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Brazilian biosafety law and the new breeding technologies

Frontiers of Agricultural Science and Engineering 2020年第2期7卷 204-210页

作者： Alexandre Lima NEPOMUCENO Renata FUGANTI-PAGLIARINI maria Sueli Soares FELIPE Hugo Bruno Correa MOLINARI Edivaldo Domingues VELINI Eduardo Romano de Campos PINTO maria lucia Zaidan DAGLI Galdino ANDRADE FILHO Patricia Machado Bueno FERNANDES Embrapa Soybean Londrina 86001970Brazil Catholic University of Brasilia Brasilia 70790160Brazil Embrapa Agroenergy Biological Station ParkBrasilia 70770901Brazil Paulista State University Julio de Mesquita Filho Botucatu Faculty of Agronomic SciencesBotucatu 18610307Brazil Embrapa Biotechnology and Genetic Resources—Biological Station Park Brasilia 70770900Brazil Sao Paulo University Veterinary FacultySao Paulo 05508900Brazil Londrina State University Microbiology DepartmentUniversity CampusLondrina 86051990Brazil Espirito Santo Federal University Biotechnology Post GraduationVitoria 29040090Brazil CTNBio(National Biosafety Technical Commission) Brasilia 70610200Brazil

Globally,the area of land cultivated with genetically modified(GM)crops has increased a thousand-fold over the last two *** this technology has become important for food production,the regulatory frameworks that underpin these outcomes are based on a list of requirements for a risk assessment that differ from country to *** recent years,policymakers have had the opportunity to learn from the controversies over transgenics to create effective regulatory milestones for emerging technologies,allowing them to reach their potential for a more sustainable agriculture,ensuring food *** Brazil,Law No.11.105 of 24 March 2005 established a framework with four main organizations responsible for risk assessment and ***,most of new breeding technologies did not exist at that time and were not considered in this ***2016,Normative Resolution No.16 of the National Biosafety Technical Commission(CTNBio)was established to address this gap based on the evaluation of the products obtained through these techniques(termed Innovative Precision Improvement Techniques in the resolution),in a case-by-case consultation ***,if the product is designated to be a GM,the developer will have to go through the biosafety requirements and will be approved only after CTNBio risk *** the product is designated not to be GM(for the purposes of the legislation),then it can be registered using the existing ***,152 GM products are commercially approved in *** 2018,CTNBio assessed the first consultation on commercial release of plants generated using the new breeding technologies and has subsequently approved six *** is expected that many institutions would be able to participate in Brazilian and world markets,developing and introducing new biotechnological solutions and products through a more sustainable approach and without facing public disapproval,a common issue for GM crops.

关键词： Brazilian legislation CTNBio genetically modified crops

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Liver transplantation in adults:Choosing the appropriate timing

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2012年第4期3卷 49-61页

作者： maria Siciliano lucia Parlati Federica Maldarelli Massimo Rossi Stefano Ginanni Corradini Department of Clinical Medicine Division of GastroenterologySapienza University of Rome00185 RomeItaly Department of General Surgery and Organ Transplantation "Paride Stefanini" Sapienza University of Rome00185 RomeItaly

Liver transplantation is indicated in patients with acute liver failure,decompensated cirrhosis,hepatocellular carcinoma and rare liver-based genetic defects that trigger damage of other *** referral to a transplant center is crucial in acute liver failure due to the high mortality with medical therapy and its unpredictable *** to a transplant center should be considered when at least one complication of cirrhosis occurs during its natural ***,because of the shortage of organ donors and the short-term mortality after liver transplantation on one hand and the possibility of managing the complications of cirrhosis with other treatments on the other,patients are carefully selected by the transplant center to ensure that transplantation is indicated and that there are no medical,surgical and psychological *** approved for transplantation are placed on the transplant waiting list and prioritized according to disease ***,the appropriate timing of transplantation depends on recipient disease severity and,although this is still a matter of debate,also on donor *** two variables are known to determine the "transplant benefit"(i.e.,when the expected patient survival is better with,than without,transplantation) and should guide donor allocation.

关键词： Liver transplantation Referral Waiting list Prioritization Allocation Timing Cirrhosis Hepatocellular carcinoma Indications Contraindications

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Localized amyloidosis of the stomach:A case report

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World Journal of Gastroenterology 2007年第12期13卷 1877-1878页

作者： Gianluca Rotondano Raffaele Salerno Fabio Cipolletta maria Antonia Bianco Antonino De Gregorio Raffaele Miele Antonio Prisco maria lucia Garofano Livio Cipolletta Division of Gastroenterology Hospital Maresca Torre del Greco Italy University of Naples School of Medicine Department of Gastroenterology Naples Italy Division of Pathology Hospital Maresca Torre del Greco Italy

We report an unusual case of primary amyloidosis of the stomach in a patient complaining of dyspeptic symptoms. The diagnosis was confirmed histologically and other gastrointestinal site or systemic involvement was ru... 详细信息

关键词： Amyloidosis Gastrointestinal tract Dyspepsia

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Clusia nemorosa的叶提取物通过肾上腺素系统依赖机制对大鼠的镇痛作用(英文)

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中国天然药物 2013年第4期11卷 385-390页

作者： Jamylle Nunes de Souza Ferro Juliane Pereira da Silva lucia maria Conserva Emiliano Barreto Laboratório de Biologia Celular Universidade Federal de AlagoasMaceió 57072-970ALBrazil Laboratório de Pesquisa em Química dos Produtos Naturais Universidade Federal de AlagoasMaceió 57072-970ALBrazil

Previous studies on the genus Clusia have shown anti-inflammatory and antiproliferative effects of the leaf extracts,but its antinociceptive activity has never been *** the present study,the antinociceptive activity of the hexane extract of the leaves of Clusia nemorosa ***,called HECn,was *** activity was evaluated using acetic acid-induced writhing,formalin,and hot-plate *** experiments were carried out on male Swiss *** extract(1 400 mg kg 1),given by intraperitoneal route(i.p.) 1 h prior to testing,produced a dose-dependent inhibition on the number of abdominal writhings,with an ID50 of 62 mg kg *** addition,HECn was able to prevent the visceral pain induced by acetic acid in mice for at least 2 *** the formalin test,HECn had no effect in the first phase,but produced an analgesic effect on the second phase with the inhibition of licking *** HECn did not show a significant analgesic effect in the hot plate *** with yohimbine attenuated the antinociceptive effect induced by HECn in the writhing ***,naloxone,atropine,or haloperidol did not affect antinociception induced by HECn in the writhing ***,these results indicate that the extract from the leaves of Clusia nemorosa produces antinociception in models of chemical pain through mechanisms that suggest participation of the adrenergic systems pathway.

关键词：实验药理学药理病理作用天然药物

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Dieulafoy Gastric Lesion: An Unusual Cause of Pediatric Hematemesis

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Open Journal of Pediatrics 2016年第1期6卷 120-123页

作者： Giulia maria Tronconi lucia Cococcioni maria Chiara Petrone Patrizia Corsin Martina Fomasi Pier Alberto Testoni Graziano Barera Department of Pediatrics San Raffaele Scientific Institute Vita-Salute San Raffaele University Milan Italy Gastroenterology and Gastrointestinal Endoscopy Unit San Raffaele Scientific Institute Vita-Salute San Raffaele University Milan Italy

Dieulafoy lesion is a vascular anomaly predominantly found in the stomach, which represents a rare cause of gastrointestinal bleeding and life-threatening haemorrhages in pediatric age with few cases reported in the literature. We experienced a 7-year-old previously healthy boy with hematemesis endoscopically diagnosed and successfully treated for a Dieulafoy lesion in the stomach. This case report illustrates the initial diagnostic workup and the possible differential diagnosis in presence of an acute episode of hematemesis in children. It focuses on an uncommon cause of gastrointestinal bleeding that is probably underestimated because of missing diagnosis. Any unusual and acute case of upper gastrointestinal bleeding should raise the suspicion of Dieulafoy lesion also in children, especially in those who have a past medical history negative for peptic disease and varices due to portal hypertension: a promptly endoscopy can provide visual diagnostic criteria and ensure an adequate hemostasis that is generally the definitive treatment of the lesion.

关键词： Dielafoy Lesion Hematemesis Pediatric Endoscopy

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Puerto Madero and Porto Maravilha： The Transformation Process of Port Areas into Tourist Zones

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Journal of Civil Engineering and Architecture 2017年第10期11卷 915-920页

作者： Antonio Colchete Filho Frederico Braida lucia maria Sa Antunes Costa Juliana Varejao Giese Graduate Program in Built Environment Federal University of Ju& de Fora Ju& de Fora 36036-900 Brazil Graduate Program in Urbanism Federal University of Rio de Janeiro Rio de Janeiro 21941-901 Brazil

Transformations in the use of urban space in contemporary cities have common features and projects in the global era take similar themes, such as requalifications of port areas and waterfronts. The main objective of this paper is to revisit the process of urban transformation and valorization of the port areas of Buenos Aires, Argentina, and Rio de Janeiro, Brazil, completed in 1990 and 2015, respectively. It recapitulates their historical processes from decay to recovery as tourist zones, following the implementation of the ＂Strategic Plan of Antiguo Puerto Madero＂, from 1990, in Buenos Aires, and of ＂Urban Operation Porto Maravilha＂, from 2009, in Rio de Janeiro. While planning and strategies differ as they sought distinct locations in different times, they were similar in attracting massive investment from the real estate market. Therefore, consequences of the projects for the cities and the local population are a more important issue than formal results achieved.

关键词： Urban design waterfront renewal Puerto Madero Buenos Aires Porto Maravilha Rio de Janeiro.

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Characterization Of Peripherical Blood And Tumor Infiltrating Lymphocytes In Cervical Carcinoma Patients By Flow Cytometry

Characterization Of Peripherical Blood And Tumor Infiltratin...

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24th International Papillomavirus Conference and Clinical Workshop

作者： maria Angelica Cespedes Ardila maria Mercedes Bravo Hernandez Susana Fiorentino Alba lucia Combita Rojas Instituto Nacional de Cancerologia Instituto Nacional de Cancerologia Pontificia Universidad Javeriana Instituto Nacional de Cancerologia

＜正＞Decreases of host immune function,alterations in frequencies of lymphocyte subsets and increase of regulatory T cells（T reg ）have been observed in patients with different types of *** cervical cancer,the changes of immune responses in tumor milieu,especially the composition of TILs,may have important implications in terms of the progression of *** characterize the tumor infiltrating lymphocytes and peripheral blood lymphocytes in patients with cervical cancer,we analyzed 39 peripheral

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Six-minute walking test performance is associated with survival in cirrhotic patients

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World Journal of Hepatology 2021年第11期13卷 1791-1801页

作者： Carolina Frade M G Pimentel Ana Cristina de Castro Amaral Adriano Miziara Gonzalez Michelle Lai Danielde Oliveira Mota maria lucia Gomes Ferraz Wilson Mathias Junior Mario Kondo Department of Medicine Federal University of Sao PauloSao Paulo 04026090Brazil Department of Gastroenterology Federal University of Sao PauloSao Paulo 04023062Brazil Department of Surgery Liver Transplantation ServiceFederal University of Sao PauloSao Paulo 04026090Brazil Department of Medicine Division of Gastroenterology and HepatologyBeth Israel Deaconess Medical CenterBostonMA 02215United States Department of Industrial Engineering University of Sao PauloSao Paulo 05508010Brazil Department of Cardiology Heart InstituteUniversity of Sao PauloSao Paulo 05403900Brazil

BACKGROUND Patients with cirrhosis are at risk of cirrhotic cardiomyopathy,with resulting cardiac dysfunction and exercise *** minute walking test(6MWT)assesses functional status and predicts morbidity and mortality in cardiopulmonary *** To determine if it associates with mortality by analyzing 6MWT performance in patients with liver *** A cohort of 106 cirrhotic patients was evaluated in the outpatient setting with echocardiogram and 6MWT and follow up for one year to document hepatic decompensation and *** distance in meters was recorded at the end of 6 min(6MWD).RESULTS This cohort had a mean age of 51 years and 56%male;patients were staged as Child A in 21.7%,B 66%and C 12.3%.Walk distance inversely correlated with Child scores,and was significantly reduced as Child stages *** who died(10.4%)showed shorter mean 6MWD(P=0.006).Low 6MWD was an independent predictor of mortality(P=0.01).CONCLUSION 6MWT is a noninvasive inexpensive test whose result is related to Child scores and *** is useful to identify patients with liver cirrhosis at high risk of mortality for closer monitoring and potential early intervention.

关键词： Six-minute walking test Liver cirrhosis Hospital admission and mortality Child score

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Evaluation of Endectocides and Conventional Acaricides in the Control of the <i>Boophilus microplus</i>on Field-Kept Dairy Cattle in the State of Pernambuco-Brazil

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Open Journal of Veterinary Medicine 2012年第3期2卷 124-128页

作者： Vania lucia Assis Santana maria Aparecida Da Gloria Faustino Erika Korinfsky Vanderley Marilene maria Lima Leucio Camara Alves Academic Unit of Serra Talhada Federal Rural University of Pernambuco Serra Talhada Brazil Department of Veterinary Medicine Federal Rural University of Pernambuco Recife Brazil Ministry of Agriculture Livestock and Food Supply National Laboratory of Animal and Plant Rua Dom Manoel de Medeiros Recife Brazil

The aim of the present study was to evaluate different acaricide treatments for the control of Boophilus microplus on field-kept dairy cattle in the state of Pernambuco, Brazil. The first phase of the experiment consisted of collecting the ingurgitated female Boophilus microplus directly from the hosts for attainment of larvae. After the attainment of larvae, the artificial infestation procedure began on the cattle, with larvae ages ranging from 7 to 14 days. On Day 0, animals were separated into 12 groups to receive the corresponding treatment: Abamectin;Ivermectin;Ivermectin LA;Amitraz;Amitraz + Ivermectin;Amitraz + Ivermectin LA;Amitraz + Abamectin;Association (Cypermethrin + Chlorpyrifos + Citronella);Association + Ivermectin;Association + Ivermectin LA;Association + Abamectin;and Control. Subsequent evaluations were made on post-treatment days +7, +14, +21, +28, +35, +42, +49, +56 and +63. Analyzing the post-treatment effectiveness per day, indices revealed considerable variation ranging from 0% to 96.63%. Such indices demonstrate the significant reduction in the number of ticks on the animals in some groups, especially in the Abamectin group. The analysis of the results demonstrates that the use of different avermectines can assist in the development of Boophilus microplus control programs, thereby reducing the number of acaricide applications and production costs related to ticks.

关键词： Boophilus microplus Tick Carrapaticide Efficiency Resistance

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Relationship between maternal pathology and infant social withdrawal: Analysis of a 268-outpatient population

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Open Journal of Psychiatry 2013年第3期3卷 311-315页

作者： maria lucia Maulucci Vincenzo Currò Silvia Maulucci Emilia de Rosa Livia De Giovanni Department of Neuroscience Catholic University Hospital Rome Italy Statistic Department Lumsa University Rome Italy

Objective: Sustained withdrawal is a sign of infant distress and may be determined by extreme conditions like organic pathology or relationship problems. The Alarm Distress Baby Scale is the best instrument to identify withdrawal in infants between 2 and 24 months of age. The aim of this study was to assess the association between infant social withdrawal behavior and maternal pathology in the perinatal period. Method: The target sample of the study was 134 mother-child couples examined at the Policlinico Agostino Gemelli General Pediatric Outpatient Clinic and Psychiatric Outpatient Clinic, in Rome. We analyzed the relationship between withdrawal behavior and psychological and organic prenatal/postnatal pathology, using the Chi Square exact test. Results: When the mother suffers from both organic and psychological pathologies in the perinatal period, the risk of withdrawal is increased: the probability of infant withdrawal behavior is increased by maternal organic postnatal pathology by 14 times, by maternal psychological postnatal pathology by 9 times, and by maternal psychological postnatal depression, measured by Edinburgh Postnatal Depression Scale, by almost 4 times. Conclusion: Increased or sustained withdrawal reactions can be observed in unsatisfactory mother-child interaction. Maternal risk factors should be strictly considered in the pediatric clinical evaluation.

关键词： Maternal Pathology Infant Social Withdrawal Early Prevention Alarm Distress Baby Scale

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