have great clinical relevance. Beside this, the alterations in their volume can be divided into benign or malignant pathologies, but of multifactorial cause and there is no examination that alone is reliable for the diagnosis. Despite the evolution of the various methods of diagnostic imaging in the evaluation of pelvic diseases, the diagnosis of prostate cancer still requires histological confirmation obtained by transrectal ultrasound guided biopsy, a procedure that is generally safe and well tolerated by the patients. The most common histological type found in prostate biopsies is adenocarcinoma. Methodology: The objective of this study was to study the values of density of the prostate-specific antigen (DPSA) compared to histopathological results of prostate biopsy, patients attended at the Urology Outpatient Clinic of the Luiz Gioseffi Jannuzzi School Hospital from 1999 to 2007, using Exploratory, retrospective and documentary descriptive study. The sample was divided into groups of patients with adenocarcinoma and patients without adenocarcinoma, who presented only benign prostatic hyperplasia. Results: Of the 251 patients undergoing prostate biopsy, 124 were diagnosed with adenocarcinoma and 127 without adenocarcinoma. It was observed in this study that the DPSA was higher in adenocarcinoma than in the cases of patients with prostatic hyperplasia alone, and could therefore be used as an auxiliary tool in both diagnosis and follow-up of patients with adenocarcinoma. Conclusion: In this study, it can be observed that DPSA was higher in patients presenting with adenocarcinoma than in patients presenting only Benign Prostatic Hyperplasia (BPH), reinforcing its promising role to assist in the diagnosis and follow-up of patients with adenocarcinoma.

关键词： Prostate Cancer Adenocarcinoma Benign Prostatic Hyperplasia Prostate Biopsy

Cassava Flour: Quantification of Cyanide Content

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Food and Nutrition Sciences 2016年第7期7卷 592-599页

作者： André Rinaldi Fukushima maria Aparecida Nicoletti Almir Junior Rodrigues Caroline Pressutti Jeandro Almeida Tamires brandão Rosilene Kinue Ito Luis Antônio Bafille Leoni Helenice De Souza Spinosa USJT-Pharmacy Course Universidade S&#227o Judas Tadeu Campus Capital S&#227o Paulo Brazil FMVZ-School of Veterinary Medicine and Animal Science Universidade de S&#227o Paulo Campus Capital S&#227o Paulo Brazil Pharmacy Course Universidade Guarulhos-Ser Educacional Campus Centro S&#227o Paulo Brazi Departamento de Farmácia Faculdade de Ciências Farmacêuticas Universidade de S&#227o Paulo Campus Capital S&#227o Paulo Brazil

Cassava flours are obtained from the roots of Manihot esculenta Crantz and daily fairly consumed by the Brazilian population considering it comes to hum food, and also inserted into food baskets, besides to present low cost and easy access, in addition to being plant easily cultivated by the population. However, the food obtained with cassava may contain hydrocyanic acid, in the form of cyanogenic glycoside when those meals are not cooked properly. The oral toxicity can range 30 - 210 mg/kg body, the average daily consumption per capita in larger rural areas than in urban areas for cassava flour 19.1 g against 4.7 g, respectively. Brazil’s North and Northeast have higher consumption of cassava flour, associated with family monthly monetary income, making this region more vulnerable to poisoning. The objective of this study was to quantify cyanogenic glycosides present in some types of Brazilian cassava foods by means of spectrophotometric technique (reading at a wavelength of 530 nm). For quantitative determination of cyanide content, linamarase hydrolysis was used. The amount of cyanide was determined, and results were: artisan toasted cassava flour: 15 mg/500g, sweet cassava starch: 32.5 mg/500g, artisan dried cassava flour: 37.5 mg/500g, “bijuzada” cassava flour: 60 mg/500g, industrialized, toasted cassava flour: 115 mg/500g, industrialized, raw cassava flour: 140 mg/500g, and wet cassava flour: 225 mg/500g. Considering the chronic ingestion of cyanide present in these foods, they can cause public health problems.

关键词： Manihot esculenta Crantz Manihot Flour Cyanides Toxicity Spectrophotometry Konigi Method

Management of Gestational Trophoblast Disease: A Review Integrative National and International Guidelines

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Health 2022年第12期14卷 1321-1333页

作者： Marcela Curvêllo Beltrão Maira de Lima Oliveira Mota Elizabeth Bacha Lusitania maria de Barros Livia Helena Gomes de Barros brandão Nelson Henriky Felix Mascarenhas Tallys Leandro Barbosa da Silva maria Fernanda Telles Pires de Souza Séfora maria Fragoso Braga Victoria de Oliveira Carmo Borges Centro Universitário Tiradentes (UNIT) Maceió Brasil Instituto de Medicina Integral Professor Fernando Figueira (IMIP) Pernambuco Brasil Estácio de Juazeiro do Norte (FMJ) Ceará Brasil Universidade Federal de Alagoas (UFAL) Maceió Brasil Sã o Leopoldo Mandic Campinas Brasil Hospital Regional de Arapiraca Arapiraca Brasil

GTD (Gestational Trophoblastic Disease) is a pathology that encompasses benign and malignant clinical forms, affects women of childbearing age, has a variable incidence and is more frequent in developing or underdeveloped countries, colliding with the economic barrier. The frequent absence of clear protocols and guidelines for the correct diagnosis and treatment of the aforementioned pathology results in inadequate risk classification, imprecise treatment and failed post-therapeutic observation, increasing the risk of relapses, morbidity and mortality. The present study aims to compare the different national and international guidelines in the management of GTD, through an integrative review. Nine articles were selected and it was observed that the main international reference centers are agreed with the management suggested by the IFGO (International Federation of Gynecology and Obstetrics), being the conduct in the Hydatidiform Mole (HM): evacuation by suction and curettage under ultrasound guidance, followed by hCG monitoring every 1 - 2 weeks until normalized;in low-risk GTN (Gestational Trophoblastic Neoplasm): chemotherapy with methotrexate or actinomycin D, in high-risk: EMA/CO protocol, in ultra-high-risk EMA/PE, methotrexate with radiotherapy for brain metastases. All medical societies recommend the registration of these patients in GTD screening centers, endorse the use of the IFGO scoring system (2000) and recommend the surgical management of placental site trophoblastic or epithelioid tumors, as chemotherapy is less effective in these cases. The controversies are in the proper follow-up after the treatment of HM, use of ultrasound to evacuate the uterus, administration of anti-D immunoglobulin, time of oxytocin infusion and rescue regimens that can be used in cases of resistant or recurrent GTN. Establishing and complying with consistent guidelines can improve patient care, with early diagnosis of the pathology and its complications, reducing the rate of

关键词： Guidelines Gestational Trophoblastic Disease Treatment

Antimicrobial and Antioxidant Activity of Anacardium occidentale L. Flowers in Comparison to Bark and Leaves Extracts

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Journal of Biosciences and Medicines 2016年第4期4卷 87-99页

作者： Rubenice Amaral da Silva Silvana Amado Liberio Flavia M. M. do Amaral Flavia Raquel Fernandes do Nascimento Luce maria brandão Torres Valério Monteiro Neto Rosane Nassar Meireles Guerra Laboratory of Immunophysiology Universidade Federal do Maranhao Campus do Bacanga Sao Luis Brazil Instituto Botanico de Sao Paulo Sao Paulo Brazil Departament of Pathology Universidade Federal do Maranhao Sao Luis Brazil Universidade Ceuma Sao Luís Brazil

Anacardium occidentale L., Anacardiaceae, is frequently used to treat infections. We evaluated the antimicrobial and antioxidant activity of extracts obtained from aerial parts of the plant in comparison with the extract prepared with the flowers. Ethanol extracts of the leaves (EEL), stem bark (EEB), and flowers (EEF) were prepared separately. The antimicrobial activity was evaluated by agar diffusion and broth dilution methods. The minimum bactericidal and fungicidal concentrations were determined against: Streptococcus mutans, Lactobacillus acidophilus, Staphylococcus aureus, MRSA, Enterococcus faecalis, Streptococcus pyogenes, Pseudomonas aeruginosa, Proteus mirabilis, Escherichia coli, Klebsiella pneumoniae, Helicobacter pylori, Salmonella choleraesuis, Candida albicans, and Candida tropicalis. The antioxidant activity of the extracts was evaluated based on their scavenger capacity of 2,2-diphenyl-1-picrylhydrazyle. The phytochemical profile was analyzed by colorimetric methods and by HPLC with UV detection. All extracts exhibited antioxidant and antimicrobial activity. Although, the EEF was the most effective since it inhibited the growth of all 14 microorganisms tested. Anacardic and galic acids were identified in all extracts as well phenolic compounds, triterpenes, flavones and xanthones. In conclusion, the extracts obtained from the aerial parts of A. occidentale, mainly the extract of flowers that was the most effective, are rich in bioactive metabolites that exert a potent antioxidant and antimicrobial effect. Taken together, the results indicate an important biotechnological potential of A. occidentale as a source of compounds with broad-spectrum antimicrobial and of antioxidant activity to be used in the food and cosmetics industry.

关键词： Anacardium occidentale Antimicrobial Agents Flowers Cashew Caju Antioxidant

Creating the Foundation of a Healthcare Research Project

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Chinese Business Review 2013年第2期12卷 131-136页

作者： Bobeica Ana maria Academy of Economic Studies Bucharest Romania

The research topic of this paper develops a case study approach that builds on the foundations of Yin＇s ＂linear model＂ and ＂the best practice＂ used in theoretical case studies at international research literature. It discusses the case study method and its role and focusing on research questions like healthcare branding, research design, and methodic. Also presents the case study research theory for a research case study. The methods used in this paper are based on hypothesis of a generic hospital branding strategy for the Romanian Private Hospital and also may apply to the Romanian strategy of development of public healthcare entities and partnerships between public and private healthcare entities. An empirical test of the relationships among branding loyalty and awareness, customer satisfaction, trust and relationship commitment suggests that Romanian hospitals can be successful in creating an image and positive brand equity if they can manage their customer relationships well. This can be done through a coordinated strategy of management and marketing development of healthcare entities. The results highlight the dominance of case-study research in qualitative marketing healthcare and highlight the importance of customer relationships in the branding practice of healthcare marketing. It also shows that marketing managers can succeed in creating positive brand equity and image if they can manage relationships with their customers well.

关键词： healthcare marketing research case study branding in healthcare customer relationship brand equity healthcare research case study research quality of research quality management

Carotid body tumours resection with ultrasound dissector

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Chinese Medical Journal 2013年第3期126卷 586-588页

作者： Joana Ferreira Alexandra Canedo Sandrina Braga Jogo Vasconcelos Ricardo Gouveia Victor Martins Pedro brandāo António Vaz Vascular Surgery Department Hospital Vila Nova de Gaia/Espinho Santa Maria da Feira Portugal (Ferreira J Canedo A Braga S Vasconcelos J Gouveia R Martins V Brandǎo P and Vaz A)不详

Carotid body tumour （CBT） is a rare neoplasm arising from para^an^lion cells of the carotid body.1 Sureical resection of the CBT is considered the primary treatment option, and the only one which can allow a definitive cure.^1-3 The resection is particularly difficult because the tumour is adherent to the carotid adventitia, is highly vascularized, often involves the cranial nerves, and is in a limited field for exposure, consequently, the intervention is associated with high morbidity due to risk of nervous injuries, stroke, was well as hemorrhage shock.^1-3

关键词： carotid body tumour ultrasound dissector advantages

Nursing Diagnoses of the Domain Safety/Protection and Socioeconomic and Clinical Aspects of Critical Patients

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Open Journal of Nursing 2016年第4期6卷 314-322页

作者： Anna Lívia de Medeiros Dantas Ana Beatriz de Almeida Medeiros Jéssica de Araújo Olímpio Jéssica Dantas de Sá Tinôco maria Isabel da Conceição Dias Fernandes Ana Luísa brandão de Carvalho Lira Nursing Federal University of Rio Grande do Norte Natal Brasil The Nursing Department and Post-Graduate Nursing Program Federal University of Rio Grande do Norte Natal Brasil

Objective: The objective is to correlate the nursing diagnoses of the domain Safety/Protection of NANDA-I in critically ill patients with sociodemographic and clinical data. Method: A cross-sectional study with 86 individuals was conducted, from October 2013 to May 2014 in the Intensive Care Unit of a university hospital in northeastern Brazil, through a formal interview and physical examination. Results: It was possible to identify a total of 20 significant statistical associations, and 15 were clinically justified by the literature, namely: risk for aspiration and reason for admission;impaired dentition and age;risk for peripheral neurovascular dysfunction and sex and comorbidity;skin integrity and comorbidity;risk for impaired skin integrity and gender and reason for admission;impaired tissue integrity and gender and reason for admission;risk for perioperative positioning injury and reason for admission;risk for thermal injury and age and comorbidity;delayed surgical recovery and reason for admission;risk for poisoning and years of schooling;and risk for imbalanced body temperature and age. Conclusions: By understanding the relationship between customers’ answers and the sociodemographic and clinical profile, positive health outcomes can be achieved in particular in the prevention of risks facing vulnerability characteristics, providing greater safety and protection for the critical customer.

关键词： Nursing Diagnosis Patient Safety Intensive Care

Evaluation of the Coagulating Potential of the Crude Extract from the Barbatimão Bark for the Treatment of Dairy Effluents

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American Journal of Plant Sciences 2016年第13期7卷 1685-1692页

作者： Vanuzia Rodrigues Fernandes Ferreira Josefina Aparecida de Souza maria das Graças Cardoso Luiz Gustavo de Lima Guimarães Rafaela Magalhães brandão Rafaela Vieira Souza Luana Isac Soares Jéssica Oliveira e Nogueira Francielli D’Carlos Cravo David Lee Nelson Department of Chemistry Federal University of Lavras Lavras Brazil Federal University of Sao Joao Del Rei Sao Joao Del Rei Brasil Pro-Reitoria de Pesquisa e Pós-Graduacao Federal University of Vales de Jequitinhonha and Mucuri Diamantina Brazil

The coagulating potential of the crude extract from the barbatimao bark for the treatment of dairy effluent was assessed and compared with industrial coagulants such as aluminum sulfate (inorganic coagulant), the crude extract of black wattle bark (used in the manufacture of natural organic coagulants), and gallic acid (the main constituent of condensed tannins). The aqueous extract of barbatimao was obtained by refluxing for 12 h, and the black wattle was provided by a producer of natural coagulants. The determinations of total phenolic compounds and tannins in the extracts were performed by the Folin-Ciocalteu method and precipitation with casein, respectively. The treatment of the effluent with coagulant was performed by the Jar-Test. After testing, the effluent was evaluated for turbidity, total solids, and biochemical oxygen demand (BOD). A higher content of phenolic compounds (19.81% mg of gallic acid/g extract) was observed in the barbatimao extract than in the black wattle extract (14.24% mg of gallic acid/g extract). However, the extracts contained the same amount of tannins, 13.95% for the barbatimao extract and 12.89% for the black wattle extract. A 63%, reduction in BOD was observed for the effluent treated with barbatimao extract, 35% for the black wattle extract, 58% for gallic acid and 60.59% for the treatment with aluminum sulfate. Treatment with gallic acid caused a 98% reduction in the turbidity of the effluent;with aluminum sulfate, a 97% reduction was obtained;with barbatimao extract, 96%, and with black wattle extract, 93%. The barbatimao extract was shown to be a potential coagulant for dairy effluents.

关键词： Stryphnodendron adstringens Acacia mearnsii Tannins